SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3j9t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT H
(Saccharomyces
cerevisiae) 		5 / 12 LEU P 314
LEU P 313
ASN P 317
LEU P 319
GLN P 323
 None
 1.37A 1a28B-3j9tP:
undetectable		 1a28B-3j9tP:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT H
(Saccharomyces
cerevisiae) 		5 / 12 LEU P 268
VAL P 264
ILE P 293
ILE P 294
PHE P 215
 None
 1.14A 2gj5A-3j9tP:
undetectable		 2gj5A-3j9tP:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT H
(Saccharomyces
cerevisiae) 		5 / 12 LEU P 402
GLY P 446
ASP P 426
ILE P 384
LEU P 433
 None
 1.22A 3eeoA-3j9tP:
undetectable		 3eeoA-3j9tP:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT H
(Saccharomyces
cerevisiae) 		5 / 12 LEU P 189
SER P 148
ASN P 145
LEU P 140
LEU P   7
 None
 1.13A 3fsuA-3j9tP:
undetectable		 3fsuA-3j9tP:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT H
(Saccharomyces
cerevisiae) 		3 / 3 ASN P 145
MET P   1
PHE P 117
 None
 0.97A 3g4lD-3j9tP:
undetectable		 3g4lD-3j9tP:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_A_CE3A303_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT F
(Saccharomyces
cerevisiae) 		4 / 4 ASN N  55
SER N  83
SER N 107
ARG N 111
 None
 1.28A 3hlwA-3j9tN:
undetectable		 3hlwA-3j9tN:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT F
(Saccharomyces
cerevisiae) 		4 / 5 ASN N  55
SER N  83
SER N 107
ARG N 111
 None
 1.28A 3hlwB-3j9tN:
undetectable		 3hlwB-3j9tN:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT H
(Saccharomyces
cerevisiae) 		5 / 12 LEU P 263
LEU P 249
LEU P 277
LEU P 274
ALA P 221
 None
 1.04A 3vw7A-3j9tP:
undetectable		 3vw7A-3j9tP:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT E
(Saccharomyces
cerevisiae) 		3 / 3 LEU K 215
GLU K 213
SER K 211
 None
 0.84A 4ccqA-3j9tK:
undetectable		 4ccqA-3j9tK:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWX_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT H
(Saccharomyces
cerevisiae) 		4 / 7 TRP P 370
TRP P 380
PHE P 379
VAL P 422
 None
 1.43A 4cwxA-3j9tP:
undetectable
4cwxB-3j9tP:
undetectable		 4cwxA-3j9tP:
20.52
4cwxB-3j9tP:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT H
(Saccharomyces
cerevisiae) 		4 / 7 VAL P 422
TRP P 370
TRP P 380
PHE P 379
 None
 1.47A 4cwyA-3j9tP:
undetectable
4cwyB-3j9tP:
undetectable		 4cwyA-3j9tP:
20.52
4cwyB-3j9tP:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT H
(Saccharomyces
cerevisiae) 		4 / 7 TRP P 370
TRP P 380
PHE P 379
VAL P 422
 None
 1.45A 4cwyA-3j9tP:
undetectable
4cwyB-3j9tP:
undetectable		 4cwyA-3j9tP:
20.52
4cwyB-3j9tP:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_A_FK5A200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT E
(Saccharomyces
cerevisiae) 		5 / 11 TYR K 117
ASP K 145
ARG K 144
ILE K 125
ILE K 174
 None
 1.36A 4dz2A-3j9tK:
undetectable
4dz2B-3j9tK:
undetectable		 4dz2A-3j9tK:
17.24
4dz2B-3j9tK:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_B_FK5B200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT E
(Saccharomyces
cerevisiae) 		5 / 11 TYR K 117
ASP K 145
ARG K 144
ILE K 125
ILE K 174
 None
 1.39A 4dz2A-3j9tK:
undetectable
4dz2B-3j9tK:
undetectable		 4dz2A-3j9tK:
17.24
4dz2B-3j9tK:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT F
(Saccharomyces
cerevisiae) 		4 / 5 ILE N  77
ASN N  70
TYR N  40
ILE N  50
 None
 1.02A 4jtpA-3j9tN:
undetectable		 4jtpA-3j9tN:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT H
(Saccharomyces
cerevisiae) 		5 / 11 LEU P 424
LEU P 402
ILE P 399
LEU P 398
ILE P 438
 None
 0.96A 4odrA-3j9tP:
undetectable
4odrB-3j9tP:
