SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jb9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_1
(DIHYDROFOLATE
REDUCTASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 4 GLU A1784
ASN A1734
ARG A1772
THR A1907
 None
 1.33A 1drfA-3jb9A:
0.0		 1drfA-3jb9A:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE B 212
LEU B 157
VAL B 268
VAL B 446
 None
 1.07A 1e7aB-3jb9B:
undetectable		 1e7aB-3jb9B:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR PRP5
(Schizosaccharomy
ces
pombe) 		4 / 8 SER K 348
HIS K 329
HIS K 330
PHE K 346
 None
 1.23A 1eqbA-3jb9K:
undetectable
1eqbB-3jb9K:
undetectable		 1eqbA-3jb9K:
17.65
1eqbB-3jb9K:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR PRP5
(Schizosaccharomy
ces
pombe) 		4 / 8 PHE K 346
SER K 348
HIS K 329
HIS K 330
 None
 1.22A 1eqbA-3jb9K:
undetectable
1eqbB-3jb9K:
undetectable		 1eqbA-3jb9K:
17.65
1eqbB-3jb9K:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR PRP5
(Schizosaccharomy
ces
pombe) 		4 / 8 SER K 348
HIS K 329
HIS K 330
PHE K 346
 None
 1.22A 1eqbC-3jb9K:
undetectable
1eqbD-3jb9K:
undetectable		 1eqbC-3jb9K:
17.65
1eqbD-3jb9K:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR PRP5
(Schizosaccharomy
ces
pombe) 		4 / 8 PHE K 346
SER K 348
HIS K 329
HIS K 330
 None
 1.23A 1eqbC-3jb9K:
undetectable
1eqbD-3jb9K:
undetectable		 1eqbC-3jb9K:
17.65
1eqbD-3jb9K:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		5 / 12 ALA A1284
PHE A1280
LEU A1349
ILE A1325
LEU A1272
 None
 1.04A 1fm6U-3jb9A:
undetectable		 1fm6U-3jb9A:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 7 PHE X 857
SER X 840
ALA X 843
ILE X 841
 None
 1.03A 1fxhA-3jb9X:
undetectable
1fxhB-3jb9X:
undetectable		 1fxhA-3jb9X:
9.67
1fxhB-3jb9X:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF17
(Schizosaccharomy
ces
pombe) 		4 / 7 PHE L  58
SER L 327
ALA L  56
ILE L 334
 None
 1.07A 1fxhA-3jb9L:
undetectable
1fxhB-3jb9L:
undetectable		 1fxhA-3jb9L:
20.00
1fxhB-3jb9L:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		3 / 4 VAL A 766
TRP A 772
TRP A 740
 None
None
U  P  22 ( 4.7A)
 1.11A 1gmkA-3jb9A:
undetectable
1gmkB-3jb9A:
undetectable		 1gmkA-3jb9A:
1.94
1gmkB-3jb9A:
1.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF4
(Schizosaccharomy
ces
pombe) 		3 / 3 TRP R 167
VAL R 160
TRP R 164
 None
 1.36A 1gmkC-3jb9R:
undetectable
1gmkD-3jb9R:
undetectable		 1gmkC-3jb9R:
1.93
1gmkD-3jb9R:
1.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 GLN X 703
ASN X 702
LEU X 736
LEU X 681
 None
 1.13A 1hk3A-3jb9X:
undetectable		 1hk3A-3jb9X:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN F
SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D2
(Schizosaccharomy
ces
pombe) 		4 / 8 ARG I  66
SER G  64
ASN G  65
ASP G 104
 U  C 101 ( 3.1A)
None
U  C 101 ( 3.2A)
U  C 101 ( 3.0A)
 1.17A 1hwiB-3jb9I:
undetectable		 1hwiB-3jb9I:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN F
SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D2
(Schizosaccharomy
ces
pombe) 		4 / 7 ARG I  66
SER G  64
ASN G  65
ASP G 104
 U  C 101 ( 3.1A)
None
U  C 101 ( 3.2A)
U  C 101 ( 3.0A)
 1.15A 1hwiC-3jb9I:
undetectable		 1hwiC-3jb9I:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN F
SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D2
(Schizosaccharomy
ces
pombe) 		4 / 7 ARG I  66
SER G  64
ASN G  65
ASP G 104
 U  C 101 ( 3.1A)
None
U  C 101 ( 3.2A)
U  C 101 ( 3.0A)
 1.15A 1hwiD-3jb9I:
undetectable		 1hwiD-3jb9I:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN F
SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D2
(Schizosaccharomy
ces
pombe) 		4 / 8 ARG I  66
SER G  64
ASN G  65
ASP G 104
 U  C 101 ( 3.1A)
None
U  C 101 ( 3.2A)
U  C 101 ( 3.0A)
 1.13A 1hwkA-3jb9I:
undetectable		 1hwkA-3jb9I:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN F
SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D2
(Schizosaccharomy
ces
pombe) 		4 / 8 ARG I  66
SER G  64
ASN G  65
ASP G 104
 U  C 101 ( 3.1A)
None
U  C 101 ( 3.2A)
U  C 101 ( 3.0A)
 1.15A 1hwkC-3jb9I:
undetectable		 1hwkC-3jb9I:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN F
SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D2
(Schizosaccharomy
ces
pombe) 		4 / 8 ARG I  66
SER G  64
ASN G  65
ASP G 104
 U  C 101 ( 3.1A)
None
U  C 101 ( 3.2A)
U  C 101 ( 3.0A)
 1.16A 1hwkD-3jb9I:
undetectable		 1hwkD-3jb9I:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGL_L_ESTL911_1
(IG GAMMA-1-CHAIN
IG KAPPA-CHAIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		5 / 10 GLY A 111
ALA A 119
LEU A 116
HIS A 118
PHE A 149
 None
None
None
C  C  65 ( 4.6A)
None
 1.47A 1jglH-3jb9A:
undetectable
1jglL-3jb9A:
undetectable		 1jglH-3jb9A:
6.70
1jglL-3jb9A:
5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3jb9 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
PPI1
PRE-MRNA-PROCESSING
FACTOR 17
(Schizosaccharomy
ces
pombe) 		5 / 11 GLY g  68
PRO g  69
GLY d  63
ASP d  56
GLN d 101
 None
 1.21A 1jzsA-3jb9g:
undetectable		 1jzsA-3jb9g:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF19
(Schizosaccharomy
ces
pombe) 		4 / 7 LEU c 437
ILE c 470
MET c 474
TRP c 568
 None
 1.16A 1kglA-3jb9c:
undetectable		 1kglA-3jb9c:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF5
(Schizosaccharomy
ces
pombe) 		4 / 4 ALA a 117
ARG a 113
GLN a 118
GLU a 114
 None
 1.44A 1lqtB-3jb9a:
undetectable		 1lqtB-3jb9a:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF5
(Schizosaccharomy
ces
pombe) 		4 / 4 ALA a 117
ARG a 113
GLN a 118
GLU a 114
 None
 1.42A 1lquB-3jb9a:
undetectable		 1lquB-3jb9a:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF17
PRE-MRNA-SPLICING
FACTOR CDC5
PRE-MRNA-SPLICING
FACTOR CWF7
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		5 / 9 GLU i 165
ARG L 282
GLU W 733
ALA W 732
LEU W 729
 None
 1.26A 1mj2A-3jb9i:
undetectable		 1mj2A-3jb9i:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF7
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS i 115
ALA i 119
PHE i 120
GLY i 116
 None
 1.29A 1mj2B-3jb9i:
undetectable		 1mj2B-3jb9i:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF7
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS i 115
ALA i 119
PHE i 120
GLY i 116
 None
 1.33A 1mj2D-3jb9i:
undetectable		 1mj2D-3jb9i:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF17
PRE-MRNA-SPLICING
FACTOR CDC5
PRE-MRNA-SPLICING
FACTOR CWF7
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		5 / 11 GLU i 165
ARG L 282
GLU W 733
ALA W 732
LEU W 729
 None
 1.34A 1mjlA-3jb9i:
undetectable
1mjlB-3jb9i:
undetectable		 1mjlA-3jb9i:
20.86
1mjlB-3jb9i:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF7
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS i 115
ALA i 119
PHE i 120
GLY i 116
 None
 1.30A 1mjoB-3jb9i:
undetectable		 1mjoB-3jb9i:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF7
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS i 115
ALA i 119
PHE i 120
GLY i 116
 None
 1.30A 1mjoD-3jb9i:
undetectable		 1mjoD-3jb9i:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		5 / 10 LEU A 113
LEU A 671
PRO A 117
ALA A 566
PHE A 567
 None
None
None
C  N  60 ( 3.1A)
None
 1.40A 1mjqC-3jb9A:
undetectable
1mjqD-3jb9A:
undetectable		 1mjqC-3jb9A:
3.86
1mjqD-3jb9A:
3.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		6 / 12 ALA B 461
ILE B 469
GLY B 467
ILE B 466
VAL B 489
ILE B 477
 None
 1.46A 1muiB-3jb9B:
undetectable		 1muiB-3jb9B:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF2
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY Y 167
VAL Y 148
ASP Y 149
VAL Y 166
GLN Y 224
 G  N  27 ( 3.9A)
None
None
G  N  27 ( 4.0A)
None
 1.30A 1n2xA-3jb9Y:
undetectable		 1n2xA-3jb9Y:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG X 795
ASP X 909
ASN X 903
 None
 0.68A 1nbhA-3jb9X:
undetectable		 1nbhA-3jb9X:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG X 795
ASP X 909
ASN X 903
 None
 0.70A 1nbhD-3jb9X:
undetectable		 1nbhD-3jb9X:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		3 / 3 THR X1236
GLU X1085
ASP X1076
 None
 0.80A 1nt2A-3jb9X:
undetectable		 1nt2A-3jb9X:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3jb9 PRE-MRNA-PROCESSING
PROTEIN 45
PRE-MRNA-SPLICING
FACTOR CWF4
(Schizosaccharomy
ces
pombe) 		4 / 8 ARG R 124
TYR M 103
GLU R 148
GLN R 159
 None
 1.15A 1nx9A-3jb9R:
undetectable		 1nx9A-3jb9R:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3jb9 PRE-MRNA-PROCESSING
PROTEIN 45
PRE-MRNA-SPLICING
FACTOR CWF4
(Schizosaccharomy
ces
pombe) 		4 / 8 ARG R 124
TYR M 103
GLU R 148
GLN R 159
 None
 1.16A 1nx9B-3jb9R:
undetectable		 1nx9B-3jb9R:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3jb9 PRE-MRNA-PROCESSING
PROTEIN 45
PRE-MRNA-SPLICING
FACTOR CWF4
(Schizosaccharomy
ces
pombe) 		4 / 8 ARG R 124
TYR M 103
GLU R 148
GLN R 159
 None
 1.16A 1nx9C-3jb9R:
undetectable		 1nx9C-3jb9R:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3jb9 PRE-MRNA-PROCESSING
PROTEIN 45
PRE-MRNA-SPLICING
FACTOR CWF4
(Schizosaccharomy
ces
pombe) 		4 / 8 ARG R 124
TYR M 103
GLU R 148
GLN R 159
 None
 1.15A 1nx9D-3jb9R:
undetectable		 1nx9D-3jb9R:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 6 TYR A1695
ILE A1359
PRO A1360
ARG A1568
 None
 1.42A 1oniA-3jb9A:
undetectable
1oniC-3jb9A:
undetectable		 1oniA-3jb9A:
4.70
1oniC-3jb9A:
4.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		5 / 11 PHE X1120
VAL X1166
GLY X1167
ILE X1182
VAL X1181
 None
 1.16A 1phgA-3jb9X:
undetectable		 1phgA-3jb9X:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		5 / 12 THR A1112
PHE A1212
PHE A1097
LEU A 985
VAL A 988
 None
 1.42A 1q23D-3jb9A:
undetectable
1q23E-3jb9A:
undetectable		 1q23D-3jb9A:
6.47
1q23E-3jb9A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		5 / 11 THR A1112
PHE A1212
PHE A1097
LEU A 985
VAL A 988
 None
 1.41A 1q23G-3jb9A:
undetectable		 1q23G-3jb9A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		5 / 11 THR A1112
PHE A1212
PHE A1097
LEU A 985
VAL A 988
 None
 1.41A 1q23I-3jb9A:
undetectable		 1q23I-3jb9A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		5 / 11 THR A 991
SER A1204
LEU A1174
VAL A1178
VAL A1202
 None
 1.42A 1q23J-3jb9A:
undetectable		 1q23J-3jb9A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		5 / 11 THR A1112
PHE A1212
PHE A1097
LEU A 985
VAL A 988
 None
 1.35A 1q23J-3jb9A:
undetectable		 1q23J-3jb9A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 3jb9 PRE-MRNA-PROCESSING
PROTEIN 45
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP M 123
LEU M 234
HIS M 113
 None
 0.75A 1qknA-3jb9M:
