SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3izk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		5 / 12 LEU A 482
LEU A 104
LEU A 105
ILE A  19
LEU A  97
 None
 1.25A 1g50B-3izkA:
undetectable		 1g50B-3izkA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		5 / 11 LEU A 482
LEU A 104
LEU A 105
ILE A  19
LEU A  97
 None
 1.26A 1g50C-3izkA:
undetectable		 1g50C-3izkA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		4 / 4 ALA A  76
ARG A  60
GLN A  79
GLU A  80
 None
 1.22A 1lqtB-3izkA:
undetectable		 1lqtB-3izkA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		4 / 4 ALA A  76
ARG A  60
GLN A  79
GLU A  80
 None
 1.22A 1lquB-3izkA:
undetectable		 1lquB-3izkA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		5 / 10 LEU A 309
ALA A 295
LEU A 228
LEU A 229
ILE A 275
 None
 1.23A 1pcgA-3izkA:
undetectable		 1pcgA-3izkA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		5 / 10 LEU A 482
LEU A 104
LEU A 105
ILE A  19
LEU A  97
 None
 1.28A 1pcgA-3izkA:
undetectable		 1pcgA-3izkA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		5 / 12 ALA A 474
ALA A  94
LYS A  77
ILE A  25
LEU A  59
 None
 0.98A 1rg7A-3izkA:
undetectable		 1rg7A-3izkA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		4 / 4 ALA A 408
VAL A  93
PHE A 405
THR A 478
 None
 1.07A 2pkkA-3izkA:
undetectable		 2pkkA-3izkA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		5 / 12 ILE A 226
PHE A 257
ASN A 254
ILE A 262
ILE A 233
 None
 1.13A 2rlcA-3izkA:
undetectable		 2rlcA-3izkA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		5 / 12 ALA A 295
LEU A 228
PHE A 257
VAL A 206
GLY A 205
 None
 0.87A 2ve3A-3izkA:
0.0		 2ve3A-3izkA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		4 / 7 ILE A  73
LEU A  72
VAL A  91
GLY A  55
 None
 0.76A 2wd9A-3izkA:
undetectable		 2wd9A-3izkA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		4 / 8 ILE A  73
LEU A  72
VAL A  91
GLY A  55
 None
 0.77A 2wd9B-3izkA:
2.3		 2wd9B-3izkA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		4 / 8 ALA A 417
ALA A 420
ILE A 427
HIS A 435
 None
 0.87A 3dtuC-3izkA:
undetectable
3dtuD-3izkA:
undetectable		 3dtuC-3izkA:
22.61
3dtuD-3izkA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		5 / 12 ASN A 419
THR A  32
VAL A  29
VAL A 447
LEU A 445
 None
 1.10A 3elzA-3izkA:
undetectable		 3elzA-3izkA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		5 / 12 ASN A 419
THR A  32
VAL A  29
VAL A 447
LEU A 445
 None
 1.12A 3elzC-3izkA:
undetectable		 3elzC-3izkA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		5 / 11 GLN A 472
LEU A 482
VAL A 114
ALA A 401
PHE A 405
 None
 1.37A 3n23C-3izkA:
undetectable		 3n23C-3izkA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		5 / 10 ASP A 357
VAL A 356
ILE A 189
VAL A 337
ILE A 168
 None
 1.00A 3oxwB-3izkA:
undetectable		 3oxwB-3izkA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		4 / 8 ASP A 454
ALA A 443
SER A 378
SER A 374
 None
 0.91A 3rodA-3izkA:
undetectable		 3rodA-3izkA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		5 / 11 THR A  89
VAL A  93
GLU A 462
LEU A 383
VAL A 381
 None
 1.05A 3tbgA-3izkA:
1.3		 3tbgA-3izkA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		5 / 11 THR A  89
VAL A  93
SER A 374
GLU A 462
LEU A 383
 None
 1.38A 3tbgA-3izkA:
1.3		 3tbgA-3izkA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		5 / 10 THR A  89
VAL A  93
GLU A 462
LEU A 383
VAL A 381
 None
 0.94A 3tbgC-3izkA:
1.2		 3tbgC-3izkA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		4 / 5 LEU A 164
ALA A 355
MET A 339
THR A 200
 None
 1.06A 3vasB-3izkA:
undetectable		 3vasB-3izkA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		3 / 3 PHE A 448
VAL A 431
ILE A 427
 None
 0.45A 4emaA-3izkA:
1.1		 4emaA-3izkA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_A_AZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		5 / 11 VAL A 315
VAL A 328
LEU A 289
THR A 293
ALA A 295
 None
 1.46A 4ygfA-3izkA:
undetectable		 4ygfA-3izkA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		4 / 8 ILE A 189
ILE A 167
ALA A 171
ILE A 168
 None
 0.74A 5mvmA-3izkA:
2.2
5mvmB-3izkA:
undetectable		 5mvmA-3izkA:
11.30
5mvmB-3izkA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		5 / 12 ALA A 470
ALA A 474
THR A 478
LEU A  98
LEU A  72
 None
 1.18A 6aybA-3izkA:
undetectable		 6aybA-3izkA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		4 / 4 LYS A 124
LEU A 128
ALA A 121
LEU A 383
 None
 1.40A 6gnrA-3izkA:
undetectable		 6gnrA-3izkA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		4 / 4 LYS A 124
LEU A 128
ALA A 121
LEU A 383
 None
 1.39A 6gnrB-3izkA:
undetectable		 6gnrB-3izkA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_0
(BETA-1 ADRENERGIC
RECEPTOR)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		5 / 12 VAL A 362
THR A  78
VAL A  75
SER A 477
VAL A 466
 None
 1.35A 6h7lA-3izkA:
undetectable		 6h7lA-3izkA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 3izk CHAPERONIN
(Methanococcus
maripaludis) 		5 / 12 VAL A 362
THR A  78
VAL A  75
SER A 477
VAL A 466
 None
 1.33A 6h7lB-3izkA:
1.4		 6h7lB-3izkA:
15.04