SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ixq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 3ixq RIBOSE-5-PHOSPHATE
ISOMERASE A
(Methanocaldococc
us
jannaschii) 		5 / 12 PHE A  82
GLY A  84
GLY A  29
ILE A  80
LEU A  17
 None
PGO  A 233 (-3.3A)
PGO  A 232 (-3.4A)
None
None
 1.01A 2hmyB-3ixqA:
undetectable		 2hmyB-3ixqA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 3ixq RIBOSE-5-PHOSPHATE
ISOMERASE A
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A 135
ARG A 149
VAL A 147
ALA A 158
 None
 0.71A 2nniA-3ixqA:
undetectable		 2nniA-3ixqA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 3ixq RIBOSE-5-PHOSPHATE
ISOMERASE A
(Methanocaldococc
us
jannaschii) 		4 / 6 ASP A 110
VAL A 109
PHE A 207
THR A  28
 None
None
None
CL  A 231 (-4.9A)
 1.12A 2q6oB-3ixqA:
undetectable		 2q6oB-3ixqA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3ixq RIBOSE-5-PHOSPHATE
ISOMERASE A
(Methanocaldococc
us
jannaschii) 		3 / 3 SER A  56
GLY A  27
GLY A  29
 None
None
PGO  A 232 (-3.4A)
 0.48A 3bogA-3ixqA:
undetectable
3bogC-3ixqA:
undetectable		 3bogA-3ixqA:
undetectable
3bogC-3ixqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 3ixq RIBOSE-5-PHOSPHATE
ISOMERASE A
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A 161
VAL A 202
THR A 104
 None
 0.79A 3cyxA-3ixqA:
undetectable		 3cyxA-3ixqA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 3ixq RIBOSE-5-PHOSPHATE
ISOMERASE A
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A 180
ILE A 178
GLU A 106
ASP A  86
PHE A 133
 None
None
CL  A 231 ( 3.0A)
PGO  A 233 (-3.4A)
None
 1.42A 4b9zA-3ixqA:
undetectable		 4b9zA-3ixqA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 3ixq RIBOSE-5-PHOSPHATE
ISOMERASE A
(Methanocaldococc
us
jannaschii) 		3 / 3 LYS A  12
LEU A   8
ALA A  11
 None
 0.69A 4ikiA-3ixqA:
undetectable		 4ikiA-3ixqA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 3ixq RIBOSE-5-PHOSPHATE
ISOMERASE A
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A 191
GLU A 192
ASN A 204
ILE A 135
 None
 0.71A 4ww7A-3ixqA:
undetectable		 4ww7A-3ixqA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3ixq RIBOSE-5-PHOSPHATE
ISOMERASE A
(Methanocaldococc
us
jannaschii) 		4 / 6 ARG A 161
PRO A 169
THR A 172
ILE A 178
 None
 1.35A 5ih0A-3ixqA:
undetectable		 5ih0A-3ixqA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3ixq RIBOSE-5-PHOSPHATE
ISOMERASE A
(Methanocaldococc
us
jannaschii) 		5 / 12 GLU A 138
GLY A 175
GLY A 101
PHE A  57
ILE A 178
 None
None
CL  A 231 (-4.4A)
None
None
 1.12A 5vooD-3ixqA:
2.2		 5vooD-3ixqA:
23.10