undetectable		 1qknA-3jb9M:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A1055
ILE A1115
TRP A1064
 None
 1.18A 1qomA-3jb9A:
undetectable		 1qomA-3jb9A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF3
(Schizosaccharomy
ces
pombe) 		4 / 8 THR r 499
TYR r 503
ILE r 536
TYR r 537
 None
 1.15A 1qvtA-3jb9r:
undetectable		 1qvtA-3jb9r:
5.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 7 PHE X1082
TYR X1248
LEU X1126
THR X1243
 None
 1.03A 1rmtB-3jb9X:
undetectable		 1rmtB-3jb9X:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 PHE X1082
TYR X1248
LEU X1126
THR X1243
 None
 0.98A 1rmtD-3jb9X:
undetectable		 1rmtD-3jb9X:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 SER X 806
LEU X 805
LYS X 801
THR X 819
 None
 0.92A 1sbrA-3jb9X:
undetectable		 1sbrA-3jb9X:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		3 / 3 LEU X 762
LEU X 765
SER X 769
 None
 0.60A 1tlmA-3jb9X:
undetectable		 1tlmA-3jb9X:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 4 SER X1151
ILE X1150
VAL X1143
THR X1100
 None
 1.01A 1u70A-3jb9X:
undetectable		 1u70A-3jb9X:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE X 989
MET X 745
THR X 744
LEU X 743
 None
 0.90A 1v55A-3jb9X:
undetectable
1v55J-3jb9X:
undetectable		 1v55A-3jb9X:
16.83
1v55J-3jb9X:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 7 LEU X 690
ASP X 714
THR X 701
TYR X 700
 None
 1.12A 1v55C-3jb9X:
undetectable
1v55N-3jb9X:
undetectable
1v55P-3jb9X:
undetectable		 1v55C-3jb9X:
11.15
1v55N-3jb9X:
16.83
1v55P-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3jb9 PRE-MRNA-PROCESSING
FACTOR 17
PRE-MRNA-PROCESSING
PROTEIN 45
PRE-MRNA-SPLICING
FACTOR CWF17
SMALL NUCLEAR
RIBONUCLEOPROTEIN-AS
SOCIATED PROTEIN B
(Schizosaccharomy
ces
pombe) 		5 / 11 SER L 289
GLY E 116
VAL g  94
GLU L 269
ILE M 201
 None
 1.48A 1vhwC-3jb9L:
undetectable
1vhwE-3jb9L:
undetectable		 1vhwC-3jb9L:
21.69
1vhwE-3jb9L:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3jb9 PRE-MRNA-PROCESSING
FACTOR 17
PRE-MRNA-PROCESSING
PROTEIN 45
PRE-MRNA-SPLICING
FACTOR CWF17
SMALL NUCLEAR
RIBONUCLEOPROTEIN-AS
SOCIATED PROTEIN B
(Schizosaccharomy
ces
pombe) 		5 / 11 SER L 289
GLY E 116
VAL g  94
GLU L 269
ILE M 201
 None
 1.47A 1vhwA-3jb9L:
undetectable
1vhwD-3jb9L:
undetectable		 1vhwA-3jb9L:
21.69
1vhwD-3jb9L:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 8 TYR A1067
PHE A1066
LEU A1015
MET A1020
 None
 1.03A 1x8vA-3jb9A:
undetectable		 1x8vA-3jb9A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF5
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE a  46
ALA a 117
GLN a 120
ASN a  78
CYH a  79
 None
 1.13A 1xdkA-3jb9a:
undetectable		 1xdkA-3jb9a:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		5 / 12 MET X 745
LEU X1032
THR X 990
ILE X 989
PHE X 642
 None
 1.37A 1xoqA-3jb9X:
undetectable		 1xoqA-3jb9X:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		3 / 3 THR A1112
GLU A 969
HIS A1096
 None
 0.91A 1xwfB-3jb9A:
undetectable		 1xwfB-3jb9A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		3 / 3 THR A1112
GLU A 969
HIS A1096
 None
 0.90A 1xwfC-3jb9A:
undetectable		 1xwfC-3jb9A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU A1471
LEU A1472
VAL A 875
GLY A 877
ARG A 878
 None
 1.29A 1y4lB-3jb9A:
undetectable		 1y4lB-3jb9A:
3.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		3 / 3 LEU X  81
HIS X  53
LYS X  85
 None
 1.08A 1y7iA-3jb9X:
undetectable		 1y7iA-3jb9X:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU X 507
SER X 615
LEU X 517
ILE X 559
 None
 0.97A 1yajF-3jb9X:
undetectable		 1yajF-3jb9X:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		5 / 12 PRO B 588
ILE B 573
VAL B 569
VAL B 492
LEU B 566
 None
 1.15A 1z9hD-3jb9B:
undetectable		 1z9hD-3jb9B:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 7 PHE X 433
TYR X 427
THR X 423
GLY X1026
 None
 0.72A 2a1mA-3jb9X:
undetectable		 2a1mA-3jb9X:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 PHE X 433
TYR X 427
THR X 423
GLY X1026
 None
 0.81A 2a1mB-3jb9X:
undetectable		 2a1mB-3jb9X:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 PHE X 433
TYR X 427
THR X 423
GLY X1026
 None
 0.74A 2a1oA-3jb9X:
undetectable		 2a1oA-3jb9X:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		3 / 3 TRP A1478
THR A1215
TYR A1114
 None
 1.26A 2a3bA-3jb9A:
undetectable		 2a3bA-3jb9A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU A 866
LEU A 869
LEU A 887
LEU A 889
 None
 0.91A 2ab2B-3jb9A:
undetectable		 2ab2B-3jb9A:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 7 GLY X 742
PHE X 657
PRO X 658
ASP X 653
 None
 1.12A 2aouB-3jb9X:
undetectable		 2aouB-3jb9X:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		6 / 12 ALA B 461
ILE B 469
GLY B 467
ILE B 466
VAL B 489
ILE B 477
 None
 1.44A 2avvB-3jb9B:
undetectable		 2avvB-3jb9B:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU A 597
ILE A 592
ILE A 580
HIS A 584
 None
 0.94A 2azxA-3jb9A:
undetectable		 2azxA-3jb9A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP A1981
ASP A2002
ASN A1994
 None
 0.78A 2bm9D-3jb9A:
undetectable		 2bm9D-3jb9A:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF14
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU e  23
ILE e  60
ILE e  19
ILE e  70
 None
 0.83A 2bu8A-3jb9e:
2.3		 2bu8A-3jb9e:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 7 ARG A 155
SER A 153
GLN A 445
GLU A 125
 U  C  67 ( 3.3A)
G  C  66 ( 3.4A)
C  C  65 ( 4.6A)
G  C  66 ( 3.7A)
 1.20A 2c8aA-3jb9A:
undetectable		 2c8aA-3jb9A:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		4 / 8 ILE B 544
ARG B 509
MET B 490
LEU B 488
 None
 0.95A 2eikN-3jb9B:
undetectable
2eikW-3jb9B:
undetectable		 2eikN-3jb9B:
17.37
2eikW-3jb9B:
5.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		4 / 6 ILE B 544
ARG B 509
MET B 490
LEU B 488
 None
 0.94A 2einN-3jb9B:
undetectable
2einW-3jb9B:
undetectable		 2einN-3jb9B:
17.37
2einW-3jb9B:
5.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 6 ILE X 989
MET X 745
THR X 744
LEU X 743
 None
 0.99A 2einN-3jb9X:
undetectable
2einW-3jb9X:
1.1		 2einN-3jb9X:
16.83
2einW-3jb9X:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 7 LEU A 579
LEU A 576
ILE A 625
TYR A 603
 None
 1.17A 2hc4A-3jb9A:
undetectable		 2hc4A-3jb9A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 496
ILE A 510
LEU A 121
VAL A 668
VAL A 519
 None
 1.20A 2hrcA-3jb9A:
undetectable		 2hrcA-3jb9A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 496
ILE A 510
LEU A 121
VAL A 668
VAL A 519
 None
 1.18A 2hrcB-3jb9A:
undetectable		 2hrcB-3jb9A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		3 / 3 ALA B 501
GLY B 620
SER B 627
 None
 0.59A 2ivuA-3jb9B:
undetectable		 2ivuA-3jb9B:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A  94
VAL A 519
THR A 148
 None
 0.81A 2nnkA-3jb9A:
undetectable		 2nnkA-3jb9A:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		6 / 12 ALA B 461
ILE B 469
GLY B 467
ILE B 466
VAL B 489
ILE B 477
 None
 1.46A 2o4kB-3jb9B:
undetectable		 2o4kB-3jb9B:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_2
(MINERALOCORTICOID
RECEPTOR)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF4
(Schizosaccharomy
ces
pombe) 		4 / 4 LEU R 108
LEU R 126
MET R 147
CYH R 113
 A  N  78 ( 4.5A)
None
None
None
 1.23A 2oaxC-3jb9R:
0.0		 2oaxC-3jb9R:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF4
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU R 108
LEU R 126
MET R 147
CYH R 113
 A  N  78 ( 4.5A)
None
None
None
 1.34A 2oaxD-3jb9R:
undetectable		 2oaxD-3jb9R:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU B 863
ILE B 889
SER B 894
GLY B 896
 None
 0.98A 2otfA-3jb9B:
undetectable		 2otfA-3jb9B:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP A 895
ASN A 896
THR A 859
 None
 0.76A 2q63B-3jb9A:
undetectable		 2q63B-3jb9A:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR PRP5
(Schizosaccharomy
ces
pombe) 		4 / 7 ASP K 399
PHE K 368
TYR K 406
TRP K 153
 None
 1.30A 2q6kA-3jb9K:
undetectable		 2q6kA-3jb9K:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 6 ILE A1831
PRO A1882
LEU A1900
ILE A1885
 None
 1.03A 2q83B-3jb9A:
undetectable		 2q83B-3jb9A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
PRE-MRNA-SPLICING
FACTOR CWF15
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		4 / 8 LEU A1019
PRO A1187
SER A1189
VAL h 230
 None
 1.01A 2qd2A-3jb9A:
undetectable		 2qd2A-3jb9A:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 3jb9 U2 SMALL NUCLEAR
RIBONUCLEOPROTEIN A'
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU j 108
LEU j 117
LEU j 144
ILE j  78
VAL j 124
 None
 1.17A 2qd3A-3jb9j:
undetectable		 2qd3A-3jb9j:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D3
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		4 / 6 TYR B 126
THR B 209
ALA B 211
PRO D  79
 None
 1.40A 2ql8A-3jb9B:
2.4
2ql8B-3jb9B:
2.4		 2ql8A-3jb9B:
10.19
2ql8B-3jb9B:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF19
(Schizosaccharomy
ces
pombe) 		4 / 8 PHE c 628
ILE c 477
PHE c 624
ILE c 505
 None
 0.86A 2qwxA-3jb9c:
undetectable
2qwxB-3jb9c:
undetectable		 2qwxA-3jb9c:
16.95
2qwxB-3jb9c:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		3 / 3 GLN A 522
THR A 577
TRP A 512
 None
 1.12A 2rctA-3jb9A:
undetectable		 2rctA-3jb9A:
4.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		4 / 5 PHE B 368
PHE B 381
PHE B 351
ILE B 294
 None
 1.27A 2v0mD-3jb9B:
undetectable		 2v0mD-3jb9B:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 7 PHE A 149
ALA A 112
LEU A 116
ALA A 119
 None
 0.84A 2vcvA-3jb9A:
undetectable		 2vcvA-3jb9A:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 7 PHE A 149
ALA A 112
LEU A 116
ALA A 119
 None
 0.83A 2vcvG-3jb9A:
undetectable		 2vcvG-3jb9A:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 7 PHE A 149
ALA A 112
LEU A 116
ALA A 119
 None
 0.84A 2vcvL-3jb9A:
undetectable		 2vcvL-3jb9A:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		4 / 6 ASP B 358
PHE B 381
TYR B 287
LEU B 332
 None
 1.15A 2w98A-3jb9B:
undetectable
2w98B-3jb9B:
undetectable		 2w98A-3jb9B:
16.65
2w98B-3jb9B:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		4 / 5 TYR B 650
MET B 191
PRO B 218
LEU B 185
 None
 1.45A 2wekA-3jb9B:
1.7		 2wekA-3jb9B:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF17
(Schizosaccharomy
ces
pombe) 		4 / 6 PRO L 179
ILE L 221
ASN L 139
LEU L 272
 None
 1.39A 2wekB-3jb9L:
undetectable		 2wekB-3jb9L:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		5 / 10 VAL X 758
SER X 783
SER X 780
