SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iy5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1H8S_A_AICA1000_1 (MUTANT AL2 6E7P9G)	3iy5	ANTIBODY FRAGMENT IGG2A (HEAVY CHAIN) ANTIBODY FRAGMENT IGG2A (LIGHT CHAIN) (Mus musculus)	6 / 12	TYR A 37 GLN A 90 TYR A 95 PHE A 99 VAL B 145 TRP B 219	None	0.81A	1h8sA-3iy5A: 20.0	1h8sA-3iy5A: 54.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G4L_A_ROFA901_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3iy5	ANTIBODY FRAGMENT IGG2A (LIGHT CHAIN) (Mus musculus)	3 / 3	ASP A 83 LEU A 105 GLN A 6	None	0.80A	3g4lA-3iy5A: undetectable	3g4lA-3iy5A: 14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7P_A_ACRA1421_1 (GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE)	3iy5	ANTIBODY FRAGMENT IGG2A (LIGHT CHAIN) (Mus musculus)	4 / 5	TYR A 88 TYR A 87 GLY A 102 GLY A 101	None	1.21A	5x7pA-3iy5A: 2.5	5x7pA-3iy5A: 6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C2M_A_SUEA1202_1 (NS3 PROTEASE)	3iy5	ANTIBODY FRAGMENT IGG2A (HEAVY CHAIN) (Mus musculus)	5 / 9	ARG B 146 ALA B 198 VAL B 227 SER B 228 ASP B 200	None	1.40A	6c2mA-3iy5B: undetectable	6c2mA-3iy5B: 22.41

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1H8S_A_AICA1000_1","MUTANT AL2 6E7P9G","3iy5","ANTIBODY FRAGMENT IGG2A (HEAVY CHAIN);ANTIBODY FRAGMENT IGG2A (LIGHT CHAIN)","Mus musculus",6,"TYR A  37;GLN A  90;TYR A  95;PHE A  99;VAL B 145;TRP B 219","None","0.81A","1h8sA-3iy5A:20.0","1h8sA-3iy5A:54.05"],["3G4L_A_ROFA901_1","CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D","3iy5","ANTIBODY FRAGMENT IGG2A (LIGHT CHAIN)","Mus musculus",3,"ASP A  83;LEU A 105;GLN A   6","None","0.80A","3g4lA-3iy5A:undetectable","3g4lA-3iy5A:14.25"],["5X7P_A_ACRA1421_1","GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE","3iy5","ANTIBODY FRAGMENT IGG2A (LIGHT CHAIN)","Mus musculus",4,"TYR A  88;TYR A  87;GLY A 102;GLY A 101","None","1.21A","5x7pA-3iy5A:2.5","5x7pA-3iy5A:6.77"],["6C2M_A_SUEA1202_1","NS3 PROTEASE","3iy5","ANTIBODY FRAGMENT IGG2A (HEAVY CHAIN)","Mus musculus",5,"ARG B 146;ALA B 198;VAL B 227;SER B 228;ASP B 200","None","1.40A","6c2mA-3iy5B:undetectable","6c2mA-3iy5B:22.41"]]