SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jcm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP3
(Saccharomyces
cerevisiae) 		3 / 3 VAL K 341
VAL K 383
TRP K 428
 None
 0.87A 1av2A-3jcmK:
undetectable
1av2B-3jcmK:
undetectable		 1av2A-3jcmK:
2.73
1av2B-3jcmK:
2.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		4 / 7 SER B 442
SER B 182
ALA B 180
ILE B 224
 None
 1.05A 1fxhA-3jcmB:
undetectable
1fxhB-3jcmB:
undetectable		 1fxhA-3jcmB:
16.34
1fxhB-3jcmB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		4 / 8 SER B 442
SER B 182
ALA B 180
ILE B 224
 None
 1.05A 1gm7A-3jcmB:
undetectable
1gm7B-3jcmB:
undetectable		 1gm7A-3jcmB:
16.34
1gm7B-3jcmB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 3jcm PRE-MRNA-SPLICING
FACTOR 6
(Saccharomyces
cerevisiae) 		4 / 6 TRP G 842
LEU G 892
LEU G 895
MET G 896
 None
 1.29A 1hz4A-3jcmG:
undetectable		 1hz4A-3jcmG:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		4 / 8 SER B 442
SER B 182
ALA B 180
ILE B 224
 None
 1.09A 1pnlA-3jcmB:
undetectable
1pnlB-3jcmB:
undetectable		 1pnlA-3jcmB:
16.34
1pnlB-3jcmB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 3jcm PRE-MRNA-SPLICING
FACTOR 6
(Saccharomyces
cerevisiae) 		3 / 3 GLU G 265
ASN G 281
TRP G 278
 None
 1.21A 1r15C-3jcmG:
undetectable		 1r15C-3jcmG:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 3jcm PRE-MRNA-SPLICING
FACTOR 6
(Saccharomyces
cerevisiae) 		3 / 3 GLU G 265
ASN G 281
TRP G 278
 None
 1.29A 1r15D-3jcmG:
undetectable		 1r15D-3jcmG:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 3jcm PRE-MRNA-SPLICING
FACTOR 6
(Saccharomyces
cerevisiae) 		3 / 3 GLU G 265
ASN G 281
TRP G 278
 None
 1.25A 1r15E-3jcmG:
undetectable		 1r15E-3jcmG:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 3jcm PRE-MRNA-SPLICING
FACTOR 6
(Saccharomyces
cerevisiae) 		4 / 8 LEU G 828
TYR G 816
TRP G 844
LEU G 809
 None
 1.00A 1s1xA-3jcmG:
undetectable		 1s1xA-3jcmG:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP3
(Saccharomyces
cerevisiae) 		3 / 3 VAL K 341
VAL K 383
TRP K 428
 None
 0.89A 1w5uA-3jcmK:
undetectable
1w5uB-3jcmK:
undetectable		 1w5uA-3jcmK:
2.73
1w5uB-3jcmK:
2.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 3jcm PRE-MRNA-SPLICING
FACTOR 6
(Saccharomyces
cerevisiae) 		3 / 3 LEU G 780
PHE G 781
ARG G 800
 None
 0.76A 1xdkB-3jcmG:
undetectable		 1xdkB-3jcmG:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 3jcm PRE-MRNA-SPLICING
FACTOR 6
(Saccharomyces
cerevisiae) 		3 / 3 LEU G 780
PHE G 781
ARG G 800
 None
 0.76A 1xdkF-3jcmG:
undetectable		 1xdkF-3jcmG:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP3
(Saccharomyces
cerevisiae) 		3 / 3 VAL K 383
TRP K 428
VAL K 341
 None
 0.99A 2izqC-3jcmK:
undetectable
2izqD-3jcmK:
undetectable		 2izqC-3jcmK:
2.73
2izqD-3jcmK:
2.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		4 / 5 LEU B 261
GLY B 263
ILE B 268
ILE B 243
 None
 0.83A 2q9rA-3jcmB:
undetectable		 2q9rA-3jcmB:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		3 / 3 MET B 287
VAL B 271
GLU B 299
 None
 0.88A 2x9gA-3jcmB:
undetectable		 2x9gA-3jcmB:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		4 / 7 TYR B 248
TRP B 226
VAL B 190
ILE B 224
 None
 1.28A 2xz5B-3jcmB:
undetectable
2xz5E-3jcmB:
undetectable		 2xz5B-3jcmB:
19.19
2xz5E-3jcmB:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		4 / 8 ILE B 224
TYR B 248
TRP B 226
VAL B 190
 None
 1.29A 2xz5A-3jcmB:
undetectable
2xz5C-3jcmB:
undetectable		 2xz5A-3jcmB:
19.19
2xz5C-3jcmB:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		4 / 7 ILE B 224
TYR B 248
TRP B 226
VAL B 190
 None
 1.28A 2xz5D-3jcmB:
undetectable
2xz5E-3jcmB:
undetectable		 2xz5D-3jcmB:
19.19
2xz5E-3jcmB:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		4 / 7 GLU B 139
ARG B 142
TYR B 362
ARG B 379
