SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ix9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  10
LEU A  31
PHE A  34
LEU A  58
ARG A  61
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.76A 1ao8A-3ix9A:
23.2		 1ao8A-3ix9A:
32.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ALA A  10
LEU A  31
PHE A  34
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.95A 1ao8A-3ix9A:
23.2		 1ao8A-3ix9A:
32.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  10
LEU A  23
LEU A  31
PHE A  34
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 ( 4.5A)
 0.88A 1bzfA-3ix9A:
22.9		 1bzfA-3ix9A:
32.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  10
LEU A  31
PHE A  34
THR A  49
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.5A)
 0.84A 1bzfA-3ix9A:
22.9		 1bzfA-3ix9A:
32.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  10
PHE A  34
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.95A 1bzfA-3ix9A:
22.9		 1bzfA-3ix9A:
32.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
LEU A  23
PHE A  34
LYS A  35
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.87A 1cd2A-3ix9A:
20.4		 1cd2A-3ix9A:
25.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
LYS A  35
THR A  49
LEU A  58
ARG A  61
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.85A 1ddrA-3ix9A:
23.0		 1ddrA-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.65A 1ddrB-3ix9A:
23.5		 1ddrB-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		9 / 12 ILE A   8
ALA A  10
LEU A  31
LYS A  35
THR A  49
ARG A  56
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
None
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.85A 1ddsA-3ix9A:
23.4		 1ddsA-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  10
LEU A  31
ARG A  56
LEU A  58
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
None
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.96A 1ddsB-3ix9A:
23.8		 1ddsB-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  10
LEU A  31
LYS A  35
ARG A  56
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
None
MTX  A 200 ( 4.5A)
 0.76A 1ddsB-3ix9A:
23.8		 1ddsB-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A   8
ALA A  10
LEU A  31
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.68A 1ddsB-3ix9A:
23.8		 1ddsB-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A   8
ALA A  10
LEU A  31
LYS A  35
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.50A 1ddsB-3ix9A:
23.8		 1ddsB-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A   8
ALA A  10
PHE A  34
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.72A 1dhfA-3ix9A:
20.7		 1dhfA-3ix9A:
32.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
PHE A  34
THR A  49
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.73A 1dhfB-3ix9A:
20.9		 1dhfB-3ix9A:
32.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.66A 1dhiA-3ix9A:
23.4		 1dhiA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 11 ILE A   8
ALA A  10
LEU A  31
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.67A 1dhiB-3ix9A:
23.9		 1dhiB-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.66A 1dhjA-3ix9A:
23.6		 1dhjA-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
LEU A  31
LYS A  35
LEU A  58
PRO A  59
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.7A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.70A 1dhjB-3ix9A:
23.9		 1dhjB-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A   8
ALA A  10
GLU A  30
LEU A  58
ARG A  61
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.48A 1dlsA-3ix9A:
21.5		 1dlsA-3ix9A:
32.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
GLU A  30
LEU A  31
LYS A  35
LEU A  58
ARG A  61
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.63A 1draA-3ix9A:
23.9		 1draA-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
GLU A  30
LEU A  31
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.61A 1draB-3ix9A:
24.0		 1draB-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A 117
ALA A  10
GLU A  30
ILE A  43
THR A 119
 None
MTX  A 200 (-3.8A)
MTX  A 200 (-2.7A)
None
MTX  A 200 ( 4.5A)
 1.07A 1draB-3ix9A:
24.0		 1draB-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.70A 1drbA-3ix9A:
23.7		 1drbA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.69A 1drbB-3ix9A:
24.0		 1drbB-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  10
LEU A  31
LYS A  35
ARG A  56
LEU A  58
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
None
MTX  A 200 ( 4.0A)
 1.01A 1dreA-3ix9A:
24.9		 1dreA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ALA A  10
LEU A  31
PHE A  34
LYS A  35
LEU A  58
ARG A  61
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.54A 1dreA-3ix9A:
24.9		 1dreA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A   8
ALA A  10
LEU A  23
PHE A  34
LEU A  58
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 ( 4.0A)
 0.83A 1drfA-3ix9A:
21.5		 1drfA-3ix9A:
32.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  10
LEU A  31
LYS A  35
ARG A  56
LEU A  58
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
None
MTX  A 200 ( 4.0A)
 1.10A 1dyiA-3ix9A:
23.7		 1dyiA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  10
LEU A  31
LYS A  35
THR A  49
ARG A  56
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
None
 1.03A 1dyiA-3ix9A:
23.7		 1dyiA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.63A 1dyiA-3ix9A:
23.7		 1dyiA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
THR A  49
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.5A)
 0.53A 1dyiA-3ix9A:
23.7		 1dyiA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.64A 1dyiB-3ix9A:
23.9		 1dyiB-3ix9A:
35.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 11 ILE A   8
ALA A  10
LEU A  23
GLU A  30
PHE A  34
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-2.7A)
MTX  A 200 (-4.4A)
MTX  A 200 ( 4.5A)
 0.31A 1dyrA-3ix9A:
20.2		 1dyrA-3ix9A:
25.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  10
LEU A  31
LYS A  35
ARG A  56
LEU A  58
