SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3j0a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		4 / 7 VAL A 790
LEU A 697
LEU A 829
LEU A 832
 None
 0.86A 1cqpA-3j0aA:
4.4
1cqpB-3j0aA:
undetectable		 1cqpA-3j0aA:
13.10
1cqpB-3j0aA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		4 / 8 ASN A 206
LEU A 231
ALA A 255
LEU A 228
 None
 0.84A 1hwiB-3j0aA:
undetectable		 1hwiB-3j0aA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		4 / 8 ASN A 206
LEU A 231
ALA A 255
LEU A 228
 None
 0.83A 1hwiD-3j0aA:
undetectable		 1hwiD-3j0aA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		4 / 8 ASN A 206
LEU A 231
ALA A 255
LEU A 228
 None
 0.83A 1hwiC-3j0aA:
undetectable		 1hwiC-3j0aA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		5 / 12 LEU A 347
LEU A 348
GLY A 349
THR A 379
ILE A 375
 None
 1.22A 1p93A-3j0aA:
undetectable		 1p93A-3j0aA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		4 / 8 VAL A 755
ASP A 694
ASP A 681
LEU A 816
 None
 1.00A 1pk2A-3j0aA:
undetectable		 1pk2A-3j0aA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		4 / 6 LEU A 285
GLY A 284
ASN A 248
PHE A 246
 None
 0.81A 1xf1B-3j0aA:
undetectable		 1xf1B-3j0aA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		5 / 12 LEU A 533
LEU A 504
LEU A 480
LEU A 493
LEU A 517
 None
 1.16A 1zucB-3j0aA:
undetectable		 1zucB-3j0aA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		4 / 8 SER A 542
LEU A 504
LEU A 528
LEU A 525
 None
 0.99A 2bfpA-3j0aA:
undetectable		 2bfpA-3j0aA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		4 / 8 SER A 542
LEU A 504
LEU A 528
LEU A 525
 None
 0.97A 2bfpB-3j0aA:
undetectable		 2bfpB-3j0aA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		4 / 8 LEU A 507
HIS A 503
SER A 502
LEU A 531
 None
 1.10A 2q0iA-3j0aA:
undetectable		 2q0iA-3j0aA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		4 / 8 ALA A 205
LEU A 160
ILE A 175
PHE A 201
 None
 0.74A 2w9sE-3j0aA:
undetectable		 2w9sE-3j0aA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		5 / 12 LEU A 150
ILE A 157
PHE A 177
PHE A 201
VAL A 185
 None
 0.94A 2ygqA-3j0aA:
undetectable		 2ygqA-3j0aA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		4 / 6 LEU A 260
GLY A 235
LEU A 258
SER A 257
 None
 0.95A 3aiaA-3j0aA:
undetectable		 3aiaA-3j0aA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		5 / 12 GLY A 270
LEU A 303
VAL A 300
ILE A 264
LYS A 326
 None
 1.27A 3g9eA-3j0aA:
undetectable		 3g9eA-3j0aA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		5 / 12 LEU A 504
LEU A 507
ALA A 488
LEU A 517
THR A 539
 None
 1.20A 3gwuA-3j0aA:
undetectable		 3gwuA-3j0aA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		4 / 6 VAL A 362
LEU A 410
ILE A 372
LEU A 386
 None
 0.96A 3kk6A-3j0aA:
undetectable		 3kk6A-3j0aA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		3 / 3 PHE A 177
GLN A 181
PHE A 166
 None
 0.85A 3rv5A-3j0aA:
undetectable		 3rv5A-3j0aA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		4 / 4 LEU A 410
LEU A 396
GLN A 368
GLU A 432
 None
 1.17A 4i41A-3j0aA:
undetectable		 4i41A-3j0aA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		4 / 6 ASP A 390
ASP A 366
ALA A 320
TYR A 321
 None
None
FUC  A1343 (-3.3A)
None
 1.06A 4mdaA-3j0aA:
undetectable		 4mdaA-3j0aA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		4 / 6 ASP A 390
ASP A 366
ALA A 320
TYR A 321
 None
None
FUC  A1343 (-3.3A)
None
 1.06A 4mdbA-3j0aA:
undetectable		 4mdbA-3j0aA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		5 / 12 LEU A 410
LEU A 389
ILE A 421
ALA A 425
ILE A 402
 None
 0.98A 4o2bD-3j0aA:
undetectable		 4o2bD-3j0aA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		4 / 6 LEU A 621
THR A 589
LEU A 624
SER A 625
 None
 0.96A 4pwjA-3j0aA:
undetectable		 4pwjA-3j0aA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		5 / 12 LEU A 341
ILE A 372
ASN A 394
ASN A 370
LEU A 347
 None
 0.99A 4r3aB-3j0aA:
undetectable		 4r3aB-3j0aA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		5 / 11 LEU A 715
LEU A 727
LEU A 787
LEU A 816
LEU A 832
 None
 1.01A 4zowA-3j0aA:
undetectable		 4zowA-3j0aA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		4 / 5 TRP A 495
LEU A 478
PRO A 469
LEU A 531
 None
 1.36A 5eshA-3j0aA:
undetectable		 5eshA-3j0aA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		5 / 12 LEU A 389
HIS A 400
PHE A 380
ILE A 372
ALA A 373
 None
 1.44A 6qyaB-3j0aA:
undetectable		 6qyaB-3j0aA:
16.95