SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iy7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3iy7 FRAGMENT FROM
NEUTRALIZING
ANTIBODY F (HEAVY
CHAIN)
(Rattus
norvegicus) 		3 / 3 ARG B 164
ILE B 148
TRP B 147
 None
 1.13A 1m8eB-3iy7B:
undetectable		 1m8eB-3iy7B:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 3iy7 FRAGMENT FROM
NEUTRALIZING
ANTIBODY F (HEAVY
CHAIN)
(Rattus
norvegicus) 		3 / 3 ARG B 164
ILE B 148
TRP B 147
 None
 1.13A 1nodB-3iy7B:
undetectable		 1nodB-3iy7B:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 3iy7 FRAGMENT FROM
NEUTRALIZING
ANTIBODY F (HEAVY
CHAIN)
(Rattus
norvegicus) 		3 / 3 ARG B 164
ILE B 148
TRP B 147
 None
 1.09A 1qomA-3iy7B:
undetectable		 1qomA-3iy7B:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 3iy7 FRAGMENT FROM
NEUTRALIZING
ANTIBODY F (HEAVY
CHAIN)
(Rattus
norvegicus) 		3 / 3 ARG B 164
ILE B 148
TRP B 147
 None
 1.07A 2nodB-3iy7B:
undetectable		 2nodB-3iy7B:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3iy7 FRAGMENT FROM
NEUTRALIZING
ANTIBODY F (LIGHT
CHAIN)
(Rattus
norvegicus) 		5 / 12 GLY A  64
GLY A  62
LEU A  31
ILE A  73
LEU A  19
 None
 0.94A 2nxeB-3iy7A:
undetectable		 2nxeB-3iy7A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 3iy7 FRAGMENT FROM
NEUTRALIZING
ANTIBODY F (LIGHT
CHAIN)
(Rattus
norvegicus) 		5 / 6 LEU A  71
TYR A  84
ILE A  56
ILE A  73
ARG A  59
 None
 1.22A 2q8hA-3iy7A:
undetectable		 2q8hA-3iy7A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3iy7 FRAGMENT FROM
NEUTRALIZING
ANTIBODY F (HEAVY
CHAIN)
(Rattus
norvegicus) 		5 / 12 LEU B 180
ILE B 169
VAL B 218
HIS B 160
ARG B 138
 None
 1.28A 2qo4A-3iy7B:
undetectable		 2qo4A-3iy7B:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3iy7 FRAGMENT FROM
NEUTRALIZING
ANTIBODY F (HEAVY
CHAIN)
(Rattus
norvegicus) 		5 / 12 LEU B 180
ILE B 169
VAL B 218
HIS B 160
ARG B 138
 None
 1.30A 2qo6A-3iy7B:
undetectable		 2qo6A-3iy7B:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3iy7 FRAGMENT FROM
NEUTRALIZING
ANTIBODY F (HEAVY
CHAIN)
(Rattus
norvegicus) 		3 / 3 ARG B 164
ILE B 148
TRP B 147
 None
 1.09A 3e68A-3iy7B:
undetectable		 3e68A-3iy7B:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3iy7 FRAGMENT FROM
NEUTRALIZING
ANTIBODY F (HEAVY
CHAIN)
(Rattus
norvegicus) 		3 / 3 ARG B 164
ILE B 148
TRP B 147
 None
 1.11A 3e6tB-3iy7B:
undetectable		 3e6tB-3iy7B:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3iy7 FRAGMENT FROM
NEUTRALIZING
ANTIBODY F (HEAVY
CHAIN)
(Rattus
norvegicus) 		3 / 3 ARG B 164
ILE B 148
TRP B 147
 None
 0.97A 3nw2A-3iy7B:
undetectable		 3nw2A-3iy7B:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3iy7 FRAGMENT FROM
NEUTRALIZING
ANTIBODY F (HEAVY
CHAIN)
(Rattus
norvegicus) 		3 / 3 ARG B 164
ILE B 148
TRP B 147
 None
 1.08A 3nw2B-3iy7B:
undetectable		 3nw2B-3iy7B:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 3iy7 FRAGMENT FROM
NEUTRALIZING
ANTIBODY F (LIGHT
CHAIN)
(Rattus
norvegicus) 		4 / 6 GLY A  96
TYR A  84
ALA A  97
TYR A  85
 None
 0.98A 4ae1A-3iy7A:
2.8		 4ae1A-3iy7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 3iy7 FRAGMENT FROM
NEUTRALIZING
ANTIBODY F (HEAVY
CHAIN)
(Rattus
norvegicus) 		5 / 9 TYR B 193
THR B 190
LEU B 167
VAL B 112
VAL B 220
 None
 1.36A 4c9kB-3iy7B:
undetectable		 4c9kB-3iy7B:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3iy7 FRAGMENT FROM
NEUTRALIZING
ANTIBODY F (HEAVY
CHAIN)
(Rattus
norvegicus) 		4 / 7 GLY B 215
GLN B 214
TYR B 211
PHE B 194
 None
 1.08A 4ws0A-3iy7B:
undetectable		 4ws0A-3iy7B:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3iy7 FRAGMENT FROM
NEUTRALIZING
ANTIBODY F (HEAVY
CHAIN)
(Rattus
norvegicus) 		3 / 3 VAL B 210
SER B 198
TRP B 208
 None
 0.98A 5jwaA-3iy7B:
undetectable		 5jwaA-3iy7B:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 3iy7 FRAGMENT FROM
NEUTRALIZING
ANTIBODY F (HEAVY
CHAIN)
(Rattus
norvegicus) 		3 / 3 TYR B 203
PRO B 201
LEU B 200
 None
 0.90A 6beoA-3iy7B:
undetectable		 6beoA-3iy7B:
14.89