SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3j08'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		4 / 6 GLU A 255
THR A 226
ALA A 224
LEU A 222
 None
 1.24A 1etb2-3j08A:
undetectable		 1etb2-3j08A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		5 / 9 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 1.08A 1hpvB-3j08A:
undetectable		 1hpvB-3j08A:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		4 / 5 ASP A 438
LEU A 449
ALA A 531
LEU A 524
 None
 1.14A 1nh8A-3j08A:
undetectable		 1nh8A-3j08A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		4 / 4 THR A 428
GLY A 646
ASP A 647
ALA A 629
 None
 1.13A 1sg9A-3j08A:
2.9		 1sg9A-3j08A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_2
(PROTEASE RETROPEPSIN)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		5 / 11 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 0.83A 1t3rB-3j08A:
undetectable		 1t3rB-3j08A:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		3 / 3 ALA A 720
VAL A 718
TRP A 678
 None
 0.95A 1tkqA-3j08A:
undetectable		 1tkqA-3j08A:
2.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 420
LEU A 590
SER A 583
LEU A 429
VAL A 558
 None
 1.29A 1u72A-3j08A:
undetectable		 1u72A-3j08A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		5 / 12 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 0.82A 2ienB-3j08A:
undetectable		 2ienB-3j08A:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 631
ASP A 424
ILE A 571
GLY A 569
VAL A 568
 None
 1.20A 2o4lA-3j08A:
undetectable		 2o4lA-3j08A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		4 / 6 LEU A 521
ILE A 533
ILE A 455
LEU A 450
 None
 0.89A 2xkwB-3j08A:
undetectable		 2xkwB-3j08A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		4 / 7 ASP A 336
LYS A 328
GLU A 413
ASP A 410
 None
 0.89A 3bc9A-3j08A:
undetectable		 3bc9A-3j08A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		4 / 5 ASP A 424
ILE A 582
ILE A 571
GLY A 427
 None
 0.95A 3bufA-3j08A:
undetectable		 3bufA-3j08A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		5 / 9 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 0.89A 3ekvB-3j08A:
undetectable		 3ekvB-3j08A:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 420
LEU A 590
LEU A 607
ILE A 571
THR A 419
 None
 1.03A 3fl9G-3j08A:
undetectable		 3fl9G-3j08A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		3 / 3 GLU A 267
GLY A 299
THR A 298
 None
 0.53A 3iazA-3j08A:
undetectable		 3iazA-3j08A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_1
(GAG-POL POLYPROTEIN)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		5 / 12 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 0.87A 3jvyA-3j08A:
undetectable		 3jvyA-3j08A:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		5 / 12 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 0.87A 3lzuB-3j08A:
undetectable		 3lzuB-3j08A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NHX_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 193
PHE A 170
PHE A 114
VAL A 377
ALA A 712
 None
 1.44A 3nhxA-3j08A:
undetectable		 3nhxA-3j08A:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		5 / 8 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 0.90A 3nu9A-3j08A:
undetectable		 3nu9A-3j08A:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		5 / 10 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 0.96A 3nujA-3j08A:
undetectable		 3nujA-3j08A:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_1
(HIV-1 PROTEASE)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		5 / 11 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 0.93A 3oy4A-3j08A:
undetectable		 3oy4A-3j08A:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		5 / 10 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 1.08A 4dqcA-3j08A:
undetectable		 4dqcA-3j08A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		5 / 12 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 0.92A 4dqfA-3j08A:
undetectable		 4dqfA-3j08A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		4 / 8 ASP A 654
ASP A 653
VAL A 616
LEU A 561
 None
 1.01A 4f8hA-3j08A:
2.9
4f8hB-3j08A:
2.9		 4f8hA-3j08A:
20.15
4f8hB-3j08A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		4 / 8 ASP A 654
ASP A 653
VAL A 616
LEU A 561
 None
 1.06A 4f8hB-3j08A:
3.2
4f8hC-3j08A:
2.9		 4f8hB-3j08A:
20.15
4f8hC-3j08A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		4 / 8 ASP A 654
ASP A 653
VAL A 616
LEU A 561
 None
 1.03A 4f8hC-3j08A:
2.9
4f8hD-3j08A:
2.9		 4f8hC-3j08A:
20.15
4f8hD-3j08A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		4 / 8 ASP A 654
ASP A 653
VAL A 616
LEU A 561
 None
 1.02A 4f8hD-3j08A:
2.9
4f8hE-3j08A:
2.9		 4f8hD-3j08A:
20.15
4f8hE-3j08A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		4 / 8 VAL A 616
LEU A 561
ASP A 654
ASP A 653
 None
 1.05A 4f8hA-3j08A:
2.9
4f8hE-3j08A:
2.9		 4f8hA-3j08A:
20.15
4f8hE-3j08A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_A_LURA201_1
(TRANSTHYRETIN)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		4 / 4 LYS A 567
LEU A 590
ALA A 420
VAL A 612
 None
 1.43A 4ik6A-3j08A:
undetectable		 4ik6A-3j08A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		4 / 8 ASP A 260
VAL A 249
GLY A 246
ALA A 227
 None
 0.87A 4m48A-3j08A:
undetectable		 4m48A-3j08A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_ACTA605_0
(SERUM ALBUMIN)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		3 / 3 LYS A 218
LYS A 407
ALA A 642
 None
 1.24A 4ot2A-3j08A:
2.3		 4ot2A-3j08A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		5 / 10 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 0.89A 4q1wB-3j08A:
undetectable		 4q1wB-3j08A:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		5 / 11 SER A 460
ALA A 453
ASP A 574
THR A 572
GLY A 573
 None
 1.44A 4zjoD-3j08A:
undetectable		 4zjoD-3j08A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		3 / 3 GLY A 310
GLY A 309
GLN A 223
 None
 0.32A 5imsA-3j08A:
undetectable		 5imsA-3j08A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		4 / 5 GLY A 736
ASP A 737
ARG A 734
GLN A 663
 None
 1.06A 5zrfB-3j08A:
undetectable		 5zrfB-3j08A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		5 / 12 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 0.87A 6dgxB-3j08A:
undetectable		 6dgxB-3j08A:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		5 / 12 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 0.91A 6dh0B-3j08A:
undetectable		 6dh0B-3j08A:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 3j08 COPPER-EXPORTING
P-TYPE ATPASE A
(Archaeoglobus
fulgidus) 		4 / 8 GLY A 617
GLY A 632
LEU A 626
GLU A 644
 None
 0.88A 6mdqA-3j08A:
2.2		 6mdqA-3j08A:
9.14