SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ixc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 3ixc HEXAPEPTIDE
TRANSFERASE FAMILY
PROTEIN
(Anaplasma
phagocytophilum) 		4 / 8 ILE A  77
LEU A  89
MET A 102
GLY A 101
 None
 0.95A 1os6A-3ixcA:
undetectable		 1os6A-3ixcA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 3ixc HEXAPEPTIDE
TRANSFERASE FAMILY
PROTEIN
(Anaplasma
phagocytophilum) 		4 / 7 LEU A 135
GLY A 138
ARG A 139
PHE A  99
 None
 0.86A 2wq5A-3ixcA:
undetectable		 2wq5A-3ixcA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 3ixc HEXAPEPTIDE
TRANSFERASE FAMILY
PROTEIN
(Anaplasma
phagocytophilum) 		5 / 12 LEU A   5
SER A 166
VAL A  15
ILE A  27
THR A  43
 None
 1.38A 3frqA-3ixcA:
undetectable		 3frqA-3ixcA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 3ixc HEXAPEPTIDE
TRANSFERASE FAMILY
PROTEIN
(Anaplasma
phagocytophilum) 		4 / 7 ILE A  77
LEU A  89
MET A 102
GLY A 101
 None
 1.00A 4hajA-3ixcA:
undetectable		 4hajA-3ixcA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3ixc HEXAPEPTIDE
TRANSFERASE FAMILY
PROTEIN
(Anaplasma
phagocytophilum) 		5 / 10 GLY A 101
GLY A 121
SER A 104
ARG A 139
ILE A 105
 None
 1.05A 5aqfC-3ixcA:
undetectable		 5aqfC-3ixcA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3ixc HEXAPEPTIDE
TRANSFERASE FAMILY
PROTEIN
(Anaplasma
phagocytophilum) 		4 / 5 THR A  68
ALA A  91
THR A  75
HIS A  90
 None
None
None
MG  A 171 (-3.5A)
 1.38A 5ecmA-3ixcA:
undetectable		 5ecmA-3ixcA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 3ixc HEXAPEPTIDE
TRANSFERASE FAMILY
PROTEIN
(Anaplasma
phagocytophilum) 		4 / 6 SER A 166
GLY A  57
ASN A  36
ILE A  39
 None
 1.06A 5j4nA-3ixcA:
undetectable		 5j4nA-3ixcA:
19.51