SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iyl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 3iyl VP1
(Aquareovirus
C) 		5 / 9 ILE W 131
LEU W  30
VAL W 117
GLY W 119
LEU W 138
 None
 1.10A 1e7aB-3iylW:
undetectable		 1e7aB-3iylW:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3iyl VP1
(Aquareovirus
C) 		5 / 11 LEU W  93
ALA W  92
LEU W  34
ILE W 131
LEU W 126
 None
 1.24A 1g50A-3iylW:
undetectable		 1g50A-3iylW:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 3iyl VP1
(Aquareovirus
C) 		5 / 9 LEU W 457
LEU W 644
ILE W 445
VAL W 631
PHE W 627
 None
 1.37A 1gx8A-3iylW:
undetectable		 1gx8A-3iylW:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 3iyl VP1
(Aquareovirus
C) 		4 / 8 VAL W 617
TYR W 579
ASP W 490
LEU W 510
 None
 1.24A 1pk2A-3iylW:
undetectable		 1pk2A-3iylW:
5.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 3iyl VP1
(Aquareovirus
C) 		5 / 12 ILE W 533
ASP W 495
PHE W 494
LEU W 577
ILE W 537
 None
 1.15A 1re7B-3iylW:
undetectable		 1re7B-3iylW:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3iyl VP1
(Aquareovirus
C) 		5 / 12 ALA W 731
LEU W 715
PHE W 720
LEU W 400
VAL W 736
 None
 1.25A 1u72A-3iylW:
undetectable		 1u72A-3iylW:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3iyl VP1
(Aquareovirus
C) 		4 / 6 LEU W 910
PHE W 913
ALA W 912
LEU W 973
 None
 0.97A 1ukbA-3iylW:
undetectable		 1ukbA-3iylW:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3iyl VP1
(Aquareovirus
C) 		5 / 12 GLY W 926
LEU W 931
LEU W 981
HIS W1027
LEU W 828
 None
 1.10A 1zgyA-3iylW:
undetectable		 1zgyA-3iylW:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3iyl VP1
(Aquareovirus
C) 		4 / 5 ASP W 490
GLY W 520
VAL W 532
ILE W 533
 None
 0.99A 2aoiA-3iylW:
undetectable		 2aoiA-3iylW:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 3iyl VP1
(Aquareovirus
C) 		4 / 8 TYR W 443
TYR W1160
HIS W1065
GLY W1106
 None
 1.12A 2ha4A-3iylW:
undetectable		 2ha4A-3iylW:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 3iyl VP1
(Aquareovirus
C) 		4 / 7 TYR W 443
TYR W1160
HIS W1065
GLY W1106
 None
 1.11A 2ha4B-3iylW:
undetectable		 2ha4B-3iylW:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 3iyl VP1
(Aquareovirus
C) 		4 / 4 LEU W 831
ILE W 819
ILE W 896
ALA W 895
 None
 0.82A 2i30A-3iylW:
undetectable		 2i30A-3iylW:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 3iyl VP1
(Aquareovirus
C) 		5 / 12 ASN W  66
LEU W  65
LEU W  34
LEU W  25
THR W 234
 None
 1.45A 2oaxF-3iylW:
undetectable		 2oaxF-3iylW:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3iyl VP1
(Aquareovirus
C) 		4 / 6 THR W 435
ARG W 480
THR W1015
ASP W 945
 None
 1.27A 2okcB-3iylW:
8.9		 2okcB-3iylW:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 3iyl VP1
(Aquareovirus
C) 		4 / 7 PRO W 548
ILE W 537
LEU W 534
ILE W 551
 None
 0.87A 2q83A-3iylW:
undetectable		 2q83A-3iylW:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3iyl VP1
(Aquareovirus
C) 		4 / 8 ILE W 178
TYR W  81
VAL W  58
TYR W  44
 None
 1.29A 2xz5A-3iylW:
undetectable
2xz5C-3iylW:
undetectable		 2xz5A-3iylW:
10.25
2xz5C-3iylW:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3iyl VP1
(Aquareovirus
C) 		4 / 8 ILE W 178
TYR W  81
VAL W  58
TYR W  44
 None
 1.27A 2xz5C-3iylW:
undetectable
2xz5D-3iylW:
undetectable		 2xz5C-3iylW:
10.25
2xz5D-3iylW:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3iyl VP1
(Aquareovirus
C) 		4 / 7 ILE W 178
TYR W  81
VAL W  58
TYR W  44
 None
 1.29A 2xz5D-3iylW:
undetectable
2xz5E-3iylW:
undetectable		 2xz5D-3iylW:
10.25
2xz5E-3iylW:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_B_ADNB502_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 3iyl VP1
(Aquareovirus
C) 		4 / 5 ASP W 136
PHE W 154
TYR W 156
VAL W 164
 None
 1.27A 2zbuB-3iylW:
1.0		 2zbuB-3iylW:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_0
(CATECHOL
O-METHYLTRANSFERASE)		 3iyl VP1
(Aquareovirus
C) 		5 / 12 VAL W 811
TYR W1019
TYR W 938
SER W 987
HIS W 989
 None
 1.24A 2zthA-3iylW:
7.1		 2zthA-3iylW:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3iyl VP1
(Aquareovirus
C) 		5 / 12 TYR W 556
PHE W 554
GLY W 520
VAL W 552
LEU W 564
 None
 0.96A 2zzmA-3iylW:
8.6		 2zzmA-3iylW:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3iyl VP1
(Aquareovirus
C) 		4 / 8 LEU W 774
SER W 866
THR W 408
ALA W 414
 None
 0.93A 3ax9A-3iylW:
undetectable		 3ax9A-3iylW:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3iyl VP1
(Aquareovirus
C) 		5 / 10 TYR W 556
PHE W 554
ALA W 521
VAL W 552
LEU W 564
 None
 1.10A 3ay0A-3iylW:
11.7		 3ay0A-3iylW:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3iyl VP1
(Aquareovirus
C) 		5 / 10 TYR W 556
PHE W 554
GLY W 520
VAL W 552
LEU W 564
 None
 1.00A 3ay0B-3iylW:
10.6		 3ay0B-3iylW:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 3iyl VP1
(Aquareovirus
C) 		5 / 11 VAL W  58
LEU W  47
SER W 189
PRO W 188
SER W 331
 None
 1.36A 3bjwE-3iylW:
undetectable		 3bjwE-3iylW:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_2
(PHOSPHOLIPASE A2)		 3iyl VP1
(Aquareovirus
C) 		4 / 4 PRO W 382
ASN W 380
PHE W 381
TRP W 349
 None
 1.46A 3bjwE-3iylW:
0.0		 3bjwE-3iylW:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3iyl VP1
(Aquareovirus
C) 		5 / 12 LEU W 657
VAL W 620
VAL W 655
LEU W 644
ILE W 445
 None
 1.10A 3gwxB-3iylW:
undetectable		 3gwxB-3iylW:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3iyl VP1
(Aquareovirus
C) 		3 / 3 LEU W 943
PRO W 944
LEU W 946
 None
 0.51A 3hcrA-3iylW:
2.2		 3hcrA-3iylW:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 3iyl VP1
(Aquareovirus
C) 		4 / 7 PHE W 381
PHE W 350
PHE W 365
SER W 363
 None
 1.34A 3hggA-3iylW:
undetectable		 3hggA-3iylW:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3iyl VP1
(Aquareovirus
C) 		4 / 8 THR W 171
GLY W 119
ALA W 121
ILE W 133
 None
 0.83A 3jusA-3iylW:
undetectable		 3jusA-3iylW:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3iyl VP1
(Aquareovirus
C) 		4 / 8 THR W 171
GLY W 119
ALA W 121
ILE W 133
 None
 0.83A 3jusA-3iylW:
undetectable		 3jusA-3iylW:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3iyl VP1
(Aquareovirus
C) 		4 / 8 LEU W1250
VAL W1271
VAL W1237
TYR W1287
 None
 0.96A 3v81C-3iylW:
undetectable		 3v81C-3iylW:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3iyl VP1
(Aquareovirus
C) 		5 / 12 VAL W1149
LEU W1196
VAL W1176
LEU W1192
VAL W1165
 None
 0.86A 3w68B-3iylW:
undetectable		 3w68B-3iylW:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3iyl VP1
(Aquareovirus
C) 		5 / 12 VAL W1149
LEU W1196
VAL W1176
LEU W1192
VAL W1165
 None