ASN X 983
GLY X1009
 None
 1.46A 2x2iB-3jb9X:
undetectable		 2x2iB-3jb9X:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		5 / 10 VAL X 758
SER X 783
SER X 780
ASN X 983
GLY X1009
 None
 1.48A 2x2iD-3jb9X:
undetectable		 2x2iD-3jb9X:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF17
(Schizosaccharomy
ces
pombe) 		4 / 6 SER L  61
TYR L  64
VAL L  79
ASP L  59
 None
 1.39A 2x45A-3jb9L:
undetectable		 2x45A-3jb9L:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D3
SMALL NUCLEAR
RIBONUCLEOPROTEIN-AS
SOCIATED PROTEIN B
(Schizosaccharomy
ces
pombe) 		3 / 3 GLU E  73
HIS D  65
GLU D  21
 U  C  99 ( 4.7A)
None
None
 0.85A 2x45B-3jb9E:
undetectable		 2x45B-3jb9E:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D3
SMALL NUCLEAR
RIBONUCLEOPROTEIN-AS
SOCIATED PROTEIN B
(Schizosaccharomy
ces
pombe) 		3 / 3 GLU E  73
HIS D  65
GLU D  21
 U  C  99 ( 4.7A)
None
None
 0.88A 2x45C-3jb9E:
undetectable		 2x45C-3jb9E:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		5 / 11 TYR B 179
LEU B 158
LEU B 161
LEU B 198
PRO B 122
 None
 1.34A 2x7hA-3jb9B:
1.7
2x7hB-3jb9B:
1.7		 2x7hA-3jb9B:
17.28
2x7hB-3jb9B:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D1
SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D2
(Schizosaccharomy
ces
pombe) 		5 / 10 VAL G 109
ILE G  45
LEU F   3
LEU G  68
ALA G  59
 None
 1.08A 2xf3A-3jb9G:
undetectable		 2xf3A-3jb9G:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		5 / 11 SER B 334
SER B 333
ALA B 336
SER B 352
LEU B 355
 None
 1.04A 2xn5A-3jb9B:
undetectable		 2xn5A-3jb9B:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CHDN1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU X 690
ASP X 714
THR X 701
TYR X 700
 None
 1.16A 2y69C-3jb9X:
undetectable
2y69N-3jb9X:
undetectable
2y69P-3jb9X:
undetectable		 2y69C-3jb9X:
11.15
2y69N-3jb9X:
16.83
2y69P-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3jb9 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
PPI1
PRE-MRNA-PROCESSING
FACTOR 17
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		5 / 12 ALA g  66
GLY d  61
THR d  60
PRO g  65
THR d  97
 None
 1.06A 2y7hC-3jb9g:
undetectable		 2y7hC-3jb9g:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 3jb9 PRE-MRNA-SPLICING
FACTOR PRP5
(Schizosaccharomy
ces
pombe) 		4 / 5 ALA K 252
GLY K 224
LYS K 227
HIS K 246
 None
 1.13A 2ylgA-3jb9K:
undetectable		 2ylgA-3jb9K:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP X1076
THR X1236
GLU X1085
 None
 0.64A 2zifB-3jb9X:
undetectable		 2zifB-3jb9X:
12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU X 690
THR X 692
THR X 701
HIS X 716
 None
 1.28A 2zj0B-3jb9X:
undetectable		 2zj0B-3jb9X:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF17
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU L 273
SER L 329
SER L 330
LEU L 306
LEU L 302
 None
 1.28A 2zlcA-3jb9L:
undetectable		 2zlcA-3jb9L:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		3 / 3 SER B 363
GLU B 387
ASP B 285
 None
 0.64A 2zulA-3jb9B:
undetectable		 2zulA-3jb9B:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE B 144
GLY B 236
PRO B 264
ILE B 215
ASP B 216
 None
 1.21A 2zznB-3jb9B:
3.2		 2zznB-3jb9B:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 5 ARG X1280
GLN X1121
PHE X1120
LEU X1126
 None
 1.10A 3ablC-3jb9X:
undetectable
3ablJ-3jb9X:
undetectable		 3ablC-3jb9X:
11.15
3ablJ-3jb9X:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 6 ARG X1280
GLN X1121
PHE X1120
LEU X1126
 None
 1.10A 3ablP-3jb9X:
undetectable
3ablW-3jb9X:
undetectable		 3ablP-3jb9X:
11.15
3ablW-3jb9X:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU X 690
ASP X 714
THR X 701
TYR X 700
 None
 1.16A 3ablC-3jb9X:
undetectable
3ablN-3jb9X:
undetectable
3ablP-3jb9X:
undetectable		 3ablC-3jb9X:
11.15
3ablN-3jb9X:
16.83
3ablP-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP X 714
THR X 701
TYR X 700
LEU X 690
 None
 1.18A 3abmA-3jb9X:
undetectable
3abmC-3jb9X:
undetectable
3abmP-3jb9X:
undetectable		 3abmA-3jb9X:
16.83
3abmC-3jb9X:
11.15
3abmP-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN-AS
SOCIATED PROTEIN B
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU E   9
GLY E  72
LEU E  39
LEU E  14
VAL E  16
 None
U  C  99 ( 3.5A)
None
None
None
 0.97A 3adxB-3jb9E:
undetectable		 3adxB-3jb9E:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE X 989
MET X 745
THR X 744
LEU X 743
 None
 0.95A 3ag3A-3jb9X:
undetectable
3ag3J-3jb9X:
undetectable		 3ag3A-3jb9X:
16.83
3ag3J-3jb9X:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF2
(Schizosaccharomy
ces
pombe) 		4 / 7 GLN Y  53
GLY Y 123
HIS Y 135
CYH Y 117
 None
None
ZN  Y 501 ( 3.8A)
ZN  Y 501 ( 2.3A)
 0.91A 3ai8A-3jb9Y:
undetectable		 3ai8A-3jb9Y:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_B_HNQB255_1
(CATHEPSIN B)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF2
(Schizosaccharomy
ces
pombe) 		4 / 6 GLN Y  53
GLY Y 123
HIS Y 135
CYH Y 117
 None
None
ZN  Y 501 ( 3.8A)
ZN  Y 501 ( 2.3A)
 0.95A 3ai8B-3jb9Y:
undetectable		 3ai8B-3jb9Y:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU X 690
ASP X 714
THR X 701
TYR X 700
 None
 1.15A 3asnC-3jb9X:
undetectable
3asnN-3jb9X:
undetectable
3asnP-3jb9X:
undetectable		 3asnC-3jb9X:
11.15
3asnN-3jb9X:
16.83
3asnP-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP X 714
THR X 701
TYR X 700
LEU X 690
 None
 1.16A 3asoA-3jb9X:
undetectable
3asoC-3jb9X:
undetectable
3asoP-3jb9X:
undetectable		 3asoA-3jb9X:
16.83
3asoC-3jb9X:
11.15
3asoP-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU X 690
ASP X 714
THR X 701
TYR X 700
 None
 1.16A 3asoC-3jb9X:
undetectable
3asoN-3jb9X:
undetectable
3asoP-3jb9X:
undetectable		 3asoC-3jb9X:
11.15
3asoN-3jb9X:
16.83
3asoP-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 3jb9 PRE-MRNA-PROCESSING
FACTOR 17
PRE-MRNA-SPLICING
FACTOR CWF5
(Schizosaccharomy
ces
pombe) 		4 / 8 ASN g  83
LYS g  82
PRO a  20
PHE a  54
 None
 1.49A 3bjwD-3jb9g:
undetectable		 3bjwD-3jb9g:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D3
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		5 / 12 ALA B 433
GLY B 327
LEU B 430
ARG D  96
PHE B 438
 None
 1.35A 3bxoA-3jb9B:
undetectable		 3bxoA-3jb9B:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D3
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		5 / 12 ALA B 433
GLY B 327
LEU B 430
ARG D  96
PHE B 438
 None
 1.36A 3bxoB-3jb9B:
undetectable		 3bxoB-3jb9B:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 3jb9 PRE-MRNA-PROCESSING
PROTEIN 45
PRE-MRNA-SPLICING
FACTOR CDC5
PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU W  72
LEU W  75
SER M 292
THR A1014
 None
 1.07A 3cfqA-3jb9W:
undetectable		 3cfqA-3jb9W:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		3 / 3 CYH B 432
PHE B 435
PHE B 436
 None
 0.56A 3cr5X-3jb9B:
undetectable		 3cr5X-3jb9B:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA301_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF4
(Schizosaccharomy
ces
pombe) 		4 / 6 ARG R  67
ILE R  63
TRP R  73
VAL R  99
 None
 1.44A 3deuA-3jb9R:
undetectable		 3deuA-3jb9R:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3jb9 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
PPI1
(Schizosaccharomy
ces
pombe) 		4 / 6 THR d 109
ILE d 118
SER d  89
THR d 105
 None
 0.74A 3deuB-3jb9d:
undetectable		 3deuB-3jb9d:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 5 TYR A1114
ARG A1461
TYR A1297
THR A1296
 None
 0.98A 3dgqA-3jb9A:
undetectable		 3dgqA-3jb9A:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		3 / 3 SER B 363
GLU B 387
ASP B 285
 None
 0.65A 3dmhA-3jb9B:
2.6		 3dmhA-3jb9B:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 3jb9 PRE-MRNA-SPLICING
FACTOR PRP5
(Schizosaccharomy
ces
pombe) 		4 / 7 GLU K 440
ASP K 442
SER K 427
THR K 377
 None
 1.32A 3dzgB-3jb9K:
undetectable		 3dzgB-3jb9K:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A1055
ILE A1115
TRP A1064
 None
 1.17A 3e7iB-3jb9A:
undetectable		 3e7iB-3jb9A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		3 / 3 ASN A 480
ASP A 446
GLN A 445
 U  C  36 ( 3.4A)
A  C  35 ( 4.0A)
C  C  65 ( 4.6A)
 0.81A 3eeyC-3jb9A:
undetectable		 3eeyC-3jb9A:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		3 / 3 ASN A 480
ASP A 446
GLN A 445
 U  C  36 ( 3.4A)
A  C  35 ( 4.0A)
C  C  65 ( 4.6A)
 0.79A 3eeyD-3jb9A:
undetectable		 3eeyD-3jb9A:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		3 / 3 ASN A 480
ASP A 446
GLN A 445
 U  C  36 ( 3.4A)
A  C  35 ( 4.0A)
C  C  65 ( 4.6A)
 0.81A 3eeyE-3jb9A:
undetectable		 3eeyE-3jb9A:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D3
SMALL NUCLEAR
RIBONUCLEOPROTEIN G
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		4 / 5 ASN J  39
ARG D  62
ASN D  36
ALA J   6
 U  C  97 ( 3.1A)
U  C  97 ( 3.2A)
U  C  98 ( 4.0A)
None
 1.43A 3frqA-3jb9J:
undetectable		 3frqA-3jb9J:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D3
SMALL NUCLEAR
RIBONUCLEOPROTEIN G
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		4 / 7 ASN J  39
ARG D  62
ASN D  36
ALA J   6
 U  C  97 ( 3.1A)
U  C  97 ( 3.2A)
U  C  98 ( 4.0A)
None
 1.43A 3frqB-3jb9J:
undetectable		 3frqB-3jb9J:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
PRE-MRNA-SPLICING
FACTOR CWF14
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		3 / 3 ARG e   5
GLU A 136
ASP A  81
 None
 0.83A 3g2oA-3jb9e:
undetectable		 3g2oA-3jb9e:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		5 / 12 MET X 745
LEU X1032
THR X 990
ILE X 989
PHE X 642
 None
 1.41A 3g4lB-3jb9X:
undetectable		 3g4lB-3jb9X:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		3 / 3 ASN X  60
MET X  70
PHE X  27
 None
 1.08A 3g4lD-3jb9X:
undetectable		 3g4lD-3jb9X:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		5 / 12 THR A1191
GLU A1194
LEU B  71
LEU A1071
TYR A1067
 None
 1.42A 3gwxB-3jb9A:
undetectable		 3gwxB-3jb9A:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		5 / 12 THR A1191
THR A1192
LEU B  71
LEU A1071
TYR A1067
 None
 1.40A 3gwxB-3jb9A:
undetectable		 3gwxB-3jb9A:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
PRE-MRNA-PROCESSING
PROTEIN 45
PRE-MRNA-SPLICING
FACTOR CWF5
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		3 / 3 THR M 206
LYS A 114
GLU a  38
 None
 0.92A 3ijdB-3jb9M:
undetectable		 3ijdB-3jb9M:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		4 / 5 PRO B 608
SER B 612
LEU B 658
SER B 663
 None
 1.43A 3ijxH-3jb9B:
undetectable		 3ijxH-3jb9B:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		4 / 5 PRO B 608
SER B 612
