SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3j9o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN B
(Francisella
tularensis) 		3 / 4 LYS B 335
ALA B 323
MET B 251
 None
 1.06A 1hk3A-3j9oB:
undetectable		 1hk3A-3j9oB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN B
(Francisella
tularensis) 		4 / 6 ARG B 310
GLU B 313
PRO B 446
ALA B 450
 None
 1.41A 2ejfB-3j9oB:
undetectable		 2ejfB-3j9oB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN B
(Francisella
tularensis) 		5 / 9 LEU B 223
LEU B 222
ILE B 216
LEU B 350
ILE B 353
 None
 1.07A 2f7aA-3j9oB:
undetectable		 2f7aA-3j9oB:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN B
(Francisella
tularensis) 		5 / 10 LEU B 223
LEU B 222
ILE B 216
LEU B 350
ILE B 353
 None
 1.05A 2f8dA-3j9oB:
undetectable		 2f8dA-3j9oB:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN B
(Francisella
tularensis) 		5 / 10 LEU B 223
LEU B 222
ILE B 216
LEU B 350
ILE B 353
 None
 1.05A 2f8dB-3j9oB:
undetectable		 2f8dB-3j9oB:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN B
(Francisella
tularensis) 		3 / 3 SER B 199
ASP B 178
ASP B 201
 None
 0.79A 2plwA-3j9oB:
undetectable		 2plwA-3j9oB:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN B
(Francisella
tularensis) 		3 / 3 VAL B 125
ASP B 124
GLU B 129
 None
 0.71A 2qeuA-3j9oB:
undetectable		 2qeuA-3j9oB:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN B
(Francisella
tularensis) 		3 / 3 VAL B 125
ASP B 124
GLU B 129
 None
 0.69A 2qeuC-3j9oB:
undetectable		 2qeuC-3j9oB:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN B
(Francisella
tularensis) 		5 / 12 LEU B 182
ALA B 198
THR B 246
ASN B 171
ILE B 200
 None
 1.14A 3a35A-3j9oB:
undetectable		 3a35A-3j9oB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN B
(Francisella
tularensis) 		5 / 12 LEU B 182
ALA B 198
THR B 246
ASN B 171
ILE B 200
 None
 1.19A 3a35B-3j9oB:
undetectable		 3a35B-3j9oB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN B
(Francisella
tularensis) 		5 / 12 LEU B 182
ALA B 198
THR B 246
ASN B 171
ILE B 200
 None
 1.16A 3a3bA-3j9oB:
undetectable		 3a3bA-3j9oB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN B
(Francisella
tularensis) 		4 / 7 ILE B 216
GLY B 206
VAL B 247
LEU B 223
 None
 0.88A 3elzA-3j9oB:
undetectable		 3elzA-3j9oB:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN B
(Francisella
tularensis) 		4 / 8 ILE B 197
SER B 374
GLY B 244
PRO B 195
 None
 0.76A 3lslA-3j9oB:
undetectable
3lslD-3j9oB:
undetectable		 3lslA-3j9oB:
18.44
3lslD-3j9oB:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN B
(Francisella
tularensis) 		4 / 8 PRO B 195
ILE B 197
SER B 374
GLY B 244
 None
 0.79A 3lslA-3j9oB:
undetectable
3lslD-3j9oB:
undetectable		 3lslA-3j9oB:
18.44
3lslD-3j9oB:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN A
INTRACELLULAR GROWTH
LOCUS PROTEIN B
(Francisella
tularensis) 		5 / 10 LEU A  33
ILE B 290
VAL B 293
GLY B 244
ILE B 243
 None
 1.31A 3ogpB-3j9oA:
undetectable		 3ogpB-3j9oA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN A
INTRACELLULAR GROWTH
LOCUS PROTEIN B
(Francisella
tularensis) 		4 / 7 ASP B 276
PHE B 271
VAL A 105
ILE A 112
 None
 0.96A 3pglA-3j9oB:
undetectable		 3pglA-3j9oB:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN A
INTRACELLULAR GROWTH
LOCUS PROTEIN B
(Francisella
tularensis;
Francisella
tularensis) 		4 / 7 VAL B 188
PHE B 146
VAL A  35
ILE B 243
 None
 0.99A 3zjqA-3j9oB:
undetectable		 3zjqA-3j9oB:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN A
INTRACELLULAR GROWTH
LOCUS PROTEIN B
(Francisella
tularensis;
Francisella
tularensis) 		4 / 7 VAL B 188
PHE B 146
VAL A  35
ILE B 243
 None
 0.97A 3zjqB-3j9oB:
undetectable		 3zjqB-3j9oB:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_ACTA1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN B
(Francisella
tularensis) 		5 / 9 ALA B 194
ILE B 166
GLY B 186
VAL B 188
SER B 192
 None
 1.27A 4a3uA-3j9oB:
undetectable		 4a3uA-3j9oB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN B
(Francisella
tularensis) 		3 / 3 ASP B  81
LYS B  82
ASP B  85
 None
 0.80A 4a7tA-3j9oB:
undetectable		 4a7tA-3j9oB:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN B
(Francisella
tularensis) 		4 / 7 ASP B 201
GLY B 248
SER B 203
PHE B 204
 None
 0.91A 4ac9C-3j9oB:
2.6		 4ac9C-3j9oB:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN A
(Francisella
tularensis) 		3 / 3 ARG A 113
LYS A 108
LYS A 107
 None
 1.37A 4k50A-3j9oA:
undetectable		 4k50A-3j9oA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN A
(Francisella
tularensis) 		3 / 3 ARG A 113
LYS A 108
LYS A 107
 None
 1.21A 4k50E-3j9oA:
undetectable		 4k50E-3j9oA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN A
(Francisella
tularensis) 		3 / 3 ARG A 113
LYS A 108
LYS A 107
 None
 1.27A 4k50I-3j9oA:
undetectable		 4k50I-3j9oA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN B
(Francisella
tularensis) 		3 / 3 ASP B 276
ASN B 261
SER B 282
 None
 0.68A 4obwA-3j9oB:
undetectable		 4obwA-3j9oB:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN A
INTRACELLULAR GROWTH
LOCUS PROTEIN B
(Francisella
tularensis) 		5 / 12 PHE B 146
SER B 153
PHE A  50
LEU B 123
LEU A  33
 None
 1.14A 4xumA-3j9oB:
undetectable		 4xumA-3j9oB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN A
INTRACELLULAR GROWTH
LOCUS PROTEIN B
(Francisella
tularensis) 		5 / 9 ALA B 165
ILE B 197
TYR A  30
ILE B 309
LEU B 292
 None
 1.14A 5mvmA-3j9oB:
undetectable
5mvmE-3j9oB:
undetectable		 5mvmA-3j9oB:
13.62
5mvmE-3j9oB:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN A
INTRACELLULAR GROWTH
LOCUS PROTEIN B
(Francisella
tularensis;
Francisella
tularensis) 		5 / 12 LEU B 167
GLY B 168
ASP A  45
VAL B 125
ASP A  37
 None
 1.40A 6bxlA-3j9oB:
undetectable		 6bxlA-3j9oB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN A
INTRACELLULAR GROWTH
LOCUS PROTEIN B
(Francisella
tularensis;
Francisella
tularensis) 		5 / 12 ASN B  89
VAL A  81
ILE B  92
VAL A 109
PHE B 271
 None
 1.39A 6j21A-3j9oB:
undetectable		 6j21A-3j9oB:
20.38