 0.99A 3w68D-3iylW:
undetectable		 3w68D-3iylW:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQE_B_DXCB1079_0
(PROTEIN PRGI, CELL
INVASION PROTEIN
SIPD)		 3iyl VP1
(Aquareovirus
C) 		5 / 11 PRO W 696
SER W 706
THR W 798
LEU W 799
TYR W 760
 None
 1.26A 3zqeA-3iylW:
0.0
3zqeB-3iylW:
0.0		 3zqeA-3iylW:
12.97
3zqeB-3iylW:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3iyl VP1
(Aquareovirus
C) 		4 / 6 ARG W 684
ILE W1002
VAL W 434
LEU W1008
 None
 1.06A 4em2A-3iylW:
undetectable		 4em2A-3iylW:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3iyl VP1
(Aquareovirus
C) 		4 / 6 PHE W 698
ILE W 695
PRO W 696
PHE W 697
 None
 1.07A 4fgkA-3iylW:
undetectable		 4fgkA-3iylW:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 3iyl VP1
(Aquareovirus
C) 		4 / 6 ARG W1175
GLY W1216
ASP W1209
GLY W1214
 None
 0.97A 4koeA-3iylW:
undetectable
4koeB-3iylW:
undetectable
4koeC-3iylW:
undetectable		 4koeA-3iylW:
16.30
4koeB-3iylW:
16.30
4koeC-3iylW:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3iyl VP1
(Aquareovirus
C) 		4 / 5 THR W1031
THR W1032
HIS W 989
ASN W 825
 None
 1.37A 4pgfB-3iylW:
3.6		 4pgfB-3iylW:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3iyl VP1
(Aquareovirus
C) 		4 / 8 LEU W1250
VAL W1271
VAL W1237
TYR W1287
 None
 0.98A 4puoC-3iylW:
undetectable		 4puoC-3iylW:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3iyl VP1
(Aquareovirus
C) 		4 / 8 LEU W1250
VAL W1271
VAL W1237
TYR W1287
 None
 1.01A 4pwdC-3iylW:
undetectable		 4pwdC-3iylW:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3iyl VP1
(Aquareovirus
C) 		4 / 8 LEU W1250
VAL W1271
VAL W1237
TYR W1287
 None
 0.85A 4q0bA-3iylW:
undetectable		 4q0bA-3iylW:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 3iyl VP1
(Aquareovirus
C) 		5 / 12 ILE W 842
PRO W 741
VAL W 740
VAL W 852
ILE W 846
 None
 0.87A 4q5mA-3iylW:
undetectable		 4q5mA-3iylW:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 3iyl VP1
(Aquareovirus
C) 		5 / 12 ASN W 502
VAL W 501
HIS W1193
LEU W1276
GLY W1150
 None
 1.30A 4qckA-3iylW:
undetectable		 4qckA-3iylW:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3iyl VP1
(Aquareovirus
C) 		4 / 5 TYR W 177
GLN W  60
ASP W 268
ASP W 286
 None
 1.35A 4qtuB-3iylW:
11.9		 4qtuB-3iylW:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 3iyl VP1
(Aquareovirus
C) 		3 / 3 PHE W1100
THR W 671
LEU W1104
 None
 0.78A 4qztA-3iylW:
undetectable		 4qztA-3iylW:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 3iyl VP1
(Aquareovirus
C) 		5 / 12 ALA W 498
SER W 499
ARG W1175
GLN W1162
GLY W1214
 None
 1.19A 4r29A-3iylW:
undetectable		 4r29A-3iylW:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3iyl VP1
(Aquareovirus
C) 		4 / 6 ASP W 184
THR W 190
THR W  57
TYR W 183
 None
 1.49A 4w5rA-3iylW:
2.5		 4w5rA-3iylW:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 3iyl VP1
(Aquareovirus
C) 		4 / 6 GLY W1216
ASP W1209
GLY W1214
ARG W1175
 None
 0.96A 4z53A-3iylW:
undetectable
4z53B-3iylW:
undetectable		 4z53A-3iylW:
19.89
4z53B-3iylW:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3iyl VP1
(Aquareovirus
C) 		5 / 12 LEU W 843
THR W 894
LEU W 831
HIS W 830
MET W 854
 None
 1.12A 4ze2A-3iylW:
undetectable		 4ze2A-3iylW:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3iyl VP1
(Aquareovirus