LEU B 658
SER B 663
 None
 1.49A 3iluH-3jb9B:
undetectable		 3iluH-3jb9B:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF19
(Schizosaccharomy
ces
pombe) 		5 / 12 GLU c 582
GLY c 586
ASP c 530
GLY c 563
SER c 496
 None
 1.18A 3k13A-3jb9c:
undetectable		 3k13A-3jb9c:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF19
(Schizosaccharomy
ces
pombe) 		5 / 12 GLU c 582
GLY c 586
ASP c 530
GLY c 563
SER c 496
 None
 1.19A 3k13B-3jb9c:
undetectable		 3k13B-3jb9c:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF19
(Schizosaccharomy
ces
pombe) 		5 / 12 GLU c 582
GLY c 586
ASP c 530
GLY c 563
SER c 496
 None
 1.21A 3k13C-3jb9c:
undetectable		 3k13C-3jb9c:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		5 / 12 GLU A1701
ASN A1670
GLY A1373
PHE A1377
ILE A1700
 None
 1.21A 3k13C-3jb9A:
undetectable		 3k13C-3jb9A:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF19
PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG c 593
THR c 528
THR A1453
 None
 0.65A 3k2hB-3jb9c:
undetectable		 3k2hB-3jb9c:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A  94
VAL A 519
THR A 148
 None
 0.77A 3k4vA-3jb9A:
undetectable		 3k4vA-3jb9A:
3.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A  94
VAL A 519
THR A 148
 None
 0.75A 3k4vD-3jb9A:
undetectable		 3k4vD-3jb9A:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 7 TYR A1203
GLU A 990
TRP A 989
LEU A1210
 None
 1.40A 3k8mA-3jb9A:
undetectable		 3k8mA-3jb9A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 7 TYR A1203
GLU A 990
TRP A 989
LEU A1210
 None
 1.42A 3k8mB-3jb9A:
undetectable		 3k8mB-3jb9A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		4 / 8 GLY B 896
CYH B 653
PHE B 644
PHE B 602
 None
 0.94A 3ko0D-3jb9B:
1.9
3ko0E-3jb9B:
undetectable		 3ko0D-3jb9B:
7.07
3ko0E-3jb9B:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		4 / 8 PHE B 602
GLY B 896
CYH B 653
PHE B 644
 None
 0.94A 3ko0B-3jb9B:
1.8
3ko0J-3jb9B:
undetectable		 3ko0B-3jb9B:
7.07
3ko0J-3jb9B:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
PRE-MRNA-SPLICING
FACTOR CWF14
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		3 / 3 SER A 509
ASP A  81
ASN e  87
 None
None
G  C  75 ( 4.7A)
 0.94A 3lsfB-3jb9A:
undetectable
3lsfE-3jb9A:
undetectable		 3lsfB-3jb9A:
7.59
3lsfE-3jb9A:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
PRE-MRNA-SPLICING
FACTOR CWF14
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		3 / 3 ASP A  81
ASN e  87
SER A 509
 None
G  C  75 ( 4.7A)
None
 0.92A 3lsfB-3jb9A:
undetectable
3lsfE-3jb9A:
undetectable		 3lsfB-3jb9A:
7.59
3lsfE-3jb9A:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		5 / 10 THR X 774
LEU X 765
LEU X 761
GLY X 738
THR X 744
 None
 1.29A 3lxiA-3jb9X:
undetectable		 3lxiA-3jb9X:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		5 / 11 THR X 774
LEU X 765
LEU X 761
GLY X 738
THR X 744
 None
 1.31A 3lxiB-3jb9X:
undetectable		 3lxiB-3jb9X:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_A_PXLA400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		5 / 11 VAL A1011
LEU A1071
THR A1191
VAL A 824
ASP A1012
 None
 1.37A 3mbhA-3jb9A:
undetectable		 3mbhA-3jb9A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		5 / 12 VAL A1011
LEU A1071
THR A1191
VAL A 824
ASP A1012
 None
 1.38A 3mbhB-3jb9A:
undetectable		 3mbhB-3jb9A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		5 / 12 VAL A1011
LEU A1071
THR A1191
VAL A 824
ASP A1012
 None
 1.39A 3mbhC-3jb9A:
undetectable		 3mbhC-3jb9A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		5 / 12 VAL A1011
LEU A1071
THR A1191
VAL A 824
ASP A1012
 None
 1.38A 3mbhD-3jb9A:
undetectable		 3mbhD-3jb9A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		5 / 12 VAL A1011
LEU A1071
THR A1191
VAL A 824
ASP A1012
 None
 1.35A 3mbhE-3jb9A:
undetectable		 3mbhE-3jb9A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_F_PXLF400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		5 / 11 VAL A1011
LEU A1071
THR A1191
VAL A 824
ASP A1012
 None
 1.38A 3mbhF-3jb9A:
undetectable		 3mbhF-3jb9A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF17
(Schizosaccharomy
ces
pombe) 		3 / 3 SER L 111
SER L 112
HIS L 131
 None
 0.73A 3mzeA-3jb9L:
undetectable		 3mzeA-3jb9L:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF17
(Schizosaccharomy
ces
pombe) 		4 / 7 GLU L 149
SER L 148
VAL L 146
VAL L 143
 None
 1.29A 3n61A-3jb9L:
undetectable
3n61B-3jb9L:
undetectable		 3n61A-3jb9L:
21.72
3n61B-3jb9L:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A  94
VAL A 519
THR A 148
 None
 0.72A 3nduD-3jb9A:
undetectable		 3nduD-3jb9A:
3.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 7 PHE A1212
LEU A 985
THR A1112
THR A1249
 None
 1.23A 3nxuA-3jb9A:
undetectable		 3nxuA-3jb9A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D1
(Schizosaccharomy
ces
pombe) 		5 / 10 LEU F  10
VAL F   4
GLY F  62
ILE F  60
LEU F   7
 None
None
U  C 100 ( 4.2A)
None
None
 1.16A 3ogpB-3jb9F:
undetectable		 3ogpB-3jb9F:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		3 / 3 THR A 379
SER A 380
ARG A 381
 None
 0.76A 3phnA-3jb9A:
undetectable		 3phnA-3jb9A:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A  94
VAL A 519
THR A 148
 None
 0.85A 3pwrA-3jb9A:
undetectable		 3pwrA-3jb9A:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN F
SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D2
(Schizosaccharomy
ces
pombe) 		3 / 3 LEU I  64
ARG G  48
ASN G  65
 None
U  C 103 ( 2.9A)
U  C 101 ( 3.2A)
 0.71A 3qxvD-3jb9I:
undetectable		 3qxvD-3jb9I:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF19
(Schizosaccharomy
ces
pombe) 		5 / 10 VAL c 567
ALA c 520
MET c 599
TYR c 491
ILE c 489
 None
 1.47A 3retA-3jb9c:
undetectable
3retB-3jb9c:
undetectable		 3retA-3jb9c:
10.34
3retB-3jb9c:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN F
SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D2
(Schizosaccharomy
ces
pombe) 		4 / 7 LEU I  12
VAL I  37
VAL I  73
LEU G  30
 None
 0.97A 3rgfA-3jb9I:
undetectable		 3rgfA-3jb9I:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 3jb9 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
PPI1
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU d  17
GLY d 120
PHE d 119
PHE d  29
 None
 1.11A 3smtA-3jb9d:
undetectable		 3smtA-3jb9d:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		3 / 3 TYR B 656
LEU B 618
LYS B 616
 None
 0.78A 3sueD-3jb9B:
undetectable		 3sueD-3jb9B:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		3 / 3 TYR A 337
LEU B 618
LYS B 616
 None
 0.72A 3sueD-3jb9A:
undetectable		 3sueD-3jb9A:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		3 / 3 TYR A 470
LEU A 482
LYS A 481
 None
None
A  C  35 ( 3.0A)
 0.59A 3sueD-3jb9A:
undetectable		 3sueD-3jb9A:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A  94
VAL A 519
THR A 148
 None
 0.77A 3tl9A-3jb9A:
undetectable		 3tl9A-3jb9A:
3.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		3 / 3 PHE X 570
LYS X 574
SER X 576
 None
 1.35A 3tyeB-3jb9X:
undetectable		 3tyeB-3jb9X:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF5
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE a  69
ILE a  93
SER a  48
THR a 108
 None
 0.76A 3ua5B-3jb9a:
undetectable		 3ua5B-3jb9a:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 5 ARG A1113
LEU A1004
VAL A1007
ASP A1072
 None
 0.74A 3ufnA-3jb9A:
undetectable
3ufnB-3jb9A:
undetectable		 3ufnA-3jb9A:
3.83
3ufnB-3jb9A:
3.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		4 / 4 SER B 464
ASP B 235
ASP B 139
ALA B 457
 None
 1.42A 3uj6A-3jb9B:
undetectable		 3uj6A-3jb9B:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP X 714
THR X 701
TYR X 700
LEU X 690
 None
 1.18A 3wg7A-3jb9X:
undetectable
3wg7C-3jb9X:
undetectable
3wg7P-3jb9X:
undetectable		 3wg7A-3jb9X:
16.83
3wg7C-3jb9X:
11.15
3wg7P-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU X 690
ASP X 714
THR X 701
TYR X 700
 None
 1.19A 3wg7C-3jb9X:
undetectable
3wg7N-3jb9X:
undetectable
3wg7P-3jb9X:
undetectable		 3wg7C-3jb9X:
11.15
3wg7N-3jb9X:
16.83
3wg7P-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		4 / 6 ILE B 544
ARG B 509
MET B 490
LEU B 488
 None
 1.04A 3wg7N-3jb9B:
undetectable
3wg7W-3jb9B:
undetectable		 3wg7N-3jb9B:
17.37
3wg7W-3jb9B:
5.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 6 ILE X 989
MET X 745
THR X 744
LEU X 743
 None
 0.98A 3wg7N-3jb9X:
undetectable
3wg7W-3jb9X:
undetectable		 3wg7N-3jb9X:
16.83
3wg7W-3jb9X:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF4
(Schizosaccharomy
ces
pombe) 		3 / 3 ASN R 240
GLU R 241
ARG R 242
 None
 1.02A 3wxoA-3jb9R:
undetectable		 3wxoA-3jb9R:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP X 714
THR X 701
TYR X 700
LEU X 690
 None
 1.15A 3x2qA-3jb9X:
undetectable
3x2qC-3jb9X:
undetectable
3x2qP-3jb9X:
undetectable		 3x2qA-3jb9X:
16.83
3x2qC-3jb9X:
11.15
3x2qP-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP308_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU X 690
ASP X 714
THR X 701
TYR X 700
 None
 1.16A 3x2qC-3jb9X:
undetectable
3x2qN-3jb9X:
undetectable
3x2qP-3jb9X:
undetectable		 3x2qC-3jb9X:
11.15
3x2qN-3jb9X:
16.83
3x2qP-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN E
SMALL NUCLEAR
RIBONUCLEOPROTEIN F
SMALL NUCLEAR
RIBONUCLEOPROTEIN G
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		5 / 12 GLY I  27
ILE H  36
ASP H  35
ASN J  22
LEU I  71
 None
 1.18A 4a81A-3jb9I:
undetectable		 4a81A-3jb9I:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF4
(Schizosaccharomy
ces
pombe) 		4 / 8 TYR R 194
VAL R 198
ASN R 206
GLU R 214
 None
 1.05A 4a97D-3jb9R:
4.8		 4a97D-3jb9R:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF4
(Schizosaccharomy
ces
pombe) 		4 / 7 TYR R 194
VAL R 198
ASN R 206
GLU R 214
 None
 1.11A 4a97H-3jb9R:
undetectable		 4a97H-3jb9R:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 5 ILE A 211
ALA A 598
MET A 172
ARG A 179
 None
 1.05A 4acaB-3jb9A:
undetectable
4acaC-3jb9A:
undetectable		 4acaB-3jb9A:
11.70
4acaC-3jb9A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 6 HIS A 602
GLY A 651
TYR A 603
ALA A 598
 None
 0.87A 4ae1A-3jb9A:
undetectable		 4ae1A-3jb9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		3 / 3 GLU B  82
GLY B  86
SER B  80
 None
 0.65A 4b53B-3jb9B:
undetectable		 4b53B-3jb9B:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 6 SER A1362
GLU A1510
ASP A1730
ASP A1696
 None
 1.13A 4blvA-3jb9A:
undetectable		 4blvA-3jb9A:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C66_A_H4CA1168_0
