SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3j4s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 9 PHE A 360
GLU A 340
ILE A 343
ASP A 354
LEU A 353
 None
 1.47A 1i00A-3j4sA:
undetectable		 1i00A-3j4sA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		3 / 3 GLU A 238
GLU A  37
LEU A  68
 None
 0.66A 1v8bA-3j4sA:
5.4		 1v8bA-3j4sA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 LEU A 248
SER A 170
SER A 310
PHE A 309
ILE A 209
 None
 1.12A 1xotA-3j4sA:
undetectable		 1xotA-3j4sA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 ILE A 209
LEU A 248
ASN A 252
ASN A 207
ILE A  23
 None
 0.94A 2nnhA-3j4sA:
undetectable		 2nnhA-3j4sA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 10 ILE A 209
LEU A 248
ASN A 252
ASN A 207
ILE A  23
 None
 0.98A 2nnhB-3j4sA:
undetectable		 2nnhB-3j4sA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 VAL A 325
PHE A 291
ILE A 288
PHE A 334
TRP A 365
 None
 1.41A 2vdyA-3j4sA:
undetectable		 2vdyA-3j4sA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 ALA A 137
GLY A 139
GLY A  31
LEU A 180
PRO A 169
 None
GDP  A 900 (-3.0A)
GDP  A 900 (-3.6A)
None
GDP  A 900 ( 4.7A)
 0.90A 2y7hB-3j4sA:
undetectable		 2y7hB-3j4sA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 ALA A 137
GLY A 139
GLY A  31
LEU A 180
PRO A 169
 None
GDP  A 900 (-3.0A)
GDP  A 900 (-3.6A)
None
GDP  A 900 ( 4.7A)
 0.90A 2y7hC-3j4sA:
2.2		 2y7hC-3j4sA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 LEU A  68
GLY A  29
LEU A 165
SER A 163
ALA A  42
 None
 1.15A 3i5uB-3j4sA:
2.9		 3i5uB-3j4sA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 LEU A  68
GLY A  34
LEU A 165
SER A 163
ALA A  42
 None
 1.14A 3i5uB-3j4sA:
2.9		 3i5uB-3j4sA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 LEU A 165
VAL A  27
GLY A  26
ILE A  21
LEU A 248
 None
 1.05A 3ijdA-3j4sA:
undetectable		 3ijdA-3j4sA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 LEU A 165
VAL A  27
GLY A  26
ILE A  21
LEU A 248
 None
 1.11A 3ijdB-3j4sA:
1.9		 3ijdB-3j4sA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 VAL A 325
PHE A 291
ILE A 288
PHE A 334
TRP A 365
 None
 1.40A 4c49D-3j4sA:
undetectable		 4c49D-3j4sA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		4 / 7 GLY A 278
GLY A 378
VAL A 208
HIS A 313
 None
 0.91A 4c5nA-3j4sA:
3.6		 4c5nA-3j4sA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 ASP A 172
ASP A 174
ASN A 177
GLY A 392
GLN A 401
 None
 1.30A 4djeB-3j4sA:
undetectable		 4djeB-3j4sA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		4 / 8 ASN A  35
GLY A  29
ALA A  57
ASP A  75
 None
 0.77A 4eyrB-3j4sA:
undetectable		 4eyrB-3j4sA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		4 / 8 LEU A 270
PRO A 161
VAL A  27
GLY A  26
 None
 0.95A 4klrB-3j4sA:
2.2		 4klrB-3j4sA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 TYR A 321
TYR A 265
GLY A 323
ILE A 251
LEU A 274
 None
 1.16A 4kovA-3j4sA:
undetectable		 4kovA-3j4sA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 11 GLY A 140
ALA A  30
GLY A 146
ILE A  23
LEU A 270
 GDP  A 900 (-4.2A)
None
None
None
None
 0.95A 4kt0A-3j4sA:
undetectable
4kt0J-3j4sA:
undetectable		 4kt0A-3j4sA:
20.16
4kt0J-3j4sA:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 ALA A  30
GLY A 144
GLY A 140
THR A  93
LEU A 108
 None
None
GDP  A 900 (-4.2A)
None
None
 1.01A 4n49A-3j4sA:
undetectable		 4n49A-3j4sA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		4 / 7 HIS A 249
TYR A  53
PHE A  46
ASN A  48
 None
 1.40A 4o7gA-3j4sA:
undetectable
4o7gB-3j4sA:
undetectable		 4o7gA-3j4sA:
19.75
4o7gB-3j4sA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		4 / 7 LEU A 148
THR A 100
ALA A 104
LEU A 108
 None
 0.79A 4ubsA-3j4sA:
undetectable		 4ubsA-3j4sA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		4 / 6 LEU A 293
LEU A 296
GLU A 297
ILE A 343
 None
 0.82A 4ww7A-3j4sA:
undetectable		 4ww7A-3j4sA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 LEU A 388
LEU A 183
THR A 143
ALA A 137
ILE A 166
 None
 1.13A 4x1iD-3j4sA:
20.4		 4x1iD-3j4sA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 11 LEU A 388
LEU A 183
THR A 143
ALA A 137
ILE A 166
 None
 1.16A 4x20D-3j4sA:
20.4		 4x20D-3j4sA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 GLY A 116
ILE A 166
GLY A 136
GLY A 142
PHE A 131
 None
None
GDP  A 900 (-3.6A)
None
None
 1.12A 5eqbA-3j4sA:
undetectable		 5eqbA-3j4sA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		3 / 3 SER A 295
SER A 299
PHE A 333
 None
 0.75A 5mugA-3j4sA:
undetectable		 5mugA-3j4sA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		4 / 6 ARG A 117
PHE A 119
CYH A 134
PHE A  41
 None
 1.45A 5mwyA-3j4sA:
undetectable		 5mwyA-3j4sA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		4 / 6 ILE A 133
ILE A 283
LEU A 281
PHE A 324
 None
 0.98A 5vkqB-3j4sA:
undetectable
5vkqC-3j4sA:
undetectable		 5vkqB-3j4sA:
13.84
5vkqC-3j4sA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		4 / 6 ILE A 133
ILE A 283
LEU A 281
PHE A 324
 None
 0.95A 5vkqC-3j4sA:
undetectable
5vkqD-3j4sA:
undetectable		 5vkqC-3j4sA:
13.84
5vkqD-3j4sA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 SER A 167
LEU A 132
VAL A  27
GLY A  29
VAL A 244
 None
 1.45A 6a94A-3j4sA:
undetectable		 6a94A-3j4sA:
23.17