undetectable		 4odrA-3j9tP:
9.41
4odrB-3j9tP:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT H
(Saccharomyces
cerevisiae) 		4 / 6 LEU P 274
MET P 211
LEU P 263
VAL P 302
 None
 0.79A 4okbA-3j9tP:
undetectable		 4okbA-3j9tP:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT H
(Saccharomyces
cerevisiae) 		5 / 12 VAL P 302
ASN P 261
LEU P 268
LEU P 272
ALA P 318
 None
 1.18A 4rtbA-3j9tP:
undetectable		 4rtbA-3j9tP:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWC_A_FK5A201_1
(FK506-BINDING
PROTEIN 1A)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT E
(Saccharomyces
cerevisiae) 		5 / 11 TYR K 117
ASP K 145
ARG K 144
ILE K 125
ILE K 174
 None
 1.41A 5hwcA-3j9tK:
undetectable		 5hwcA-3j9tK:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT H
(Saccharomyces
cerevisiae) 		5 / 12 MET P 211
LEU P 214
LEU P 218
LEU P 274
LEU P 253
 None
 1.07A 5toaB-3j9tP:
undetectable		 5toaB-3j9tP:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UOC_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT H
(Saccharomyces
cerevisiae) 		4 / 6 TRP P 370
TRP P 380
PHE P 379
VAL P 422
 None
 1.42A 5uocA-3j9tP:
0.0
5uocB-3j9tP:
0.0		 5uocA-3j9tP:
20.81
5uocB-3j9tP:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UOC_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT H
(Saccharomyces
cerevisiae) 		4 / 5 TRP P 370
TRP P 380
PHE P 379
VAL P 422
 None
 1.35A 5uocC-3j9tP:
0.0
5uocD-3j9tP:
0.0		 5uocC-3j9tP:
20.81
5uocD-3j9tP:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT E
(Saccharomyces
cerevisiae) 		4 / 8 LEU K 132
VAL K 190
LEU K 169
ILE K 125
 None
 0.98A 5v0vA-3j9tK:
undetectable		 5v0vA-3j9tK:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT H
(Saccharomyces
cerevisiae) 		5 / 10 LEU P 127
ILE P 141
LEU P 140
LEU P 190
LEU P 164
 None
 1.15A 5y7pB-3j9tP:
undetectable		 5y7pB-3j9tP:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT H
(Saccharomyces
cerevisiae) 		5 / 10 LEU P 127
ILE P 141
LEU P 140
LEU P 190
LEU P 164
 None
 1.21A 5y7pD-3j9tP:
undetectable		 5y7pD-3j9tP:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT H
(Saccharomyces
cerevisiae) 		5 / 10 LEU P 127
ILE P 141
LEU P 140
LEU P 190
LEU P 164
 None
 1.18A 5y7pH-3j9tP:
undetectable		 5y7pH-3j9tP:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_1
(CARNOSINE
N-METHYLTRANSFERASE)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT H
(Saccharomyces
cerevisiae) 		4 / 5 GLN P 191
ARG P 188
TYR P 184
ASP P 332
 None
 1.36A 5yf0A-3j9tP:
0.6		 5yf0A-3j9tP:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_1
(CARNOSINE
N-METHYLTRANSFERASE)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT H
(Saccharomyces
cerevisiae) 		4 / 5 GLN P 191
ARG P 188
TYR P 184
ASP P 338
 None
 1.40A 5yf0A-3j9tP:
0.6		 5yf0A-3j9tP:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3j9t V-TYPE PROTON ATPASE
SUBUNIT F
(Saccharomyces
cerevisiae) 		4 / 8 ILE N  50
THR N  51
THR N  58
SER N  83
 None
 1.04A 6c06C-3j9tN:
undetectable		 6c06C-3j9tN:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT E
(Saccharomyces
cerevisiae) 		3 / 3 GLU K 213
LEU K 210
ARG K 206
 None
 0.68A 6d8fA-3j9tK:
undetectable		 6d8fA-3j9tK:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT H
(Saccharomyces
cerevisiae) 		3 / 3 HIS P 456
ASN P 455
LEU P 454
 None
 0.90A 6f7lB-3j9tP:
undetectable		 6f7lB-3j9tP:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA820_0
(GEPHYRIN)		 3j9t V-TYPE PROTON ATPASE
SUBUNIT F
(Saccharomyces
cerevisiae) 		4 / 5 GLU N  31
PRO N  30
THR N  29
GLN N  27
 None
 1.12A 6fgdA-3j9tN:
4.2		 6fgdA-3j9tN:
16.14