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
None
MTX  A 200 ( 4.0A)
 0.98A 1jolA-3ix9A:
23.7		 1jolA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.61A 1jolA-3ix9A:
23.7		 1jolA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
LEU A  58
PRO A  59
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.7A)
MTX  A 200 ( 4.5A)
 0.69A 1jolB-3ix9A:
23.8		 1jolB-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 11 ALA A  10
LEU A  31
PHE A  34
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.65A 1jomA-3ix9A:
23.1		 1jomA-3ix9A:
35.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ALA A  10
LEU A  23
LEU A  31
THR A  49
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.56A 1qzfA-3ix9A:
12.4		 1qzfA-3ix9A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ALA A  10
LEU A  23
LEU A  31
THR A  49
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.58A 1qzfB-3ix9A:
21.1		 1qzfB-3ix9A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ALA A  10
LEU A  23
LEU A  31
THR A  49
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.57A 1qzfC-3ix9A:
13.0		 1qzfC-3ix9A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ALA A  10
LEU A  23
LEU A  31
THR A  49
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.58A 1qzfD-3ix9A:
12.4		 1qzfD-3ix9A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ALA A  10
LEU A  23
LEU A  31
THR A  49
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.58A 1qzfE-3ix9A:
12.4		 1qzfE-3ix9A:
16.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.74A 1ra2A-3ix9A:
23.9		 1ra2A-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  10
LEU A  31
ARG A  56
LEU A  58
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
None
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.93A 1ra3A-3ix9A:
23.8		 1ra3A-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.57A 1ra3A-3ix9A:
23.8		 1ra3A-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  10
THR A  49
ARG A  56
LEU A  58
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 (-3.4A)
None
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.98A 1ra8A-3ix9A:
23.8		 1ra8A-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.67A 1ra8A-3ix9A:
23.8		 1ra8A-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.62A 1rb2A-3ix9A:
23.9		 1rb2A-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.64A 1rb2B-3ix9A:
23.8		 1rb2B-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A   8
ALA A  10
PHE A  34
LYS A  35
LEU A  58
ARG A  61
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.90A 1rb2B-3ix9A:
23.8		 1rb2B-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 10 ILE A   8
ALA A  10
LEU A  31
LYS A  35
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.37A 1rb3A-3ix9A:
24.0		 1rb3A-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.94A 1rb3B-3ix9A:
24.0		 1rb3B-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.66A 1rd7A-3ix9A:
23.4		 1rd7A-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
LYS A  35
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.64A 1rd7B-3ix9A:
23.3		 1rd7B-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
THR A  49
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.5A)
 0.49A 1re7A-3ix9A:
23.7		 1re7A-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
LEU A  58
PRO A  59
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.7A)
MTX  A 200 ( 4.5A)
 0.68A 1re7B-3ix9A:
23.3		 1re7B-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ALA A  10
LEU A  31
LYS A  35
THR A  49
LEU A  58
ARG A  61
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.80A 1rg7A-3ix9A:
22.8		 1rg7A-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A   8
LEU A  31
PHE A  34
LYS A  35
LEU A  58
ARG A  61
 MTX  A 200 (-4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.58A 1rh3A-3ix9A:
24.9		 1rh3A-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.71A 1rx2A-3ix9A:
25.5		 1rx2A-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LEU A  58
ARG A  61
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.69A 1rx3A-3ix9A:
25.4		 1rx3A-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
LYS A  35
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.65A 1rx7A-3ix9A:
23.3		 1rx7A-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.62A 1rx7A-3ix9A:
23.3		 1rx7A-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
LYS A  35
LEU A  58
PRO A  59
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.7A)
MTX  A 200 ( 4.5A)
 0.81A 1rx8A-3ix9A:
25.1		 1rx8A-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LEU A  58
PRO A  59
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.7A)
MTX  A 200 ( 4.5A)
 0.72A 1rx8A-3ix9A:
25.1		 1rx8A-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
LEU A  58
ARG A  61
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.72A 1tdrA-3ix9A:
23.7		 1tdrA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
THR A  49
ARG A  61
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 (-2.9A)
 0.67A 1tdrA-3ix9A:
23.7		 1tdrA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 10 ALA A  10
LEU A  31
LYS A  35
ARG A  56
LEU A  58
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
None
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.97A 1tdrB-3ix9A:
23.7		 1tdrB-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 10 ALA A  10
LEU A  31
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.68A 1tdrB-3ix9A:
23.7		 1tdrB-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A   8
ALA A  10
GLU A  30
LEU A  58
ARG A  61
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.50A 1u70A-3ix9A:
21.2		 1u70A-3ix9A:
32.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  10
LEU A  23
GLU A  30
ARG A  61
VAL A 100
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-2.7A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.0A)
 0.45A 1u72A-3ix9A:
21.4		 1u72A-3ix9A:
32.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  10
LEU A  23
GLU A  30
LEU A  58
ARG A  61
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.75A 1u72A-3ix9A:
21.4		 1u72A-3ix9A:
32.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A   8
ALA A  10
LEU A  23
PHE A  34
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 ( 4.5A)
 0.43A 2bl9A-3ix9A:
21.3		 2bl9A-3ix9A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  23
THR A  49
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.87A 2cd2A-3ix9A:
20.5		 2cd2A-3ix9A:
25.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LEU A  58
PRO A  59
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.7A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.82A 2d0kA-3ix9A:
23.4		 2d0kA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.63A 2d0kB-3ix9A:
23.5		 2d0kB-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
THR A  49
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.51A 2d0kB-3ix9A:
23.5		 2d0kB-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A   8
ALA A  10
LEU A  31
LYS A  35
LEU A  58
ARG A  61
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.62A 2drcA-3ix9A:
23.8		 2drcA-3ix9A:
34.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.64A 2drcB-3ix9A:
23.9		 2drcB-3ix9A:
34.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ALA A  10
LEU A  23
LEU A  31
PHE A  34
THR A  49
LEU A  58
ARG A  61
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.58A 2oipA-3ix9A:
21.8		 2oipA-3ix9A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ALA A  10
LEU A  23
LEU A  31
PHE A  34
THR A  49
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.55A 2oipB-3ix9A:
20.2		 2oipB-3ix9A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ALA A  10
LEU A  23
LEU A  31
PHE A  34
THR A  49
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.62A 2oipC-3ix9A:
21.6		 2oipC-3ix9A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ALA A  10
LEU A  23
LEU A  31
PHE A  34
THR A  49
LEU A  58
ARG A  61
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.57A 2oipD-3ix9A:
22.2		 2oipD-3ix9A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ALA A  10
LEU A  23
LEU A  31
PHE A  34
THR A  49
LEU A  58
ARG A  61
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.68A 2oipE-3ix9A:
21.4		 2oipE-3ix9A:
16.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  10
GLU A  30
LEU A  31
ARG A  56
LEU A  58
 MTX  A 200 (-3.8A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.1A)
None
MTX  A 200 ( 4.0A)
 0.96A 2qk8A-3ix9A:
25.7		 2qk8A-3ix9A:
37.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ALA A  10
GLU A  30
LEU A  31
LYS A  35
LEU A  58
PRO A  59
ARG A  61
 MTX  A 200 (-3.8A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.7A)
MTX  A 200 (-2.9A)
 0.49A 2qk8A-3ix9A:
25.7		 2qk8A-3ix9A:
37.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 11 ILE A   8
ALA A  10
GLU A  30
PHE A  34
THR A  49
VAL A 100
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-2.7A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.45A 2w3aA-3ix9A:
21.0		 2w3aA-3ix9A:
31.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 10 ILE A   8
ALA A  10
GLU A  30
PHE A  34
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-2.7A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.71A 2w3aB-3ix9A:
21.0		 2w3aB-3ix9A:
31.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  23
PHE A  34
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.80A 2w3bA-3ix9A:
20.6		 2w3bA-3ix9A:
31.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A   8
ALA A  10
LEU A  23
PHE A  34
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.70A 2w3bB-3ix9A:
20.7		 2w3bB-3ix9A:
31.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A   8
ALA A  10
LEU A  23
PHE A  34
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.69A 2w3mA-3ix9A:
21.0		 2w3mA-3ix9A:
31.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
LEU A  23
GLU A  30
PHE A  34
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-2.7A)
MTX  A 200 (-4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.67A 2w3mB-3ix9A:
21.1		 2w3mB-3ix9A:
31.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 TRP A   9
ALA A  10
LEU A  31
PHE A  34
THR A 119
 None
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 ( 4.5A)
 0.39A 2w3vA-3ix9A:
22.9		 2w3vA-3ix9A:
27.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 11 ILE A   8
ALA A  10
LEU A  23
LEU A  31
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.5A)
 0.30A 2w9sA-3ix9A:
25.1		 2w9sA-3ix9A:
34.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 11 ILE A   8
ALA A  10
LEU A  23
LEU A  31
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.5A)
 0.28A 2w9sB-3ix9A:
25.1		 2w9sB-3ix9A:
34.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 10 ILE A   8
ALA A  10
LEU A  23
LEU A  31
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.5A)
 0.47A 2w9sD-3ix9A:
24.4		 2w9sD-3ix9A:
34.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		4 / 8 ILE A   8
ALA A  10
LEU A  23
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.5A)
 0.48A 2w9sE-3ix9A:
24.4		 2w9sE-3ix9A:
34.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 10 ILE A   8
ALA A  10
LEU A  23
LEU A  31
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.5A)
 0.46A 2w9sF-3ix9A:
24.3		 2w9sF-3ix9A:
34.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 GLU A  30
LEU A  31
LYS A  35
ARG A  56
LEU A  58
 MTX  A 200 (-2.7A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
None
MTX  A 200 ( 4.0A)
 0.85A 2zzaA-3ix9A:
25.2		 2zzaA-3ix9A:
36.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
GLU A  30
LEU A  31
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.44A 2zzaA-3ix9A:
25.2		 2zzaA-3ix9A:
36.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 11 ILE A   8
ALA A  10
GLU A  30
LEU A  31
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.67A 2zzaB-3ix9A:
25.1		 2zzaB-3ix9A:
36.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A   8
LEU A  23
GLU A  30
LYS A  35
LEU A  58
ARG A  61
 MTX  A 200 (-4.1A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-2.7A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.61A 3cd2A-3ix9A:
20.3		 3cd2A-3ix9A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  10
THR A  49
LEU A  58
PRO A  59
ARG A  61
 MTX  A 200 (-3.8A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.7A)
MTX  A 200 (-2.9A)
 0.74A 3cl9A-3ix9A:
18.9		 3cl9A-3ix9A:
16.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  10
LEU A  23
GLU A  30
LEU A  31
GLN A  32
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.1A)
None
 1.01A 3datA-3ix9A:
25.6		 3datA-3ix9A:
37.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ALA A  10
LEU A  23
GLU A  30
LEU A  31
LEU A  58
ARG A  61
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.60A 3datA-3ix9A:
25.6		 3datA-3ix9A:
37.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A   8
ALA A  10
LEU A  31
LYS A  35
LEU A  58
ARG A  61
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.51A 3dauA-3ix9A:
25.4		 3dauA-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ALA A  10
LEU A  23
LEU A  31
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.36A 3dfrA-3ix9A:
25.6		 3dfrA-3ix9A:
32.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A   8
ALA A  10
LEU A  31
LYS A  35
LEU A  58
ARG A  61
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.65A 3drcA-3ix9A:
23.7		 3drcA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.62A 3drcB-3ix9A:
23.9		 3drcB-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A   8
ALA A  10
LEU A  23
GLU A  30
LEU A  58
ARG A  61
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.69A 3eigA-3ix9A:
20.7		 3eigA-3ix9A:
32.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ALA A  10
LEU A  23
GLU A  30
LEU A  31
LEU A  58
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.70A 3fl9B-3ix9A:
24.6		 3fl9B-3ix9A:
36.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 11 ALA A  10
GLU A  30
LEU A  31
LEU A  58
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.69A 3fl9C-3ix9A:
24.7		 3fl9C-3ix9A:
36.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 10 ALA A  10
LEU A  23
GLU A  30
LEU A  31
LEU A  58
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.71A 3fl9E-3ix9A:
24.6		 3fl9E-3ix9A:
36.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ALA A  10
LEU A  23
GLU A  30
LEU A  31
LEU A  58
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.69A 3fl9G-3ix9A:
24.6		 3fl9G-3ix9A:
36.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 9 ALA A  10
GLU A  30
LEU A  31
LEU A  58
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.68A 3fl9H-3ix9A:
24.6		 3fl9H-3ix9A:
36.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ALA A  10
LEU A  23
LEU A  31
PHE A  34
THR A  49
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.60A 3hj3A-3ix9A:
22.6		 3hj3A-3ix9A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ALA A  10
LEU A  23
LEU A  31
PHE A  34
THR A  49
LEU A  58
ARG A  61
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.65A 3hj3B-3ix9A:
22.5		 3hj3B-3ix9A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ALA A  10
LEU A  23
LEU A  31
PHE A  34
THR A  49
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.64A 3hj3C-3ix9A:
21.2		 3hj3C-3ix9A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ALA A  10
LEU A  23
LEU A  31
PHE A  34
THR A  49
LEU A  58
ARG A  61
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.60A 3hj3D-3ix9A:
18.1		 3hj3D-3ix9A:
16.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  10
GLU A  30
LEU A  31
ARG A  56
LEU A  58
 MTX  A 200 (-3.8A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.1A)
None
MTX  A 200 ( 4.0A)
 0.97A 3ia4A-3ix9A:
25.2		 3ia4A-3ix9A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ALA A  10
GLU A  30
LEU A  31
LYS A  35
LEU A  58
ARG A  61
 MTX  A 200 (-3.8A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.34A 3ia4A-3ix9A:
25.2		 3ia4A-3ix9A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  10
GLU A  30
LEU A  31
ARG A  56
LEU A  58
 MTX  A 200 (-3.8A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.1A)
None
MTX  A 200 ( 4.0A)
 0.94A 3ia4B-3ix9A:
25.2		 3ia4B-3ix9A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A   8
ALA A  10
GLU A  30
LEU A  31
GLN A  32
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.1A)
None
 0.93A 3ia4B-3ix9A:
25.2		 3ia4B-3ix9A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A   8
ALA A  10
GLU A  30
LEU A  31
LEU A  58
ARG A  61
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.27A 3ia4B-3ix9A:
25.2		 3ia4B-3ix9A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ALA A  10
GLU A  30
LEU A  31
PHE A  34
LYS A  35
LEU A  58
ARG A  61
 MTX  A 200 (-3.8A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.53A 3ia4C-3ix9A:
25.1		 3ia4C-3ix9A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
GLU A  30
LEU A  31
PHE A  34
LYS A  35
LEU A  58
ARG A  61
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.37A 3ia4D-3ix9A:
25.2		 3ia4D-3ix9A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 10 ALA A  10
GLU A  30
LEU A  31
LEU A  58
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.53A 3jw3A-3ix9A:
26.2		 3jw3A-3ix9A:
41.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 11 ALA A  10
LEU A  23
GLU A  30
LEU A  31
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.5A)
 0.45A 3jw5A-3ix9A:
26.1		 3jw5A-3ix9A:
42.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 10 ALA A  10
LEU A  23
GLU A  30
LEU A  31
LEU A  58
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.47A 3jw5B-3ix9A:
26.1		 3jw5B-3ix9A:
42.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 11 ILE A   8
ALA A  10
GLU A  30
PHE A  34
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-2.7A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.80A 3n0hA-3ix9A:
20.9		 3n0hA-3ix9A:
32.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 11 ILE A   8
ALA A  10
GLU A  30
PHE A  34
THR A  49
VAL A 100
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-2.7A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.51A 3n0hA-3ix9A:
20.9		 3n0hA-3ix9A:
32.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.60A 3ql0A-3ix9A:
25.2		 3ql0A-3ix9A:
35.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A   8
ALA A  10
LEU A  31
LYS A  35
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.62A 3ql3A-3ix9A:
25.6		 3ql3A-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
GLU A  30
PHE A  34
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-2.7A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.82A 3s3vA-3ix9A:
20.8		 3s3vA-3ix9A:
33.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
GLU A  30
PHE A  34
THR A  49
VAL A 100
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-2.7A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.50A 3s3vA-3ix9A:
20.8		 3s3vA-3ix9A:
33.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		4 / 5 THR A  38
ILE A  43
PHE A  34
LEU A  58
 None
None
MTX  A 200 (-4.4A)
MTX  A 200 ( 4.0A)
 1.47A 3tf1A-3ix9A:
undetectable		 3tf1A-3ix9A:
22.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 9 ILE A   8
ALA A  10
LEU A  23
PHE A  34
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 ( 4.5A)
 0.32A 3tq8A-3ix9A:
25.2		 3tq8A-3ix9A:
35.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
LEU A  23
LEU A  31
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.65A 3tq9A-3ix9A:
24.5		 3tq9A-3ix9A:
35.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 11 ALA A  10
LEU A  23
LEU A  31
LYS A  35
THR A  49
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.76A 3tqbA-3ix9A:
24.3		 3tqbA-3ix9A:
35.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
GLU A  30
PHE A  34
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-2.7A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.71A 4cd2A-3ix9A:
19.0		 4cd2A-3ix9A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
GLU A  30
PHE A  34
THR A  49
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-2.7A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.54A 4cd2A-3ix9A:
19.0		 4cd2A-3ix9A:
25.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ALA A  10
LEU A  31
LYS A  35
THR A  49
ARG A  56
LEU A  58
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
None
MTX  A 200 ( 4.0A)
 1.03A 4dfrA-3ix9A:
23.6		 4dfrA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
LYS A  35
THR A  49
LEU A  58
ARG A  61
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.78A 4dfrA-3ix9A:
23.6		 4dfrA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.69A 4dfrB-3ix9A:
23.9		 4dfrB-3ix9A:
35.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ALA A  10
LEU A  23
PHE A  34
MET A  53
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 ( 4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.99A 4eckA-3ix9A:
19.2		 4eckA-3ix9A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 VAL A 100
LEU A  23
PHE A  34
LEU A  58
ARG A  61
 MTX  A 200 ( 4.0A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 1.13A 4eckA-3ix9A:
19.2		 4eckA-3ix9A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ALA A  10
LEU A  23
PHE A  34
MET A  53
LEU A  58
ARG A  61
VAL A 100
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 ( 4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.99A 4eckB-3ix9A:
19.1		 4eckB-3ix9A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 VAL A 100
LEU A  23
PHE A  34
LEU A  58
ARG A  61
 MTX  A 200 ( 4.0A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 1.05A 4eckB-3ix9A:
19.1		 4eckB-3ix9A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 11 ALA A  10
MET A  53
LEU A  58
ARG A  61
VAL A 100
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.76A 4eilA-3ix9A:
20.5		 4eilA-3ix9A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 11 ALA A  10
MET A  53
ARG A  61
VAL A 100
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.4A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.56A 4eilC-3ix9A:
20.4		 4eilC-3ix9A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 11 ALA A  10
MET A  53
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.76A 4eilC-3ix9A:
20.4		 4eilC-3ix9A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 10 ALA A  10
MET A  53
ARG A  61
VAL A 100
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.4A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.45A 4eilD-3ix9A:
20.1		 4eilD-3ix9A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 11 ALA A  10
MET A  53
ARG A  61
VAL A 100
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.4A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.54A 4eilE-3ix9A:
21.0		 4eilE-3ix9A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 11 ALA A  10
MET A  53
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.74A 4eilE-3ix9A:
21.0		 4eilE-3ix9A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 9 ALA A  10
MET A  53
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.84A 4eilF-3ix9A:
20.1		 4eilF-3ix9A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 10 ALA A  10
MET A  53
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.77A 4eilG-3ix9A:
20.5		 4eilG-3ix9A:
15.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
THR A  49
LEU A  58
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
 0.75A 4ej1A-3ix9A:
22.9		 4ej1A-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.83A 4ej1B-3ix9A:
22.8		 4ej1B-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		9 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
THR A  49
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.66A 4fhbA-3ix9A:
23.8		 4fhbA-3ix9A:
35.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 10 ILE A   8
ALA A  10
LEU A  23
GLU A  30
PHE A  34
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-2.7A)
MTX  A 200 (-4.4A)
MTX  A 200 ( 4.5A)
 0.36A 4g8zX-3ix9A:
20.4		 4g8zX-3ix9A:
24.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A   8
ALA A  10
LEU A  31
LEU A  58
ARG A  61
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.64A 4gh8A-3ix9A:
24.6		 4gh8A-3ix9A:
34.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A   8
