SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3j7a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES1
40S RIBOSOMAL
PROTEIN US11
(Plasmodium
falciparum;
Plasmodium
falciparum) 		4 / 6 THR B  46
LEU P  47
GLY P  49
TYR B  66
 None
None
U  A 987 ( 3.2A)
None
 1.11A 1gtiC-3j7aB:
undetectable		 1gtiC-3j7aB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 9 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.96A 1hpvA-3j7aH:
undetectable		 1hpvA-3j7aH:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 3j7a 40S RIBOSOMAL
PROTEIN ES21
40S RIBOSOMAL
PROTEIN US2
(Plasmodium
falciparum) 		4 / 7 GLN C 179
GLU C 180
MET C 173
PHE Z  80
 None
 1.35A 1linA-3j7aC:
undetectable		 1linA-3j7aC:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 3j7a 40S RIBOSOMAL
PROTEIN US14
(Plasmodium
falciparum) 		3 / 3 CYH T  40
ARG T  44
CYH T  22
 ZN  T 100 (-2.5A)
G  A1679 ( 4.4A)
ZN  T 100 (-2.7A)
 1.21A 1p9gA-3j7aT:
undetectable		 1p9gA-3j7aT:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3j7a 40S RIBOSOMAL
PROTEIN US2
(Plasmodium
falciparum) 		3 / 3 HIS C  23
ASP C 148
ASN C  28
 None
 0.68A 1wg8B-3j7aC:
undetectable		 1wg8B-3j7aC:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		 3j7a 40S RIBOSOMAL
PROTEIN ES21
40S RIBOSOMAL
PROTEIN US2
(Plasmodium
falciparum) 		4 / 5 PRO C 126
LEU C 153
GLY Z  62
LYS C  32
 None
 1.45A 1ya4C-3j7aC:
undetectable		 1ya4C-3j7aC:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3j7a 40S RIBOSOMAL
PROTEIN US2
(Plasmodium
falciparum) 		5 / 12 THR C 124
PRO C 126
TYR C 174
ILE C 170
VAL C 123
 None
 1.25A 1z9hA-3j7aC:
undetectable		 1z9hA-3j7aC:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3j7a 40S RIBOSOMAL
PROTEIN US2
(Plasmodium
falciparum) 		5 / 12 THR C 124
PRO C 126
TYR C 174
ILE C 170
VAL C 123
 None
 1.23A 1z9hB-3j7aC:
undetectable		 1z9hB-3j7aC:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3j7a 40S RIBOSOMAL
PROTEIN US2
(Plasmodium
falciparum) 		5 / 12 THR C 124
PRO C 126
TYR C 174
ILE C 170
VAL C 123
 None
 1.24A 1z9hC-3j7aC:
undetectable		 1z9hC-3j7aC:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3j7a 40S RIBOSOMAL
PROTEIN US2
(Plasmodium
falciparum) 		5 / 12 THR C 124
PRO C 126
TYR C 174
ILE C 170
VAL C 123
 None
 1.23A 1z9hD-3j7aC:
undetectable		 1z9hD-3j7aC:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 3j7a 40S RIBOSOMAL
PROTEIN US2
(Plasmodium
falciparum) 		3 / 3 GLY C 166
GLU C 168
ASN C 164
 None
 0.63A 1zq9A-3j7aC:
undetectable		 1zq9A-3j7aC:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.75A 2avsA-3j7aH:
undetectable		 2avsA-3j7aH:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.80A 2avvA-3j7aH:
undetectable		 2avvA-3j7aH:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3j7a 40S RIBOSOMAL
PROTEIN ES26
40S RIBOSOMAL
PROTEIN US11
(Plasmodium
falciparum;
Plasmodium
falciparum) 		5 / 12 LEU 3  67
GLY P 109
ARG 3  42
ALA P 112
ALA P 115
 None
 1.13A 2bm9D-3j7a3:
undetectable		 2bm9D-3j7a3:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES12
(Plasmodium
falciparum) 		5 / 12 TYR R  68
ILE R  42
SER R 116
ILE R  46
ILE R  72
 None
 1.27A 2efjA-3j7aR:
undetectable		 2efjA-3j7aR:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.87A 2f8gB-3j7aH:
undetectable		 2f8gB-3j7aH:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 3j7a 40S RIBOSOMAL
PROTEIN US2
(Plasmodium
falciparum) 		5 / 12 TYR C  36
ILE C  24
GLY C  25
GLY C 166
GLU C 168
 None
 0.95A 2fk8A-3j7aC:
undetectable		 2fk8A-3j7aC:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3j7a 40S RIBOSOMAL
PROTEIN US5
(Plasmodium
falciparum) 		4 / 6 GLY G 121
TYR G 234
