SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jbz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 12 ILE A1994
ALA A1991
ALA A1990
LEU A1976
ALA A1979
 None
 1.06A 1fbyA-3jbzA:
undetectable		 1fbyA-3jbzA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 12 ILE A1994
ALA A1991
ALA A1990
LEU A1976
ALA A1979
 None
 1.05A 1fbyB-3jbzA:
undetectable		 1fbyB-3jbzA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 7 LEU A2174
GLY A2142
LEU A2236
TYR A1974
 None
 0.84A 1gtiA-3jbzA:
2.8		 1gtiA-3jbzA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 12 ILE A1603
PHE A1557
LEU A1559
ALA A1560
LEU A1642
 None
 0.99A 1og5B-3jbzA:
undetectable		 1og5B-3jbzA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 6 LEU A2246
ARG A2317
THR A2321
LEU A2324
 None
 1.00A 1v54A-3jbzA:
3.9
1v54J-3jbzA:
undetectable		 1v54A-3jbzA:
17.21
1v54J-3jbzA:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 7 PHE A2548
ASN A2292
ARG A2381
VAL A2286
 None
 1.39A 1wu8A-3jbzA:
undetectable
1wu8C-3jbzA:
undetectable		 1wu8A-3jbzA:
12.85
1wu8C-3jbzA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 11 GLY A2391
GLU A2388
LEU A2379
HIS A2401
ALA A1428
 None
 1.41A 2a58A-3jbzA:
undetectable
2a58E-3jbzA:
undetectable		 2a58A-3jbzA:
9.50
2a58E-3jbzA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 11 HIS A2401
ALA A1428
GLY A2391
GLU A2388
LEU A2379
 None
 1.42A 2a58C-3jbzA:
undetectable
2a58D-3jbzA:
undetectable		 2a58C-3jbzA:
9.50
2a58D-3jbzA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		6 / 12 ILE A1994
ALA A1991
ALA A1990
ILE A1957
LEU A1976
ALA A1979
 None
 1.12A 2aclG-3jbzA:
undetectable		 2aclG-3jbzA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 6 LEU A2246
ARG A2317
THR A2321
LEU A2324
 None
 1.00A 2dyrA-3jbzA:
2.0
2dyrJ-3jbzA:
undetectable		 2dyrA-3jbzA:
17.21
2dyrJ-3jbzA:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 6 LEU A2246
ARG A2317
THR A2321
LEU A2324
 None
 1.01A 2dysA-3jbzA:
undetectable
2dysJ-3jbzA:
undetectable		 2dysA-3jbzA:
17.21
2dysJ-3jbzA:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 6 LEU A2246
ARG A2317
THR A2321
LEU A2324
 None
 1.01A 2dysN-3jbzA:
undetectable
2dysW-3jbzA:
undetectable		 2dysN-3jbzA:
17.21
2dysW-3jbzA:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 6 LEU A2246
ARG A2317
THR A2321
LEU A2324
 None
 1.01A 2eijA-3jbzA:
undetectable
2eijJ-3jbzA:
undetectable		 2eijA-3jbzA:
17.21
2eijJ-3jbzA:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 6 LEU A2246
ARG A2317
THR A2321
LEU A2324
 None
 0.95A 2eilA-3jbzA:
undetectable
2eilJ-3jbzA:
undetectable		 2eilA-3jbzA:
17.21
2eilJ-3jbzA:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 12 PHE A1798
ASN A2494
ILE A2498
ILE A2501
LEU A1802
 None
 1.27A 2ft9A-3jbzA:
undetectable		 2ft9A-3jbzA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		6 / 12 ASP A2347
LEU A2346
GLY A2351
LEU A2349
LEU A2303
LEU A2299
 None
 1.33A 2nxeA-3jbzA:
undetectable		 2nxeA-3jbzA:
12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 6 LEU A2208
THR A2207
LEU A1900
ASP A2412
 None
 1.07A 2wm3A-3jbzA:
undetectable		 2wm3A-3jbzA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 6 LEU A2246
ARG A2317
THR A2321
LEU A2324
 None
 1.02A 2zxwA-3jbzA:
3.8
2zxwJ-3jbzA:
undetectable		 2zxwA-3jbzA:
17.21
