SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jav'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		4 / 8 ASP A2570
VAL A2538
GLY A2546
GLY A2548
 None
 0.65A 1aq7A-3javA:
undetectable		 1aq7A-3javA:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		5 / 9 ASP A 228
ALA A 296
SER A 301
GLY A 236
GLY A 294
 None
 1.32A 1bcuH-3javA:
undetectable		 1bcuH-3javA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		4 / 8 SER A 401
THR A 420
ASN A 403
LYS A 348
 None
 0.87A 1mxgA-3javA:
undetectable		 1mxgA-3javA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		4 / 6 ASP A2570
VAL A2538
GLY A2546
GLY A2548
 None
 0.67A 1tnlA-3javA:
undetectable		 1tnlA-3javA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		3 / 3 THR A2315
GLU A2306
HIS A2331
 None
 0.57A 1xwfA-3javA:
undetectable		 1xwfA-3javA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		3 / 3 THR A2315
GLU A2306
HIS A2331
 None
 0.57A 1xwfB-3javA:
undetectable		 1xwfB-3javA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		3 / 3 THR A2315
GLU A2306
HIS A2331
 None
 0.60A 1xwfC-3javA:
undetectable		 1xwfC-3javA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		3 / 3 THR A2315
GLU A2306
HIS A2331
 None
 0.57A 1xwfD-3javA:
undetectable		 1xwfD-3javA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_A_CHDA1_0
(LIVER
CARBOXYLESTERASE 1)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		4 / 5 GLY A 268
LYS A 249
LEU A 251
PRO A 413
 None
 1.28A 2dqyA-3javA:
0.0		 2dqyA-3javA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		4 / 6 LEU A 523
ASN A 514
LYS A 576
PHE A 580
 None
 1.15A 2jn3A-3javA:
undetectable		 2jn3A-3javA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		5 / 10 ARG A  54
SER A  16
PHE A 303
ILE A 220
GLY A 236
 None
 1.33A 2v0mA-3javA:
0.0		 2v0mA-3javA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		5 / 12 PHE A 161
GLN A 122
ILE A  14
MET A 224
VAL A 114
 None
 1.11A 3gwxB-3javA:
undetectable		 3gwxB-3javA:
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		3 / 3 GLU A 461
GLY A 463
THR A 464
 None
 0.56A 3iazA-3javA:
undetectable		 3iazA-3javA:
8.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		5 / 10 GLY A  21
ILE A  27
CYH A  56
PHE A  53
PHE A 223
 None
 1.28A 3ko0L-3javA:
undetectable
3ko0N-3javA:
undetectable		 3ko0L-3javA:
3.26
3ko0N-3javA:
3.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		4 / 6 VAL A 284
VAL A 286
PHE A 223
GLU A 283
 None
 1.39A 3n61A-3javA:
undetectable
3n61B-3javA:
undetectable		 3n61A-3javA:
9.64
3n61B-3javA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		5 / 9 LEU A2290
LEU A2313
ILE A2323
ILE A2325
PHE A2294
 None
 1.48A 3tmzA-3javA:
undetectable		 3tmzA-3javA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		5 / 12 ILE A 220
LEU A 126
ILE A  14
ILE A  27
LEU A 123
 None
 0.89A 3vrmA-3javA:
undetectable		 3vrmA-3javA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		3 / 3 CYH A  61
ASN A 107
LYS A  59
 None
 1.45A 4k50A-3javA:
undetectable		 4k50A-3javA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		3 / 3 ARG A 293
ASP A 228
ASP A 231
 None
 0.81A 4kicB-3javA:
undetectable		 4kicB-3javA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		5 / 11 ASN A 119
GLY A 118
ASP A 174
ILE A 178
THR A 113
 None
 1.15A 4l1aA-3javA:
undetectable		 4l1aA-3javA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		4 / 5 ASN A 229
LEU A 111
SER A 227
LEU A   9
 None
 1.03A 4n09C-3javA:
undetectable		 4n09C-3javA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		5 / 12 HIS A 198
GLU A 208
LEU A 142
LEU A 141
HIS A 194
 None
 1.36A 4pgfB-3javA:
undetectable		 4pgfB-3javA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		3 / 3 VAL A 433
ALA A 272
PHE A 243
 None
 0.90A 4w5nA-3javA:
undetectable		 4w5nA-3javA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		3 / 3 THR A 113
HIS A 125
LEU A 123
 None
 0.81A 5axdA-3javA:
undetectable		 5axdA-3javA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		5 / 12 GLY A 268
ARG A 269
THR A 276
PHE A 263
LEU A 264
 None
 1.38A 5fhzA-3javA:
undetectable		 5fhzA-3javA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		4 / 6 CYH A 556
LEU A 555
HIS A 562
LEU A 480
 None
 1.18A 5hpuC-3javA:
undetectable
5hpuD-3javA:
undetectable		 5hpuC-3javA:
0.85
5hpuD-3javA:
1.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		4 / 8 ILE A 432
PRO A 434
MET A 224
LEU A 242
 None
 1.02A 5ieoA-3javA:
undetectable		 5ieoA-3javA:
4.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		4 / 4 ASN A 229
LEU A 111
SER A 227
LEU A   9
 None
 0.95A 5kb5A-3javA:
undetectable		 5kb5A-3javA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		4 / 7 ILE A 178
VAL A 177
TYR A 117
ARG A 170
 None
 1.19A 5kkzC-3javA:
undetectable
5kkzE-3javA:
3.3		 5kkzC-3javA:
5.04
5kkzE-3javA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		4 / 7 ILE A 178
VAL A 177
TYR A 117
ARG A 170
 None
 1.21A 5kkzK-3javA:
3.5
5kkzQ-3javA:
undetectable		 5kkzK-3javA:
9.67
5kkzQ-3javA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		4 / 8 LEU A 242
VAL A 262
LEU A 390
ILE A 418
 None
 1.01A 5v0vA-3javA:
undetectable		 5v0vA-3javA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		5 / 12 LEU A  60
PRO A  62
GLY A  12
ILE A 121
ILE A 115
 None
 0.99A 6emuA-3javA:
undetectable		 6emuA-3javA:
5.35