SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jck'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3jck 26S PROTEASOME
REGULATORY SUBUNIT
RPN3
(Saccharomyces
cerevisiae) 		3 / 3 THR A 262
GLU A 258
HIS A 225
 None
 0.72A 1xwfA-3jckA:
undetectable		 1xwfA-3jckA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3jck 26S PROTEASOME
REGULATORY SUBUNIT
RPN3
(Saccharomyces
cerevisiae) 		3 / 3 THR A 262
GLU A 258
HIS A 225
 None
 0.68A 1xwfB-3jckA:
undetectable		 1xwfB-3jckA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3jck 26S PROTEASOME
REGULATORY SUBUNIT
RPN3
(Saccharomyces
cerevisiae) 		3 / 3 THR A 262
GLU A 258
HIS A 225
 None
 0.68A 1xwfC-3jckA:
undetectable		 1xwfC-3jckA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3jck 26S PROTEASOME
REGULATORY SUBUNIT
RPN3
(Saccharomyces
cerevisiae) 		3 / 3 THR A 262
GLU A 258
HIS A 225
 None
 0.70A 1xwfD-3jckA:
undetectable		 1xwfD-3jckA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3jck 26S PROTEASOME
REGULATORY SUBUNIT
RPN3
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 196
ASP A 375
ASN A 243
 None
 0.75A 2zzmA-3jckA:
undetectable		 2zzmA-3jckA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_B_SFYB806_0
(SEPIAPTERIN
REDUCTASE)		 3jck 26S PROTEASOME
REGULATORY SUBUNIT
RPN3
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 342
LEU A 379
CYH A 319
TYR A 345
GLN A 312
 None
 1.48A 4hwkB-3jckA:
undetectable		 4hwkB-3jckA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		 3jck 26S PROTEASOME
REGULATORY SUBUNIT
RPN3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 342
LEU A 379
CYH A 319
TYR A 345
GLN A 312
 None
 1.48A 4hwkC-3jckA:
undetectable		 4hwkC-3jckA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_D_SFYD803_0
(SEPIAPTERIN
REDUCTASE)		 3jck 26S PROTEASOME
REGULATORY SUBUNIT
RPN3
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 342
LEU A 379
CYH A 319
TYR A 345
GLN A 312
 None
 1.48A 4hwkD-3jckA:
undetectable		 4hwkD-3jckA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 3jck 26S PROTEASOME
REGULATORY SUBUNIT
RPN3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 342
LEU A 379
CYH A 319
TYR A 345
GLN A 312
 None
 1.48A 4j7xJ-3jckA:
2.1		 4j7xJ-3jckA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 3jck 26S PROTEASOME
REGULATORY SUBUNIT
RPN3
(Saccharomyces
cerevisiae) 		4 / 5 ASN A 280
LEU A 276
SER A 251
LEU A 257
 None
 1.16A 4n09C-3jckA:
undetectable		 4n09C-3jckA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 3jck 26S PROTEASOME
REGULATORY SUBUNIT
RPN3
(Saccharomyces
cerevisiae) 		4 / 4 ASN A 280
LEU A 276
SER A 251
LEU A 257
 None
 1.18A 5kb5A-3jckA:
undetectable		 5kb5A-3jckA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_2
(TYROSINE-PROTEIN
KINASE BTK)		 3jck 26S PROTEASOME
REGULATORY SUBUNIT
RPN3
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 379
TYR A 286
MET A 324
CYH A 318
 None
 1.50A 5p9iA-3jckA:
undetectable		 5p9iA-3jckA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 3jck 26S PROTEASOME
REGULATORY SUBUNIT
RPN3
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 293
ALA A 270
LEU A 310
ILE A 294
 None
 0.89A 5uihA-3jckA:
undetectable		 5uihA-3jckA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3jck 26S PROTEASOME
REGULATORY SUBUNIT
RPN3
(Saccharomyces
cerevisiae) 		3 / 3 ILE A 294
ASN A 314
CYH A 319
 None
 0.91A 6bp4A-3jckA:
undetectable		 6bp4A-3jckA:
18.36