SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jcc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 3jcc T-CELL SURFACE
GLYCOPROTEIN CD4
(Homo
sapiens) 		4 / 5 ASP D  80
ILE D  76
PRO D 121
PHE D  98
 None
 1.17A 3s3vA-3jccD:
undetectable		 3s3vA-3jccD:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 3jcc T-CELL SURFACE
GLYCOPROTEIN CD4
(Homo
sapiens) 		5 / 11 ILE D 172
ASP D 173
ILE D 174
GLY D 155
VAL D 146
 None
 0.92A 4ac9B-3jccD:
undetectable
4ac9C-3jccD:
undetectable		 4ac9B-3jccD:
16.63
4ac9C-3jccD:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 3jcc T-CELL SURFACE
GLYCOPROTEIN CD4
(Homo
sapiens) 		4 / 6 VAL D   4
GLN D  94
VAL D  93
TYR D  82
 None
 0.97A 5i8fA-3jccD:
undetectable		 5i8fA-3jccD:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3jcc T-CELL SURFACE
GLYCOPROTEIN CD4
(Homo
sapiens) 		3 / 3 ARG D  58
PRO D  68
ASN D  66
 None
 0.98A 5jwaA-3jccD:
undetectable
5jwaH-3jccD:
undetectable		 5jwaA-3jccD:
16.46
5jwaH-3jccD:
16.46