SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3j5y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 3j5y EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Homo
sapiens) 		3 / 3 ALA A   8
VAL A  12
TRP A  15
 None
 0.91A 1tkqB-3j5yA:
undetectable		 1tkqB-3j5yA:
3.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 3j5y EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Homo
sapiens) 		3 / 3 LEU A 212
PHE A 158
ARG A 203
 None
 0.77A 1xdkB-3j5yA:
undetectable		 1xdkB-3j5yA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 3j5y EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Homo
sapiens) 		3 / 3 LEU A 212
PHE A 158
ARG A 203
 None
 0.77A 1xdkF-3j5yA:
undetectable		 1xdkF-3j5yA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 3j5y EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Homo
sapiens) 		4 / 7 ILE A 120
ILE A  21
LEU A  20
ILE A  17
 None
 0.87A 2q83A-3j5yA:
undetectable		 2q83A-3j5yA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3j5y EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Homo
sapiens) 		4 / 8 PHE A 291
ILE A 294
GLY A 410
GLY A 411
 None
 0.88A 2qx4A-3j5yA:
undetectable
2qx4B-3j5yA:
undetectable		 2qx4A-3j5yA:
20.14
2qx4B-3j5yA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3j5y EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Homo
sapiens) 		4 / 8 THR A 234
ARG A 198
LEU A 226
SER A 229
 None
 1.02A 2zw9A-3j5yA:
undetectable		 2zw9A-3j5yA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3j5y EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Homo
sapiens) 		5 / 11 GLY A 410
GLY A 411
GLY A 405
PHE A 291
ILE A 294
 None
 1.01A 4qoiA-3j5yA:
undetectable
4qoiB-3j5yA:
undetectable		 4qoiA-3j5yA:
20.14
4qoiB-3j5yA:
20.14