SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ja6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ja6 CHEMOTAXIS PROTEIN
CHEW
(Escherichia
coli) 		5 / 10 LEU A 132
VAL A 126
GLY A 124
SER A 122
LEU A 136
 None
 1.08A 1pxxA-3ja6A:
undetectable		 1pxxA-3ja6A:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ja6 CHEMOTAXIS PROTEIN
CHEW
(Escherichia
coli) 		5 / 12 LEU A 132
VAL A 126
GLY A 124
SER A 122
LEU A 136
 None
 1.08A 1pxxC-3ja6A:
undetectable		 1pxxC-3ja6A:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 3ja6 CHEMOTAXIS PROTEIN
CHEW
(Escherichia
coli) 		5 / 11 ASN A  64
VAL A  63
ILE A  82
ALA A  84
ASP A  19
 None
 1.23A 2iyfA-3ja6A:
undetectable		 2iyfA-3ja6A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 3ja6 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN 2
(Escherichia
coli) 		5 / 11 SER H 399
GLN H 397
ALA H 398
ALA H 355
ALA H 357
 None
 1.08A 3mg0V-3ja6H:
undetectable
3mg0W-3ja6H:
undetectable		 3mg0V-3ja6H:
22.22
3mg0W-3ja6H:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 3ja6 CHEMOTAXIS PROTEIN
CHEW
(Escherichia
coli) 		5 / 12 LEU A 132
VAL A 126
GLY A 124
SER A 122
LEU A 136
 None
 1.04A 4coxC-3ja6A:
undetectable		 4coxC-3ja6A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 3ja6 CHEMOTAXIS PROTEIN
CHEW
(Escherichia
coli) 		5 / 10 ALA A  24
ILE A 104
VAL A 126
GLY A 124
VAL A  13
 None
 0.97A 4j5jB-3ja6A:
undetectable		 4j5jB-3ja6A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 3ja6 CHEMOTAXIS PROTEIN
CHEW
(Escherichia
coli) 		5 / 12 GLU A  17
SER A  15
LEU A 102
ILE A 104
LEU A 109
 None
 1.49A 4k36A-3ja6A:
undetectable		 4k36A-3ja6A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 3ja6 CHEMOTAXIS PROTEIN
CHEW
(Escherichia
coli) 		5 / 11 GLU A  17
SER A  15
LEU A 102
ILE A 104
LEU A 109
 None
 1.50A 4k37A-3ja6A:
undetectable		 4k37A-3ja6A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 3ja6 CHEMOTAXIS PROTEIN
CHEW
(Escherichia
coli) 		5 / 12 GLU A  17
SER A  15
LEU A 102
ILE A 104
LEU A 109
 None
 1.47A 4k38A-3ja6A:
undetectable
4k38D-3ja6A:
undetectable		 4k38A-3ja6A:
17.78
4k38D-3ja6A:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 3ja6 CHEMOTAXIS PROTEIN
CHEW
(Escherichia
coli) 		5 / 12 GLU A  17
SER A  15
LEU A 102
ILE A 104
LEU A 109
 None
 1.41A 4k39A-3ja6A:
undetectable		 4k39A-3ja6A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3ja6 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN 2
(Escherichia
coli) 		4 / 4 ALA H 294
ALA H 297
ALA H 298
ALA H 301
 None
 0.13A 4oadA-3ja6H:
undetectable		 4oadA-3ja6H:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3ja6 CHEMOTAXIS PROTEIN
CHEW
(Escherichia
coli) 		4 / 4 GLY A 124
LEU A  65
PHE A  93
ILE A 141
 None
 0.99A 4xv2A-3ja6A:
undetectable		 4xv2A-3ja6A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZP_A_CFFA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 3ja6 CHEMOTAXIS PROTEIN
CHEW
(Escherichia
coli) 		5 / 9 ILE A  82
VAL A  62
GLU A  31
LEU A  55
ILE A  34
 None
 1.12A 5mzpA-3ja6A:
undetectable		 5mzpA-3ja6A:
16.47