SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3j9u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 5 LEU C 193
LEU C 133
LEU C 339
GLY C  99
 None
 1.00A 1a4lC-3j9uC:
undetectable		 1a4lC-3j9uC:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 11 ILE C  70
ASP C  83
LEU C  79
GLY C  52
VAL C  30
 None
 1.43A 1axwB-3j9uC:
undetectable		 1axwB-3j9uC:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI3_A_PE2A1_1
(THYMIDINE KINASE)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 12 ILE C 333
ILE C 337
TYR C 334
MET C 352
ARG C 394
 None
 1.41A 1ki3A-3j9uC:
undetectable		 1ki3A-3j9uC:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI3_B_PE2B2_1
(THYMIDINE KINASE)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 12 ILE C 333
ILE C 337
TYR C 334
MET C 352
ARG C 394
 None
 1.41A 1ki3B-3j9uC:
1.5		 1ki3B-3j9uC:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 11 PRO C  84
VAL C  72
VAL C  49
GLY C  58
LEU C  79
 None
 1.38A 1lwcA-3j9uC:
2.7		 1lwcA-3j9uC:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8D_A_CLWA906_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 5 PRO C  91
VAL C 217
MET C  45
GLU C  59
 None
 1.46A 1m8dA-3j9uC:
0.0		 1m8dA-3j9uC:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8D_B_CLWB907_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 5 PRO C  91
VAL C 217
MET C  45
GLU C  59
 None
 1.49A 1m8dB-3j9uC:
0.0		 1m8dB-3j9uC:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M9J_A_CLWA906_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 5 PRO C  91
VAL C 217
MET C  45
GLU C  59
 None
 1.34A 1m9jA-3j9uC:
undetectable		 1m9jA-3j9uC:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 5 LEU C 339
VAL C 318
TYR C 105
THR C 335
 None
 1.32A 1nw3A-3j9uC:
undetectable		 1nw3A-3j9uC:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 12 PHE C 343
GLY C 408
ILE C 167
VAL C 350
ALA C 277
 None
 0.86A 1v2xA-3j9uC:
undetectable		 1v2xA-3j9uC:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 12 TYR C 334
LEU C 384
TYR C 392
ILE C 333
SER C 356
 None
 1.35A 1xmuA-3j9uC:
undetectable		 1xmuA-3j9uC:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 12 TYR C 334
LEU C 384
TYR C 392
ILE C 333
SER C 356
 None
 1.43A 1xmuB-3j9uC:
undetectable		 1xmuB-3j9uC:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 4 LEU C 520
THR C 519
ILE C 551
HIS C 554
 None
 1.40A 2jfaB-3j9uC:
undetectable		 2jfaB-3j9uC:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		3 / 3 THR C 315
ASP C 355
SER C 357
 None
 0.77A 2nxeA-3j9uC:
undetectable		 2nxeA-3j9uC:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		3 / 3 THR C 315
ASP C 355
SER C 357
 None
 0.80A 2nxeB-3j9uC:
undetectable		 2nxeB-3j9uC:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 4 ILE C 353
GLN C 267
ILE C 254
LEU C 300
 None
 1.20A 3dzyD-3j9uC:
undetectable		 3dzyD-3j9uC:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 8 GLY C 336
VAL C 281
VAL C  94
VAL C 217
 None
 0.72A 3fi0G-3j9uC:
undetectable		 3fi0G-3j9uC:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 8 GLY C 336
VAL C 281
VAL C  94
VAL C 217
 None
 0.76A 3fi0I-3j9uC:
undetectable		 3fi0I-3j9uC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 8 GLY C 336
VAL C 281
VAL C  94
VAL C 217
 None
 0.76A 3fi0Q-3j9uC:
undetectable		 3fi0Q-3j9uC:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 8 ASP C 230
LEU C 467
SER C 473
ASN C 474
 None
 0.96A 3lm8A-3j9uC:
2.4
3lm8C-3j9uC:
undetectable		 3lm8A-3j9uC:
16.91
3lm8C-3j9uC:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		3 / 3 ASP C 545
GLU C 593
SER C 552
 None
 0.78A 3p2kA-3j9uC:
undetectable		 3p2kA-3j9uC:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 5 ILE C 278
THR C 315
THR C 316
PHE C 297
 None
 0.98A 3snfA-3j9uC:
undetectable		 3snfA-3j9uC:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 8 VAL C 217
TYR C 342
LEU C 100
TYR C 105
 None
 1.06A 3v81A-3j9uC:
undetectable		 3v81A-3j9uC:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 12 LEU C 371
ILE C  36
ILE C 367
ALA C 327
VAL C  85
 None
 1.26A 3vw1D-3j9uC:
undetectable		 3vw1D-3j9uC:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 11 PRO C  84
ALA C  26
GLY C  82
GLU C  38
ASN C  39
 None
 1.25A 4a6nA-3j9uC:
undetectable		 4a6nA-3j9uC:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 7 ARG C 179
PRO C 216
SER C  93
TRP C 215
 None
 1.48A 4kmmA-3j9uC:
undetectable		 4kmmA-3j9uC:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 12 ALA C 340
GLY C 396
ALA C 395
ALA C 354
ILE C 279
 None
 1.10A 4nkxC-3j9uC:
undetectable		 4nkxC-3j9uC:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 12 ALA C 340
GLY C 396
ALA C 395
ALA C 354
ILE C 279
 None
 1.11A 4nkxD-3j9uC:
undetectable		 4nkxD-3j9uC:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_C_3CJC607_1
(LACTOPEROXIDASE)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 6 GLN C 346
ASP C 345
ARG C 221
ARG C 344
 None
 1.46A 4qyqC-3j9uC:
undetectable		 4qyqC-3j9uC:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 11 PRO C  84
VAL C  72
VAL C  49
GLY C  58
LEU C  79
 None
 1.32A 5hbmA-3j9uC:
undetectable		 5hbmA-3j9uC:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_C_3CJC609_1
(LACTOPEROXIDASE)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 6 GLN C 346
ASP C 345
ARG C 221
ARG C 344
 None
 1.46A 5hpwC-3j9uC:
undetectable		 5hpwC-3j9uC:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WP1_A_BEZA403_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 4 GLY C 530
PHE C 451
ASN C 529
LYS C 449
 None
 1.46A 5wp1A-3j9uC:
0.0		 5wp1A-3j9uC:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 5 ILE C 333
SER C 332
ALA C 361
LEU C 388
 None
 0.83A 6dwnA-3j9uC:
undetectable		 6dwnA-3j9uC:
8.84