SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3j70'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 3j70 ENVELOPE
GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 8 LEU D 483
TYR D 486
ILE D 251
ILE D 215
 None
 0.83A 2bu8A-3j70D:
undetectable		 2bu8A-3j70D:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 3j70 ENVELOPE
GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 7 SER D 405
ASN D 340
GLN D 344
TRP D 395
 None
 0.95A 2cmlA-3j70D:
undetectable		 2cmlA-3j70D:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 3j70 ENVELOPE
GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 8 SER D 405
ASN D 340
GLN D 344
TRP D 395
 None
 0.98A 2cmlB-3j70D:
undetectable		 2cmlB-3j70D:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 3j70 ENVELOPE
GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 8 SER D 405
ASN D 340
GLN D 344
TRP D 395
 None
 1.00A 2cmlD-3j70D:
undetectable		 2cmlD-3j70D:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 3j70 ENVELOPE
GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		3 / 3 ARG D 311
ARG D 308
PRO D 313
 None
 0.76A 2wljA-3j70D:
undetectable		 2wljA-3j70D:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 3j70 ENVELOPE
GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 8 LEU D 483
ILE D 251
HIS D 249
GLY D 263
 None
 0.87A 3b9lA-3j70D:
undetectable		 3b9lA-3j70D:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 3j70 ENVELOPE
GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 8 ASN D 392
LYS D 362
PHE D 396
TRP D 400
 None
 1.48A 3bjwD-3j70D:
undetectable		 3bjwD-3j70D:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3j70 ENVELOPE
GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 8 ASN D 448
THR D 450
LEU D 260
SER D 256
 None
 1.02A 3kp6A-3j70D:
undetectable		 3kp6A-3j70D:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 3j70 ENVELOPE
GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		3 / 3 ASP D 457
ASN D 462
SER D 365
 None
 0.77A 3lslA-3j70D:
undetectable
3lslD-3j70D:
undetectable		 3lslA-3j70D:
19.70
3lslD-3j70D:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 3j70 ENVELOPE
GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		3 / 3 SER D 365
ASP D 457
ASN D 462
 None
 0.73A 3lslA-3j70D:
undetectable
3lslD-3j70D:
undetectable		 3lslA-3j70D:
19.70
3lslD-3j70D:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 3j70 MONOCLONAL ANTIBODY
17B LIGHT CHAIN
(Homo
sapiens) 		4 / 5 SER A 203
GLY A 118
THR A 151
VAL A 142
 None
 0.92A 4eohA-3j70A:
undetectable		 4eohA-3j70A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3j70 MONOCLONAL ANTIBODY
17B LIGHT CHAIN
(Homo
sapiens) 		5 / 12 ILE A  69
THR A  70
THR A 107
VAL A 109
ARG A  66
 None
 1.26A 4i41A-3j70A:
undetectable		 4i41A-3j70A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 3j70 ENVELOPE
GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		5 / 12 PHE D 391
ASN D 332
VAL D 292
ILE D 449
LEU D 452
 None
 1.37A 4k39A-3j70D:
undetectable		 4k39A-3j70D:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3j70 ENVELOPE
GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		5 / 11 ILE D 215
ALA D  55
LEU D  52
LEU D 483
ILE D 251
 None
 1.10A 4p66A-3j70D:
undetectable		 4p66A-3j70D:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3j70 MONOCLONAL ANTIBODY
17B LIGHT CHAIN
ENVELOPE
GLYCOPROTEIN GP120
(Homo
sapiens;
Human
immunodeficiency
virus
1) 		3 / 3 ASP A  56
ASN D 325
PHE D 382
 None
 0.92A 5jglB-3j70A:
undetectable		 5jglB-3j70A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 3j70 ENVELOPE
GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		5 / 11 ILE D 491
TRP D  45
VAL D  84
VAL D 245
LEU D  86
 None
 1.42A 5jkwA-3j70D:
undetectable		 5jkwA-3j70D:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 3j70 ENVELOPE
GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 6 PHE D 468
LEU D 452
ARG D 469
GLY D 471
 None
 1.04A 5o4yA-3j70D:
undetectable		 5o4yA-3j70D:
4.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3j70 ENVELOPE
GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 5 LEU D 342
LYS D 343
ALA D 346
LEU D 349
 None
 0.80A 5vkqA-3j70D:
undetectable
5vkqD-3j70D:
undetectable		 5vkqA-3j70D:
12.76
5vkqD-3j70D:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3j70 ENVELOPE
GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 5 LEU D 342
LYS D 343
ALA D 346
LEU D 349
 None
 0.78A 5vkqA-3j70D:
undetectable
5vkqB-3j70D:
undetectable		 5vkqA-3j70D:
12.76
5vkqB-3j70D:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3j70 ENVELOPE
GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 5 LEU D 342
LYS D 343
ALA D 346
LEU D 349
 None
 0.80A 5vkqB-3j70D:
undetectable
5vkqC-3j70D:
undetectable		 5vkqB-3j70D:
12.76
5vkqC-3j70D:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3j70 ENVELOPE
GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 5 LEU D 342
LYS D 343
ALA D 346
LEU D 349
 None
 0.79A 5vkqC-3j70D:
undetectable
5vkqD-3j70D:
undetectable		 5vkqC-3j70D:
12.76
5vkqD-3j70D:
12.76