SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3j81'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 3j81 US2
(Kluyveromyces
lactis) 		3 / 3 THR A 124
PRO A 126
THR A 147
 None
 0.92A 1dscC-3j81A:
undetectable		 1dscC-3j81A:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3j81 US2
(Kluyveromyces
lactis) 		3 / 3 ARG A 183
ILE A  57
TRP A  54
 None
 1.15A 1m8eB-3j81A:
undetectable		 1m8eB-3j81A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 3j81 EIF2 ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 PHE j 145
TRP j 155
GLU j 152
 None
 1.11A 1mogA-3j81j:
undetectable		 1mogA-3j81j:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 3j81 US2
(Kluyveromyces
lactis) 		3 / 3 ARG A 183
ILE A  57
TRP A  54
 None
 1.13A 1nodB-3j81A:
undetectable		 1nodB-3j81A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 3j81 US2
(Kluyveromyces
lactis) 		3 / 3 ARG A 183
ILE A  57
TRP A  54
 None
 1.20A 1qomA-3j81A:
undetectable		 1qomA-3j81A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 3j81 US2
(Kluyveromyces
lactis) 		3 / 3 THR A 147
THR A 124
PRO A 126
 None
 0.87A 209dC-3j81A:
undetectable		 209dC-3j81A:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 3j81 US19
(Kluyveromyces
lactis) 		4 / 5 LEU P  60
LEU P 116
ILE P  85
ILE P 107
 None
 0.75A 2i2zA-3j81P:
undetectable		 2i2zA-3j81P:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 3j81 US2
(Kluyveromyces
lactis) 		3 / 3 ARG A 183
ILE A  57
TRP A  54
 None
 1.11A 2nodB-3j81A:
undetectable		 2nodB-3j81A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 3j81 US2
(Kluyveromyces
lactis) 		3 / 3 THR A 124
PRO A 126
THR A 147
 None
 0.79A 316dC-3j81A:
undetectable		 316dC-3j81A:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3j81 US2
(Kluyveromyces
lactis) 		3 / 3 ARG A 183
ILE A  57
TRP A  54
 None
 1.14A 3e68A-3j81A:
undetectable		 3e68A-3j81A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3j81 US2
(Kluyveromyces
lactis) 		3 / 3 ARG A 183
ILE A  57
TRP A  54
 None
 1.16A 3e6tB-3j81A:
undetectable		 3e6tB-3j81A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3j81 US5
(Kluyveromyces
lactis) 		3 / 3 VAL C 170
VAL C 189
SER C 186
 C  2  14 ( 4.5A)
None
U  2   5 ( 3.2A)
 0.72A 3n8xB-3j81C:
undetectable		 3n8xB-3j81C:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 3j81 US2
(Kluyveromyces
lactis) 		5 / 12 ASP A 157
PRO A 161
ILE A 133
VAL A 143
ILE A 122
 None
 1.19A 4eb6B-3j81A:
undetectable
4eb6C-3j81A:
undetectable		 4eb6B-3j81A:
20.18
4eb6C-3j81A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3j81 US5
(Kluyveromyces
lactis) 		5 / 12 ILE C 135
ILE C 134
GLY C 128
VAL C 107
VAL C  85
 None
None
None
None
C  3  24 ( 4.0A)
 0.89A 4nkvA-3j81C:
undetectable		 4nkvA-3j81C:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3j81 US5
(Kluyveromyces
lactis) 		5 / 12 ILE C 135
ILE C 134
GLY C 128
VAL C 107
VAL C  85
 None
None
None
None
C  3  24 ( 4.0A)
 0.89A 4nkvB-3j81C:
undetectable		 4nkvB-3j81C:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3j81 US5
(Kluyveromyces
lactis) 		5 / 12 ILE C 135
ILE C 134
GLY C 128
VAL C 107
VAL C  85
 None
None
None
None
C  3  24 ( 4.0A)
 0.96A 4nkvC-3j81C:
undetectable		 4nkvC-3j81C:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3j81 US5
(Kluyveromyces
lactis) 		5 / 12 ILE C 135
ILE C 134
GLY C 128
VAL C 107
VAL C  85
 None
None
None
None
C  3  24 ( 4.0A)
 0.95A 4nkvD-3j81C:
undetectable		 4nkvD-3j81C:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 3j81 EIF2 ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 ILE j  59
LEU j  51
ALA j  32
ILE j  27
 None
 0.84A 4y03A-3j81j:
2.3		 4y03A-3j81j:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3j81 US2
(Kluyveromyces
lactis) 		4 / 5 ILE A 160
LEU A   9
HIS A  23
VAL A  22
 None
 1.22A 5jmnB-3j81A:
undetectable		 5jmnB-3j81A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3j81 US2
US5
(Kluyveromyces
lactis;
Kluyveromyces
lactis) 		4 / 7 HIS C  64
THR C 241
ARG A 119
ASP C 246
 None
 1.25A 6mn4E-3j81C:
undetectable		 6mn4E-3j81C:
25.24