SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3j47'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 3j47 26S PROTEASOME
REGULATORY SUBUNIT
RPN8
(Saccharomyces
cerevisiae) 		3 / 3 GLU U 272
ILE U 276
ARG U 189
 None
 0.84A 1cd2A-3j47U:
undetectable		 1cd2A-3j47U:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 3j47 26S PROTEASOME
REGULATORY SUBUNIT
RPN6
26S PROTEASOME
REGULATORY SUBUNIT
RPN8
(Saccharomyces
cerevisiae) 		4 / 6 ASN Q 420
ILE U 286
ILE U 285
VAL U 282
 None
 0.93A 4olmA-3j47Q:
undetectable		 4olmA-3j47Q:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 3j47 26S PROTEASOME
REGULATORY SUBUNIT
RPN11
26S PROTEASOME
REGULATORY SUBUNIT
RPN3
(Saccharomyces
cerevisiae) 		4 / 5 LEU V 288
ALA S 468
ASN S 469
ILE S 465
 None
 1.16A 4y03B-3j47V:
2.9		 4y03B-3j47V:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3j47 26S PROTEASOME
REGULATORY SUBUNIT
RPN3
26S PROTEASOME
REGULATORY SUBUNIT
RPN8
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 ILE U 286
HIS S 472
LEU S 471
ALA S 468
 None
 0.81A 5hrqE-3j47U:
undetectable
5hrqF-3j47U:
undetectable
5hrqJ-3j47U:
undetectable		 5hrqE-3j47U:
12.00
5hrqF-3j47U:
20.73
5hrqJ-3j47U:
20.73