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		5 / 9 PRO B 890
GLN B 919
VAL B 921
LEU B 943
ILE B 892
 None
 1.23A 4c66A-3jb9B:
undetectable		 4c66A-3jb9B:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		5 / 9 THR X 774
LEU X 765
LEU X 761
GLY X 738
THR X 744
 None
 1.28A 4c9kA-3jb9X:
undetectable		 4c9kA-3jb9X:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE B 699
THR B 692
GLY B 819
VAL B 776
ILE B 780
 None
 1.06A 4c9oA-3jb9B:
undetectable		 4c9oA-3jb9B:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE B 699
THR B 692
GLY B 819
VAL B 776
ILE B 780
 None
 1.06A 4c9oB-3jb9B:
undetectable		 4c9oB-3jb9B:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		3 / 3 LEU A1432
GLU A1433
SER A1435
 None
 0.82A 4ccqA-3jb9A:
undetectable		 4ccqA-3jb9A:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR CDC5
(Schizosaccharomy
ces
pombe) 		4 / 7 LEU W 170
ARG W 169
GLY W  25
TYR W  24
 None
G  N  43 ( 3.4A)
None
A  N  42 ( 4.7A)
 1.00A 4cp3A-3jb9W:
undetectable
4cp3B-3jb9W:
undetectable		 4cp3A-3jb9W:
6.50
4cp3B-3jb9W:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		3 / 3 TYR A1695
HIS A1511
ARG A1568
 None
 0.93A 4e7bC-3jb9A:
undetectable		 4e7bC-3jb9A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF19
PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 6 ARG c 537
ILE A1499
VAL A1505
LEU A1346
 None
 1.00A 4em2A-3jb9c:
undetectable		 4em2A-3jb9c:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3jb9 U2 SMALL NUCLEAR
RIBONUCLEOPROTEIN A'
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU j 108
LEU j 117
LEU j 144
ILE j  78
VAL j 124
 None
 1.20A 4f4dA-3jb9j:
undetectable		 4f4dA-3jb9j:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		3 / 3 PHE X1180
TYR X1248
TYR X1128
 None
 1.01A 4ffwA-3jb9X:
undetectable		 4ffwA-3jb9X:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF4
(Schizosaccharomy
ces
pombe) 		3 / 3 PHE R 161
VAL R 145
GLU R 149
 None
 0.82A 4fvqA-3jb9R:
undetectable		 4fvqA-3jb9R:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE A1771
LEU A1560
THR A1559
LEU A1597
ILE A1590
 None
 1.14A 4g1bD-3jb9A:
undetectable		 4g1bD-3jb9A:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		4 / 4 SER B 684
ASP B 762
MET B 806
ASP B 739
 None
 1.43A 4iv0A-3jb9B:
undetectable		 4iv0A-3jb9B:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF2
PRE-MRNA-SPLICING
FACTOR CWF5
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		4 / 5 LYS a 101
LEU a 100
GLU Y 263
LEU a 143
 None
 1.03A 4k4yA-3jb9a:
undetectable		 4k4yA-3jb9a:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF2
PRE-MRNA-SPLICING
FACTOR CWF5
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		4 / 4 LYS a 101
LEU a 100
GLU Y 263
LEU a 143
 None
 1.05A 4k4yE-3jb9a:
undetectable		 4k4yE-3jb9a:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF2
PRE-MRNA-SPLICING
FACTOR CWF5
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		4 / 5 LYS a 101
LEU a 100
GLU Y 263
LEU a 143
 None
 1.05A 4k4yI-3jb9a:
undetectable		 4k4yI-3jb9a:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF17
(Schizosaccharomy
ces
pombe) 		4 / 6 SER L 212
GLY L 199
ASP L 198
GLY L 195
 None
 1.01A 4koeA-3jb9L:
undetectable
4koeB-3jb9L:
undetectable
4koeC-3jb9L:
undetectable		 4koeA-3jb9L:
22.35
4koeB-3jb9L:
22.35
4koeC-3jb9L:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		5 / 10 PRO B 890
ALA B 674
PHE B 676
PHE B 947
LEU B 943
 None
 1.42A 4la0A-3jb9B:
undetectable		 4la0A-3jb9B:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D3
(Schizosaccharomy
ces
pombe) 		4 / 6 GLY B 561
ASP B 140
HIS D  14
ARG B 482
 None
 0.75A 4lajA-3jb9B:
undetectable
4lajB-3jb9B:
undetectable		 4lajA-3jb9B:
17.05
4lajB-3jb9B:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D1
SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D2
(Schizosaccharomy
ces
pombe) 		4 / 8 SER G  97
ASP F  72
VAL F  15
THR F  14
 None
 1.00A 4lnwA-3jb9G:
undetectable		 4lnwA-3jb9G:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3jb9 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
PPI1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE d  43
MET d 132
ILE d 149
VAL d 122
 None
 1.40A 4mk4B-3jb9d:
undetectable		 4mk4B-3jb9d:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		4 / 4 SER B 684
ASP B 762
MET B 806
ASP B 739
 None
 1.41A 4mwzB-3jb9B:
undetectable		 4mwzB-3jb9B:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG B 550
ASP B 159
ARG B 187
 C  C  28 ( 3.8A)
None
A  C  30 ( 3.6A)
 1.02A 4mx0A-3jb9B:
undetectable		 4mx0A-3jb9B:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 3jb9 U2 SMALL NUCLEAR
RIBONUCLEOPROTEIN A'
(Schizosaccharomy
ces
pombe) 		4 / 4 LEU j  92
SER j 118
LEU j  69
LEU j  56
 None
 1.05A 4n09A-3jb9j:
undetectable		 4n09A-3jb9j:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 3jb9 U2 SMALL NUCLEAR
RIBONUCLEOPROTEIN A'
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU j  92
SER j 118
LEU j  69
LEU j  56
 None
 1.06A 4n09B-3jb9j:
undetectable		 4n09B-3jb9j:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 3jb9 U2 SMALL NUCLEAR
RIBONUCLEOPROTEIN A'
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU j  92
SER j 118
LEU j  69
LEU j  56
 None
 1.05A 4n09D-3jb9j:
undetectable		 4n09D-3jb9j:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF17
(Schizosaccharomy
ces
pombe) 		5 / 12 ALA L 122
GLY L  87
ASN L  78
ILE L 334
LEU L 326
 None
 0.92A 4n49A-3jb9L:
undetectable		 4n49A-3jb9L:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 6 GLU A 782
ASP A 923
ASN A1266
ARG A1269
 None
 1.41A 4ntxA-3jb9A:
undetectable
4ntxC-3jb9A:
undetectable		 4ntxA-3jb9A:
10.77
4ntxC-3jb9A:
4.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF17
(Schizosaccharomy
ces
pombe) 		5 / 12 ASN L  85
GLY L  68
SER L  67
GLY L  94
ASN L  90
 None
 1.25A 4obwA-3jb9L:
undetectable		 4obwA-3jb9L:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 7 LEU A 908
LEU A1057
MET A 937
ILE A1063
 None
 1.03A 4okwA-3jb9A:
undetectable		 4okwA-3jb9A:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP X 624
TYR X 441
TRP X 956
 None
 1.07A 4p7nA-3jb9X:
undetectable		 4p7nA-3jb9X:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP X 624
TYR X 621
TRP X 956
 None
 1.19A 4p7nA-3jb9X:
undetectable		 4p7nA-3jb9X:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR PRP5
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE K 221
ASP K 260
LEU K 255
HIS K 217
 None
 1.34A 4paeA-3jb9K:
undetectable		 4paeA-3jb9K:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		3 / 3 LEU X 386
ASP X 389
TYR X 390
 None
 0.60A 4qc6B-3jb9X:
undetectable		 4qc6B-3jb9X:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF19
(Schizosaccharomy
ces
pombe) 		4 / 8 PHE c 628
ILE c 477
PHE c 624
ILE c 505
 None
 0.86A 4qogA-3jb9c:
undetectable
4qogB-3jb9c:
undetectable		 4qogA-3jb9c:
16.95
4qogB-3jb9c:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF17
(Schizosaccharomy
ces
pombe) 		5 / 9 VAL L 293
GLY L 308
THR L 333
SER L 330
VAL L 313
 None
 1.10A 4r20B-3jb9L:
undetectable		 4r20B-3jb9L:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		6 / 12 ALA B 748
GLY B 750
ALA B 826
GLY B 783
PHE B 784
GLU B 778
 None
 1.32A 4r29C-3jb9B:
undetectable		 4r29C-3jb9B:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3jb9 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
PPI1
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU d  32
PHE d  43
GLY d  55
PHE d 102
LEU d  88
 None
 1.19A 4retA-3jb9d:
undetectable		 4retA-3jb9d:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 5 ILE A1963
PHE A1941
SER A1958
ASP A1945
 None
 1.04A 4rzvB-3jb9A:
undetectable		 4rzvB-3jb9A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_C_CLQC1079_0
(SAPOSIN-B)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 5 ARG A 259
MET A 170
MET A 213
LEU A 260
 None
 1.42A 4v2oA-3jb9A:
undetectable
4v2oC-3jb9A:
0.0		 4v2oA-3jb9A:
2.91
4v2oC-3jb9A:
2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 7 PHE A 652
TRP A 653
TRP A 657
PHE A 605
 None
 1.48A 4v32A-3jb9A:
undetectable		 4v32A-3jb9A:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 3jb9 PRE-MRNA-PROCESSING
PROTEIN 45
PRE-MRNA-SPLICING
FACTOR CWF4
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		3 / 3 ASP R 170
ARG R 136
PRO M 237
 None
 0.89A 4wanC-3jb9R:
undetectable		 4wanC-3jb9R:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D2
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU G 101
ASN G  65
MET G  66
VAL G 107
ILE G  45
 None
U  C 101 ( 3.2A)
None
None
None
 1.08A 4x1yB-3jb9G:
undetectable		 4x1yB-3jb9G:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D2
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU G 101
ASN G  65
MET G  66
VAL G 107
ILE G  45
 None
U  C 101 ( 3.2A)
None
None
None
 1.13A 4x20D-3jb9G:
undetectable		 4x20D-3jb9G:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
PRE-MRNA-SPLICING
FACTOR PRP5
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		3 / 3 ASP A 771
GLY K 164
ASP K 184
 None
 0.68A 4xdtA-3jb9A:
undetectable		 4xdtA-3jb9A:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D2
SMALL NUCLEAR
RIBONUCLEOPROTEIN F
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		5 / 12 LEU I  60
VAL G 110
ILE I  65
VAL I  20
LEU I  34
 None
 1.11A 4y0qA-3jb9I:
undetectable		 4y0qA-3jb9I:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		3 / 3 LYS X 581
ILE X 583
ILE X 559
 None
 0.68A 4y0qA-3jb9X:
undetectable		 4y0qA-3jb9X:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		5 / 10 GLY B 246
VAL B 247
GLU B 296
VAL B 241
LEU B 267
 None
 0.89A 4yb6A-3jb9B:
8.4
4yb6E-3jb9B:
8.5		 4yb6A-3jb9B:
14.13
4yb6E-3jb9B:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		5 / 10 GLY B 246
VAL B 247
GLU B 296
VAL B 241
LEU B 267
 None
 0.90A 4yb6B-3jb9B:
8.5
4yb6C-3jb9B:
8.5		 4yb6B-3jb9B:
14.13
4yb6C-3jb9B:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		5 / 10 GLY B 246
VAL B 247
GLU B 296
VAL B 241
LEU B 267
 None
 0.98A 4yb6C-3jb9B:
8.5
4yb6F-3jb9B:
undetectable		 4yb6C-3jb9B:
14.13
4yb6F-3jb9B:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		5 / 10 LEU B 267
GLY B 246
VAL B 247
GLU B 296
VAL B 241
 None
 1.02A 4yb6A-3jb9B:
8.4
4yb6D-3jb9B:
8.5		 4yb6A-3jb9B:
14.13
4yb6D-3jb9B:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		5 / 10 LEU B 267
GLY B 246
VAL B 247
GLU B 296
VAL B 241
 None
 0.98A 4yb6D-3jb9B:
8.4
4yb6E-3jb9B:
8.5		 4yb6D-3jb9B:
14.13
4yb6E-3jb9B:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		5 / 10 LEU B 267
