SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3j8g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 3j8g GTPASE DER
(Escherichia
coli) 		3 / 3 VAL X 320
VAL X 350
TRP X 323
 None
 0.87A 1av2A-3j8gX:
undetectable
1av2B-3j8gX:
undetectable		 1av2A-3j8gX:
4.10
1av2B-3j8gX:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 3j8g GTPASE DER
(Escherichia
coli) 		5 / 12 ILE X 143
PRO X   3
VAL X   2
VAL X 158
TRP X 162
 None
 1.38A 1hrkB-3j8gX:
2.9		 1hrkB-3j8gX:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 3j8g GTPASE DER
(Escherichia
coli) 		5 / 12 LEU X   7
ILE X 143
PRO X   3
VAL X 158
TRP X 162
 None
 1.27A 1hrkB-3j8gX:
2.9		 1hrkB-3j8gX:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 3j8g GTPASE DER
(Escherichia
coli) 		5 / 12 ARG X 210
ILE X 318
LEU X 290
ASP X 293
LEU X 218
 None
 1.07A 1r9oA-3j8gX:
undetectable		 1r9oA-3j8gX:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 3j8g GTPASE DER
(Escherichia
coli) 		5 / 12 ILE X 292
ALA X 294
GLU X 332
PHE X 352
ASN X 363
 None
None
None
None
G  B1845 ( 3.2A)
 1.49A 1u70A-3j8gX:
undetectable		 1u70A-3j8gX:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3j8g GTPASE DER
(Escherichia
coli) 		6 / 12 LEU X   7
ILE X 143
PRO X   3
VAL X   2
VAL X 158
TRP X 162
 None
 1.34A 2pnjB-3j8gX:
2.9		 2pnjB-3j8gX:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 3j8g GTPASE DER
(Escherichia
coli) 		5 / 12 LEU X   7
PRO X   3
VAL X   2
VAL X 158
TRP X 162
 None
 1.34A 2qd4A-3j8gX:
2.9		 2qd4A-3j8gX:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 3j8g GTPASE DER
(Escherichia
coli) 		4 / 6 LEU X 306
LEU X 303
ASP X 302
ILE X 318
 None
U  B2076 ( 4.0A)
None
None
 0.85A 2rlfB-3j8gX:
undetectable
2rlfC-3j8gX:
undetectable		 2rlfB-3j8gX:
8.33
2rlfC-3j8gX:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA1_0
(FERROCHELATASE)		 3j8g GTPASE DER
(Escherichia
coli) 		5 / 11 ILE X 143
PRO X   3
VAL X   2
VAL X 158
TRP X 162
 None
 1.40A 3aqiA-3j8gX:
4.0		 3aqiA-3j8gX:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA1_0
(FERROCHELATASE)		 3j8g GTPASE DER
(Escherichia
coli) 		5 / 11 LEU X   7
ILE X 143
PRO X   3
VAL X 158
TRP X 162
 None
 1.29A 3aqiA-3j8gX:
4.0		 3aqiA-3j8gX:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 3j8g GTPASE DER
(Escherichia
coli) 		5 / 12 LEU X   7
ILE X 143
PRO X   3
VAL X 158
TRP X 162
 None
 1.27A 3aqiB-3j8gX:
undetectable		 3aqiB-3j8gX:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 3j8g GTPASE DER
(Escherichia
coli) 		5 / 12 LEU X   7
ASP X  56
ASP X 232
GLY X  43
VAL X   5
 None
 0.97A 3em6B-3j8gX:
undetectable		 3em6B-3j8gX:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3j8g GTPASE DER
(Escherichia
coli) 		4 / 6 TYR X 415
THR X 376
GLU X 283
GLU X 246
 None
 1.05A 3fpjA-3j8gX:
undetectable		 3fpjA-3j8gX:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3j8g GTPASE DER
(Escherichia
coli) 		4 / 6 VAL X 253
VAL X 291
ILE X 222
ARG X 314
 None
 1.04A 3ms9A-3j8gX:
undetectable		 3ms9A-3j8gX:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3j8g GTPASE DER
(Escherichia
coli) 		4 / 6 VAL X 253
VAL X 291
ILE X 222
ARG X 314
 None
 1.09A 3mssA-3j8gX:
undetectable		 3mssA-3j8gX:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3j8g GTPASE DER
(Escherichia
coli) 		4 / 6 VAL X 253
VAL X 291
ILE X 222
ARG X 314
 None
 1.05A 3mssC-3j8gX:
undetectable		 3mssC-3j8gX:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3j8g GTPASE DER
(Escherichia
coli) 		4 / 6 VAL X 253
VAL X 291
ILE X 222
ARG X 314
 None
 1.03A 3pyyA-3j8gX:
undetectable		 3pyyA-3j8gX:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3j8g GTPASE DER
(Escherichia
coli) 		5 / 12 LEU X   7
ILE X 143
PRO X   3
VAL X 158
TRP X 162
 None
 1.25A 3w1wA-3j8gX:
4.1		 3w1wA-3j8gX:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3j8g GTPASE DER
(Escherichia
coli) 		5 / 12 ILE X 143
PRO X   3
VAL X   2
VAL X 158
TRP X 162
 None
 1.40A 3w1wB-3j8gX:
2.5		 3w1wB-3j8gX:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3j8g GTPASE DER
(Escherichia
coli) 		5 / 12 LEU X   7
ILE X 143
PRO X   3
VAL X 158
TRP X 162
 None
 1.27A 3w1wB-3j8gX:
2.5		 3w1wB-3j8gX:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 3j8g GTPASE DER
(Escherichia
coli) 		5 / 11 LEU X   7
ASP X  56
ASP X 232
GLY X  43
VAL X   5
 None
 0.97A 4dqhA-3j8gX:
undetectable		 4dqhA-3j8gX:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 3j8g GTPASE DER
(Escherichia
coli) 		4 / 8 VAL X 129
ILE X 140
SER X 134
ALA X 103
 None
 0.99A 4eyzA-3j8gX:
undetectable		 4eyzA-3j8gX:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 3j8g GTPASE DER
(Escherichia
coli) 		3 / 3 HIS X 351
TRP X 323
SER X 367
 None
 1.17A 4lrhD-3j8gX:
undetectable		 4lrhD-3j8gX:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 3j8g GTPASE DER
(Escherichia
coli) 		4 / 4 GLU X 366
GLY X 362
HIS X 351
ARG X 349
 None
G  B1846 ( 3.8A)
None
None
 1.37A 4r82A-3j8gX:
0.0
4r82B-3j8gX:
0.0		 4r82A-3j8gX:
19.08
4r82B-3j8gX:
19.08