 None
 1.18A 2zt7A-3jcmB:
undetectable		 2zt7A-3jcmB:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		5 / 11 VAL B 453
GLY B 455
ILE B 441
SER B 179
SER B 194
 None
 1.23A 3bjwB-3jcmB:
undetectable		 3bjwB-3jcmB:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		5 / 11 VAL B 453
GLY B 455
ILE B 441
SER B 179
SER B 194
 None
 1.33A 3bjwE-3jcmB:
undetectable		 3bjwE-3jcmB:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		5 / 11 GLU B 116
LEU B 117
ILE B 336
LEU B 124
PHE B 279
 None
 1.32A 3fl9C-3jcmB:
undetectable		 3fl9C-3jcmB:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		5 / 9 GLU B 116
LEU B 117
ILE B 336
LEU B 124
PHE B 279
 None
 1.32A 3fl9H-3jcmB:
undetectable		 3fl9H-3jcmB:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		5 / 12 THR B 185
PHE B 279
ASP B 293
ALA B 294
ASP B 229
 None
 1.02A 3id6C-3jcmB:
undetectable		 3id6C-3jcmB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		5 / 12 VAL B 322
LEU B 321
LEU B 313
SER B 128
GLY B 339
 None
 1.25A 3kk6B-3jcmB:
undetectable		 3kk6B-3jcmB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		5 / 12 ASP B 198
ILE B 461
ILE B 178
SER B 179
VAL B 181
 None
 1.08A 3kpdC-3jcmB:
undetectable		 3kpdC-3jcmB:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		3 / 3 ASN B 374
TRP B 376
ASP B 370
 None
 1.18A 4a7tA-3jcmB:
undetectable
4a7tF-3jcmB:
undetectable		 4a7tA-3jcmB:
17.42
4a7tF-3jcmB:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		4 / 6 GLY B 222
ILE B 224
VAL B 218
SER B 236
 None
 0.88A 4kcnA-3jcmB:
undetectable		 4kcnA-3jcmB:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		5 / 10 ASP B 425
VAL B 375
GLY B 407
SER B 423
ASP B 377
 None
 1.16A 4mmcA-3jcmB:
undetectable		 4mmcA-3jcmB:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA601_1
(SERUM ALBUMIN)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP3
U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		5 / 11 VAL K 383
GLY K 384
CYH K 389
LEU K 432
SER B 349
 None
 1.36A 4or0A-3jcmK:
undetectable		 4or0A-3jcmK:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP3
U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		5 / 12 VAL K 383
GLY K 384
CYH K 389
LEU K 432
SER B 349
 None
 1.29A 4ot2A-3jcmK:
undetectable		 4ot2A-3jcmK:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		5 / 9 THR B 192
ALA B 191
GLY B 456
GLY B 455
ASP B 444
 None
 1.14A 4qwuK-3jcmB:
undetectable
4qwuL-3jcmB:
undetectable		 4qwuK-3jcmB:
18.20
4qwuL-3jcmB:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		5 / 9 THR B 192
ALA B 191
GLY B 456
GLY B 455
ASP B 444
 None
 1.13A 4qwuY-3jcmB:
undetectable
4qwuZ-3jcmB:
undetectable		 4qwuY-3jcmB:
18.20
4qwuZ-3jcmB:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		4 / 7 GLU B  50
LEU B  54
LEU B  76
LEU B  80
 None
 0.76A 4wg0B-3jcmB:
undetectable
4wg0C-3jcmB:
undetectable		 4wg0B-3jcmB:
2.40
4wg0C-3jcmB:
2.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		5 / 10 GLY B 281
ASP B 293
ALA B 120
ILE B 336
LEU B 291
 None
 1.09A 4xj7A-3jcmB:
undetectable
4xj7B-3jcmB:
undetectable		 4xj7A-3jcmB:
18.72
4xj7B-3jcmB:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		5 / 11 ASP B 425
ALA B 365
VAL B 375
GLY B 407
SER B 423
 None
 1.11A 4xnxA-3jcmB:
undetectable		 4xnxA-3jcmB:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP3
U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		4 / 7 GLU K 167
ARG B 135
TYR K 159
GLU B 139
 None
 1.16A 4zz8A-3jcmK:
undetectable		 4zz8A-3jcmK:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		4 / 6 TYR B 248
ILE B 224
VAL B 201
ALA B 191
 None
 0.73A 5cu6A-3jcmB:
undetectable		 5cu6A-3jcmB:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		5 / 10 ASP B 425
ALA B 365
GLY B 407
PHE B 401
SER B 423
 None
 0.81A 5i6xA-3jcmB:
undetectable		 5i6xA-3jcmB:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_A_ACTA305_0
(CARBONIC ANHYDRASE 4)		 3jcm PRE-MRNA-SPLICING
FACTOR 6
(Saccharomyces
cerevisiae) 		4 / 4 GLN G 777
VAL G 760
GLU G 776
ILE G 744
 None
 1.36A 5jncA-3jcmG:
undetectable		 5jncA-3jcmG:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		3 / 3 HIS B 274
LYS B 278
PHE B 279
 None
 1.27A 5klaA-3jcmB:
undetectable		 5klaA-3jcmB:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M67_B_ACTB505_0
(ADENOSYLHOMOCYSTEINA
SE)		 3jcm PRE-MRNA-SPLICING
FACTOR 6
(Saccharomyces
cerevisiae) 		4 / 4 ASP G 712
ILE G 725
ARG G 728
ARG G 721
 None
 1.36A 5m67B-3jcmG:
0.0		 5m67B-3jcmG:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP3
(Saccharomyces
cerevisiae) 		3 / 3 THR K 427
PRO K 377
ARG K 371
 None
None
C  D  85 ( 3.8A)
 0.78A 5nd7B-3jcmK:
undetectable		 5nd7B-3jcmK:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		4 / 7 TYR B 248
ILE B 224
VAL B 201
ALA B 191
 None
 0.76A 5ospA-3jcmB:
undetectable		 5ospA-3jcmB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		4 / 7 TYR B 248
ILE B 224
VAL B 201
ALA B 191
 None
 0.75A 5osrA-3jcmB:
undetectable		 5osrA-3jcmB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		3 / 3 PHE B 311
ASP B 270
LEU B 333
 None
 0.70A 5uhbC-3jcmB:
undetectable		 5uhbC-3jcmB:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		3 / 3 PHE B 311
ASP B 270
LEU B 333
 None
 0.79A 5uhcC-3jcmB:
undetectable		 5uhcC-3jcmB:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3jcm PRE-MRNA-SPLICING
FACTOR 6
(Saccharomyces
cerevisiae) 		4 / 9 TYR G 740
ILE G 744
ILE G 748
LEU G 753
 None
 0.80A 5vkqB-3jcmG:
undetectable
5vkqC-3jcmG:
undetectable		 5vkqB-3jcmG:
19.35
5vkqC-3jcmG:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP3
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ARG B 135
PHE K 156
ARG B 379
 None
 1.04A 5y9yA-3jcmB:
undetectable		 5y9yA-3jcmB:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP3
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 ASP B 335
ILE B 378
ASN B 126
TYR K 173
 None
 1.08A 6a93B-3jcmB:
undetectable		 6a93B-3jcmB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		3 / 3 GLN B 303
TRP B 334
VAL B 322
 None
 0.60A 6auuA-3jcmB:
undetectable		 6auuA-3jcmB:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		5 / 10 SER B 314
LEU B 410
ASP B 444
ILE B 373
GLY B 367
 None
 1.17A 6dlzA-3jcmB:
undetectable
6dlzD-3jcmB:
undetectable		 6dlzA-3jcmB:
9.73
6dlzD-3jcmB:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		5 / 10 ILE B 373
GLY B 367
SER B 314
LEU B 410
ASP B 444
 None
 1.17A 6dlzB-3jcmB:
undetectable
6dlzC-3jcmB:
undetectable		 6dlzB-3jcmB:
9.73
6dlzC-3jcmB:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		5 / 10 SER B 314
LEU B 410
ASP B 444
ILE B 373
GLY B 367
 None
 1.11A 6dm0B-3jcmB:
undetectable
6dm0C-3jcmB:
undetectable		 6dm0B-3jcmB:
9.73
6dm0C-3jcmB:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		5 / 10 SER B 314
LEU B 410
ASP B 444
ILE B 373
GLY B 367
 None
 1.18A 6dm1A-3jcmB:
undetectable
6dm1D-3jcmB:
undetectable		 6dm1A-3jcmB:
9.73
6dm1D-3jcmB:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		5 / 10 ILE B 373
GLY B 367
SER B 314
LEU B 410
ASP B 444
 None
 1.18A 6dm1B-3jcmB:
undetectable
6dm1C-3jcmB:
undetectable		 6dm1B-3jcmB:
9.73
6dm1C-3jcmB:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 443
ILE B 440
GLY B 455
ILE B 178
THR B 192
 None
 1.06A 6emuB-3jcmB:
undetectable		 6emuB-3jcmB:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		4 / 5 GLY B 309
HIS B 306
SER B 331
SER B 324
 None
 1.06A 6jmjA-3jcmB:
undetectable		 6jmjA-3jcmB:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4
(Saccharomyces
cerevisiae) 		4 / 6 GLY B 309
HIS B 306
SER B 331
SER B 324
 None
 1.06A 6jogA-3jcmB:
undetectable		 6jogA-3jcmB:
14.62