2zxwJ-3jbzA:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 12 PHE A2182
LEU A2174
GLY A2238
ILE A2356
ASP A2357
 None
None
None
ADP  A2601 (-4.0A)
MG  A2603 ( 2.3A)
 1.43A 2zznB-3jbzA:
undetectable		 2zznB-3jbzA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 6 LEU A2246
ARG A2317
THR A2321
LEU A2324
 None
 1.00A 3abmA-3jbzA:
3.6
3abmJ-3jbzA:
undetectable		 3abmA-3jbzA:
17.21
3abmJ-3jbzA:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 7 LEU A1423
GLN A1424
PHE A2314
LEU A1397
 None
 1.03A 3ag2C-3jbzA:
3.2		 3ag2C-3jbzA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 6 LEU A2246
ARG A2317
THR A2321
LEU A2324
 None
 1.03A 3asnA-3jbzA:
2.5
3asnJ-3jbzA:
undetectable		 3asnA-3jbzA:
17.21
3asnJ-3jbzA:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 6 LEU A2246
ARG A2317
THR A2321
LEU A2324
 None
 1.01A 3asoA-3jbzA:
undetectable
3asoJ-3jbzA:
undetectable		 3asoA-3jbzA:
17.21
3asoJ-3jbzA:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 10 ILE A1994
ALA A1991
ALA A1990
LEU A1976
ALA A1979
 None
 1.05A 3falC-3jbzA:
undetectable		 3falC-3jbzA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		3 / 3 LEU A2204
LEU A1900
ARG A1905
 None
 0.67A 3hcnB-3jbzA:
undetectable		 3hcnB-3jbzA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		3 / 3 LEU A1453
TRP A1449
GLY A1441
 None
 0.78A 3l35A-3jbzA:
undetectable
3l35H-3jbzA:
undetectable		 3l35A-3jbzA:
4.33
3l35H-3jbzA:
1.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		3 / 3 LEU A1453
TRP A1449
GLY A1441
 None
 0.82A 3l35B-3jbzA:
undetectable
3l35K-3jbzA:
undetectable		 3l35B-3jbzA:
4.33
3l35K-3jbzA:
1.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 12 HIS A2001
SER A2002
ILE A1932
ASP A1933
LEU A1936
 None
 1.27A 3lcvB-3jbzA:
undetectable		 3lcvB-3jbzA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 5 LEU A2201
GLY A2203
MET A2327
PHE A2358
 None
 1.24A 3uq6B-3jbzA:
undetectable		 3uq6B-3jbzA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 4 LEU A2201
GLY A2203
MET A2327
PHE A2358
 None
 1.33A 3vaqB-3jbzA:
undetectable		 3vaqB-3jbzA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 12 LEU A2172
GLY A2238
LEU A2186
GLY A2235
PRO A2141
 None
 1.16A 4blvA-3jbzA:
undetectable		 4blvA-3jbzA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 12 ILE A1636
GLY A1588
ALA A1589
SER A1592
LEU A1596
 None
 0.99A 4e1gA-3jbzA:
undetectable		 4e1gA-3jbzA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 12 ILE A1636
GLY A1588
ALA A1589
SER A1592
LEU A1596
 None
 1.01A 4e1gB-3jbzA:
2.1		 4e1gB-3jbzA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		3 / 3 PHE A2377
VAL A2205
ILE A2222
 None
 0.64A 4emaA-3jbzA:
undetectable		 4emaA-3jbzA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 6 PRO A1770
ILE A1764
TYR A1880
TYR A1804
 None
 1.18A 4g10A-3jbzA:
undetectable		 4g10A-3jbzA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 12 MET A2011
LEU A2186
ILE A2156
LEU A2172
LEU A2138
 None
 1.12A 4j24D-3jbzA:
undetectable		 4j24D-3jbzA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 6 ARG A1987
ALA A1991
ASP A1947
LEU A1976
 None
 1.04A 4ot2A-3jbzA:
3.4		 4ot2A-3jbzA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		3 / 3 MET A2387
GLU A2388
LEU A2392
 None
 0.80A 4v2oB-3jbzA:
2.3		 4v2oB-3jbzA:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 12 ILE A2237
