SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3j2s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
5 / 12 LEU B1752
HIS B1755
ARG B1764
ARG B1705
GLY B1760
None
1.39A 1ia0B-3j2sB:
undetectable
1ia0B-3j2sB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 4 HIS B1954
CYH B2000
HIS B2005
MET B2010
None
0.68A 1oe1A-3j2sB:
19.3
1oe1A-3j2sB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 5 HIS B1954
CYH B2000
HIS B2005
MET B2010
None
0.65A 1oe2A-3j2sB:
11.3
1oe2A-3j2sB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 4 HIS B1954
CYH B2000
HIS B2005
MET B2010
None
0.64A 1oe3A-3j2sB:
19.6
1oe3A-3j2sB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 6 ARG B1764
ILE B1700
PRO B1761
GLU B1737
None
1.21A 1oniB-3j2sB:
undetectable
1oniC-3j2sB:
undetectable
1oniB-3j2sB:
13.18
1oniC-3j2sB:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 6 ILE B1700
PRO B1761
GLU B1737
ARG B1764
None
1.32A 1oniA-3j2sB:
undetectable
1oniC-3j2sB:
undetectable
1oniA-3j2sB:
13.18
1oniC-3j2sB:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_G_BEZG513_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 5 ARG B1764
ILE B1700
PRO B1761
GLU B1737
None
1.25A 1oniG-3j2sB:
undetectable
1oniH-3j2sB:
undetectable
1oniG-3j2sB:
13.18
1oniH-3j2sB:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 8 ASN B1922
TYR B1924
LEU B1759
GLY B1760
None
0.86A 1rukH-3j2sB:
undetectable
1rukL-3j2sB:
2.3
1rukH-3j2sB:
16.04
1rukL-3j2sB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
5 / 12 LEU B1752
HIS B1755
ARG B1764
ARG B1705
GLY B1760
None
1.39A 1tubB-3j2sB:
undetectable
1tubB-3j2sB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 6 ASP B1831
PHE B1830
THR B1964
GLU B1970
None
1.27A 2dttB-3j2sB:
undetectable
2dttC-3j2sB:
undetectable
2dttB-3j2sB:
11.77
2dttC-3j2sB:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQD_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 4 HIS B1954
CYH B2000
HIS B2005
MET B2010
None
0.68A 2fqdA-3j2sB:
17.3
2fqdA-3j2sB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 4 HIS B1954
CYH B2000
HIS B2005
MET B2010
None
0.66A 2fqeA-3j2sB:
17.3
2fqeA-3j2sB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQF_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 4 HIS B1954
CYH B2000
HIS B2005
MET B2010
None
0.66A 2fqfA-3j2sB:
17.3
2fqfA-3j2sB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQG_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 4 HIS B1954
CYH B2000
HIS B2005
MET B2010
None
0.66A 2fqgA-3j2sB:
17.3
2fqgA-3j2sB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
3 / 3 TRP B2219
GLN B2222
TRP B2271
None
1.14A 2vqyA-3j2sB:
1.1
2vqyA-3j2sB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
3 / 3 ARG B1997
GLU B1999
SER B1713
None
0.88A 2xctD-3j2sB:
undetectable
2xctD-3j2sB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1337_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 4 HIS B1954
CYH B2000
HIS B2005
MET B2010
None
0.60A 2xxgA-3j2sB:
19.5
2xxgA-3j2sB:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 5 HIS B1954
CYH B2000
HIS B2005
MET B2010
None
0.64A 2xxgC-3j2sB:
undetectable
2xxgC-3j2sB:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA601_0
(LACCASE-1)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 5 HIS B1954
CYH B2000
ILE B2002
HIS B2005
None
0.37A 3qpkA-3j2sB:
10.8
3qpkA-3j2sB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB601_0
(LACCASE-1)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
None
0.39A 3qpkB-3j2sB:
15.3
3qpkB-3j2sB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1001_0
(BLUE COPPER OXIDASE
CUEO)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 4 HIS B1954
CYH B2000
HIS B2005
MET B2010
None
0.66A 4ef3A-3j2sB:
17.2
4ef3A-3j2sB:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
3 / 3 VAL B1734
GLY B1850
LYS B1732
None
0.72A 4k50E-3j2sB:
undetectable
4k50E-3j2sB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA504_0
(LACCASE 2)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
None
0.38A 5mejA-3j2sB:
10.2
5mejA-3j2sB:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA504_0
(LACCASE 2)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
None
0.38A 5mewA-3j2sB:
10.2
5mewA-3j2sB:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA504_0
(LACCASE 2)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
None
0.38A 5mhuA-3j2sB:
10.1
5mhuA-3j2sB:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA504_0
(LACCASE 2)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
None
0.39A 5mhvA-3j2sB:
17.5
5mhvA-3j2sB:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA604_0
(LACCASE 2)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
None
0.38A 5mhwA-3j2sB:
17.5
5mhwA-3j2sB:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA604_0
(LACCASE 2)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
None
0.38A 5mhxA-3j2sB:
17.5
5mhxA-3j2sB:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA604_0
(LACCASE 2)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
None
0.38A 5mhyA-3j2sB:
10.2
5mhyA-3j2sB:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA604_0
(LACCASE 2)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
None
0.38A 5mhzA-3j2sB:
17.5
5mhzA-3j2sB:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA604_0
(LACCASE 2)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
None
0.37A 5mi1A-3j2sB:
10.1
5mi1A-3j2sB:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA604_0
(LACCASE 2)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
None
0.37A 5mi2A-3j2sB:
10.2
5mi2A-3j2sB:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA604_0
(LACCASE 2)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
None
0.38A 5miaA-3j2sB:
17.5
5miaA-3j2sB:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA604_0
(LACCASE 2)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
None
0.37A 5mibA-3j2sB:
17.5
5mibA-3j2sB:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA604_0
(LACCASE 2)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
None
0.38A 5micA-3j2sB:
17.5
5micA-3j2sB:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA604_0
(LACCASE 2)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
None
0.38A 5midA-3j2sB:
17.5
5midA-3j2sB:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA604_0
(LACCASE 2)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
None
0.38A 5mieA-3j2sB:
17.5
5mieA-3j2sB:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA604_0
(LACCASE 2)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
None
0.38A 5migA-3j2sB:
10.1
5migA-3j2sB:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 7 LEU B1945
ALA B1877
ILE B1921
LEU B1880
None
0.97A 5te8A-3j2sB:
undetectable
5te8A-3j2sB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 5 VAL B1933
PRO B2024
GLY B2026
TYR B2017
None
1.40A 5x80A-3j2sB:
undetectable
5x80B-3j2sB:
undetectable
5x80A-3j2sB:
13.71
5x80B-3j2sB:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
3 / 3 TYR B2105
ALA B2328
LEU B2302
None
0.77A 6d9kF-3j2sB:
undetectable
6d9kF-3j2sB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
5 / 11 PHE B2014
LEU B1932
GLY B1994
PHE B1876
ILE B1940
None
1.04A 6ebzC-3j2sB:
undetectable
6ebzC-3j2sB:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
5 / 11 PHE B2014
LEU B1932
GLY B1994
PHE B1876
ILE B1940
None
1.08A 6ebzD-3j2sB:
undetectable
6ebzD-3j2sB:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 5 LEU B2306
LEU B2178
THR B2237
ARG B2147
None
1.09A 6ew0F-3j2sB:
undetectable
6ew0F-3j2sB:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo
sapiens)
4 / 6 LEU B2306
LEU B2178
THR B2237
ARG B2147
None
1.09A 6ew0G-3j2sB:
undetectable
6ew0G-3j2sB:
8.43