SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jcl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		4 / 4 ILE A 764
LEU A1110
VAL A1103
ALA A 933
 None
 0.78A 1mz9A-3jclA:
undetectable		 1mz9A-3jclA:
3.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		4 / 5 ILE A 764
LEU A1110
VAL A1103
ALA A 933
 None
 0.79A 1mz9C-3jclA:
undetectable		 1mz9C-3jclA:
3.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		5 / 12 PHE A 877
LEU A 822
VAL A 818
VAL A1103
THR A 932
 None
 1.34A 1q23B-3jclA:
undetectable		 1q23B-3jclA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		5 / 11 PHE A 877
LEU A 822
VAL A 818
VAL A1103
THR A 932
 None
 1.31A 1q23F-3jclA:
undetectable		 1q23F-3jclA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		5 / 12 TYR A  51
ILE A 126
VAL A 260
LEU A 263
PHE A 206
 None
 1.26A 1udtA-3jclA:
undetectable		 1udtA-3jclA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		5 / 12 TYR A 258
TYR A  51
ILE A 141
LEU A 263
PHE A 206
 None
 1.33A 1udtA-3jclA:
undetectable		 1udtA-3jclA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		3 / 3 GLN A1061
ILE A1058
TYR A1057
 None
 0.73A 1vifA-3jclA:
undetectable		 1vifA-3jclA:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		4 / 6 PHE A 123
PRO A 124
THR A 163
TRP A 178
 None
 1.47A 2q6oB-3jclA:
undetectable		 2q6oB-3jclA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		4 / 6 VAL A 127
PRO A 124
THR A 163
TRP A 178
 None
 1.44A 2q6oB-3jclA:
undetectable		 2q6oB-3jclA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		5 / 12 ALA A1075
ILE A1113
ILE A 872
THR A 928
LEU A 822
 None
 1.08A 2rlcA-3jclA:
undetectable		 2rlcA-3jclA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		3 / 3 LEU A1110
ARG A 767
ILE A 764
 None
 0.56A 2xn5B-3jclA:
undetectable		 2xn5B-3jclA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		5 / 12 PHE A 213
VAL A 152
PHE A 123
LEU A 195
PHE A 204
 None
 1.39A 3apxA-3jclA:
undetectable		 3apxA-3jclA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		5 / 11 ALA A  80
LEU A  81
ARG A  82
PHE A 254
ILE A 245
 None
 1.14A 3bpxA-3jclA:
undetectable
3bpxB-3jclA:
2.6		 3bpxA-3jclA:
7.92
3bpxB-3jclA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		5 / 12 ALA A1004
LYS A 770
SER A1071
ILE A1068
LEU A 811
 None
 1.37A 3ia4A-3jclA:
undetectable		 3ia4A-3jclA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		4 / 8 SER A 667
TYR A 288
LEU A 673
PRO A 672
 None
 1.17A 3jq7B-3jclA:
undetectable		 3jq7B-3jclA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		3 / 3 ALA A1004
VAL A1001
GLN A 765
 None
 0.75A 3of4B-3jclA:
undetectable		 3of4B-3jclA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		4 / 6 GLY A 758
VAL A1118
SER A1116
THR A 756
 None
 0.93A 3tj7A-3jclA:
undetectable
3tj7B-3jclA:
undetectable		 3tj7A-3jclA:
9.90
3tj7B-3jclA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		4 / 6 GLY A 758
VAL A1118
SER A1116
THR A 756
 None
 0.88A 3tj7C-3jclA:
undetectable
3tj7D-3jclA:
1.5		 3tj7C-3jclA:
9.90
3tj7D-3jclA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		4 / 6 VAL A1118
SER A1116
THR A 756
GLY A 758
 None
 0.91A 3tj7C-3jclA:
undetectable
3tj7D-3jclA:
1.5		 3tj7C-3jclA:
9.90
3tj7D-3jclA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		4 / 6 THR A 784
ASN A 783
GLY A 781
ASP A 782
 None
 1.14A 3w9tE-3jclA:
undetectable		 3w9tE-3jclA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		4 / 4 ASN A1048
SER A1026
LEU A1027
THR A1052
 None
 1.48A 4an2A-3jclA:
1.6		 4an2A-3jclA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA408_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		4 / 6 TYR A 268
THR A  50
PRO A  70
PHE A 105
 None
 1.46A 4kf9A-3jclA:
undetectable		 4kf9A-3jclA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		4 / 6 ILE A 388
ILE A 375
PHE A 356
LEU A 358
 None
 0.94A 4m51A-3jclA:
undetectable		 4m51A-3jclA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0O_A_URFA303_1
(RRNA N-GLYCOSIDASE)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		4 / 5 TYR A 478
ASN A 415
TYR A 416
ARG A 348
 None
 1.15A 4o0oA-3jclA:
undetectable		 4o0oA-3jclA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		3 / 3 HIS A 716
SER A 720
ASN A1091
 None
 0.90A 5cprB-3jclA:
undetectable		 5cprB-3jclA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		5 / 12 LEU A 790
LEU A 804
PHE A 778
ALA A1053
LEU A1012
 None
 1.22A 5iepA-3jclA:
undetectable		 5iepA-3jclA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		3 / 3 ASP A 219
ASN A 110
PHE A 193
 None
 0.92A 5jglB-3jclA:
undetectable		 5jglB-3jclA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		3 / 3 VAL A  32
SER A  90
TRP A  91
 None
 0.84A 5jwaA-3jclA:
undetectable		 5jwaA-3jclA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		5 / 12 ALA A 819
THR A 932
ARG A 767
GLY A1109
LEU A1110
 None
 1.26A 5m54E-3jclA:
2.8		 5m54E-3jclA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		4 / 8 LEU A  63
TYR A  58
ASN A1014
LEU A1013
 None
 0.84A 5y7pC-3jclA:
undetectable		 5y7pC-3jclA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		5 / 12 TYR A  96
SER A 136
THR A 135
LEU A 242
VAL A 127
 None
 1.17A 6a93B-3jclA:
undetectable		 6a93B-3jclA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		5 / 12 PHE A 213
ILE A 128
PHE A 228
PHE A 123
THR A 194
 None
 1.24A 6e8qA-3jclA:
1.2		 6e8qA-3jclA:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3jcl SPIKE GLYCOPROTEIN
(Murine
coronavirus) 		3 / 3 LEU A 822
GLY A 926
PHE A 877
 None
 0.67A 6exiC-3jclA:
undetectable		 6exiC-3jclA:
5.79