SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3j0k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3j0k DNA-DIRECTED RNA
POLYMERASES I, II,
AND III 23 KDA
POLYPEPTIDE
DNA-DIRECTED RNA
POLYMERASE II 19 KDA
POLYPEPTIDE
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ILE F 130
PRO F 131
GLU F 124
PHE G  18
 None
 1.38A 1oniA-3j0kF:
undetectable
1oniC-3j0kF:
undetectable		 1oniA-3j0kF:
20.28
1oniC-3j0kF:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 3j0k DNA-DIRECTED RNA
POLYMERASES I, II,
AND III 23 KDA
POLYPEPTIDE
(Homo
sapiens) 		5 / 12 GLU F 124
VAL F 109
LEU F 111
ARG F  97
ALA F  98
 None
 1.34A 2jj8C-3j0kF:
undetectable		 2jj8C-3j0kF:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 3j0k DNA-DIRECTED RNA
POLYMERASE II 19 KDA
POLYPEPTIDE
(Homo
sapiens) 		4 / 6 TYR G  74
ASN G  10
LEU G   9
LYS G  73
 None
 1.43A 3lslG-3j0kG:
undetectable		 3lslG-3j0kG:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 3j0k DNA-DIRECTED RNA
POLYMERASE II 19 KDA
POLYPEPTIDE
(Homo
sapiens) 		5 / 11 GLY G 169
ARG G 142
VAL G 145
PRO G 116
ILE G 137
 None
 1.25A 4j4vA-3j0kG:
undetectable		 4j4vA-3j0kG:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 3j0k DNA-DIRECTED RNA
POLYMERASE II 19 KDA
POLYPEPTIDE
(Homo
sapiens) 		4 / 8 TYR G  74
ILE G  56
ASP G  50
ASP G  52
 None
 0.84A 6ag0A-3j0kG:
undetectable		 6ag0A-3j0kG:
18.59