SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3j4r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 3j4r CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-ALPHA REGULATORY
SUBUNIT
(Mus
musculus) 		4 / 8 ASN B 242
ASP B 142
LEU B 146
LEU B 141
 None
 1.01A 1e7cA-3j4rB:
undetectable		 1e7cA-3j4rB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 3j4r CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-ALPHA REGULATORY
SUBUNIT
(Mus
musculus) 		3 / 3 ASP B 183
ASP B 199
ASP B 161
 None
 0.72A 1eizA-3j4rB:
undetectable		 1eizA-3j4rB:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 3j4r CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-ALPHA REGULATORY
SUBUNIT
(Mus
musculus) 		3 / 3 ASP B 183
ASP B 199
ASP B 161
 None
 0.71A 1ej0A-3j4rB:
undetectable		 1ej0A-3j4rB:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 3j4r A-KINASE ANCHOR
PROTEIN 18
(Homo
sapiens) 		5 / 12 THR A 150
ALA A 152
GLU A 155
LEU A 156
LEU A 140
 None
 1.25A 1errA-3j4rA:
undetectable		 1errA-3j4rA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 3j4r CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-ALPHA REGULATORY
SUBUNIT
(Mus
musculus) 		4 / 7 LEU B 227
VAL B 158
GLY B 225
ILE B 220
 None
 0.81A 1p2yA-3j4rB:
undetectable		 1p2yA-3j4rB:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3j4r A-KINASE ANCHOR
PROTEIN 18
(Homo
sapiens) 		4 / 6 LEU A 171
ALA A 196
LEU A 198
ALA A 201
 None
 0.93A 2vcvK-3j4rA:
undetectable		 2vcvK-3j4rA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 3j4r A-KINASE ANCHOR
PROTEIN 18
(Homo
sapiens) 		4 / 6 LEU A 267
PHE A 208
LEU A 156
ASP A 151
 None
 1.01A 2wm3A-3j4rA:
undetectable		 2wm3A-3j4rA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3j4r A-KINASE ANCHOR
PROTEIN 18
(Homo
sapiens) 		4 / 8 TYR A 280
CYH A 268
CYH A 282
TYR A 279
 None
 1.28A 2xz5A-3j4rA:
undetectable
2xz5C-3j4rA:
undetectable		 2xz5A-3j4rA:
19.84
2xz5C-3j4rA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3j4r A-KINASE ANCHOR
PROTEIN 18
(Homo
sapiens) 		4 / 8 TYR A 280
CYH A 268
CYH A 282
TYR A 279
 None
 1.28A 2xz5C-3j4rA:
undetectable
2xz5D-3j4rA:
undetectable		 2xz5C-3j4rA:
19.84
2xz5D-3j4rA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 3j4r CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-ALPHA REGULATORY
SUBUNIT
(Mus
musculus) 		3 / 3 TYR B 182
VAL B 158
THR B 181
 None
 0.79A 2ygnA-3j4rB:
undetectable		 2ygnA-3j4rB:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 3j4r A-KINASE ANCHOR
PROTEIN 18
(Homo
sapiens) 		5 / 11 GLU A 260
LEU A 171
ILE A 200
LEU A 164
THR A  99
 None
 1.32A 2zzaB-3j4rA:
undetectable		 2zzaB-3j4rA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3j4r CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-ALPHA REGULATORY
SUBUNIT
(Mus
musculus) 		3 / 3 ASP B 183
ASP B 199
ASP B 161
 None
 0.71A 3douA-3j4rB:
undetectable		 3douA-3j4rB:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3j4r CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-ALPHA REGULATORY
SUBUNIT
(Mus
musculus) 		5 / 11 ILE B 165
ALA B 217
PHE B 204
LEU B 227
VAL B 164
 None
 1.14A 3n0hA-3j4rB:
undetectable		 3n0hA-3j4rB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3j4r A-KINASE ANCHOR
PROTEIN 18
(Homo
sapiens) 		4 / 7 TYR A 280
CYH A 268
CYH A 282
TYR A 279
 None
 1.34A 3peoF-3j4rA:
0.0		 3peoF-3j4rA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3j4r CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-ALPHA REGULATORY
SUBUNIT
(Mus
musculus) 		5 / 12 ILE B 165
ALA B 217
PHE B 204
LEU B 227
VAL B 164
 None
 1.13A 3s3vA-3j4rB:
undetectable		 3s3vA-3j4rB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3j4r A-KINASE ANCHOR
PROTEIN 18
(Homo
sapiens) 		4 / 8 TYR A 280
CYH A 268
CYH A 282
TYR A 279
 None
 1.24A 4bqtC-3j4rA:
undetectable
4bqtD-3j4rA:
undetectable		 4bqtC-3j4rA:
19.84
4bqtD-3j4rA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3j4r A-KINASE ANCHOR
PROTEIN 18
(Homo
sapiens) 		5 / 9 ALA A 204
THR A 203
ALA A 201
ILE A 213
ALA A 215
 None
 1.18A 4qvqK-3j4rA:
undetectable
4qvqL-3j4rA:
undetectable		 4qvqK-3j4rA:
20.33
4qvqL-3j4rA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3j4r A-KINASE ANCHOR
PROTEIN 18
(Homo
sapiens) 		5 / 9 ALA A 204
THR A 203
ALA A 201
ILE A 213
ALA A 215
 None
 1.17A 4qvqY-3j4rA:
undetectable
4qvqZ-3j4rA:
undetectable		 4qvqY-3j4rA:
20.33
4qvqZ-3j4rA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 3j4r A-KINASE ANCHOR
PROTEIN 18
(Homo
sapiens) 		5 / 12 THR A 150
ALA A 152
GLU A 155
LEU A 156
LEU A 140
 None
 1.20A 4xi3A-3j4rA:
undetectable		 4xi3A-3j4rA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 3j4r CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-ALPHA REGULATORY
SUBUNIT
(Mus
musculus) 		4 / 8 VAL B 176
GLN B 129
GLU B 130
CYH B 132
 None
 0.91A 5dqyA-3j4rB:
undetectable		 5dqyA-3j4rB:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 3j4r CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-ALPHA REGULATORY
SUBUNIT
(Mus
musculus) 		3 / 3 VAL B 176
GLN B 129
CYH B 132
 None
 0.79A 5icxA-3j4rB:
undetectable
5icxE-3j4rB:
undetectable		 5icxA-3j4rB:
18.91
5icxE-3j4rB:
4.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 3j4r CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-ALPHA REGULATORY
SUBUNIT
(Mus
musculus) 		3 / 3 VAL B 176
GLN B 129
CYH B 132
 None
 0.86A 5icxC-3j4rB:
undetectable
5icxF-3j4rB:
undetectable		 5icxC-3j4rB:
18.91
5icxF-3j4rB:
4.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3j4r A-KINASE ANCHOR
PROTEIN 18
(Homo
sapiens) 		3 / 3 THR A  99
PRO A  97
ASP A 266
 None
 0.76A 5l8dB-3j4rA:
undetectable		 5l8dB-3j4rA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3j4r A-KINASE ANCHOR
PROTEIN 18
(Homo
sapiens) 		3 / 3 THR A  99
PRO A  97
ASP A 266
 None
 0.76A 5mwuB-3j4rA:
undetectable		 5mwuB-3j4rA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3j4r CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-ALPHA REGULATORY
SUBUNIT
(Mus
musculus) 		5 / 11 ASP B 231
LEU B 230
PHE B 235
LEU B 141
ILE B 239
 None
 1.08A 5z6mA-3j4rB:
undetectable		 5z6mA-3j4rB:
15.88