GLY B 246
VAL B 247
GLU B 296
VAL B 241
 None
 0.88A 4yb6B-3jb9B:
8.5
4yb6F-3jb9B:
undetectable		 4yb6B-3jb9B:
14.13
4yb6F-3jb9B:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_1
(PROLINE--TRNA LIGASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D3
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		4 / 4 THR B 209
GLU D  10
THR B 138
HIS D  14
 None
 1.45A 4ydqA-3jb9B:
undetectable		 4ydqA-3jb9B:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR PRP5
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE K 429
THR K 438
GLU K 440
PHE K 397
GLY K 393
 None
 1.32A 4ydqB-3jb9K:
undetectable		 4ydqB-3jb9K:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_A_AZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3jb9 PRE-MRNA-PROCESSING
PROTEIN 45
PRE-MRNA-SPLICING
FACTOR PRP5
(Schizosaccharomy
ces
pombe) 		5 / 11 HIS K 256
VAL K 261
LEU M 157
THR M 153
ALA K 319
 None
 1.24A 4ygfA-3jb9K:
undetectable		 4ygfA-3jb9K:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_C_AZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3jb9 PRE-MRNA-PROCESSING
PROTEIN 45
PRE-MRNA-SPLICING
FACTOR PRP5
(Schizosaccharomy
ces
pombe) 		5 / 11 HIS K 256
VAL K 261
LEU M 157
THR M 153
ALA K 319
 None
 1.26A 4ygfC-3jb9K:
undetectable		 4ygfC-3jb9K:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3jb9 PRE-MRNA-PROCESSING
PROTEIN 45
PRE-MRNA-SPLICING
FACTOR PRP5
(Schizosaccharomy
ces
pombe) 		5 / 12 HIS K 256
VAL K 261
LEU M 157
THR M 153
ALA K 319
 None
 1.24A 4yhaA-3jb9K:
undetectable		 4yhaA-3jb9K:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3jb9 PRE-MRNA-PROCESSING
PROTEIN 45
PRE-MRNA-SPLICING
FACTOR PRP5
(Schizosaccharomy
ces
pombe) 		5 / 12 HIS K 256
VAL K 261
LEU M 157
THR M 153
ALA K 319
 None
 1.28A 4yhaG-3jb9K:
undetectable		 4yhaG-3jb9K:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF17
(Schizosaccharomy
ces
pombe) 		4 / 6 GLY L 199
ASP L 198
GLY L 195
SER L 212
 None
 1.02A 4z53A-3jb9L:
undetectable
4z53B-3jb9L:
undetectable		 4z53A-3jb9L:
18.15
4z53B-3jb9L:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		5 / 9 PHE A1122
ILE A1108
THR A1002
LEU A1193
LEU A1186
 None
 1.36A 4ze0A-3jb9A:
undetectable		 4ze0A-3jb9A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 6 TRP A1478
PRO A 971
ILE A1254
VAL A1219
 None
 0.94A 4zj8A-3jb9A:
undetectable		 4zj8A-3jb9A:
12.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		6 / 11 ASN A1567
MET A1586
LEU A1593
LEU A1597
ILE A1584
LEU A1767
 None
 1.47A 4zowA-3jb9A:
undetectable		 4zowA-3jb9A:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		4 / 7 MET B 597
LYS B 154
GLY B 219
ASN B 250
 None
GDP  B1000 ( 3.5A)
GDP  B1000 ( 4.7A)
None
 1.29A 5a5zC-3jb9B:
undetectable		 5a5zC-3jb9B:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 8 TYR A1298
GLY A1216
ILE A1115
PHE A1217
 None
 0.81A 5alcL-3jb9A:
undetectable		 5alcL-3jb9A:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 8 ASN A1835
PRO A1836
PHE A1842
PHE A1803
 None
 1.41A 5amkA-3jb9A:
undetectable		 5amkA-3jb9A:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		3 / 3 TYR B 163
THR B 165
THR B 169
 None
 0.81A 5aoxB-3jb9B:
undetectable		 5aoxB-3jb9B:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP X 714
THR X 701
TYR X 700
LEU X 690
 None
 1.17A 5b1aA-3jb9X:
undetectable
5b1aC-3jb9X:
undetectable
5b1aP-3jb9X:
undetectable		 5b1aA-3jb9X:
16.83
5b1aC-3jb9X:
11.15
5b1aP-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE X 989
MET X 745
THR X 744
LEU X 743
 None
 0.92A 5b1aA-3jb9X:
undetectable
5b1aJ-3jb9X:
undetectable		 5b1aA-3jb9X:
16.83
5b1aJ-3jb9X:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 6 ARG X1280
GLN X1121
PHE X1120
LEU X1126
 None
 1.13A 5b1bC-3jb9X:
undetectable
5b1bJ-3jb9X:
undetectable		 5b1bC-3jb9X:
11.15
5b1bJ-3jb9X:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP X 714
THR X 701
TYR X 700
LEU X 690
 None
 1.11A 5b1bA-3jb9X:
undetectable
5b1bC-3jb9X:
undetectable
5b1bP-3jb9X:
undetectable		 5b1bA-3jb9X:
16.83
5b1bC-3jb9X:
11.15
5b1bP-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP X 714
THR X 701
TYR X 700
LEU X 690
 None
 1.16A 5b3sA-3jb9X:
undetectable
5b3sC-3jb9X:
undetectable
5b3sP-3jb9X:
undetectable		 5b3sA-3jb9X:
16.83
5b3sC-3jb9X:
11.15
5b3sP-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE X 989
MET X 745
THR X 744
LEU X 743
 None
 0.95A 5b3sA-3jb9X:
undetectable
5b3sJ-3jb9X:
undetectable		 5b3sA-3jb9X:
16.83
5b3sJ-3jb9X:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 4 VAL A  68
GLY A  67
ARG A  70
VAL A  75
 None
None
C  N  14 ( 3.8A)
C  N  14 ( 4.4A)
 1.38A 5d4nA-3jb9A:
4.6
5d4nB-3jb9A:
4.9		 5d4nA-3jb9A:
4.19
5d4nB-3jb9A:
4.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 4 LEU A1726
ILE A1727
GLY A1740
ILE A1750
 None
 0.90A 5dzk3-3jb9A:
undetectable
5dzkm-3jb9A:
undetectable		 5dzk3-3jb9A:
1.61
5dzkm-3jb9A:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE X 478
SER X 508
LEU X 480
LEU X 612
 None
 1.22A 5dzke-3jb9X:
undetectable
5dzks-3jb9X:
undetectable		 5dzke-3jb9X:
10.02
5dzks-3jb9X:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
PRE-MRNA-SPLICING
FACTOR PRP5
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		5 / 11 GLU A 707
GLY K 224
TYR K 251
GLY K 249
ALA K 206
 None
 1.31A 5e3iB-3jb9A:
undetectable		 5e3iB-3jb9A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 7 VAL A1118
LEU A1186
VAL A1007
THR A1191
 None
 0.95A 5e4dA-3jb9A:
undetectable
5e4dB-3jb9A:
undetectable		 5e4dA-3jb9A:
5.99
5e4dB-3jb9A:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN-AS
SOCIATED PROTEIN B
SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D1
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		4 / 7 VAL F  47
THR F  23
VAL E  76
THR E  17
 None
 1.03A 5e4dA-3jb9F:
undetectable
5e4dB-3jb9F:
undetectable		 5e4dA-3jb9F:
19.72
5e4dB-3jb9F:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3jb9 PRE-MRNA-PROCESSING
PROTEIN 45
(Schizosaccharomy
ces
pombe) 		3 / 3 MET M 312
GLN M 314
ARG M 313
 None
 0.98A 5ewzB-3jb9M:
undetectable		 5ewzB-3jb9M:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN-AS
SOCIATED PROTEIN B
PRE-MRNA-SPLICING
FACTOR CWF17
PRE-MRNA-PROCESSING
FACTOR 17
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		5 / 11 ILE L 324
ASN g  56
LEU L 306
LEU L  44
ALA E 104
 None
 1.37A 5fctA-3jb9L:
undetectable		 5fctA-3jb9L:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3jb9 PRE-MRNA-PROCESSING
FACTOR 17
PRE-MRNA-SPLICING
FACTOR CWF5
(Schizosaccharomy
ces
pombe) 		4 / 8 GLU g  92
PHE a  19
THR g  86
TYR g  88
 None
 0.99A 5flcB-3jb9g:
undetectable		 5flcB-3jb9g:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3jb9 PRE-MRNA-PROCESSING
FACTOR 17
PRE-MRNA-SPLICING
FACTOR CWF5
(Schizosaccharomy
ces
pombe) 		4 / 8 GLU g  92
PHE a  19
THR g  86
TYR g  88
 None
 1.00A 5flcF-3jb9g:
undetectable		 5flcF-3jb9g:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF17
(Schizosaccharomy
ces
pombe) 		4 / 7 VAL L 313
SER L 288
GLY L 285
VAL L 316
 None
 0.95A 5fpdA-3jb9L:
undetectable		 5fpdA-3jb9L:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_B_BEZB601_0
(EUGENOL OXIDASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
PRE-MRNA-SPLICING
FACTOR CWF19
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		5 / 10 ASP A1450
ILE c 607
VAL A 863
LEU A 864
TYR A 894
 None
 1.34A 5fxfB-3jb9A:
undetectable		 5fxfB-3jb9A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG X 256
ASN X 275
ASP X 389
 None
 0.87A 5gwxA-3jb9X:
undetectable		 5gwxA-3jb9X:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE X 528
SER X 479
VAL X 613
ASP X 519
 None
 1.10A 5hesA-3jb9X:
undetectable		 5hesA-3jb9X:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3jb9 PRE-MRNA-SPLICING
FACTOR PRP5
(Schizosaccharomy
ces
pombe) 		5 / 12 ALA K 390
ASP K 352
GLY K 349
SER K 348
SER K 388
 None
 1.26A 5hfjB-3jb9K:
undetectable		 5hfjB-3jb9K:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 8 TRP A1489
TRP A1399
GLU A1402
THR A1464
 None
 1.30A 5hqaA-3jb9A:
undetectable		 5hqaA-3jb9A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		4 / 6 HIS B 220
LEU B 150
CYH B 911
HIS B 151
 None
None
None
GDP  B1000 ( 4.8A)
 1.41A 5hrqD-3jb9B:
undetectable
5hrqG-3jb9B:
undetectable
5hrqH-3jb9B:
undetectable		 5hrqD-3jb9B:
2.65
5hrqG-3jb9B:
3.57
5hrqH-3jb9B:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF19
PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		5 / 9 ILE c 336
PRO A1762
VAL A1688
LEU A1690
ILE A1729
 None
 0.93A 5iepA-3jb9c:
undetectable		 5iepA-3jb9c:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		3 / 3 GLY X 748
GLN X1045
LYS X 754
 None
 0.83A 5imsB-3jb9X:
undetectable		 5imsB-3jb9X:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU X 690
ASP X 714
THR X 701
TYR X 700
 None
 1.15A 5iy5C-3jb9X:
undetectable
5iy5N-3jb9X:
undetectable
5iy5P-3jb9X:
undetectable		 5iy5C-3jb9X:
10.99
5iy5N-3jb9X:
16.83
5iy5P-3jb9X:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP B 570
ASN B 502
PHE B 507
 None
 0.63A 5jglB-3jb9B:
undetectable		 5jglB-3jb9B:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 7 VAL X 407
GLU X 404
ILE X 226
LYS X 269
 None
 0.91A 5jh7C-3jb9X:
undetectable		 5jh7C-3jb9X:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 7 ARG X1004
VAL X1006
LEU X1008
LEU X 765
 None
 0.55A 5jq7A-3jb9X:
undetectable		 5jq7A-3jb9X:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A1691
ILE A1584
PHE A1692
 None
 0.75A 5kirA-3jb9A:
undetectable		 5kirA-3jb9A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN E
SMALL NUCLEAR
RIBONUCLEOPROTEIN G
(Schizosaccharomy
ces
pombe) 		5 / 9 ALA J  61
GLY J  58
ILE J  57
THR H  24
PRO H  25
 None
 1.31A 5kr2C-3jb9J:
undetectable		 5kr2C-3jb9J:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 3jb9 PRE-MRNA-PROCESSING
FACTOR 19
(Schizosaccharomy
ces
pombe) 		4 / 7 SER S   4
PRO S  10
SER S  19
ASN S  21
 None
 1.14A 5l1fC-3jb9S:
undetectable		 5l1fC-3jb9S:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF19
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU c 437
ILE c 470
MET c 474
TRP c 568
 None
 1.27A 5ljeA-3jb9c:
undetectable		 5ljeA-3jb9c:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
PRE-MRNA-SPLICING
FACTOR CWF15
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		4 / 5 LEU A1132
PHE A1122
LEU A1174
TRP h 225
 None
 1.49A 5m10A-3jb9A:
undetectable		 5m10A-3jb9A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3jb9 PRE-MRNA-PROCESSING
PROTEIN 45
