SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jc7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
SLD5
(Saccharomyces
cerevisiae) 		3 / 3 GLN D  82
HIS D  81
PRO D  80
 None
 0.77A 1d8cA-3jc7D:
undetectable		 1d8cA-3jc7D:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2
(Saccharomyces
cerevisiae) 		5 / 12 GLU B  97
LEU B  93
LEU B  98
ILE B 151
LEU B 126
 None
 1.12A 1errB-3jc7B:
undetectable		 1errB-3jc7B:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2
(Saccharomyces
cerevisiae) 		4 / 8 ASN B 118
LEU B  73
ALA B  76
LEU B  77
 None
 0.93A 1hwiD-3jc7B:
undetectable		 1hwiD-3jc7B:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2
DNA REPLICATION
COMPLEX GINS PROTEIN
SLD5
(Saccharomyces
cerevisiae) 		5 / 11 THR B  55
GLU D 132
ARG D 141
GLU D 134
ILE D  91
 None
 1.20A 1t6zB-3jc7B:
undetectable		 1t6zB-3jc7B:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2
(Saccharomyces
cerevisiae) 		4 / 7 ILE B 188
LEU B 192
ARG B 182
LEU B 168
 None
 0.91A 1v55A-3jc7B:
undetectable
1v55J-3jc7B:
undetectable		 1v55A-3jc7B:
16.60
1v55J-3jc7B:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2
(Saccharomyces
cerevisiae) 		4 / 8 ILE B 188
LEU B 192
ARG B 182
LEU B 168
 None
 0.92A 1v55N-3jc7B:
undetectable
1v55W-3jc7B:
undetectable		 1v55N-3jc7B:
16.60
1v55W-3jc7B:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
SLD5
(Saccharomyces
cerevisiae) 		3 / 3 GLY D 104
ASP D 107
ASN D 100
 None
 0.50A 1vq1A-3jc7D:
undetectable		 1vq1A-3jc7D:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
SLD5
(Saccharomyces
cerevisiae) 		5 / 11 LEU D 174
SER D 155
LEU D 158
ASN D 162
LEU D 175
 None
 0.98A 2ceoA-3jc7D:
undetectable		 2ceoA-3jc7D:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2
(Saccharomyces
cerevisiae) 		4 / 6 LEU B  93
ALA B 130
HIS B 135
ASP B 136
 None
 1.19A 2dpzA-3jc7B:
undetectable		 2dpzA-3jc7B:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2
(Saccharomyces
cerevisiae) 		3 / 3 PRO B  13
ASN B 179
ARG B 182
 None
 1.07A 2qeuB-3jc7B:
2.3		 2qeuB-3jc7B:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
SLD5
(Saccharomyces
cerevisiae) 		5 / 10 LEU D 174
SER D 155
LEU D 158
ASN D 162
LEU D 175
 None
 1.09A 2xn7A-3jc7D:
undetectable
2xn7B-3jc7D:
undetectable		 2xn7A-3jc7D:
20.74
2xn7B-3jc7D:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2
(Saccharomyces
cerevisiae) 		4 / 8 ILE B 188
LEU B 192
ARG B 182
LEU B 168
 None
 0.92A 3abmN-3jc7B:
undetectable
3abmW-3jc7B:
undetectable		 3abmN-3jc7B:
16.60
3abmW-3jc7B:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 168
LEU B 170
ILE B 185
GLY B 159
LEU B 163
 None
 0.97A 4lmnA-3jc7B:
undetectable		 4lmnA-3jc7B:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
SLD5
(Saccharomyces
cerevisiae) 		3 / 3 ASP D 289
TRP D 224
SER D  66
 None
 1.02A 4lrhA-3jc7D:
undetectable		 4lrhA-3jc7D:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2
DNA REPLICATION
COMPLEX GINS PROTEIN
SLD5
(Saccharomyces
cerevisiae) 		5 / 11 ARG B 182
LEU B 181
VAL D 276
LEU B 168
LEU B 160
 None
 1.28A 4or0B-3jc7B:
undetectable		 4or0B-3jc7B:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2
(Saccharomyces
cerevisiae) 		4 / 6 ILE B  16
PHE B  11
ARG B 182
ILE B 178
 None
 1.36A 4zzcA-3jc7B:
undetectable
4zzcB-3jc7B:
undetectable		 4zzcA-3jc7B:
18.99
4zzcB-3jc7B:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2
(Saccharomyces
cerevisiae) 		4 / 6 ILE B  16
PHE B  11
ARG B 182
ILE B 178
 None
 1.36A 4zzcB-3jc7B:
undetectable
4zzcC-3jc7B:
undetectable		 4zzcB-3jc7B:
18.99
4zzcC-3jc7B:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2
DNA REPLICATION
COMPLEX GINS PROTEIN
SLD5
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 LYS B   3
LYS D 150
SER D 149
 None
 1.22A 5odiA-3jc7B:
undetectable		 5odiA-3jc7B:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
SLD5
(Saccharomyces
cerevisiae) 		3 / 3 LEU D 136
LEU D  87
ARG D  90
 None
 0.66A 6fgcA-3jc7D:
undetectable		 6fgcA-3jc7D:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
SLD5
(Saccharomyces
cerevisiae) 		3 / 3 LEU D 136
LEU D  87
ARG D  90
 None
 0.63A 6fgdA-3jc7D:
undetectable		 6fgdA-3jc7D:
22.04