SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jap'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 3jap EIF3C
(Saccharomyces
cerevisiae) 		3 / 3 ASP p 324
ARG p 303
ILE p 276
 None
 0.85A 1a4gB-3japp:
undetectable		 1a4gB-3japp:
3.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 3jap EIF3A
(Saccharomyces
cerevisiae) 		3 / 3 GLU o 101
ILE o 104
ARG o 195
 None
 0.74A 1cd2A-3japo:
undetectable		 1cd2A-3japo:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 3jap EIF3A
(Saccharomyces
cerevisiae) 		4 / 8 LEU o 387
SER o 334
VAL o 427
GLU o 392
 None
 1.14A 1jtvA-3japo:
undetectable		 1jtvA-3japo:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 3jap EIF3A
(Saccharomyces
cerevisiae) 		4 / 6 PHE o 290
LEU o 286
ILE o 260
SER o 293
 None
 1.21A 1sbrA-3japo:
undetectable
1sbrB-3japo:
undetectable		 1sbrA-3japo:
16.58
1sbrB-3japo:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 3jap EIF3A
EIF3C
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 THR o 490
THR o 481
SER p 734
VAL p 777
 None
 1.07A 1tv8A-3japo:
undetectable		 1tv8A-3japo:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 3jap EIF3A
EIF3C
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 THR o 490
THR o 481
SER p 734
VAL p 777
 None
 1.06A 1tv8B-3japo:
undetectable		 1tv8B-3japo:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 3jap EIF3A
EIF3C
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 THR o 490
THR o 481
SER p 734
VAL p 777
 None
 1.08A 2fb2A-3japo:
undetectable		 2fb2A-3japo:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 3jap EIF3A
EIF3C
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 THR o 490
THR o 481
SER p 734
VAL p 777
 None
 1.08A 2fb2B-3japo:
undetectable		 2fb2B-3japo:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 3jap EIF3C
(Saccharomyces
cerevisiae) 		5 / 12 LEU p 713
LEU p 557
ALA p 554
LEU p 616
THR p 623
 None
 1.25A 2oaxB-3japp:
undetectable		 2oaxB-3japp:
2.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3jap EIF3C
(Saccharomyces
cerevisiae) 		3 / 3 ARG p 716
ASN p 686
THR p 724
 None
 0.83A 2q63A-3japp:
undetectable		 2q63A-3japp:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_B_HNQB255_1
(CATHEPSIN B)		 3jap EIF3C
(Saccharomyces
cerevisiae) 		4 / 6 GLN p 582
GLY p 581
HIS p 611
HIS p 609
 None
 1.25A 3ai8B-3japp:
undetectable		 3ai8B-3japp:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3jap EIF1A
(Saccharomyces
cerevisiae) 		4 / 8 GLU i  34
VAL i  92
LEU i  78
ALA i  36
 None
 0.85A 3ax7A-3japi:
undetectable		 3ax7A-3japi:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 3jap EIF3C
(Saccharomyces
cerevisiae) 		4 / 6 LEU p 376
ASP p 324
LEU p 299
TRP p 318
 None
 1.09A 3bj8C-3japp:
undetectable
3bj8D-3japp:
undetectable		 3bj8C-3japp:
5.06
3bj8D-3japp:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 3jap EIF3A
(Saccharomyces
cerevisiae) 		4 / 6 LYS o 410
GLN o 403
LEU o 387
GLU o 386
 None
 1.10A 3h5gB-3japo:
undetectable
3h5gC-3japo:
undetectable		 3h5gB-3japo:
4.25
3h5gC-3japo:
4.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3jap EIF3C
(Saccharomyces
cerevisiae) 		3 / 3 VAL p 270
SER p 264
LEU p 275
 None
 0.62A 3n8xA-3japp:
undetectable		 3n8xA-3japp:
2.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 3jap EIF3C
(Saccharomyces
cerevisiae) 		3 / 3 ARG p 716
LEU p 627
THR p 724
 None
 0.91A 3oxcA-3japp:
undetectable		 3oxcA-3japp:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 3jap EIF3A
EIF3C
(Saccharomyces
cerevisiae) 		4 / 5 TYR p 733
THR o 481
PHE p 732
ARG p 731
 None
 1.36A 3qelC-3japp:
undetectable		 3qelC-3japp:
3.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3jap EIF3A
(Saccharomyces
cerevisiae) 		3 / 3 TYR o 179
LEU o  68
LYS o  69
 None
 0.75A 3sueD-3japo:
undetectable		 3sueD-3japo:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3jap EIF1A
(Saccharomyces
cerevisiae) 		4 / 7 GLU i  34
VAL i  92
LEU i  78
ALA i  36
 None
 0.87A 3uniA-3japi:
undetectable		 3uniA-3japi:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3jap EIF3C
(Saccharomyces
cerevisiae) 		4 / 4 PRO p 355
LEU p 258
ILE p 262
ARG p 265
 None
 1.41A 4f4dA-3japp:
undetectable		 4f4dA-3japp:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3jap EIF3A
(Saccharomyces
cerevisiae) 		4 / 4 LEU o 454
PRO o 455
LEU o 458
ILE o 428
 None
 0.89A 4f4dB-3japo:
undetectable		 4f4dB-3japo:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 3jap EIF3A
(Saccharomyces
cerevisiae) 		4 / 8 ILE o 376
ILE o 370
ALA o 332
TRP o 303
 None
 0.99A 4ou1A-3japo:
undetectable		 4ou1A-3japo:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 3jap EIF3C
(Saccharomyces
cerevisiae) 		3 / 3 ARG p 436
THR p 453
TRP p 456
 None
 1.04A 4uglA-3japp:
undetectable		 4uglA-3japp:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 3jap EIF3A
(Saccharomyces
cerevisiae) 		4 / 5 GLU o 101
MET o 187
LEU o 202
HIS o 209
 None
 1.21A 4xi3B-3japo:
undetectable		 4xi3B-3japo:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 3jap EIF3C
(Saccharomyces
cerevisiae) 		4 / 6 PHE p 729
LYS p 684
GLY p 685
TYR p 725
 None
 1.16A 4yshB-3japp:
undetectable		 4yshB-3japp:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3jap EIF3C
(Saccharomyces
cerevisiae) 		4 / 5 GLN p 259
PRO p 355
ILE p 351
ASP p 353
 None
 1.41A 4z4hA-3japp:
undetectable		 4z4hA-3japp:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 3jap EIF3A
EIF3C
(Saccharomyces
cerevisiae) 		3 / 3 TYR p 733
TYR o 449
GLN o 445
 None
 1.04A 5jsdA-3japp:
undetectable
5jsdB-3japp:
undetectable		 5jsdA-3japp:
2.38
5jsdB-3japp:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 3jap EIF3A
EIF3C
(Saccharomyces
cerevisiae) 		3 / 3 TYR p 733
TYR o 449
GLN o 445
 None
 1.05A 5jsdB-3japp:
undetectable
5jsdC-3japp:
undetectable		 5jsdB-3japp:
2.38
5jsdC-3japp:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 3jap EIF3C
(Saccharomyces
cerevisiae) 		4 / 7 ARG p 436
TYR p 405
GLU p 452
LEU p 413
 None
 1.10A 5umwB-3japp:
undetectable
5umwE-3japp:
undetectable		 5umwB-3japp:
0.00
5umwE-3japp:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3jap EIF3C
(Saccharomyces
cerevisiae) 		4 / 5 VAL p 675
LEU p 627
CYH p 624
ASP p 618
 None
 1.33A 5vcvA-3japp:
2.1		 5vcvA-3japp:
4.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3jap EIF3A
(Saccharomyces
cerevisiae) 		5 / 12 LEU o 408
ILE o 390
VAL o 432
LEU o 330
TYR o 416
 None
 1.23A 6djzA-3japo:
undetectable		 6djzA-3japo:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3jap EIF3C
(Saccharomyces
cerevisiae) 		3 / 3 LEU p 571
ASN p 613
LEU p 671
 None
 0.77A 6exiD-3japp:
undetectable		 6exiD-3japp:
1.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 3jap EIF3A
(Saccharomyces
cerevisiae) 		4 / 4 ARG o 431
GLU o 392
GLU o 339
ARG o 363
 None
 1.05A 6fk2A-3japo:
undetectable		 6fk2A-3japo:
13.67