SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3j15'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3j15 PROTEIN PELOTA
(Pyrococcus
furiosus) 		4 / 7 ASP A  22
ALA A 127
ARG A 123
ASP A  21
 None
 1.26A 2e5dA-3j15A:
undetectable
2e5dB-3j15A:
undetectable		 2e5dA-3j15A:
21.85
2e5dB-3j15A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3j15 PROTEIN PELOTA
(Pyrococcus
furiosus) 		4 / 5 ALA A 321
ALA A 350
ALA A 282
VAL A 356
 None
 0.93A 2nyrB-3j15A:
undetectable		 2nyrB-3j15A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3j15 PROTEIN PELOTA
(Pyrococcus
furiosus) 		3 / 3 GLY A 238
ASP A 147
SER A 161
 None
 0.52A 3brfA-3j15A:
undetectable		 3brfA-3j15A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3j15 PROTEIN PELOTA
(Pyrococcus
furiosus) 		3 / 3 ARG A 152
GLU A  18
THR A  19
 None
 0.79A 3v4tA-3j15A:
undetectable		 3v4tA-3j15A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 3j15 PROTEIN PELOTA
(Pyrococcus
furiosus) 		5 / 12 LEU A 124
GLU A   6
VAL A  13
GLU A  18
GLY A 155
 None
 1.34A 4hvcB-3j15A:
undetectable		 4hvcB-3j15A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 3j15 PROTEIN PELOTA
(Pyrococcus
furiosus) 		5 / 12 GLY A 206
GLY A 208
ILE A 231
ARG A 248
ASP A 233
 None
 1.07A 4kicA-3j15A:
undetectable		 4kicA-3j15A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 3j15 PROTEIN PELOTA
(Pyrococcus
furiosus) 		5 / 12 GLY A 206
GLY A 208
ILE A 231
ARG A 248
ASP A 233
 None
 1.07A 4kicB-3j15A:
undetectable		 4kicB-3j15A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 3j15 PROTEIN PELOTA
(Pyrococcus
furiosus) 		5 / 12 LEU A 124
GLU A   6
VAL A  13
GLU A  18
GLY A 155
 None
 1.38A 4ydqA-3j15A:
undetectable		 4ydqA-3j15A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 3j15 PROTEIN PELOTA
(Pyrococcus
furiosus) 		5 / 12 LEU A 124
GLU A   6
VAL A  13
GLU A  18
GLY A 155
 None
 1.29A 5f9zA-3j15A:
undetectable		 5f9zA-3j15A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 3j15 PROTEIN PELOTA
(Pyrococcus
furiosus) 		5 / 12 LEU A 124
GLU A   6
VAL A  13
GLU A  18
GLY A 155
 None
 1.31A 5f9zB-3j15A:
undetectable		 5f9zB-3j15A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 3j15 PROTEIN PELOTA
(Pyrococcus
furiosus) 		5 / 12 LEU A 124
GLU A   6
VAL A  13
GLU A  18
GLY A 155
 None
 1.40A 6mn8A-3j15A:
undetectable		 6mn8A-3j15A:
21.85