ASP G 118
ASN G 120
 None
 1.19A 2g72A-3j7aG:
undetectable		 2g72A-3j7aG:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.91A 2hs1B-3j7aH:
undetectable		 2hs1B-3j7aH:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES26
40S RIBOSOMAL
PROTEIN US11
(Plasmodium
falciparum) 		5 / 12 GLY P 111
ALA P 112
ILE 3  44
ALA P  31
ILE P  33
 None
 0.95A 2nmyB-3j7aP:
undetectable		 2nmyB-3j7aP:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.83A 2nmzA-3j7aH:
undetectable		 2nmzA-3j7aH:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.83A 2nmzB-3j7aH:
undetectable		 2nmzB-3j7aH:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 3j7a 40S RIBOSOMAL
PROTEIN US13
(Plasmodium
falciparum) 		5 / 10 ILE S  17
ILE S  69
LEU S  32
ASN S  21
ILE S  38
 None
None
None
None
U  A1864 ( 3.3A)
 1.16A 2nnhB-3j7aS:
undetectable		 2nnhB-3j7aS:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.78A 2o4lB-3j7aH:
undetectable		 2o4lB-3j7aH:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3j7a 40S RIBOSOMAL
PROTEIN ES10
(Plasmodium
falciparum) 		5 / 12 HIS O  45
TYR O  25
LEU O  26
VAL O  66
HIS O  43
 None
 1.38A 2prgB-3j7aO:
undetectable		 2prgB-3j7aO:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.89A 2pymB-3j7aH:
undetectable		 2pymB-3j7aH:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.87A 2q63A-3j7aH:
undetectable		 2q63A-3j7aH:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.71A 2q64A-3j7aH:
undetectable		 2q64A-3j7aH:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.77A 2q64B-3j7aH:
undetectable		 2q64B-3j7aH:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.75A 2qakA-3j7aH:
undetectable		 2qakA-3j7aH:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 3j7a 40S RIBOSOMAL
PROTEIN US5
(Plasmodium
falciparum) 		4 / 5 VAL G  92
VAL G  93
PHE G 110
ARG G 224
 None
 1.18A 3bjwH-3j7aG:
undetectable		 3bjwH-3j7aG:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 3j7a 40S RIBOSOMAL
PROTEIN US5
(Plasmodium
falciparum) 		4 / 6 VAL G  92
VAL G  93
PHE G 110
ARG G 224
 None
 1.07A 3bjwF-3j7aG:
undetectable		 3bjwF-3j7aG:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.81A 3bvbA-3j7aH:
undetectable		 3bvbA-3j7aH:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 3j7a 40S RIBOSOMAL
PROTEIN US19
(Plasmodium
falciparum) 		5 / 11 ILE X  34
ILE X  86
PRO X  87
LEU X  57
ILE X  49
 None
 1.04A 3clbA-3j7aX:
undetectable		 3clbA-3j7aX:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.77A 3d1xB-3j7aH:
undetectable		 3d1xB-3j7aH:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3j7a 40S RIBOSOMAL
PROTEIN ES10
(Plasmodium
falciparum) 		5 / 12 HIS O  45
TYR O  25
LEU O  26
VAL O  66
HIS O  43
 None
 1.31A 3dzyD-3j7aO:
1.5		 3dzyD-3j7aO:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 10 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.78A 3ekpD-3j7aH:
undetectable		 3ekpD-3j7aH:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES26
40S RIBOSOMAL
PROTEIN US11
(Plasmodium
falciparum) 		5 / 12 GLY P 111
ALA P 112
ILE 3  44
ALA P  31
ILE P  33
 None
 0.93A 3ekwB-3j7aP:
undetectable		 3ekwB-3j7aP:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3j7a 40S RIBOSOMAL
PROTEIN US19
(Plasmodium
falciparum) 		5 / 10 ILE X  34
ILE X  86
PRO X  87
LEU X  57
ILE X  49
 None
 1.06A 3hbbA-3j7aX:
undetectable		 3hbbA-3j7aX:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES1
(Plasmodium
falciparum) 		3 / 3 CYH B  96
PRO B  35
ASP B  89
 None
 0.89A 3hlwB-3j7aB:
undetectable		 3hlwB-3j7aB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 3j7a 40S RIBOSOMAL
PROTEIN ES1
40S RIBOSOMAL
PROTEIN US11
(Plasmodium
