SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ixl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3ixl ARYLMALONATE
DECARBOXYLASE
(Bordetella
bronchiseptica) 		4 / 6 LEU A 134
PHE A 137
ALA A 136
LEU A 122
 None
None
None
CME  A 148 ( 4.3A)
 0.77A 1ukbA-3ixlA:
undetectable		 1ukbA-3ixlA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 3ixl ARYLMALONATE
DECARBOXYLASE
(Bordetella
bronchiseptica) 		4 / 7 SER A  71
MET A  11
GLY A 189
ILE A 197
 None
None
PAC  A5000 (-3.7A)
None
 0.80A 2bdmA-3ixlA:
undetectable		 2bdmA-3ixlA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 3ixl ARYLMALONATE
DECARBOXYLASE
(Bordetella
bronchiseptica) 		5 / 12 GLY A 111
VAL A 208
LEU A 112
GLY A 234
ASP A 218
 None
 1.11A 2f8lA-3ixlA:
2.5		 2f8lA-3ixlA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3ixl ARYLMALONATE
DECARBOXYLASE
(Bordetella
bronchiseptica) 		3 / 3 LEU A  99
LEU A  72
MET A  73
 None
 0.76A 2itzA-3ixlA:
undetectable		 2itzA-3ixlA:
23.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)		 3ixl ARYLMALONATE
DECARBOXYLASE
(Bordetella
bronchiseptica) 		10 / 10 PRO A  14
CYH A  74
THR A  75
SER A  76
MET A 104
TYR A 126
VAL A 156
SER A 188
GLY A 189
GLY A 190
 PAC  A5000 (-4.2A)
PAC  A5000 (-3.5A)
PAC  A5000 (-3.8A)
PAC  A5000 (-2.6A)
PAC  A5000 ( 3.8A)
PAC  A5000 (-4.4A)
PAC  A5000 ( 4.1A)
PAC  A5000 (-3.7A)
PAC  A5000 (-3.7A)
PAC  A5000 (-3.4A)
 0.01A 3ixlA-3ixlA:
48.7		 3ixlA-3ixlA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 3ixl ARYLMALONATE
DECARBOXYLASE
(Bordetella
bronchiseptica) 		4 / 7 LEU A  40
LEU A  77
CYH A  74
THR A  90
 None
None
PAC  A5000 (-3.5A)
None
 1.04A 3lm8B-3ixlA:
undetectable
3lm8D-3ixlA:
4.0		 3lm8B-3ixlA:
21.65
3lm8D-3ixlA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 3ixl ARYLMALONATE
DECARBOXYLASE
(Bordetella
bronchiseptica) 		5 / 12 LEU A 112
LEU A 109
VAL A 108
SER A 105
VAL A 120
 None
 1.28A 3m7rA-3ixlA:
undetectable		 3m7rA-3ixlA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3ixl ARYLMALONATE
DECARBOXYLASE
(Bordetella
bronchiseptica) 		3 / 3 LEU A  99
MET A  93
ASP A  57
 None
 0.67A 3v5wA-3ixlA:
undetectable		 3v5wA-3ixlA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ixl ARYLMALONATE
DECARBOXYLASE
(Bordetella
bronchiseptica) 		5 / 12 VAL A 209
LEU A 236
LEU A 185
ALA A 107
LEU A 109
 None
 1.37A 4m11A-3ixlA:
undetectable		 4m11A-3ixlA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ixl ARYLMALONATE
DECARBOXYLASE
(Bordetella
bronchiseptica) 		5 / 12 VAL A 209
LEU A 236
LEU A 185
ALA A 107
LEU A 109
 None
 1.33A 4m11C-3ixlA:
undetectable		 4m11C-3ixlA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ixl ARYLMALONATE
DECARBOXYLASE
(Bordetella
bronchiseptica) 		5 / 8 SER A  76
LEU A  40
LEU A  38
VAL A  51
ILE A  52
 PAC  A5000 (-2.6A)
None
None
None
None
 1.20A 4oj4A-3ixlA:
undetectable		 4oj4A-3ixlA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ixl ARYLMALONATE
DECARBOXYLASE
(Bordetella
bronchiseptica) 		4 / 8 SER A 105
LEU A 138
LEU A 143
VAL A 120
 None
 0.91A 4oj4A-3ixlA:
undetectable		 4oj4A-3ixlA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 3ixl ARYLMALONATE
DECARBOXYLASE
(Bordetella
bronchiseptica) 		3 / 3 VAL A  20
ALA A  25
PHE A 216
 None
 0.90A 4olbA-3ixlA:
6.1		 4olbA-3ixlA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ixl ARYLMALONATE
DECARBOXYLASE
(Bordetella
bronchiseptica) 		5 / 12 LEU A 134
ALA A 135
PHE A 137
THR A 103
LEU A 109
 None
 0.95A 4pssA-3ixlA:
undetectable		 4pssA-3ixlA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3ixl ARYLMALONATE
DECARBOXYLASE
(Bordetella
bronchiseptica) 		3 / 3 VAL A  20
ALA A  25
PHE A 216
 None
 0.92A 4w5nA-3ixlA:
5.8		 4w5nA-3ixlA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ixl ARYLMALONATE
DECARBOXYLASE
(Bordetella
bronchiseptica) 		4 / 8 SER A  76
LEU A  40
LEU A  38
ILE A  52
 PAC  A5000 (-2.6A)
None
None
None
 0.95A 4xtaB-3ixlA:
undetectable		 4xtaB-3ixlA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ixl ARYLMALONATE
DECARBOXYLASE
(Bordetella
bronchiseptica) 		4 / 5 VAL A 168
ILE A  12
PRO A 213
THR A 106
 None
 1.18A 4ze1A-3ixlA:
undetectable		 4ze1A-3ixlA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3ixl ARYLMALONATE
DECARBOXYLASE
(Bordetella
bronchiseptica) 		5 / 12 ALA A 219
LEU A 222
ALA A  35
GLY A  10
PRO A 100
 None
 1.14A 5jglA-3ixlA:
2.3		 5jglA-3ixlA:
21.71