SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3j7y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 3j7y UL16
(Homo
sapiens) 		4 / 6 TYR N 241
GLY N  74
GLY N  93
SER N  76
 None
 0.94A 1eswA-3j7yN:
undetectable		 1eswA-3j7yN:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NB9_A_RBFA401_1
(HYPOTHETICAL PROTEIN
FLJ11149)		 3j7y ICT1
(Homo
sapiens) 		5 / 9 THR p 122
ILE p 158
VAL p 115
GLU p 160
LEU p 135
 None
 1.50A 1nb9A-3j7yp:
undetectable		 1nb9A-3j7yp:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 3j7y CRIF1
(Homo
sapiens) 		5 / 12 TRP q  76
GLY q  69
SER q  68
ALA q  58
ALA q  57
 None
 1.21A 1nw5A-3j7yq:
undetectable		 1nw5A-3j7yq:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 3j7y BL19
(Homo
sapiens) 		4 / 8 ILE Q 136
LEU Q 190
LYS Q 241
GLY Q 242
 None
 1.02A 1os6A-3j7yQ:
undetectable		 1os6A-3j7yQ:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 3j7y BL21
(Homo
sapiens) 		5 / 11 LEU S 149
VAL S 136
THR S 142
VAL S  83
ILE S  87
 None
 1.12A 1phgA-3j7yS:
undetectable		 1phgA-3j7yS:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3j7y BL21
(Homo
sapiens) 		4 / 7 LEU S 149
VAL S 136
VAL S  83
ILE S  87
 None
 0.90A 1t87B-3j7yS:
undetectable		 1t87B-3j7yS:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3j7y ML43
ML50
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ILE b  63
SER b  67
ILE h 154
VAL b  75
ALA b  43
 None
 0.75A 1vq1B-3j7yb:
undetectable		 1vq1B-3j7yb:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 3j7y ML50
(Homo
sapiens) 		3 / 3 PRO h 133
THR h  61
PRO h  63
 None
 0.82A 2d55C-3j7yh:
undetectable		 2d55C-3j7yh:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 3j7y MS30
(Homo
sapiens) 		4 / 6 HIS s 154
PHE s 176
GLY s 364
LYS s 365
 None
 1.33A 2i30A-3j7ys:
undetectable		 2i30A-3j7ys:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 3j7y BL21
ML43
(Homo
sapiens) 		5 / 12 ILE S 195
SER S 197
ILE S 198
ASN b 123
VAL S 136
 None
 0.99A 2nnhA-3j7yS:
undetectable		 2nnhA-3j7yS:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3j7y MS30
(Homo
sapiens) 		4 / 5 ALA s 248
ALA s 194
ALA s 198
GLN s 358
 None
 0.92A 2nyrB-3j7ys:
undetectable		 2nyrB-3j7ys:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 3j7y MS30
(Homo
sapiens) 		4 / 7 LEU s 332
PHE s 299
ASN s 427
PHE s 424
 None
 0.95A 2opxA-3j7ys:
undetectable		 2opxA-3j7ys:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 3j7y BL21
(Homo
sapiens) 		5 / 9 LEU S  95
ILE S  87
ALA S 201
GLY S 145
LEU S 149
 None
 1.26A 2v0mB-3j7yS:
undetectable		 2v0mB-3j7yS:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 3j7y BL17
MS30
(Homo
sapiens) 		4 / 6 LEU O  85
SER s  55
LYS O  83
GLU O  82
 None
C  A2326 ( 2.6A)
None
U  A2325 ( 3.5A)
 1.32A 2vn1B-3j7yO:
undetectable		 2vn1B-3j7yO:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3j7y MS30
(Homo
sapiens) 		4 / 4 ARG s 325
GLY s 395
GLU s 321
SER s 357
 None
 1.41A 2xctS-3j7ys:
undetectable
2xctU-3j7ys:
undetectable		 2xctS-3j7ys:
20.86
2xctU-3j7ys:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 3j7y MS30
(Homo
sapiens) 		5 / 12 ILE s 241
SER s 182
ALA s 146
VAL s 145
VAL s 422
 None
 1.28A 2yvlC-3j7ys:
undetectable		 2yvlC-3j7ys:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 3j7y ICT1
(Homo
sapiens) 		4 / 5 SER p  79
LEU p 135
GLU p 100
CYH p 150
 None
 1.20A 3aiaA-3j7yp:
undetectable
3aiaB-3j7yp:
undetectable		 3aiaA-3j7yp:
20.61
3aiaB-3j7yp:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3j7y MS30
(Homo
sapiens) 		4 / 6 HIS s 300
VAL s 181
LEU s 118
LEU s 425
 None
 0.81A 3kk6A-3j7ys:
undetectable		 3kk6A-3j7ys:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 3j7y ML53
(Homo
sapiens) 		5 / 10 PHE k  90
GLY k  71
ILE k  75
MET k  76
PHE k  33
 None
 1.28A 3ko0L-3j7yk:
undetectable
3ko0N-3j7yk:
undetectable		 3ko0L-3j7yk:
21.05
3ko0N-3j7yk:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 3j7y ML53
(Homo
sapiens) 		5 / 10 GLY k  71
ILE k  75
MET k  76
PHE k  33
PHE k  90
 None
 1.29A 3ko0R-3j7yk:
undetectable
3ko0T-3j7yk:
undetectable		 3ko0R-3j7yk:
21.05
3ko0T-3j7yk:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 3j7y BL19
(Homo
sapiens) 		4 / 8 ILE Q 136
LEU Q 190
LYS Q 241
GLY Q 242
 None
 1.05A 3selX-3j7yQ:
undetectable		 3selX-3j7yQ:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 3j7y MS30
(Homo
sapiens) 		5 / 12 LEU s 118
PHE s 367
THR s 297
LEU s 332
ILE s 361
 None
 1.18A 3sp9A-3j7ys:
undetectable		 3sp9A-3j7ys:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3j7y ML49
(Homo
sapiens) 		3 / 3 ARG g  87
LYS g 112
ARG g  90
 None
A  A1881 ( 3.1A)
C  A1880 ( 4.1A)
 1.43A 3w1wA-3j7yg:
undetectable
3w1wB-3j7yg:
undetectable		 3w1wA-3j7yg:
17.47
3w1wB-3j7yg:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3j7y ML49
(Homo
sapiens) 		3 / 3 ARG g  90
ARG g  87
LYS g 112
 C  A1880 ( 4.1A)
None
A  A1881 ( 3.1A)
 1.48A 3w1wA-3j7yg:
undetectable
3w1wB-3j7yg:
undetectable		 3w1wA-3j7yg:
17.47
3w1wB-3j7yg:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3j7y UL16
(Homo
sapiens) 		4 / 6 LEU N 183
PHE N 185
LEU N  97
PHE N 102
 None
 1.04A 3wg7C-3j7yN:
undetectable
3wg7J-3j7yN:
undetectable		 3wg7C-3j7yN:
21.38
3wg7J-3j7yN:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 3j7y UL16
(Homo
sapiens) 		4 / 8 ARG N 192
LEU N 195
ARG N 199
GLU N  81
 None
 1.19A 3zmdA-3j7yN:
undetectable
3zmdB-3j7yN:
undetectable		 3zmdA-3j7yN:
17.97
3zmdB-3j7yN:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3j7y BL17
(Homo
sapiens) 		4 / 6 GLY O  35
ARG O 113
ILE O  42
LEU O  33
 A  A2319 ( 3.5A)
G  A2454 ( 4.6A)
A  A2319 ( 3.9A)
None
 1.01A 4acaC-3j7yO:
undetectable		 4acaC-3j7yO:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3j7y BL17
(Homo
sapiens) 		4 / 6 GLY O  35
ARG O 113
ILE O  42
LEU O  33
 A  A2319 ( 3.5A)
G  A2454 ( 4.6A)
A  A2319 ( 3.9A)
None
 1.01A 4acbC-3j7yO:
undetectable		 4acbC-3j7yO:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 3j7y MS30
(Homo
sapiens) 		4 / 8 TYR s 402