C) 		5 / 12 THR W 280
SER W  16
THR W  17
THR W 283
ASP W 231
 None
 1.48A 5d0xH-3iylW:
undetectable
5d0xI-3iylW:
undetectable		 5d0xH-3iylW:
11.27
5d0xI-3iylW:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3iyl VP1
(Aquareovirus
C) 		4 / 6 PHE W 632
ALA W 636
HIS W 638
LEU W 634
 None
 1.11A 5dzkB-3iylW:
undetectable
5dzkP-3iylW:
undetectable		 5dzkB-3iylW:
10.38
5dzkP-3iylW:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3iyl VP1
(Aquareovirus
C) 		4 / 6 PHE W 632
ALA W 636
HIS W 638
LEU W 634
 None
 1.28A 5dzkg-3iylW:
undetectable
5dzku-3iylW:
undetectable		 5dzkg-3iylW:
10.38
5dzku-3iylW:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3iyl VP1
(Aquareovirus
C) 		4 / 7 GLY W 123
SER W  69
GLY W 174
ALA W 120
 None
 0.89A 5e26C-3iylW:
undetectable
5e26D-3iylW:
undetectable		 5e26C-3iylW:
14.47
5e26D-3iylW:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 3iyl VP1
(Aquareovirus
C) 		5 / 12 ASP W1197
ILE W1226
GLY W1150
PRO W1139
ILE W1229
 None
 0.79A 5e5kA-3iylW:
undetectable		 5e5kA-3iylW:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3iyl VP1
(Aquareovirus
C) 		5 / 12 ILE W 695
GLY W 709
ILE W 710
ARG W 478
THR W 798
 None
 1.04A 5e72A-3iylW:
10.4		 5e72A-3iylW:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 3iyl VP1
(Aquareovirus
C) 		3 / 3 THR W 435
ALA W 804
ASN W1009
 None
 0.57A 5ersA-3iylW:
2.4		 5ersA-3iylW:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3iyl VP1
(Aquareovirus
C) 		5 / 12 LEU W 618
LEU W 566
ALA W 606
ILE W 537
TYR W 518
 None
 1.14A 5h8tA-3iylW:
undetectable		 5h8tA-3iylW:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 3iyl VP1
(Aquareovirus
C) 		5 / 12 ASP W1197
ILE W1226
GLY W1150
PRO W1139
ILE W1229
 None
 0.80A 5t8hA-3iylW:
undetectable		 5t8hA-3iylW:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 3iyl VP1
(Aquareovirus
C) 		5 / 8 THR W 610
GLY W 614
ALA W 612
GLY W 576
SER W 515
 None
 1.42A 5vw9A-3iylW:
4.4		 5vw9A-3iylW:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 3iyl VP1
(Aquareovirus
C) 		4 / 8 PRO W 454
ALA W 673
THR W 671
ALA W 636
 None
 0.94A 5x2tI-3iylW:
undetectable
5x2tJ-3iylW:
undetectable
5x2tK-3iylW:
undetectable
5x2tL-3iylW:
undetectable		 5x2tI-3iylW:
8.68
5x2tJ-3iylW:
7.43
5x2tK-3iylW:
8.68
5x2tL-3iylW:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 3iyl VP1
(Aquareovirus
C) 		4 / 4 VAL W1004
LEU W 708
LEU W 799
ASP W 702
 None
 1.48A 5xv7A-3iylW:
0.7		 5xv7A-3iylW:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 3iyl VP1
(Aquareovirus
C) 		4 / 8 ARG W 129
TRP W  68
PRO W 199
ILE W 178
 None
 1.06A 6a4iA-3iylW:
undetectable		 6a4iA-3iylW:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 3iyl VP1
(Aquareovirus
C) 		3 / 3 GLU W 343
ASP W 345
PRO W 346
 None
 0.65A 6berA-3iylW:
undetectable		 6berA-3iylW:
0.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 3iyl VP1
(Aquareovirus
C) 		5 / 10 LEU W  93
ALA W  92
LEU W  34
ILE W 131
LEU W 126
 None
 1.27A 6cbzB-3iylW:
undetectable		 6cbzB-3iylW:
5.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3iyl VP1
(Aquareovirus
C) 		4 / 8 ASP W 490
SER W 486
TYR W 518
GLY W 561
 None
 1.02A 6giqL-3iylW:
undetectable
6giqP-3iylW:
undetectable
6giqT-3iylW:
undetectable		 6giqL-3iylW:
16.32
6giqP-3iylW:
10.51
6giqT-3iylW:
3.77