falciparum;
Plasmodium
falciparum) 		3 / 3 LYS B  83
ILE P  33
PHE P  41
 None
None
U  A 986 ( 4.4A)
 0.96A 3j7zS-3j7aB:
undetectable
3j7za-3j7aB:
undetectable		 3j7zS-3j7aB:
18.22
3j7za-3j7aB:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.81A 3jw2B-3j7aH:
undetectable		 3jw2B-3j7aH:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3j7a 40S RIBOSOMAL
PROTEIN US5
(Plasmodium
falciparum) 		5 / 12 ALA G 115
ILE G 179
SER G 210
LEU G 181
LEU G 230
 None
 1.01A 3k2hA-3j7aG:
undetectable		 3k2hA-3j7aG:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.81A 3k4vA-3j7aH:
undetectable		 3k4vA-3j7aH:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.78A 3k4vB-3j7aH:
undetectable		 3k4vB-3j7aH:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3j7a 40S RIBOSOMAL
PROTEIN US2
(Plasmodium
falciparum) 		5 / 10 ILE C 160
MET C 200
PHE C 201
ALA C  90
ALA C  85
 None
 1.38A 3lw5B-3j7aC:
undetectable		 3lw5B-3j7aC:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_1
(PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.78A 3ndtA-3j7aH:
undetectable		 3ndtA-3j7aH:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.77A 3ndtB-3j7aH:
undetectable		 3ndtB-3j7aH:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_1
(PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.79A 3nduA-3j7aH:
undetectable		 3nduA-3j7aH:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.79A 3nduB-3j7aH:
undetectable		 3nduB-3j7aH:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_1
(PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.89A 3nu3A-3j7aH:
undetectable		 3nu3A-3j7aH:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_1
(PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.85A 3nu5A-3j7aH:
undetectable		 3nu5A-3j7aH:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.75A 3oxxA-3j7aH:
undetectable		 3oxxA-3j7aH:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.83A 3oxxC-3j7aH:
undetectable		 3oxxC-3j7aH:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_1
(PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.83A 3pwrA-3j7aH:
undetectable		 3pwrA-3j7aH:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.78A 3pwrB-3j7aH:
undetectable		 3pwrB-3j7aH:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 3j7a 40S RIBOSOMAL
PROTEIN US11
(Plasmodium
falciparum) 		3 / 3 LYS P  96
VAL P  30
HIS P  94
 None
 0.89A 3tj7A-3j7aP:
undetectable		 3tj7A-3j7aP:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_1
(PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.79A 3tkgA-3j7aH:
undetectable		 3tkgA-3j7aH:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.79A 3tkgD-3j7aH:
undetectable		 3tkgD-3j7aH:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.75A 3tkwB-3j7aH:
undetectable		 3tkwB-3j7aH:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.78A 3tl9A-3j7aH:
undetectable		 3tl9A-3j7aH:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.74A 3tl9B-3j7aH:
undetectable		 3tl9B-3j7aH:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 3j7a 40S RIBOSOMAL
PROTEIN US5
(Plasmodium
falciparum) 		4 / 7 ILE G  75
GLU G  61
LEU G  47
VAL G  51
 None
 0.76A 3ua5B-3j7aG:
undetectable		 3ua5B-3j7aG:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3j7a 40S RIBOSOMAL
PROTEIN US10
(Plasmodium
falciparum) 		5 / 12 VAL N  34
VAL N  96
ILE N  88
VAL N  49
LEU N  90
 None
 1.20A 3w68C-3j7aN:
undetectable		 3w68C-3j7aN:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3j7a 40S RIBOSOMAL
PROTEIN US19
(Plasmodium
falciparum) 		3 / 3 ASP X  27
LYS X  24
ASP X  23
 None
 0.86A 4a7tA-3j7aX:
undetectable		 4a7tA-3j7aX:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 3j7a 40S RIBOSOMAL
PROTEIN ES21
40S RIBOSOMAL
PROTEIN US2
(Plasmodium
falciparum) 		5 / 11 GLY Z  37
ALA C  66
PRO C 142
LEU Z  68
ILE Z  34
 None
 0.80A 4dt8A-3j7aZ:
undetectable		 4dt8A-3j7aZ:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 3j7a 40S RIBOSOMAL
PROTEIN ES21
40S RIBOSOMAL
PROTEIN US2
(Plasmodium
falciparum) 		5 / 10 GLY Z  37
ALA C  66
PRO C 142
LEU Z  68
ILE Z  34
 None
 0.82A 4dt8B-3j7aZ:
undetectable		 4dt8B-3j7aZ:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 3j7a 40S RIBOSOMAL
PROTEIN US5
(Plasmodium
falciparum) 		5 / 9 ALA G 112
ALA G 144
ILE G 142
GLY G 139
ILE G 141
 None
 1.02A 4eatB-3j7aG:
undetectable		 4eatB-3j7aG:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_D_VK3D202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES10
(Plasmodium
falciparum) 		4 / 5 ARG O  63
TYR O  23
TYR O  86
LEU O  87
 None
 1.45A 4f8yC-3j7aO:
undetectable
4f8yD-3j7aO:
undetectable		 4f8yC-3j7aO:
23.32
4f8yD-3j7aO:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3j7a 40S RIBOSOMAL
PROTEIN ES17
40S RIBOSOMAL
PROTEIN US2
(Plasmodium
falciparum) 		4 / 8 ASP C 148
ASP C 150
GLU W  99
GLU C 168
 None
 1.00A 4feuD-3j7aC:
undetectable		 4feuD-3j7aC:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.76A 4jecA-3j7aH:
undetectable		 4jecA-3j7aH:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.79A 4jecB-3j7aH:
undetectable		 4jecB-3j7aH:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES26
40S RIBOSOMAL
PROTEIN US11
(Plasmodium
falciparum) 		5 / 10 ILE P  33
ALA P  35
LEU 3  64
ILE P  95
THR P  40
 None
 1.31A 4km0A-3j7aP:
undetectable		 4km0A-3j7aP:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 3j7a 40S RIBOSOMAL
PROTEIN ES10
(Plasmodium
falciparum) 		4 / 5 TYR O  65
LEU O  87
GLU O  89
TYR O  23
 None
 1.33A 4olbA-3j7aO:
undetectable		 4olbA-3j7aO:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 3j7a 40S RIBOSOMAL
PROTEIN ES1
(Plasmodium
falciparum) 		3 / 3 CYH B  96
PRO B  35
ASP B  89
 None
 0.83A 4pm5A-3j7aB:
undetectable		 4pm5A-3j7aB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3j7a 40S RIBOSOMAL
PROTEIN ES21
40S RIBOSOMAL
PROTEIN US5
(Plasmodium
falciparum) 		4 / 5 ILE G  69
PHE G 258
SER G  66
HIS Z  29
 None
 1.09A 4rzvB-3j7aG:
undetectable		 4rzvB-3j7aG:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3j7a 40S RIBOSOMAL
PROTEIN US5
(Plasmodium
falciparum) 		4 / 4 TYR G 234
THR G 233
GLY G 235
LEU G 241
 None
 1.39A 4w5nA-3j7aG:
undetectable		 4w5nA-3j7aG:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 3j7a 40S RIBOSOMAL
PROTEIN ES26
(Plasmodium
falciparum) 		5 / 10 PHE 3  83
GLY 3  27
LEU 3  21
ALA 3  35
ALA 3  78
 None
 1.08A 4wnuD-3j7a3:
undetectable		 4wnuD-3j7a3:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 3j7a 40S RIBOSOMAL
PROTEIN US5
40S RIBOSOMAL
PROTEIN ES21
(Plasmodium
falciparum;
Plasmodium
falciparum) 		4 / 5 LEU G 241
ASP G 240
LEU Z  23
THR G 245
 None
 1.22A 4wozF-3j7aG:
undetectable
4wozH-3j7aG:
undetectable		 4wozF-3j7aG:
21.99
4wozH-3j7aG:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 3j7a 40S RIBOSOMAL
PROTEIN ES26
40S RIBOSOMAL
PROTEIN US11
(Plasmodium
falciparum) 		6 / 12 ASP P 131
LEU P  97
LEU P 116
SER 3  57
LEU 3  64
ILE 3  44
 None
 1.37A 4x1gA-3j7aP:
undetectable		 4x1gA-3j7aP:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3j7a 40S RIBOSOMAL
PROTEIN US19
(Plasmodium
falciparum) 		4 / 7 PHE X  37
ILE X 112
PHE X  45
LEU X  57
 None
 0.94A 4zdzA-3j7aX:
undetectable		 4zdzA-3j7aX:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 3j7a 40S RIBOSOMAL
PROTEIN US10