ALA A  10
LEU A  31
LYS A  35
ARG A  61
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 (-2.9A)
 0.30A 4gh8B-3ix9A:
24.3		 4gh8B-3ix9A:
34.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
LEU A  58
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
 0.67A 4i13A-3ix9A:
23.4		 4i13A-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
THR A  49
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
 0.43A 4i13A-3ix9A:
23.4		 4i13A-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 11 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.58A 4i1nA-3ix9A:
23.4		 4i1nA-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  23
PHE A  34
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.81A 4kebB-3ix9A:
20.9		 4kebB-3ix9A:
32.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  23
PHE A  34
LEU A  58
VAL A 100
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.70A 4kfjB-3ix9A:
21.1		 4kfjB-3ix9A:
32.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A   8
ALA A  10
PHE A  34
LYS A  35
THR A  49
LEU A  58
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
 0.67A 4kjjA-3ix9A:
24.2		 4kjjA-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A   8
ALA A  10
PHE A  34
LYS A  35
THR A  49
LEU A  58
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
 0.71A 4kjkA-3ix9A:
25.2		 4kjkA-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
PHE A  34
LYS A  35
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.52A 4kjlA-3ix9A:
24.9		 4kjlA-3ix9A:
35.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A   8
ALA A  10
PHE A  34
THR A  49
ARG A  56
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
None
MTX  A 200 ( 4.5A)
 0.99A 4kjlA-3ix9A:
24.9		 4kjlA-3ix9A:
35.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 10 ILE A   8
TRP A   9
ALA A  10
PHE A  34
THR A  49
THR A 119
 MTX  A 200 (-4.1A)
None
MTX  A 200 (-3.8A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.5A)
 0.43A 4km0A-3ix9A:
21.1		 4km0A-3ix9A:
35.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A   8
TRP A   9
ALA A  10
PHE A  34
THR A  49
THR A 119
 MTX  A 200 (-4.1A)
None
MTX  A 200 (-3.8A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.5A)
 0.40A 4km0B-3ix9A:
21.5		 4km0B-3ix9A:
35.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A   8
ALA A  10
PHE A  34
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.68A 4km2A-3ix9A:
21.7		 4km2A-3ix9A:
35.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A   8
ALA A  10
PHE A  34
THR A  49
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.5A)
 0.35A 4km2A-3ix9A:
21.7		 4km2A-3ix9A:
35.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A   8
ALA A  10
PHE A  34
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.68A 4km2B-3ix9A:
21.1		 4km2B-3ix9A:
35.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		3 / 3 GLY A  76
GLU A  62
THR A  63
 None
 0.52A 4kouA-3ix9A:
undetectable		 4kouA-3ix9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ALA A  10
LEU A  23
LEU A  31
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.57A 4ky8A-3ix9A:
14.9		 4ky8A-3ix9A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ALA A  10
LEU A  23
LEU A  31
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.54A 4ky8B-3ix9A:
16.0		 4ky8B-3ix9A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ALA A  10
LEU A  23
LEU A  31
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.59A 4ky8C-3ix9A:
22.2		 4ky8C-3ix9A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ALA A  10
LEU A  23
LEU A  31
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.53A 4ky8D-3ix9A:
18.6		 4ky8D-3ix9A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ALA A  10
LEU A  23
LEU A  31
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.61A 4ky8E-3ix9A:
22.1		 4ky8E-3ix9A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 11 ALA A  10
THR A  49
MET A  53
LEU A  58
ARG A  61
VAL A 100
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.75A 4kyaA-3ix9A:
20.5		 4kyaA-3ix9A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ALA A  10
MET A  53
LEU A  58
ARG A  61
VAL A 100
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.78A 4kyaB-3ix9A:
20.7		 4kyaB-3ix9A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 10 ALA A  10
MET A  53
LEU A  58
ARG A  61
VAL A 100
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.75A 4kyaC-3ix9A:
15.0		 4kyaC-3ix9A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ALA A  10
MET A  53
LEU A  58
ARG A  61
VAL A 100
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.81A 4kyaD-3ix9A:
13.5		 4kyaD-3ix9A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 11 ALA A  10
THR A  49
MET A  53
ARG A  61
VAL A 100
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.4A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.62A 4kyaE-3ix9A:
20.5		 4kyaE-3ix9A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 11 ALA A  10
THR A  49
MET A  53
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.76A 4kyaE-3ix9A:
20.5		 4kyaE-3ix9A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  10
MET A  53
ARG A  61
VAL A 100
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.4A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.53A 4kyaF-3ix9A:
13.3		 4kyaF-3ix9A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  10
MET A  53
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.83A 4kyaF-3ix9A:
13.3		 4kyaF-3ix9A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 11 ALA A  10
THR A  49
MET A  53
LEU A  58
ARG A  61
VAL A 100
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.77A 4kyaG-3ix9A:
20.5		 4kyaG-3ix9A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ALA A  10
MET A  53
LEU A  58
ARG A  61
VAL A 100
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.80A 4kyaH-3ix9A:
20.0		 4kyaH-3ix9A:
15.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  23
PHE A  34
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.75A 4m6kA-3ix9A:
21.5		 4m6kA-3ix9A:
31.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A  39
GLY A  46
THR A  38
MET A  53
THR A  49
 None
NDP  A 193 (-3.4A)
None
MTX  A 200 ( 4.4A)
NDP  A 193 (-3.4A)
 1.38A 4mubA-3ix9A:
undetectable		 4mubA-3ix9A:
20.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ALA A  10
LEU A  31
PHE A  34
LYS A  35
THR A  49
LEU A  58
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
 0.69A 4nx6A-3ix9A:
25.5		 4nx6A-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ALA A  10
LEU A  31
PHE A  34
LYS A  35
THR A  49
LEU A  58
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
 0.75A 4nx7A-3ix9A:
25.5		 4nx7A-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
PHE A  34
LYS A  35
THR A  49
LEU A  58
PRO A  59
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.7A)
 0.91A 4p3qA-3ix9A:
25.3		 4p3qA-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
THR A  49
LEU A  58
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
 0.67A 4p3rA-3ix9A:
25.5		 4p3rA-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 11 ILE A   8
ALA A  10
LEU A  31
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.62A 4p66A-3ix9A:
25.6		 4p66A-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 11 ILE A   8
PHE A  34
LYS A  35
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.37A 4p68A-3ix9A:
25.1		 4p68A-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
THR A  49
LEU A  58
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
 0.67A 4pssA-3ix9A:
undetectable		 4pssA-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ALA A  10
LEU A  31
PHE A  34
LYS A  35
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.58A 4pstA-3ix9A:
undetectable		 4pstA-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.58A 4psyA-3ix9A:
25.5		 4psyA-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LYS A  35
THR A  49
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.66A 4pthA-3ix9A:
25.3		 4pthA-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
THR A  49
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.42A 4ptjA-3ix9A:
25.4		 4ptjA-3ix9A:
35.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ALA A  10
LEU A  23
LEU A  31
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.62A 4q0dA-3ix9A:
22.2		 4q0dA-3ix9A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ALA A  10
LEU A  23
LEU A  31
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.62A 4q0dB-3ix9A:
22.2		 4q0dB-3ix9A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ALA A  10
LEU A  23
LEU A  31
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.62A 4q0dC-3ix9A:
22.1		 4q0dC-3ix9A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ALA A  10
LEU A  23
LEU A  31
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.63A 4q0dD-3ix9A:
22.2		 4q0dD-3ix9A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ALA A  10
LEU A  23
LEU A  31
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.62A 4q0dE-3ix9A:
22.2		 4q0dE-3ix9A:
16.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
LYS A  35
ARG A  56
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
None
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.90A 4qi9A-3ix9A:
22.2		 4qi9A-3ix9A:
33.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.59A 4qi9A-3ix9A:
22.2		 4qi9A-3ix9A:
33.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ALA A  10
LEU A  31
LYS A  35
ARG A  56
LEU A  58
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
None
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 1.00A 4qi9B-3ix9A:
22.8		 4qi9B-3ix9A:
33.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.65A 4qi9B-3ix9A:
22.8		 4qi9B-3ix9A:
33.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 11 ILE A   8
ALA A  10
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.67A 4qi9C-3ix9A:
22.0		 4qi9C-3ix9A:
33.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  10
LEU A  31
THR A  49
ARG A  56
LEU A  58
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
NDP  A 193 (-3.4A)
None
MTX  A 200 ( 4.0A)
 1.10A 4qleA-3ix9A:
24.0		 4qleA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.66A 4qleA-3ix9A:
24.0		 4qleA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 11 ILE A   8
ALA A  10
LEU A  31
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.55A 4qleB-3ix9A:
23.8		 4qleB-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 11 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.71A 4qlfA-3ix9A:
21.1		 4qlfA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.61A 4qlgA-3ix9A:
24.0		 4qlgA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		9 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
THR A  49
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.63A 4qlgB-3ix9A:
23.7		 4qlgB-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.59A 4rgcA-3ix9A:
25.6		 4rgcA-3ix9A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  10
LEU A  31
THR A  49
ARG A  56
LEU A  58
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
NDP  A 193 (-3.4A)
None
MTX  A 200 ( 4.0A)
 1.03A 4x5fA-3ix9A:
23.8		 4x5fA-3ix9A:
41.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
THR A  49
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.60A 4x5fA-3ix9A:
23.8		 4x5fA-3ix9A:
41.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
PHE A  34
LYS A  35
THR A  49
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.86A 4x5fA-3ix9A:
23.8		 4x5fA-3ix9A:
41.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  10
THR A  49
ARG A  56
LEU A  58
THR A 119
 MTX  A 200 (-3.8A)
NDP  A 193 (-3.4A)
None
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 1.00A 4x5fB-3ix9A:
24.1		 4x5fB-3ix9A:
41.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
THR A  49
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.59A 4x5fB-3ix9A:
24.1		 4x5fB-3ix9A:
41.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A   8
LEU A  31
PHE A  34
LYS A  35
THR A  49
ARG A  61
 MTX  A 200 (-4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 (-2.9A)
 0.97A 4x5fB-3ix9A:
24.1		 4x5fB-3ix9A:
41.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.65A 4x5gA-3ix9A:
23.7		 4x5gA-3ix9A:
41.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A   8
PHE A  34
LYS A  35
THR A  49
LEU A  58
 MTX  A 200 (-4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
 1.02A 4x5gA-3ix9A:
23.7		 4x5gA-3ix9A:
41.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
THR A  49
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.68A 4x5gB-3ix9A:
24.1		 4x5gB-3ix9A:
41.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.80A 4x5hA-3ix9A:
23.3		 4x5hA-3ix9A:
41.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A   8
LEU A  31
PHE A  34
LYS A  35
THR A  49
LEU A  58
 MTX  A 200 (-4.1A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
 1.05A 4x5hA-3ix9A:
23.3		 4x5hA-3ix9A:
41.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.87A 4x5iA-3ix9A:
23.0		 4x5iA-3ix9A:
41.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
THR A  49
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.5A)
 0.57A 4x5jA-3ix9A:
23.0		 4x5jA-3ix9A:
41.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
THR A  49
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.5A)
 0.52A 5e8qA-3ix9A:
23.5		 5e8qA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
THR A  49
ARG A  56
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
None
MTX  A 200 ( 4.5A)
 0.92A 5e8qA-3ix9A:
23.5		 5e8qA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.69A 5e8qB-3ix9A:
23.7		 5e8qB-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A   8
ALA A  10
LEU A  31
ARG A  56
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
None
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.99A 5eajA-3ix9A:
23.6		 5eajA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.59A 5eajA-3ix9A:
23.6		 5eajA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
THR A  49
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.5A)
 0.58A 5eajA-3ix9A:
23.6		 5eajA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 12 ILE A   8
ALA A  10
LEU A  31
THR A  49
ARG A  56
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
NDP  A 193 (-3.4A)
None
MTX  A 200 ( 4.5A)
 0.95A 5eajA-3ix9A:
23.6		 5eajA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
LEU A  58
PRO A  59
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.7A)
MTX  A 200 ( 4.5A)
 0.65A 5eajB-3ix9A:
23.8		 5eajB-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.72A 5eajB-3ix9A:
23.8		 5eajB-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  10
LEU A  31
LYS A  35
ARG A  56
LEU A  58
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
None
MTX  A 200 ( 4.0A)
 1.10A 5hi6A-3ix9A:
24.1		 5hi6A-3ix9A:
37.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.66A 5hi6A-3ix9A:
24.1		 5hi6A-3ix9A:
37.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
LYS A  35
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.66A 5hi6B-3ix9A:
23.8		 5hi6B-3ix9A:
37.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		4 / 8 ILE A   8
ALA A  10
LEU A  31
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.5A)
 0.32A 5uihA-3ix9A:
23.0		 5uihA-3ix9A:
21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
ARG A  56
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
None
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.95A 5ujxA-3ix9A:
23.5		 5ujxA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.58A 5ujxA-3ix9A:
23.5		 5ujxA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
THR A  49
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.5A)
 0.53A 5ujxA-3ix9A:
23.5		 5ujxA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
THR A  49
ARG A  56
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
None
MTX  A 200 ( 4.5A)
 0.93A 5ujxA-3ix9A:
23.5		 5ujxA-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		9 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
THR A  49
LEU A  58
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.68A 5ujxB-3ix9A:
23.7		 5ujxB-3ix9A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
THR A  49
ARG A  61
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.5A)
 0.38A 5z6fA-3ix9A:
25.5		 5z6fA-3ix9A:
41.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.60A 5z6jA-3ix9A:
25.6		 5z6jA-3ix9A:
41.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		8 / 12 ILE A   8
ALA A  10
LEU A  31
PHE A  34
LYS A  35
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.65A 5z6kA-3ix9A:
25.4		 5z6kA-3ix9A:
41.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		6 / 9 ILE A   8
ALA A  10
LEU A  31
LYS A  35
PRO A  59
ARG A  61
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.1A)
MTX  A 200 ( 4.7A)
MTX  A 200 (-2.9A)
 0.61A 5z6lA-3ix9A:
24.5		 5z6lA-3ix9A:
41.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 11 ALA A  10
LEU A  31
PHE A  34
LEU A  58
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.98A 5z6mA-3ix9A:
23.8		 5z6mA-3ix9A:
41.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 11 ILE A   8
ALA A  10
LEU A  31
PHE A  34
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 (-4.4A)
MTX  A 200 ( 4.5A)
 0.67A 5z6mA-3ix9A:
23.8		 5z6mA-3ix9A:
41.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 10 ALA A  10
HIS A  33
PHE A  34
THR A  49
MET A  53
VAL A 100
THR A 119
 MTX  A 200 (-3.8A)
None
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.58A 6aogA-3ix9A:
20.5		 6aogA-3ix9A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 10 ALA A  10
HIS A  33
PHE A  34
THR A  49
MET A  53
VAL A 100
THR A 119
 MTX  A 200 (-3.8A)
None
MTX  A 200 (-4.4A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.60A 6aogB-3ix9A:
20.5		 6aogB-3ix9A:
23.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ix9 DIHYDROFOLATE
REDUCTASE
(Streptococcus
pneumoniae) 		7 / 12 ILE A   8
ALA A  10
PHE A  34
LYS A  35
THR A  49
LEU A  58
THR A 119
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-4.4A)
MTX  A 200 (-4.1A)
NDP  A 193 (-3.4A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.59A 7dfrA-3ix9A:
25.2		 7dfrA-3ix9A:
35.26