SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jby'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1
(Danio
rerio) 		5 / 12 ALA A 581
LEU A 677
LEU A1010
LEU A1015
LEU A 530
 None
 1.07A 1g5yB-3jbyA:
undetectable		 1g5yB-3jbyA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1
(Danio
rerio) 		4 / 7 TYR A 950
VAL A 837
GLU A 825
LEU A 904
 None
 0.90A 1j96B-3jbyA:
undetectable		 1j96B-3jbyA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1
(Danio
rerio) 		5 / 11 LEU A 904
GLU A 833
ILE A 829
LEU A 962
LEU A 958
 None
 1.30A 1mrqA-3jbyA:
undetectable		 1mrqA-3jbyA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1
(Danio
rerio) 		3 / 3 LEU A1015
HIS A1012
LYS A1011
 None
 1.08A 1y7iA-3jbyA:
undetectable		 1y7iA-3jbyA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_E_H4BE1004_1
(HYPOTHETICAL PROTEIN
PH0634)		 3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1
(Danio
rerio) 		5 / 11 HIS A 964
HIS A 959
HIS A 766
THR A 769
GLU A 774
 ZN  A1101 (-3.2A)
ZN  A1101 (-3.2A)
ZN  A1101 ( 4.8A)
None
None
 1.21A 2dttD-3jbyA:
undetectable
2dttE-3jbyA:
undetectable		 2dttD-3jbyA:
10.31
2dttE-3jbyA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1
(Danio
rerio) 		3 / 3 ARG A 701
GLU A 617
SER A 558
 None
 0.87A 2xctD-3jbyA:
undetectable		 2xctD-3jbyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1
(Danio
rerio) 		5 / 10 LEU A 597
VAL A 713
ILE A 649
LEU A 586
PHE A 720
 None
 1.15A 3fl9A-3jbyA:
undetectable		 3fl9A-3jbyA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1
(Danio
rerio) 		5 / 9 LEU A 597
VAL A 713
ILE A 649
LEU A 586
PHE A 720
 None
 1.19A 3fl9D-3jbyA:
undetectable		 3fl9D-3jbyA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1
(Danio
rerio) 		5 / 10 LEU A 597
VAL A 713
ILE A 649
LEU A 586
PHE A 720
 None
 1.11A 3fl9E-3jbyA:
undetectable		 3fl9E-3jbyA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1
(Danio
rerio) 		5 / 10 LEU A 597
VAL A 713
ILE A 649
LEU A 586
PHE A 720
 None
 1.14A 3fl9F-3jbyA:
undetectable		 3fl9F-3jbyA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1
(Danio
rerio) 		3 / 3 ALA A 979
ARG A 916
LYS A 912
 None
 0.88A 3kp5B-3jbyA:
undetectable		 3kp5B-3jbyA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1
(Danio
rerio) 		5 / 12 TYR A 578
LEU A 709
PHE A 724
PHE A 720
VAL A 613
 None
 1.43A 3nuvA-3jbyA:
undetectable		 3nuvA-3jbyA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1
(Danio
rerio) 		4 / 5 LEU A1015
SER A1018
ARG A 675
LEU A 529
 None
 1.27A 3onnA-3jbyA:
2.9		 3onnA-3jbyA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1
(Danio
rerio) 		4 / 6 LEU A1015
HIS A1012
THR A1017
ARG A 675
 None
 1.37A 3thrB-3jbyA:
undetectable		 3thrB-3jbyA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1
(Danio
rerio) 		5 / 7 LEU A 816
ASP A 819
ALA A 876
VAL A 868
ILE A 820
 None
 1.47A 3wsjB-3jbyA:
undetectable		 3wsjB-3jbyA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1
(Danio
rerio) 		5 / 12 LEU A 529
LEU A 530
ASN A 997
SER A1018
LEU A1021
 None
 0.86A 4lmnA-3jbyA:
undetectable		 4lmnA-3jbyA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1
(Danio
rerio) 		4 / 6 GLU A 808
THR A 809
THR A 691
HIS A 687
 None
 1.34A 4pfjB-3jbyA:
undetectable		 4pfjB-3jbyA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1
(Danio
rerio) 		4 / 5 LEU A 582
VAL A 545
VAL A 551
TYR A 578
 None
 1.11A 4r7iA-3jbyA:
undetectable		 4r7iA-3jbyA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1
(Danio
rerio) 		5 / 12 ASP A 555
SER A 558
TRP A 560
THR A 689
ALA A 692
 None
 1.42A 4u15A-3jbyA:
undetectable		 4u15A-3jbyA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1
(Danio
rerio) 		3 / 3 ARG A 770
ASP A 753
TYR A 747
 None
 0.90A 4yo9B-3jbyA:
undetectable		 4yo9B-3jbyA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1
(Danio
rerio) 		5 / 11 GLY A 821
TYR A 950
HIS A 959
CYH A 749
ILE A 748
 None
None
ZN  A1101 (-3.2A)
ZN  A1101 (-2.2A)
None
 1.50A 4ypeB-3jbyA:
undetectable		 4ypeB-3jbyA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1
(Danio
rerio) 		5 / 11 SER A 673
THR A 645
SER A 618
ALA A 815
GLY A 986
 None
 1.36A 4zjoD-3jbyA:
undetectable		 4zjoD-3jbyA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1
(Danio
rerio) 		4 / 7 ARG A 574
ILE A 554
THR A 689
ARG A 641
 None
 0.98A 5vc0A-3jbyA:
undetectable		 5vc0A-3jbyA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_1
(SERUM ALBUMIN)		 3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1
(Danio
rerio) 		4 / 6 ASN A 822
PHE A 826
TYR A 950
LEU A 962
 None
 1.30A 6a7pB-3jbyA:
undetectable		 6a7pB-3jbyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1
(Danio
rerio) 		3 / 3 PHE A 993
ASP A1008
LYS A1011
 None
 0.75A 6awtD-3jbyA:
undetectable		 6awtD-3jbyA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB803_0
(UNCHARACTERIZED
PROTEIN)		 3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1
(Danio
rerio) 		4 / 4 MET A 763
TYR A 950
ARG A 756
LEU A 958
 None
 1.49A 6d8pB-3jbyA:
1.9		 6d8pB-3jbyA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1
(Danio
rerio) 		3 / 3 LEU A 958
ASP A 814
ILE A 975
 None
 0.40A 6dh0B-3jbyA:
undetectable		 6dh0B-3jbyA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1
(Danio
rerio) 		3 / 3 ARG A 652
GLY A 655
GLU A 656
 None
 0.60A 6fgdA-3jbyA:
undetectable		 6fgdA-3jbyA:
20.98