SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3j2u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 3j2u KINESIN-LIKE PROTEIN
KLP10A
(Drosophila
melanogaster) 		4 / 4 SER K 503
ILE K 506
VAL K 416
THR K 404
 None
 1.25A 1u70A-3j2uK:
undetectable		 1u70A-3j2uK:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 3j2u KINESIN-LIKE PROTEIN
KLP10A
(Drosophila
melanogaster) 		5 / 12 PHE K 365
TYR K 367
ALA K 397
ALA K 349
TYR K 345
 None
 1.48A 2avdA-3j2uK:
undetectable		 2avdA-3j2uK:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 3j2u KINESIN-LIKE PROTEIN
KLP10A
(Drosophila
melanogaster) 		3 / 3 ARG K 286
ARG K 284
PRO K 287
 None
 1.04A 2wljA-3j2uK:
undetectable		 2wljA-3j2uK:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3j2u KINESIN-LIKE PROTEIN
KLP10A
(Drosophila
melanogaster) 		4 / 7 GLY K 360
THR K 355
ILE K 356
PHE K 512
 None
 0.81A 4acaC-3j2uK:
undetectable		 4acaC-3j2uK:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 3j2u KINESIN-LIKE PROTEIN
KLP10A
(Drosophila
melanogaster) 		3 / 3 ASP K 514
LEU K 432
VAL K 465
 None
 0.63A 4jecB-3j2uK:
undetectable		 4jecB-3j2uK:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA408_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 3j2u KINESIN-LIKE PROTEIN
KLP10A
(Drosophila
melanogaster) 		4 / 6 TYR K 345
THR K 348
PRO K 351
PHE K 512
 None
 1.36A 4kf9A-3j2uK:
undetectable		 4kf9A-3j2uK:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 3j2u KINESIN-LIKE PROTEIN
KLP10A
(Drosophila
melanogaster) 		5 / 12 ARG K 409
GLY K 359
ALA K 412
MET K 413
TYR K 410
 None
 1.26A 4r29A-3j2uK:
undetectable		 4r29A-3j2uK:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 3j2u KINESIN-LIKE PROTEIN
KLP10A
(Drosophila
melanogaster) 		5 / 12 LEU K 352
ILE K 549
ILE K 279
VAL K 281
VAL K 283
 None
 1.24A 4y0pA-3j2uK:
undetectable		 4y0pA-3j2uK:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3j2u KINESIN-LIKE PROTEIN
KLP10A
(Drosophila
melanogaster) 		5 / 12 TYR K 367
SER K 511
ALA K 397
ALA K 349
TYR K 345
 None
 1.40A 4ymgA-3j2uK:
undetectable		 4ymgA-3j2uK:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3j2u KINESIN-LIKE PROTEIN
KLP10A
(Drosophila
melanogaster) 		5 / 12 TYR K 367
SER K 511
ALA K 397
ALA K 349
TYR K 345
 None
 1.38A 4ymgB-3j2uK:
undetectable		 4ymgB-3j2uK:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJQ_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3j2u KINESIN-LIKE PROTEIN
KLP10A
(Drosophila
melanogaster) 		5 / 11 SER K 488
LEU K 591
GLU K 292
ASN K 518
GLY K 373
 None
 1.37A 4zjqA-3j2uK:
0.0		 4zjqA-3j2uK:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3j2u KINESIN-LIKE PROTEIN
KLP10A
(Drosophila
melanogaster) 		5 / 12 ALA K 585
GLY K 371
ASP K 605
ALA K 604
PHE K 331
 None
 1.32A 5zvgA-3j2uK:
undetectable		 5zvgA-3j2uK:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3j2u KINESIN-LIKE PROTEIN
KLP10A
(Drosophila
melanogaster) 		5 / 12 ALA K 585
GLY K 373
ASP K 605
ALA K 604
PHE K 331
 None
 1.25A 5zvgA-3j2uK:
undetectable		 5zvgA-3j2uK:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3j2u KINESIN-LIKE PROTEIN
KLP10A
(Drosophila
melanogaster) 		5 / 12 ALA K 585
GLY K 371
ASP K 605
ALA K 604
PHE K 331
 None
 1.35A 5zvgB-3j2uK:
undetectable		 5zvgB-3j2uK:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3j2u KINESIN-LIKE PROTEIN
KLP10A
(Drosophila
melanogaster) 		5 / 12 ALA K 585
GLY K 373
ASP K 605
ALA K 604
PHE K 331
 None
 1.26A 5zvgB-3j2uK:
undetectable		 5zvgB-3j2uK:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 3j2u KINESIN-LIKE PROTEIN
KLP10A
(Drosophila
melanogaster) 		3 / 3 SER K 478
SER K 487
ALA K 483
 None
 0.65A 6dwnC-3j2uK:
undetectable		 6dwnC-3j2uK:
11.75