(Plasmodium
falciparum) 		3 / 3 VAL N  57
THR N  59
ARG N  82
 A  A1628 ( 3.8A)
G  A1732 ( 4.1A)
U  A1437 ( 3.2A)
 0.68A 5b2sB-3j7aN:
undetectable		 5b2sB-3j7aN:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 3j7a 40S RIBOSOMAL
PROTEIN US10
(Plasmodium
falciparum) 		3 / 3 VAL N  57
THR N  59
ARG N  82
 A  A1628 ( 3.8A)
G  A1732 ( 4.1A)
U  A1437 ( 3.2A)
 0.70A 5b2tB-3j7aN:
undetectable		 5b2tB-3j7aN:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3j7a 40S RIBOSOMAL
PROTEIN US19
(Plasmodium
falciparum) 		4 / 8 PHE X  37
ILE X 112
PHE X  45
LEU X  57
 None
 0.93A 5esfA-3j7aX:
undetectable		 5esfA-3j7aX:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3j7a 40S RIBOSOMAL
PROTEIN US19
(Plasmodium
falciparum) 		4 / 7 PHE X  37
ILE X 112
PHE X  45
LEU X  57
 None
 0.95A 5esmA-3j7aX:
undetectable		 5esmA-3j7aX:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EU8_B_010B6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES1
(Plasmodium
falciparum) 		4 / 5 ASN B  69
LEU B  70
HIS B  81
THR B 106
 None
 1.12A 5eu8A-3j7aB:
undetectable		 5eu8A-3j7aB:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 3j7a 40S RIBOSOMAL
PROTEIN ES1
(Plasmodium
falciparum) 		5 / 12 ALA B  71
LEU B  32
ILE B  91
PHE B  43
GLY B  63
 None
 1.13A 5fsaA-3j7aB:
undetectable		 5fsaA-3j7aB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3j7a 40S RIBOSOMAL
PROTEIN US11
(Plasmodium
falciparum) 		3 / 3 VAL P 132
HIS P  94
VAL P  30
 None
 0.49A 5jmnC-3j7aP:
undetectable		 5jmnC-3j7aP:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3j7a 40S RIBOSOMAL
PROTEIN ES1
(Plasmodium
falciparum) 		4 / 6 ASP B  76
ARG B  41
ASN B  42
ASN B  74
 None
 1.04A 5l6eA-3j7aB:
undetectable		 5l6eA-3j7aB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		4 / 7 PHE H  77
THR H  69
ILE H  64
GLY H  99
 None
 0.94A 5nzyA-3j7aH:
undetectable		 5nzyA-3j7aH:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3j7a 40S RIBOSOMAL
PROTEIN US2
(Plasmodium
falciparum) 		3 / 3 LEU C 120
ILE C  64
TYR C 174
 None
 0.61A 5uunB-3j7aC:
undetectable		 5uunB-3j7aC:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 3j7a 40S RIBOSOMAL
PROTEIN US5
(Plasmodium
falciparum) 		4 / 8 ILE G  75
GLN G  80
TRP G  41
VAL G  51
 None
 1.14A 5vlmF-3j7aG:
undetectable		 5vlmF-3j7aG:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3j7a 40S RIBOSOMAL
PROTEIN US2
(Plasmodium
falciparum) 		3 / 3 GLN C 179
TRP C 175
VAL C 196
 None
 1.16A 6auuA-3j7aC:
undetectable		 6auuA-3j7aC:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.83A 6dh3B-3j7aH:
undetectable		 6dh3B-3j7aH:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.84A 6dh6B-3j7aH:
undetectable		 6dh6B-3j7aH:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 3j7a 40S RIBOSOMAL
PROTEIN ES6
(Plasmodium
falciparum) 		5 / 12 LEU H 111
GLY H  55
ILE H 101
GLY H 103
ILE H  52
 None
G  A 160 ( 3.9A)
None
None
None
 0.78A 6dilB-3j7aH:
undetectable		 6dilB-3j7aH:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3j7a 40S RIBOSOMAL
PROTEIN ES10
(Plasmodium
falciparum) 		5 / 10 VAL O  66
LEU O  57
LEU O  87
TYR O  86
LEU O  26
 None
 0.93A 6f5uA-3j7aO:
undetectable
6f5uB-3j7aO:
undetectable		 6f5uA-3j7aO:
19.12
6f5uB-3j7aO:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 3j7a 40S RIBOSOMAL
PROTEIN ES1
(Plasmodium
falciparum) 		4 / 6 LEU B  86
ALA B  34
LEU B  70
ASN B  75
 None
 0.95A 6f88B-3j7aB:
undetectable		 6f88B-3j7aB:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3j7a 40S RIBOSOMAL
PROTEIN US2
(Plasmodium
falciparum) 		3 / 3 THR C 124
GLU C 168
ASN C 164
 None
 0.83A 6nj9K-3j7aC:
undetectable		 6nj9K-3j7aC:
19.47