(Schizosaccharomy
ces
pombe) 		3 / 3 MET M 312
GLN M 314
ARG M 313
 None
 1.01A 5m35B-3jb9M:
undetectable		 5m35B-3jb9M:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3jb9 PRE-MRNA-PROCESSING
PROTEIN 45
(Schizosaccharomy
ces
pombe) 		3 / 3 MET M 312
GLN M 314
ARG M 313
 None
 1.01A 5m36A-3jb9M:
undetectable		 5m36A-3jb9M:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3jb9 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
PPI1
(Schizosaccharomy
ces
pombe) 		4 / 8 ASN d   3
LEU d  17
GLY d 120
VAL d 122
 None
 1.03A 5m8rC-3jb9d:
undetectable		 5m8rC-3jb9d:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF4
(Schizosaccharomy
ces
pombe) 		4 / 6 ILE R 111
MET R 115
ALA R 123
LEU R 126
 None
 0.74A 5mvmB-3jb9R:
1.6
5mvmC-3jb9R:
undetectable		 5mvmB-3jb9R:
17.29
5mvmC-3jb9R:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		3 / 3 HIS A1170
ASN A1173
ALA A1177
 None
 0.67A 5n4tB-3jb9A:
undetectable		 5n4tB-3jb9A:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D1
SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D2
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		5 / 12 ILE F  69
THR F  23
LEU G  53
LEU G 101
MET G  99
 None
 1.22A 5nfjB-3jb9F:
undetectable		 5nfjB-3jb9F:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D1
SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D2
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		5 / 12 ILE F  69
THR F  23
LEU G  53
LEU G 101
MET G  99
 None
 1.25A 5nfjC-3jb9F:
undetectable		 5nfjC-3jb9F:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 5 LYS X 218
VAL X 219
LYS X 214
LYS X 205
 None
 1.49A 5odqA-3jb9X:
undetectable		 5odqA-3jb9X:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 7 THR A 859
LEU A 862
VAL A 890
TYR A 894
 None
 1.05A 5ov9A-3jb9A:
undetectable		 5ov9A-3jb9A:
12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 8 THR A 859
LEU A 862
VAL A 890
TYR A 894
 None
 1.05A 5ov9B-3jb9A:
undetectable		 5ov9B-3jb9A:
12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_C_EZLC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3jb9 PRE-MRNA-PROCESSING
PROTEIN 45
PRE-MRNA-SPLICING
FACTOR PRP5
(Schizosaccharomy
ces
pombe) 		5 / 10 HIS K 256
VAL K 261
LEU M 157
THR M 153
ALA K 319
 None
 1.21A 5tt3C-3jb9K:
undetectable		 5tt3C-3jb9K:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_E_EZLE303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3jb9 PRE-MRNA-PROCESSING
PROTEIN 45
PRE-MRNA-SPLICING
FACTOR PRP5
(Schizosaccharomy
ces
pombe) 		5 / 9 HIS K 256
VAL K 261
LEU M 157
THR M 153
ALA K 319
 None
 1.33A 5tt3E-3jb9K:
undetectable		 5tt3E-3jb9K:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_E_EZLE303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3jb9 PRE-MRNA-PROCESSING
PROTEIN 45
PRE-MRNA-SPLICING
FACTOR PRP5
(Schizosaccharomy
ces
pombe) 		5 / 9 HIS K 256
VAL K 261
LEU M 157
THR M 153
ALA K 319
 None
 1.38A 5tt3E-3jb9K:
undetectable		 5tt3E-3jb9K:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_G_EZLG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3jb9 PRE-MRNA-PROCESSING
PROTEIN 45
PRE-MRNA-SPLICING
FACTOR PRP5
(Schizosaccharomy
ces
pombe) 		5 / 9 HIS K 256
VAL K 261
LEU M 157
THR M 153
ALA K 319
 None
 1.27A 5tt3G-3jb9K:
undetectable		 5tt3G-3jb9K:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_G_EZLG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3jb9 PRE-MRNA-PROCESSING
PROTEIN 45
PRE-MRNA-SPLICING
FACTOR PRP5
(Schizosaccharomy
ces
pombe) 		5 / 9 HIS K 256
VAL K 261
LEU M 157
THR M 153
ALA K 319
 None
 1.32A 5tt3G-3jb9K:
undetectable		 5tt3G-3jb9K:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN-AS
SOCIATED PROTEIN B
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU E  37
ILE E  69
ILE E  75
GLY E  72
LEU E  39
 None
None
None
U  C  99 ( 3.5A)
None
 0.88A 5twjD-3jb9E:
undetectable		 5twjD-3jb9E:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		3 / 3 GLY B 219
LEU B 150
HIS B 220
 GDP  B1000 ( 4.7A)
None
None
 0.70A 5u63B-3jb9B:
undetectable		 5u63B-3jb9B:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		3 / 3 PHE A 274
ASP A 270
LEU B 901
 None
 0.73A 5uhbC-3jb9A:
undetectable		 5uhbC-3jb9A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		3 / 3 PHE A 274
ASP A 270
LEU B 901
 None
 0.73A 5uhcC-3jb9A:
undetectable		 5uhcC-3jb9A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 5 THR A1215
GLU A1465
THR A1464
HIS A1484
 None
 1.01A 5utuH-3jb9A:
undetectable		 5utuH-3jb9A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		3 / 3 TYR X 621
ALA X 440
TYR X 441
 None
 0.73A 5uunB-3jb9X:
undetectable		 5uunB-3jb9X:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		4 / 8 THR B 165
TYR B 179
PRO B 122
TYR B 126
 None
 1.08A 5v4vA-3jb9B:
undetectable		 5v4vA-3jb9B:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		4 / 8 THR B 165
TYR B 179
PRO B 122
TYR B 126
 None
 1.08A 5v4vB-3jb9B:
undetectable		 5v4vB-3jb9B:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D1
SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D2
(Schizosaccharomy
ces
pombe) 		4 / 4 VAL G  67
LEU F  79
ASN G  65
ASP G  61
 None
None
U  C 101 ( 3.2A)
None
 1.17A 5vcyA-3jb9G:
undetectable		 5vcyA-3jb9G:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 6 ILE X1039
ILE X 735
LEU X 757
PHE X 671
 None
 1.03A 5vkqB-3jb9X:
undetectable
5vkqC-3jb9X:
undetectable		 5vkqB-3jb9X:
21.99
5vkqC-3jb9X:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 6 ILE X1039
ILE X 735
LEU X 757
PHE X 671
 None
 1.02A 5vkqC-3jb9X:
undetectable
5vkqD-3jb9X:
undetectable		 5vkqC-3jb9X:
21.99
5vkqD-3jb9X:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP X 714
THR X 701
TYR X 700
LEU X 690
 None
 1.08A 5w97A-3jb9X:
undetectable
5w97C-3jb9X:
undetectable
5w97c-3jb9X:
undetectable		 5w97A-3jb9X:
16.83
5w97C-3jb9X:
11.15
5w97c-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 7 LEU X 690
ASP X 714
THR X 701
TYR X 700
 None
 1.11A 5w97C-3jb9X:
undetectable
5w97a-3jb9X:
undetectable
5w97c-3jb9X:
undetectable		 5w97C-3jb9X:
11.15
5w97a-3jb9X:
16.83
5w97c-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP X 714
THR X 701
TYR X 700
LEU X 690
 None
 1.08A 5wauA-3jb9X:
undetectable
5wauC-3jb9X:
undetectable
5wauc-3jb9X:
undetectable		 5wauA-3jb9X:
16.83
5wauC-3jb9X:
11.15
5wauc-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 7 LEU X 690
ASP X 714
THR X 701
TYR X 700
 None
 1.13A 5wauC-3jb9X:
undetectable
5waua-3jb9X:
undetectable
5wauc-3jb9X:
undetectable		 5wauC-3jb9X:
11.15
5waua-3jb9X:
16.83
5wauc-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 7 ASP X 714
THR X 701
TYR X 700
LEU X 690
 None
 1.17A 5x1bA-3jb9X:
undetectable
5x1bC-3jb9X:
undetectable
5x1bP-3jb9X:
undetectable		 5x1bA-3jb9X:
16.83
5x1bC-3jb9X:
11.15
5x1bP-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN-AS
SOCIATED PROTEIN B
SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D1
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		5 / 11 PHE E  34
GLY E  72
GLY F  62
GLN F  35
THR E   3
 U  C  99 ( 3.0A)
U  C  99 ( 3.5A)
U  C 100 ( 4.2A)
U  C 100 ( 4.5A)
U  C  90 ( 3.6A)
 0.95A 5x1bG-3jb9E:
undetectable
5x1bN-3jb9E:
undetectable
5x1bO-3jb9E:
undetectable		 5x1bG-3jb9E:
21.48
5x1bN-3jb9E:
14.87
5x1bO-3jb9E:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 7 ASP X 714
THR X 701
TYR X 700
LEU X 690
 None
 1.18A 5x1fA-3jb9X:
undetectable
5x1fC-3jb9X:
undetectable
5x1fP-3jb9X:
undetectable		 5x1fA-3jb9X:
16.83
5x1fC-3jb9X:
11.15
5x1fP-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP X 714
THR X 701
TYR X 700
LEU X 690
 None
 1.16A 5xdqA-3jb9X:
undetectable
5xdqC-3jb9X:
undetectable
5xdqP-3jb9X:
undetectable		 5xdqA-3jb9X:
16.83
5xdqC-3jb9X:
11.15
5xdqP-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU X 690
ASP X 714
THR X 701
TYR X 700
 None
 1.14A 5xdqC-3jb9X:
undetectable
5xdqN-3jb9X:
undetectable
5xdqP-3jb9X:
undetectable		 5xdqC-3jb9X:
11.15
5xdqN-3jb9X:
16.83
5xdqP-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE X 989
MET X 745
THR X 744
LEU X 743
 None
 0.95A 5xdxA-3jb9X:
undetectable
5xdxJ-3jb9X:
undetectable		 5xdxA-3jb9X:
16.83
5xdxJ-3jb9X:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU X 690
ASP X 714
THR X 701
TYR X 700
 None
 1.17A 5xdxC-3jb9X:
undetectable
5xdxN-3jb9X:
undetectable
5xdxP-3jb9X:
undetectable		 5xdxC-3jb9X:
11.33
5xdxN-3jb9X:
16.83
5xdxP-3jb9X:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF4
PRE-MRNA-SPLICING
FACTOR CWF3
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		3 / 3 GLU r 538
TRP r 553
HIS R 285
 None
 0.77A 5xipA-3jb9r:
undetectable		 5xipA-3jb9r:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 4 PHE A 663
LEU A 574
LEU A 569
VAL A 120
 None
 1.34A 5xxiA-3jb9A:
undetectable		 5xxiA-3jb9A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		3 / 3 LYS B 425
PRO B 426
LYS A 436
 None
 1.26A 5y9yA-3jb9B:
undetectable		 5y9yA-3jb9B:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 6 ARG X 357
SER X 249
THR X 253
VAL X 376
 None
 1.20A 5ysiA-3jb9X:
undetectable		 5ysiA-3jb9X:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF19
(Schizosaccharomy
ces
pombe) 		4 / 4 GLY c 563
LEU c 562
VAL c 578
GLU c 580
 None
 1.20A 5yw0A-3jb9c:
undetectable		 5yw0A-3jb9c:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP X 714
THR X 701
TYR X 700
LEU X 690
 None
 1.15A 5z84A-3jb9X:
undetectable
5z84C-3jb9X:
undetectable
5z84P-3jb9X:
undetectable		 5z84A-3jb9X:
16.83
5z84C-3jb9X:
11.15
5z84P-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
PRE-MRNA-SPLICING
FACTOR CWF19
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		3 / 3 TYR A1810
ARG c 432
THR A1824
 None
 0.97A 5z84J-3jb9A:
undetectable		 5z84J-3jb9A:
2.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 7 LEU X 690
ASP X 714
THR X 701
TYR X 700
 None
 1.16A 5z84C-3jb9X:
undetectable
5z84N-3jb9X:
undetectable
5z84P-3jb9X:
undetectable		 5z84C-3jb9X:
11.15
5z84N-3jb9X:
16.83
5z84P-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP X 714
THR X 701
TYR X 700
LEU X 690
 None
 1.15A 5z85A-3jb9X:
undetectable
5z85C-3jb9X:
undetectable
5z85P-3jb9X:
undetectable		 5z85A-3jb9X:
16.83
5z85C-3jb9X:
11.15
5z85P-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 7 LEU X 690
ASP X 714
THR X 701
TYR X 700
 None
 1.18A 5z85C-3jb9X:
undetectable
5z85N-3jb9X:
undetectable
5z85P-3jb9X:
undetectable		 5z85C-3jb9X:
11.15
5z85N-3jb9X:
16.83
5z85P-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP X 714
THR X 701
TYR X 700
LEU X 690
 None
 1.13A 5z86A-3jb9X:
undetectable
