SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3j2i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)		 3j2i PROLIFERATION-ASSOCI
ATED PROTEIN 2G4
(Homo
sapiens) 		5 / 12 ASP A  53
GLY A  52
VAL A 121
PRO A 277
ILE A  74
 None
 1.01A 1fb7A-3j2iA:
undetectable		 1fb7A-3j2iA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 3j2i PROLIFERATION-ASSOCI
ATED PROTEIN 2G4
(Homo
sapiens) 		3 / 3 TYR A  21
GLY A  24
PHE A 117
 None
 0.71A 2m2pB-3j2iA:
undetectable		 2m2pB-3j2iA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3j2i PROLIFERATION-ASSOCI
ATED PROTEIN 2G4
(Homo
sapiens) 		4 / 5 GLU A 183
PRO A 181
ILE A 182
GLY A 235
 None
 1.19A 2qeuA-3j2iA:
undetectable
2qeuC-3j2iA:
undetectable		 2qeuA-3j2iA:
16.97
2qeuC-3j2iA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 3j2i PROLIFERATION-ASSOCI
ATED PROTEIN 2G4
(Homo
sapiens) 		4 / 7 CYH A 296
PHE A 283
PHE A 278
PHE A 266
 None
 1.37A 3hggA-3j2iA:
undetectable		 3hggA-3j2iA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 3j2i PROLIFERATION-ASSOCI
ATED PROTEIN 2G4
(Homo
sapiens) 		3 / 3 GLU A  58
GLY A  61
THR A  60
 None
 0.55A 3iazA-3j2iA:
undetectable		 3iazA-3j2iA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 3j2i PROLIFERATION-ASSOCI
ATED PROTEIN 2G4
(Homo
sapiens) 		5 / 12 GLY A  24
ALA A 119
PHE A 117
ASP A 115
ASP A  26
 None
 1.13A 3nmuA-3j2iA:
undetectable
3nmuF-3j2iA:
undetectable		 3nmuA-3j2iA:
22.04
3nmuF-3j2iA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 3j2i PROLIFERATION-ASSOCI
ATED PROTEIN 2G4
(Homo
sapiens) 		5 / 12 SER A  47
ILE A  80
GLN A 318
ILE A 108
SER A  39
 None
 1.37A 4uroA-3j2iA:
undetectable		 4uroA-3j2iA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 3j2i PROLIFERATION-ASSOCI
ATED PROTEIN 2G4
(Homo
sapiens) 		5 / 12 ASP A  97
ARG A 281
ILE A  80
ILE A 108
SER A  39
 None
 1.34A 4uroB-3j2iA:
undetectable		 4uroB-3j2iA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 3j2i PROLIFERATION-ASSOCI
ATED PROTEIN 2G4
(Homo
sapiens) 		5 / 12 SER A  47
ILE A  80
GLN A 318
ILE A 108
SER A  39
 None
 1.38A 4uroB-3j2iA:
undetectable		 4uroB-3j2iA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 3j2i PROLIFERATION-ASSOCI
ATED PROTEIN 2G4
(Homo
sapiens) 		5 / 12 ASP A  97
ARG A 281
ILE A  80
ILE A 108
SER A  39
 None
 1.38A 4uroD-3j2iA:
undetectable		 4uroD-3j2iA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 3j2i PROLIFERATION-ASSOCI
ATED PROTEIN 2G4
(Homo
sapiens) 		3 / 3 ASN A 120
ASP A 196
GLY A 197
 None
 0.61A 5fctB-3j2iA:
undetectable		 5fctB-3j2iA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3j2i PROLIFERATION-ASSOCI
ATED PROTEIN 2G4
(Homo
sapiens) 		4 / 8 ILE A 182
GLY A 235
ASN A 171
PHE A 177
 None
 0.95A 5hieD-3j2iA:
undetectable		 5hieD-3j2iA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 3j2i PROLIFERATION-ASSOCI
ATED PROTEIN 2G4
(Homo
sapiens) 		4 / 8 VAL A 323
PHE A 218
LEU A 325
VAL A 166
 None
 0.83A 5nujA-3j2iA:
undetectable		 5nujA-3j2iA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 3j2i PROLIFERATION-ASSOCI
ATED PROTEIN 2G4
(Homo
sapiens) 		4 / 8 GLN A 242
TYR A 309
VAL A  45
ASP A  53
 None
 1.16A 5vlmF-3j2iA:
undetectable		 5vlmF-3j2iA:
17.87