SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jac'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3jac PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		5 / 10 LEU A2342
LEU A2354
ALA A2350
PHE A2239
ILE A2403
 None
 1.22A 1g5yC-3jacA:
undetectable		 1g5yC-3jacA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 3jac PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		4 / 4 LEU A2444
PRO A2445
LEU A2434
ARG A2402
 None
 1.39A 1hrkB-3jacA:
undetectable		 1hrkB-3jacA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3jac PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		4 / 6 ILE A2403
ARG A2318
THR A2316
LEU A2344
 None
 0.99A 2einN-3jacA:
2.0
2einW-3jacA:
1.7		 2einN-3jacA:
5.15
2einW-3jacA:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3jac PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		4 / 8 GLU A2307
GLY A2311
THR A2312
ALA A2313
 None
 0.58A 2ej3A-3jacA:
undetectable		 2ej3A-3jacA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 3jac PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		4 / 4 LEU A2444
PRO A2445
LEU A2434
ARG A2402
 None
 1.37A 2hrcB-3jacA:
undetectable		 2hrcB-3jacA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3jac PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		4 / 4 LEU A2444
PRO A2445
LEU A2434
ARG A2402
 None
 1.42A 2pnjB-3jacA:
undetectable		 2pnjB-3jacA:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3jac PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		4 / 7 ILE A2403
ARG A2318
THR A2316
LEU A2344
 None
 0.97A 3ag3A-3jacA:
undetectable
3ag3J-3jacA:
1.7		 3ag3A-3jacA:
5.15
3ag3J-3jacA:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 3jac PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		5 / 12 LEU A2342
VAL A2401
TYR A2398
GLY A2400
GLU A2395
 None
 1.37A 3medA-3jacA:
undetectable
3medB-3jacA:
undetectable		 3medA-3jacA:
5.28
3medB-3jacA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 3jac PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		4 / 8 GLY A2360
ARG A2301
LEU A2357
LEU A2405
 None
 0.91A 3nbqB-3jacA:
undetectable		 3nbqB-3jacA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 3jac PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		4 / 8 GLY A2360
ARG A2301
LEU A2357
LEU A2405
 None
 0.93A 3nbqC-3jacA:
undetectable		 3nbqC-3jacA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 3jac PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		4 / 7 ASP A2264
TYR A2266
PRO A2267
GLN A2271
 None
 1.30A 3s3oA-3jacA:
undetectable		 3s3oA-3jacA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 3jac PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		5 / 12 THR A2336
ILE A2448
GLN A2222
SER A2450
PHE A2323
 None
 1.37A 5hgcA-3jacA:
undetectable		 5hgcA-3jacA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3jac PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		5 / 11 ILE A2403
LEU A2232
LEU A2357
ALA A2355
LEU A2371
 None
 1.23A 5ji0A-3jacA:
undetectable		 5ji0A-3jacA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3jac PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		4 / 6 GLN A2389
PHE A2263
LEU A2259
PHE A2251
 None
 1.06A 5z84P-3jacA:
undetectable
5z84W-3jacA:
undetectable		 5z84P-3jacA:
4.54
5z84W-3jacA:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3jac PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		4 / 6 GLN A2389
PHE A2263
LEU A2259
PHE A2251
 None
 1.07A 5z85P-3jacA:
undetectable
5z85W-3jacA:
1.7		 5z85P-3jacA:
4.54
5z85W-3jacA:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3jac PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		4 / 6 GLN A2389
PHE A2263
LEU A2259
PHE A2251
 None
 1.11A 5z86C-3jacA:
undetectable
5z86J-3jacA:
1.7		 5z86C-3jacA:
4.54
5z86J-3jacA:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3jac PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		4 / 6 GLN A2389
PHE A2263
LEU A2259
PHE A2251
 None
 1.05A 5z86P-3jacA:
undetectable
5z86W-3jacA:
1.7		 5z86P-3jacA:
4.54
5z86W-3jacA:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3jac PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		4 / 6 GLN A2389
PHE A2263
LEU A2259
PHE A2251
 None
 1.08A 5zcoP-3jacA:
4.7
5zcoW-3jacA:
1.7		 5zcoP-3jacA:
4.54
5zcoW-3jacA:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3jac PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		4 / 6 GLN A2389
PHE A2263
LEU A2259
PHE A2251
 None
 1.08A 5zcpC-3jacA:
undetectable
5zcpJ-3jacA:
1.7		 5zcpC-3jacA:
4.54
5zcpJ-3jacA:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3jac PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		4 / 6 GLN A2389
PHE A2263
LEU A2259
PHE A2251
 None
 1.09A 5zcpP-3jacA:
undetectable
5zcpW-3jacA:
1.7		 5zcpP-3jacA:
4.54
5zcpW-3jacA:
7.90