ASP s 363
PHE s 176
LEU s 150
 None
 1.02A 4f8hA-3j7ys:
undetectable
4f8hB-3j7ys:
undetectable		 4f8hA-3j7ys:
22.39
4f8hB-3j7ys:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 3j7y MS30
(Homo
sapiens) 		4 / 8 TYR s 402
ASP s 363
PHE s 176
LEU s 150
 None
 1.09A 4f8hB-3j7ys:
undetectable
4f8hC-3j7ys:
undetectable		 4f8hB-3j7ys:
22.39
4f8hC-3j7ys:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 3j7y MS30
(Homo
sapiens) 		4 / 8 TYR s 402
ASP s 363
PHE s 176
LEU s 150
 None
 1.05A 4f8hC-3j7ys:
undetectable
4f8hD-3j7ys:
undetectable		 4f8hC-3j7ys:
22.39
4f8hD-3j7ys:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 3j7y MS30
(Homo
sapiens) 		4 / 8 TYR s 402
ASP s 363
PHE s 176
LEU s 150
 None
 1.04A 4f8hD-3j7ys:
undetectable
4f8hE-3j7ys:
undetectable		 4f8hD-3j7ys:
22.39
4f8hE-3j7ys:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 3j7y MS30
(Homo
sapiens) 		4 / 8 PHE s 176
LEU s 150
TYR s 402
ASP s 363
 None
 1.08A 4f8hA-3j7ys:
undetectable
4f8hE-3j7ys:
undetectable		 4f8hA-3j7ys:
22.39
4f8hE-3j7ys:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3j7y UL16
(Homo
sapiens) 		4 / 7 PHE N 128
ILE N 131
TYR N  96
PRO N 153
 None
None
A  A2110 ( 4.5A)
None
 1.11A 4g5jA-3j7yN:
undetectable		 4g5jA-3j7yN:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3j7y ML51
(Homo
sapiens) 		3 / 3 LYS i 119
TYR i 118
ARG i 123
 U  A2013 ( 3.0A)
A  A1731 ( 3.5A)
A  A1722 ( 2.8A)
 1.27A 4gc9A-3j7yi:
undetectable		 4gc9A-3j7yi:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 3j7y MS30
(Homo
sapiens) 		4 / 8 SER s 169
LEU s 180
LEU s 177
SER s 173
 None
 0.96A 4iklA-3j7ys:
undetectable
4iklB-3j7ys:
undetectable		 4iklA-3j7ys:
15.48
4iklB-3j7ys:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 3j7y BL21
ML43
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ARG S 194
GLU S 162
ARG b   9
SER b 108
 None
 1.32A 4kr3A-3j7yS:
undetectable		 4kr3A-3j7yS:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 3j7y MS30
(Homo
sapiens) 		5 / 8 VAL s 284
ALA s 338
MET s 341
ASP s  77
LEU s  80
 None
 1.45A 4l9iB-3j7ys:
undetectable		 4l9iB-3j7ys:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 3j7y MS30
(Homo
sapiens) 		5 / 12 ILE s 264
ILE s 329
PHE s 109
PRO s  95
LEU s 273
 None
 0.99A 4m2xA-3j7ys:
undetectable		 4m2xA-3j7ys:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_A_HQEA503_1
(CATALASE)		 3j7y BS18A
(Homo
sapiens) 		5 / 9 PRO r  71
PHE r  92
LEU r  88
TYR r  81
LEU r 107
 None
 1.24A 4qopA-3j7yr:
undetectable		 4qopA-3j7yr:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_B_HQEB503_1
(CATALASE)		 3j7y BS18A
(Homo
sapiens) 		5 / 9 PRO r  71
PHE r  92
LEU r  88
TYR r  81
LEU r 107
 None
 1.23A 4qopB-3j7yr:
undetectable		 4qopB-3j7yr:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 3j7y ML43
ML50
(Homo
sapiens;
Homo
sapiens) 		3 / 3 THR h 155
ASN b  66
SER b  67
 None
 0.70A 4tvtA-3j7yh:
undetectable		 4tvtA-3j7yh:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3j7y MS30
