SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jr3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		5 / 6 ALA A  22
SER A  25
ASN A  99
ILE A 100
ASP A 101
 None
 0.23A 1yc2A-3jr3A:
26.9		 1yc2A-3jr3A:
42.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		4 / 5 ALA A  22
ASN A  99
ILE A 100
ASP A 101
 None
 0.19A 1yc2D-3jr3A:
26.7		 1yc2D-3jr3A:
42.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		4 / 7 ILE A  30
ASN A  99
ILE A 100
ASP A 101
 None
 0.50A 1yc2E-3jr3A:
27.6		 1yc2E-3jr3A:
42.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		7 / 7 ALA A  22
SER A  25
ILE A  30
ASP A  32
ASN A  99
ILE A 100
ASP A 101
 None
 0.25A 1yc5A-3jr3A:
40.5		 1yc5A-3jr3A:
99.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		5 / 12 HIS A 104
PHE A   6
VAL A 211
VAL A 232
THR A  20
 None
 1.12A 1z9yA-3jr3A:
undetectable		 1z9yA-3jr3A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_A_T98A201_1
(PROGESTERONE
RECEPTOR)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		5 / 10 MET A  71
LEU A  72
ARG A 106
TYR A  61
PHE A 161
 None
 0.86A 1zucA-3jr3A:
undetectable		 1zucA-3jr3A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		5 / 12 ILE A 185
THR A  97
ASN A  99
SER A  25
HIS A 104
 None
 1.24A 2gl0A-3jr3A:
undetectable
2gl0C-3jr3A:
undetectable		 2gl0A-3jr3A:
24.08
2gl0C-3jr3A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		5 / 12 SER A  25
HIS A 104
ILE A 185
THR A  97
ASN A  99
 None
 1.26A 2gl0D-3jr3A:
undetectable
2gl0E-3jr3A:
undetectable		 2gl0D-3jr3A:
24.08
2gl0E-3jr3A:
24.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		5 / 5 ALA A  22
ILE A  30
ASN A  99
ILE A 100
ASP A 101
 None
 0.29A 2h4jA-3jr3A:
40.5		 2h4jA-3jr3A:
99.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		4 / 8 ILE A  50
ASN A  46
SER A  44
SER A  55
 None
 1.09A 2zw9B-3jr3A:
2.4		 2zw9B-3jr3A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		5 / 12 SER A  25
THR A  26
GLY A 188
ILE A 185
VAL A  95
 None
 1.20A 3fzgA-3jr3A:
undetectable		 3fzgA-3jr3A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		5 / 12 LEU A  19
PHE A  48
LEU A 115
ASP A 101
SER A  25
 None
 1.14A 3ko0A-3jr3A:
undetectable
3ko0B-3jr3A:
undetectable
3ko0C-3jr3A:
undetectable
3ko0D-3jr3A:
undetectable		 3ko0A-3jr3A:
20.18
3ko0B-3jr3A:
20.18
3ko0C-3jr3A:
20.18
3ko0D-3jr3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		5 / 12 ASP A 101
SER A  25
LEU A  19
PHE A  48
LEU A 115
 None
 1.20A 3ko0G-3jr3A:
undetectable
3ko0H-3jr3A:
undetectable
3ko0I-3jr3A:
undetectable
3ko0J-3jr3A:
undetectable		 3ko0G-3jr3A:
20.18
3ko0H-3jr3A:
20.18
3ko0I-3jr3A:
20.18
3ko0J-3jr3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		5 / 11 ASP A 101
SER A  25
LEU A 115
LEU A  19
PHE A  48
 None
 1.08A 3ko0A-3jr3A:
undetectable
3ko0B-3jr3A:
undetectable
3ko0I-3jr3A:
undetectable
3ko0J-3jr3A:
undetectable		 3ko0A-3jr3A:
20.18
3ko0B-3jr3A:
20.18
3ko0I-3jr3A:
20.18
3ko0J-3jr3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		5 / 12 LEU A 115
LEU A  19
PHE A  48
ASP A 101
SER A  25
 None
 1.17A 3ko0K-3jr3A:
undetectable
3ko0L-3jr3A:
undetectable
3ko0M-3jr3A:
undetectable
3ko0N-3jr3A:
undetectable		 3ko0K-3jr3A:
20.18
3ko0L-3jr3A:
20.18
3ko0M-3jr3A:
20.18
3ko0N-3jr3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		5 / 12 LEU A  19
PHE A  48
LEU A 115
ASP A 101
SER A  25
 None
 1.17A 3ko0M-3jr3A:
undetectable
3ko0N-3jr3A:
undetectable
3ko0O-3jr3A:
undetectable
3ko0P-3jr3A:
undetectable		 3ko0M-3jr3A:
20.18
3ko0N-3jr3A:
20.18
3ko0O-3jr3A:
20.18
3ko0P-3jr3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		4 / 7 VAL A 211
PHE A 235
MET A   3
LEU A  10
 None
 1.00A 3rfmA-3jr3A:
undetectable		 3rfmA-3jr3A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		4 / 5 SER A 153
PRO A 146
TYR A 131
VAL A 145
 None
 1.24A 3sufC-3jr3A:
undetectable		 3sufC-3jr3A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		4 / 7 PHE A  48
PHE A 161
PHE A  63
ALA A  64
 None
 1.06A 4ejgA-3jr3A:
undetectable		 4ejgA-3jr3A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		4 / 7 ASN A  99
ALA A  22
SER A  25
VAL A 232
 None
 1.10A 4ijiH-3jr3A:
undetectable		 4ijiH-3jr3A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		5 / 9 THR A  20
GLY A  21
LEU A 187
VAL A 232
VAL A 213
 None
 1.05A 4mjrA-3jr3A:
undetectable		 4mjrA-3jr3A:
21.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		4 / 7 ILE A  30
ASN A  99
ILE A 100
ASP A 101
 None
 0.49A 4rmjA-3jr3A:
25.5		 4rmjA-3jr3A:
34.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		5 / 11 GLY A  23
PHE A  33
ILE A  68
ASP A  32
PRO A  31
 None
 1.41A 4rtrA-3jr3A:
3.2		 4rtrA-3jr3A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		5 / 12 GLY A 216
ILE A 245
PHE A   6
THR A  18
LEU A 187
 None
 0.99A 4zdyA-3jr3A:
undetectable		 4zdyA-3jr3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		4 / 7 ILE A 245
PHE A   6
THR A  18
LEU A 187
 None
 0.82A 4zdzA-3jr3A:
undetectable		 4zdzA-3jr3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		5 / 12 GLY A 216
ILE A 245
PHE A   6
THR A  18
LEU A 187
 None
 1.02A 4ze2A-3jr3A:
undetectable		 4ze2A-3jr3A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		4 / 7 ILE A 245
PHE A   6
THR A  18
LEU A 187
 None
 0.90A 4ze3A-3jr3A:
undetectable		 4ze3A-3jr3A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		4 / 8 ILE A 245
PHE A   6
THR A  18
LEU A 187
 None
 0.85A 5esfA-3jr3A:
undetectable		 5esfA-3jr3A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		4 / 8 ILE A 245
PHE A   6
THR A  18
LEU A 187
 None
 0.84A 5esjA-3jr3A:
undetectable		 5esjA-3jr3A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		4 / 7 ILE A 245
PHE A   6
THR A  18
LEU A 187
 None
 0.82A 5esmA-3jr3A:
undetectable		 5esmA-3jr3A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		5 / 12 ALA A 236
THR A  97
GLN A  98
GLY A 188
SER A 189
 None
 1.14A 5hfjF-3jr3A:
3.3		 5hfjF-3jr3A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		4 / 8 ILE A 245
PHE A   6
THR A  18
LEU A 187
 None
 0.73A 5hs1A-3jr3A:
undetectable		 5hs1A-3jr3A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		5 / 12 LEU A 187
ILE A 212
ILE A  24
GLY A  21
VAL A 232
 None
 0.99A 5twjA-3jr3A:
undetectable		 5twjA-3jr3A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		5 / 10 LEU A 187
ILE A 212
ILE A  24
GLY A  21
VAL A 232
 None
 1.04A 5twjB-3jr3A:
undetectable		 5twjB-3jr3A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		5 / 12 LEU A 187
ILE A 212
ILE A  24
GLY A  21
VAL A 232
 None
 1.00A 5twjC-3jr3A:
undetectable		 5twjC-3jr3A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		5 / 12 GLY A 216
ILE A 245
PHE A   6
THR A  18
LEU A 187
 None
 1.03A 6e8qA-3jr3A:
undetectable		 6e8qA-3jr3A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 3jr3 NAD-DEPENDENT
DEACETYLASE
(Thermotoga
maritima) 		4 / 7 ASP A 101
GLY A 188
SER A  25
VAL A 232
 None
 0.97A 6ekzA-3jr3A:
undetectable		 6ekzA-3jr3A:
13.14