SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jaf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 3jaf GLYCINE RECEPTOR
SUBUNIT ALPHAZ1
(Danio
rerio) 		5 / 12 ILE A 169
LEU A 211
ILE A  59
LEU A 172
TYR A  74
 None
 1.21A 1ddrB-3jafA:
undetectable		 1ddrB-3jafA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3jaf GLYCINE RECEPTOR
SUBUNIT ALPHAZ1
(Danio
rerio) 		5 / 12 ILE A 169
LEU A 211
ILE A  59
LEU A 172
TYR A  74
 None
 1.31A 1rh3A-3jafA:
undetectable		 1rh3A-3jafA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3jaf GLYCINE RECEPTOR
SUBUNIT ALPHAZ1
(Danio
rerio) 		5 / 12 TYR A 357
ALA A 298
ILE A 299
ILE A 301
LEU A 248
 None
 1.07A 1xozA-3jafA:
undetectable		 1xozA-3jafA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3jaf GLYCINE RECEPTOR
SUBUNIT ALPHAZ1
(Danio
rerio) 		4 / 6 LEU A 114
ARG A 147
THR A 149
LEU A 150
 None
 1.04A 2dysA-3jafA:
1.7
2dysJ-3jafA:
undetectable		 2dysA-3jafA:
21.03
2dysJ-3jafA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3jaf GLYCINE RECEPTOR
SUBUNIT ALPHAZ1
(Danio
rerio) 		4 / 6 LEU A 114
ARG A 147
THR A 149
LEU A 150
 None
 1.10A 2zxwA-3jafA:
1.3
2zxwJ-3jafA:
undetectable		 2zxwA-3jafA:
21.03
2zxwJ-3jafA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3jaf GLYCINE RECEPTOR
SUBUNIT ALPHAZ1
(Danio
rerio) 		4 / 6 LEU A 114
ARG A 147
THR A 149
LEU A 150
 None
 1.06A 3asnA-3jafA:
2.8
3asnJ-3jafA:
undetectable		 3asnA-3jafA:
21.03
3asnJ-3jafA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 3jaf GLYCINE RECEPTOR
SUBUNIT ALPHAZ1
(Danio
rerio) 		4 / 5 LEU A 200
GLY A  65
PHE A 230
ASN A  77
 None
 1.11A 3uq6B-3jafA:
undetectable		 3uq6B-3jafA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 3jaf GLYCINE RECEPTOR
SUBUNIT ALPHAZ1
(Danio
rerio) 		4 / 7 TYR A 144
LEU A 106
TRP A  84
TYR A  40
 None
 1.34A 4f8yC-3jafA:
undetectable
4f8yD-3jafA:
undetectable		 4f8yC-3jafA:
21.08
4f8yD-3jafA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3jaf GLYCINE RECEPTOR
SUBUNIT ALPHAZ1
(Danio
rerio) 		5 / 12 ILE A 169
LEU A 211
ILE A  59
LEU A 172
TYR A  74
 None
 1.07A 4gh8A-3jafA:
undetectable		 4gh8A-3jafA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O79_B_ASCB303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 3jaf GLYCINE RECEPTOR
SUBUNIT ALPHAZ1
(Danio
rerio) 		4 / 6 LYS A 336
TYR A 317
ARG A 268
ALA A 264
 None
 1.33A 4o79B-3jafA:
5.4		 4o79B-3jafA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O79_B_ASCB303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 3jaf GLYCINE RECEPTOR
SUBUNIT ALPHAZ1
(Danio
rerio) 		4 / 6 LYS A 336
TYR A 317
ARG A 268
ALA A 267
 None
 1.45A 4o79B-3jafA:
5.4		 4o79B-3jafA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 3jaf GLYCINE RECEPTOR
SUBUNIT ALPHAZ1
(Danio
rerio) 		4 / 6 LYS A 336
TYR A 317
ARG A 268
ALA A 264
 None
 1.39A 4o7gB-3jafA:
5.3		 4o7gB-3jafA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 3jaf GLYCINE RECEPTOR
SUBUNIT ALPHAZ1
(Danio
rerio) 		4 / 6 LYS A 336
TYR A 317
ARG A 268
ALA A 267
 None
 1.38A 4o7gB-3jafA:
5.3		 4o7gB-3jafA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3jaf GLYCINE RECEPTOR
SUBUNIT ALPHAZ1
(Danio
rerio) 		5 / 12 ILE A 169
LEU A 211
ILE A  59
LEU A 172
TYR A  74
 None
 1.06A 4psyA-3jafA:
undetectable		 4psyA-3jafA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3jaf GLYCINE RECEPTOR
SUBUNIT ALPHAZ1
(Danio
rerio) 		5 / 12 ILE A 169
LEU A 211
ILE A  59
LEU A 172
TYR A  74
 None
 1.15A 4qleA-3jafA:
undetectable		 4qleA-3jafA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3jaf GLYCINE RECEPTOR
SUBUNIT ALPHAZ1
(Danio
rerio) 		5 / 12 ILE A 169
LEU A 211
ILE A  59
LEU A 172
TYR A  74
 None
 1.14A 4qlgA-3jafA:
undetectable		 4qlgA-3jafA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3jaf GLYCINE RECEPTOR
SUBUNIT ALPHAZ1
(Danio
rerio) 		5 / 12 ILE A 169
LEU A 211
ILE A  59
LEU A 172
TYR A  74
 None
 1.10A 4rgcA-3jafA:
undetectable		 4rgcA-3jafA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_1
(SERUM ALBUMIN)		 3jaf GLYCINE RECEPTOR
SUBUNIT ALPHAZ1
(Danio
rerio) 		4 / 6 PHE A 203
TYR A 239
LEU A 158
SER A 289
 None
 1.10A 6a7pB-3jafA:
2.1		 6a7pB-3jafA:
21.99