5z86C-3jb9X:
undetectable
5z86P-3jb9X:
undetectable		 5z86A-3jb9X:
16.83
5z86C-3jb9X:
11.15
5z86P-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D3
(Schizosaccharomy
ces
pombe) 		4 / 5 ARG D  27
MET D  18
THR D  25
LEU D  20
 None
 1.17A 5z86J-3jb9D:
undetectable		 5z86J-3jb9D:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU X 690
ASP X 714
THR X 701
TYR X 700
 None
 1.15A 5z86C-3jb9X:
undetectable
5z86N-3jb9X:
undetectable
5z86P-3jb9X:
undetectable		 5z86C-3jb9X:
11.15
5z86N-3jb9X:
16.83
5z86P-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		4 / 6 ILE B 544
ARG B 509
MET B 490
LEU B 488
 None
 1.05A 5z86N-3jb9B:
undetectable
5z86W-3jb9B:
undetectable		 5z86N-3jb9B:
17.37
5z86W-3jb9B:
5.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 6 ILE X 989
MET X 745
THR X 744
LEU X 743
 None
 0.97A 5z86N-3jb9X:
undetectable
5z86W-3jb9X:
undetectable		 5z86N-3jb9X:
16.83
5z86W-3jb9X:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP X 714
THR X 701
TYR X 700
LEU X 690
 None
 1.19A 5zcoA-3jb9X:
undetectable
5zcoC-3jb9X:
undetectable
5zcoP-3jb9X:
undetectable		 5zcoA-3jb9X:
16.83
5zcoC-3jb9X:
11.15
5zcoP-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU X 690
ASP X 714
THR X 701
TYR X 700
 None
 1.16A 5zcoC-3jb9X:
undetectable
5zcoN-3jb9X:
undetectable
5zcoP-3jb9X:
undetectable		 5zcoC-3jb9X:
11.15
5zcoN-3jb9X:
16.83
5zcoP-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 6 ILE X 989
MET X 745
THR X 744
LEU X 743
 None
 0.96A 5zcoN-3jb9X:
undetectable
5zcoW-3jb9X:
undetectable		 5zcoN-3jb9X:
16.83
5zcoW-3jb9X:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP X 714
THR X 701
TYR X 700
LEU X 690
 None
 1.14A 5zcpA-3jb9X:
undetectable
5zcpC-3jb9X:
undetectable
5zcpP-3jb9X:
undetectable		 5zcpA-3jb9X:
16.83
5zcpC-3jb9X:
11.15
5zcpP-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE X 989
MET X 745
THR X 744
LEU X 743
 None
 0.94A 5zcpA-3jb9X:
undetectable
5zcpJ-3jb9X:
undetectable		 5zcpA-3jb9X:
16.83
5zcpJ-3jb9X:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU X 690
ASP X 714
THR X 701
TYR X 700
 None
 1.17A 5zcpC-3jb9X:
undetectable
5zcpN-3jb9X:
undetectable
5zcpP-3jb9X:
undetectable		 5zcpC-3jb9X:
11.15
5zcpN-3jb9X:
16.83
5zcpP-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP X 714
THR X 701
TYR X 700
LEU X 690
 None
 1.15A 5zcqA-3jb9X:
undetectable
5zcqC-3jb9X:
undetectable
5zcqP-3jb9X:
undetectable		 5zcqA-3jb9X:
16.83
5zcqC-3jb9X:
11.15
5zcqP-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE X 989
MET X 745
THR X 744
LEU X 743
 None
 0.91A 5zcqA-3jb9X:
undetectable
5zcqJ-3jb9X:
undetectable		 5zcqA-3jb9X:
16.83
5zcqJ-3jb9X:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF2
PRE-MRNA-SPLICING
FACTOR CWF5
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		5 / 12 ALA a  98
GLY a 106
ALA Y 266
ARG Y 265
TYR Y 174
 None
 1.22A 5zvgA-3jb9a:
undetectable		 5zvgA-3jb9a:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF2
PRE-MRNA-SPLICING
FACTOR CWF5
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		5 / 12 ALA a  98
GLY a 106
ALA Y 266
ARG Y 265
TYR Y 174
 None
 1.22A 5zvgB-3jb9a:
undetectable		 5zvgB-3jb9a:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		4 / 8 THR B 217
PRO B 218
ILE B 145
PRO B 230
 None
 1.05A 6a4iA-3jb9B:
undetectable		 6a4iA-3jb9B:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_1
(SERUM ALBUMIN)		 3jb9 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
PPI1
(Schizosaccharomy
ces
pombe) 		4 / 6 CYH d 129
PHE d  43
TYR d  38
LEU d  88
 None
 1.49A 6a7pB-3jb9d:
undetectable		 6a7pB-3jb9d:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		4 / 5 THR B 182
THR B 169
HIS B 166
LEU B 198
 None
 1.33A 6aphA-3jb9B:
3.1		 6aphA-3jb9B:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF15
PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE A1120
HIS h 235
LEU A1004
THR A1192
THR A1191
 None
 1.18A 6bbsA-3jb9A:
undetectable		 6bbsA-3jb9A:
2.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
PRE-MRNA-PROCESSING
PROTEIN 45
PRE-MRNA-SPLICING
FACTOR CWF15
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		3 / 3 ARG A 673
LYS h  24
ARG M 218
 G  C  39 ( 3.8A)
None
None
 1.37A 6c06D-3jb9A:
undetectable		 6c06D-3jb9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 ILE X 366
PRO X 361
ALA X 254
THR X 253
 None
 0.89A 6cduD-3jb9X:
undetectable
6cduE-3jb9X:
undetectable		 6cduD-3jb9X:
13.72
6cduE-3jb9X:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF15
PRE-MRNA-SPLICING
FACTOR PRP5
(Schizosaccharomy
ces
pombe) 		4 / 8 THR K 278
CYH K 231
TYR K 243
LEU h  35
 None
 1.29A 6cnjD-3jb9K:
undetectable
6cnjE-3jb9K:
undetectable		 6cnjD-3jb9K:
15.44
6cnjE-3jb9K:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF19
(Schizosaccharomy
ces
pombe) 		4 / 8 THR c 503
CYH c 412
TRP c 613
LEU c 414
 None
ZN  c 701 ( 2.0A)
None
ZN  c 701 ( 4.5A)
 1.46A 6cnjD-3jb9c:
undetectable
6cnjE-3jb9c:
undetectable		 6cnjD-3jb9c:
8.89
6cnjE-3jb9c:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU A1294
THR A1257
PRO A 972
ARG A1461
 None
 1.33A 6ew0B-3jb9A:
undetectable		 6ew0B-3jb9A:
2.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU A1294
THR A1257
PRO A 972
ARG A1461
 None
 1.33A 6ew0D-3jb9A:
undetectable		 6ew0D-3jb9A:
2.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU A1294
THR A1257
PRO A 972
ARG A1461
 None
 1.34A 6ew0H-3jb9A:
undetectable		 6ew0H-3jb9A:
2.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU A1294
THR A1257
PRO A 972
ARG A1461
 None
 1.33A 6ew0I-3jb9A:
undetectable		 6ew0I-3jb9A:
2.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3jb9 PRE-MRNA-PROCESSING
PROTEIN 45
(Schizosaccharomy
ces
pombe) 		3 / 3 MET M 312
GLN M 314
ARG M 313
 None
 1.01A 6fn9A-3jb9M:
undetectable		 6fn9A-3jb9M:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3jb9 PRE-MRNA-PROCESSING
PROTEIN 45
(Schizosaccharomy
ces
pombe) 		3 / 3 MET M 312
GLN M 314
ARG M 313
 None
 1.02A 6fnaB-3jb9M:
undetectable		 6fnaB-3jb9M:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3jb9 PRE-MRNA-PROCESSING
PROTEIN 45
(Schizosaccharomy
ces
pombe) 		3 / 3 MET M 312
GLN M 314
ARG M 313
 None
 1.02A 6fnbA-3jb9M:
undetectable		 6fnbA-3jb9M:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		4 / 7 TYR B 589
LEU B 524
TYR B 465
VAL B 580
 None
 1.33A 6g2pA-3jb9B:
undetectable		 6g2pA-3jb9B:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		4 / 5 THR B 182
THR B 169
HIS B 166
LEU B 198
 None
 1.34A 6gbnB-3jb9B:
2.4		 6gbnB-3jb9B:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
PRE-MRNA-SPLICING
FACTOR PRP5
(Schizosaccharomy
ces
pombe) 		4 / 8 VAL B  93
HIS K 162
GLU K 440
CYH K 439
 None
 0.88A 6gneB-3jb9B:
4.1		 6gneB-3jb9B:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_0
(BETA-1 ADRENERGIC
RECEPTOR)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
PRE-MRNA-SPLICING
FACTOR CWF17
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		5 / 12 VAL L 154
TRP A  58
SER L 312
SER L 289
ASN L 314
 None
 1.29A 6h7lA-3jb9L:
undetectable		 6h7lA-3jb9L:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
PRE-MRNA-SPLICING
FACTOR CWF17
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		5 / 12 VAL L 154
TRP A  58
SER L 312
SER L 289
ASN L 314
 None
 1.32A 6h7lB-3jb9L:
undetectable		 6h7lB-3jb9L:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3jb9 PRE-MRNA-SPLICING
FACTOR CDC5
(Schizosaccharomy
ces
pombe) 		4 / 8 ILE W  52
TRP W  48
TRP W  29
TYR W  24
 None
None
None
A  N  42 ( 4.7A)
 1.14A 6hisA-3jb9W:
3.0
6hisB-3jb9W:
3.0		 6hisA-3jb9W:
5.36
6hisB-3jb9W:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3jb9 PRE-MRNA-SPLICING
FACTOR CDC5
(Schizosaccharomy
ces
pombe) 		4 / 8 ILE W  52
TRP W  48
TRP W  29
TYR W  24
 None
None
None
A  N  42 ( 4.7A)
 1.14A 6hisB-3jb9W:
3.0
6hisC-3jb9W:
3.0		 6hisB-3jb9W:
5.36
6hisC-3jb9W:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3jb9 PRE-MRNA-SPLICING
FACTOR CDC5
(Schizosaccharomy
ces
pombe) 		4 / 8 ILE W  52
TRP W  48
TRP W  29
TYR W  24
 None
None
None
A  N  42 ( 4.7A)
 1.16A 6hisC-3jb9W:
3.0
6hisD-3jb9W:
3.0		 6hisC-3jb9W:
5.36
6hisD-3jb9W:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3jb9 PRE-MRNA-SPLICING
FACTOR CDC5
(Schizosaccharomy
ces
pombe) 		4 / 8 ILE W  52
TRP W  48
TRP W  29
TYR W  24
 None
None
None
A  N  42 ( 4.7A)
 1.16A 6hisD-3jb9W:
3.0
6hisE-3jb9W:
3.0		 6hisD-3jb9W:
5.36
6hisE-3jb9W:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3jb9 PRE-MRNA-SPLICING
FACTOR CDC5
(Schizosaccharomy
ces
pombe) 		4 / 8 TRP W  29
TYR W  24
ILE W  52
TRP W  48
 None
A  N  42 ( 4.7A)
None
None
 1.17A 6hisA-3jb9W:
3.0
6hisE-3jb9W:
3.0		 6hisA-3jb9W:
5.36
6hisE-3jb9W:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE A 573
GLU A 672
VAL A 120
TRP A 660
 None
 1.13A 6j20A-3jb9A:
undetectable		 6j20A-3jb9A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF17
(Schizosaccharomy
ces
pombe) 		4 / 7 GLY L 308
PHE L 335
SER L 330
SER L 329
 None
 0.94A 6jnhA-3jb9L:
undetectable		 6jnhA-3jb9L:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
(Schizosaccharomy
ces
pombe) 		4 / 8 GLY A 111
LEU A 675
GLY A 676
LEU A 679
 None
 0.66A 6mdqA-3jb9A:
undetectable		 6mdqA-3jb9A:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
PRE-MRNA-SPLICING
FACTOR CWF15
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		4 / 7 HIS A 927
ARG A1055
ASP h 265
GLU A1009
 None
 1.42A 6mn4F-3jb9A:
undetectable		 6mn4F-3jb9A:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU X 690
ASP X 714
THR X 701
TYR X 700
 None
 1.09A 6nknC-3jb9X:
undetectable
6nknN-3jb9X:
undetectable
6nknP-3jb9X:
undetectable		 6nknC-3jb9X:
11.15
6nknN-3jb9X:
16.83
6nknP-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D3
(Schizosaccharomy
ces
pombe) 		4 / 5 ARG D  27
MET D  18
THR D  25
LEU D  20
 None
 1.31A 6nknW-3jb9D:
undetectable		 6nknW-3jb9D:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 4 ARG X1280
GLN X1121
PHE X1120
LEU X1126
 None
 1.22A 6nmfC-3jb9X:
undetectable		 6nmfC-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF11
(Schizosaccharomy
ces
pombe) 		4 / 7 ASP X 714
THR X 701
TYR X 700
LEU X 690
 None
 1.11A 6nmfA-3jb9X:
undetectable
6nmfC-3jb9X:
undetectable
6nmfP-3jb9X:
undetectable		 6nmfA-3jb9X:
16.83
6nmfC-3jb9X:
11.15
6nmfP-3jb9X:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3jb9 PRE-MRNA-SPLICING
FACTOR PRP5
(Schizosaccharomy
ces
pombe) 		5 / 10 THR K 264
GLY K 249
GLY K 224
VAL K 229
GLU K 225
 None
 1.25A 6nqaK-3jb9K:
undetectable		 6nqaK-3jb9K:
16.06