VAL A2240
THR A2245
MET A2345
ILE A2356
 ADP  A2601 (-4.8A)
ADP  A2601 (-4.1A)
ADP  A2601 (-4.1A)
ADP  A2601 ( 4.1A)
ADP  A2601 (-4.0A)
 1.07A 4xe0A-3jbzA:
19.9		 4xe0A-3jbzA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		6 / 12 PRO A2169
TYR A2225
VAL A2240
ASP A2244
MET A2345
ILE A2356
 None
ADP  A2601 ( 3.8A)
ADP  A2601 (-4.1A)
None
ADP  A2601 ( 4.1A)
ADP  A2601 (-4.0A)
 0.90A 4xe0A-3jbzA:
19.9		 4xe0A-3jbzA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		6 / 12 PRO A2169
TYR A2225
VAL A2240
THR A2245
MET A2345
ILE A2356
 None
ADP  A2601 ( 3.8A)
ADP  A2601 (-4.1A)
ADP  A2601 (-4.1A)
ADP  A2601 ( 4.1A)
ADP  A2601 (-4.0A)
 0.54A 4xe0A-3jbzA:
19.9		 4xe0A-3jbzA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 8 ARG A2408
ARG A2511
VAL A2504
ASP A2512
 None
 1.00A 4xqgA-3jbzA:
undetectable		 4xqgA-3jbzA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 8 ARG A2408
ARG A2511
VAL A2504
ASP A2512
 None
 0.99A 4xqgB-3jbzA:
undetectable		 4xqgB-3jbzA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 8 ALA A1922
HIS A1915
ASN A1920
THR A1881
 None
 1.32A 5db5A-3jbzA:
undetectable
5db5B-3jbzA:
undetectable		 5db5A-3jbzA:
17.11
5db5B-3jbzA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 5 THR A1984
HIS A1988
ALA A1986
ASP A1947
 None
 1.13A 5mfxA-3jbzA:
undetectable		 5mfxA-3jbzA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 12 ILE A2153
ILE A2228
LEU A2174
LEU A2016
LEU A2172
 None
 1.04A 5tiwA-3jbzA:
undetectable		 5tiwA-3jbzA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		3 / 3 LEU A2344
ILE A2353
TYR A2396
 None
 0.58A 5uunB-3jbzA:
undetectable		 5uunB-3jbzA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 7 GLU A1401
ALA A1429
GLY A1431
TYR A1435
 None
 1.00A 5uxdA-3jbzA:
4.9		 5uxdA-3jbzA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 8 LEU A2392
ARG A2397
HIS A2401
LEU A2324
 None
 1.01A 5v0vA-3jbzA:
3.3		 5v0vA-3jbzA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 7 LEU A2302
HIS A2340
ASP A2244
THR A2245
 None
MGF  A2604 (-3.9A)
None
ADP  A2601 (-4.1A)
 1.21A 5w97C-3jbzA:
3.2
5w97a-3jbzA:
undetectable
5w97c-3jbzA:
3.2		 5w97C-3jbzA:
12.77
5w97a-3jbzA:
17.21
5w97c-3jbzA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 7 LEU A2302
HIS A2340
ASP A2244
THR A2245
 None
MGF  A2604 (-3.9A)
None
ADP  A2601 (-4.1A)
 1.21A 5wauC-3jbzA:
3.2
5waua-3jbzA:
2.3
5wauc-3jbzA:
3.2		 5wauC-3jbzA:
12.77
5waua-3jbzA:
17.21
5wauc-3jbzA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 12 LEU A2334
VAL A2330
VAL A2205
GLY A2203
LEU A1904
 None
 1.14A 5x24A-3jbzA:
undetectable		 5x24A-3jbzA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 7 ILE A2353
LEU A2324
ARG A2348
LEU A2299
 None
 0.98A 5xdxA-3jbzA:
3.8
5xdxJ-3jbzA:
undetectable		 5xdxA-3jbzA:
17.21
5xdxJ-3jbzA:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 6 GLN A2524
LYS A2507
LEU A2508
LEU A2407
 None
 1.11A 5yvnA-3jbzA:
4.8		 5yvnA-3jbzA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		5 / 12 ILE A1994
ALA A1991
ALA A1990
LEU A1976
ALA A1979
 None
 1.01A 5z12C-3jbzA:
undetectable		 5z12C-3jbzA:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens) 		4 / 6 GLN A1405
PHE A1404
LEU A1397
PHE A2314
 None
 1.04A 5zcpP-3jbzA:
3.2
5zcpW-3jbzA:
undetectable		 5zcpP-3jbzA:
12.77
5zcpW-3jbzA:
4.40