SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3j4j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3j4j TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		4 / 8 SER A 254
ASN A 265
ILE A 251
GLY A 410
 None
 0.80A 1meiA-3j4jA:
undetectable		 1meiA-3j4jA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 3j4j TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		4 / 6 TYR A 206
GLU A 190
PRO A 189
VAL A 212
 None
 1.43A 1q13A-3j4jA:
undetectable		 1q13A-3j4jA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 3j4j TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		4 / 4 ASP A  25
LEU A  20
LEU A  23
LEU A  21
 None
 1.31A 1u18A-3j4jA:
undetectable		 1u18A-3j4jA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 3j4j TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 GLY A 111
VAL A 250
ALA A 307
ASP A 126
ALA A 112
 None
 1.35A 2avdB-3j4jA:
undetectable		 2avdB-3j4jA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 3j4j TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		3 / 3 TYR A  92
VAL A 223
THR A 219
 None
 0.90A 2ygnA-3j4jA:
undetectable		 2ygnA-3j4jA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 3j4j TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		4 / 6 LEU A 392
ILE A 402
MET A 465
VAL A 438
 None
 1.13A 2ygoA-3j4jA:
undetectable		 2ygoA-3j4jA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 3j4j TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 ILE A 182
ILE A 213
ALA A 178
VAL A 192
PRO A 189
 None
 1.09A 3a51E-3j4jA:
undetectable		 3a51E-3j4jA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3j4j TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		3 / 3 ILE A 149
PHE A 201
HIS A 167
 None
 0.75A 3h0aA-3j4jA:
undetectable		 3h0aA-3j4jA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 3j4j TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		3 / 3 PHE A 430
TYR A 456
LEU A 449
 None
 0.76A 3keeB-3j4jA:
undetectable		 3keeB-3j4jA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 3j4j TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 11 ILE A 288
ALA A 264
VAL A 323
VAL A 279
GLY A 286
 None
 0.75A 3kw4A-3j4jA:
undetectable		 3kw4A-3j4jA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 3j4j TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		4 / 6 GLY A 431
VAL A 432
ASP A 380
THR A 381
 None
 1.13A 3vqrA-3j4jA:
undetectable		 3vqrA-3j4jA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 3j4j TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		4 / 5 GLY A 431
VAL A 432
ASP A 380
THR A 381
 None
 1.13A 3vqrB-3j4jA:
undetectable		 3vqrB-3j4jA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3j4j TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 GLY A 305
PRO A 304
GLY A 303
PHE A 273
THR A 127
 None
 0.97A 4n49A-3j4jA:
undetectable		 4n49A-3j4jA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 3j4j TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		3 / 3 MET A  15
GLU A  19
LEU A  23
 None
 0.65A 4v2oB-3j4jA:
undetectable		 4v2oB-3j4jA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 3j4j TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		3 / 3 LYS A 169
ARG A 137
HIS A 167
 None
 0.80A 4zbrA-3j4jA:
undetectable		 4zbrA-3j4jA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3j4j TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 GLY A 222
GLY A 220
ALA A 217
ALA A 178
ILE A 213
 None
 1.10A 5bw4B-3j4jA:
undetectable		 5bw4B-3j4jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3j4j TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 VAL A 326
GLU A 324
LEU A 329
ALA A 332
ARG A 339
 None
 1.24A 5nd4B-3j4jA:
3.2		 5nd4B-3j4jA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3j4j TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 ILE A 136
THR A 135
THR A 381
VAL A 432
VAL A  77
 None
 1.35A 6bzoC-3j4jA:
2.2		 6bzoC-3j4jA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3j4j TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		4 / 7 ALA A 395
THR A 396
ILE A 388
VAL A 459
 None
 0.94A 6cduF-3j4jA:
undetectable
6cduJ-3j4jA:
undetectable		 6cduF-3j4jA:
21.22
6cduJ-3j4jA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 3j4j TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		4 / 5 ILE A 149
GLN A 160
THR A 161
LEU A  90
 None
 1.15A 6f3mD-3j4jA:
undetectable		 6f3mD-3j4jA:
23.73