(Homo
sapiens) 		5 / 9 ALA s 330
ALA s 328
ALA s 359
SER s 357
ALA s 334
 None
 1.12A 4twdA-3j7ys:
undetectable
4twdB-3j7ys:
undetectable
4twdC-3j7ys:
undetectable
4twdD-3j7ys:
undetectable
4twdE-3j7ys:
undetectable		 4twdA-3j7ys:
21.72
4twdB-3j7ys:
21.72
4twdC-3j7ys:
21.72
4twdD-3j7ys:
21.72
4twdE-3j7ys:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3j7y ML43
(Homo
sapiens) 		4 / 5 PHE b  54
PRO b  59
VAL b  61
ALA b  55
 None
 1.32A 4w5oA-3j7yb:
undetectable		 4w5oA-3j7yb:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 3j7y MS30
(Homo
sapiens) 		5 / 12 LEU s 401
TYR s 402
VAL s 417
ILE s 421
LEU s 177
 None
 1.33A 4yvpB-3j7ys:
undetectable		 4yvpB-3j7ys:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3j7y ML43
(Homo
sapiens) 		4 / 5 PHE b  54
PRO b  59
VAL b  61
ALA b  55
 None
 1.33A 4z4cA-3j7yb:
undetectable		 4z4cA-3j7yb:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3j7y ML43
(Homo
sapiens) 		4 / 5 PHE b  54
PRO b  59
VAL b  61
ALA b  55
 None
 1.34A 4z4dA-3j7yb:
undetectable		 4z4dA-3j7yb:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3j7y ML43
(Homo
sapiens) 		4 / 5 PHE b  54
PRO b  59
VAL b  61
ALA b  55
 None
 1.32A 4z4eA-3j7yb:
undetectable		 4z4eA-3j7yb:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3j7y MS30
(Homo
sapiens) 		4 / 8 LEU s  80
LEU s 377
GLY s 337
ALA s 338
 None
 0.66A 5f1aA-3j7ys:
undetectable		 5f1aA-3j7ys:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 3j7y BS18A
(Homo
sapiens) 		3 / 3 GLY r  68
CYH r  73
CYH r  70
 None
ZN  r 200 (-3.1A)
ZN  r 200 (-2.0A)
 0.91A 5inzB-3j7yr:
undetectable		 5inzB-3j7yr:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3j7y MS30
(Homo
sapiens) 		3 / 3 VAL s  93
TYR s 231
GLN s 232
 None
 0.76A 5qgkA-3j7ys:
undetectable		 5qgkA-3j7ys:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3j7y MS30
(Homo
sapiens) 		3 / 3 VAL s  93
TYR s 231
GLN s 232
 None
 0.74A 5qgrA-3j7ys:
undetectable		 5qgrA-3j7ys:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 3j7y MS30
(Homo
sapiens) 		5 / 7 ASN s 280
GLY s 337
ALA s 340
VAL s  76
LEU s  80
 None
 1.48A 6dwnB-3j7ys:
undetectable		 6dwnB-3j7ys:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3j7y BL21
ML43
(Homo
sapiens;
Homo
sapiens) 		4 / 8 GLN b 127
ILE S 200
ALA S  97
VAL S 108
 None
 1.04A 6hu9a-3j7yb:
undetectable
6hu9e-3j7yb:
undetectable		 6hu9a-3j7yb:
14.23
6hu9e-3j7yb:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3j7y ML43
ML50
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASN h 151
PRO b  59
GLN b  24
 None
 0.88A 6jnhA-3j7yh:
undetectable		 6jnhA-3j7yh:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3j7y ML43
ML50
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASN h 151
PRO b  59
GLN b  24
 None
 0.87A 6jogA-3j7yh:
undetectable		 6jogA-3j7yh:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3j7y BL19
(Homo
sapiens) 		3 / 3 ARG Q 103
LEU Q 166
PHE Q 164
 None
 0.78A 6nknP-3j7yQ:
undetectable		 6nknP-3j7yQ:
18.36