SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jr7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307
([Ruminococcus]
gnavus) 		5 / 11 SER A 282
SER A 285
TYR A 288
GLU A 143
GLY A 142
 None
PG6  A 299 ( 4.2A)
PG6  A 299 ( 3.8A)
None
None
 1.40A 1i9jH-3jr7A:
undetectable
1i9jL-3jr7A:
undetectable		 1i9jH-3jr7A:
20.26
1i9jL-3jr7A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307
([Ruminococcus]
gnavus) 		4 / 5 LEU A 108
ALA A 106
LEU A 104
SER A 111
 PG6  A 299 (-4.3A)
None
PG6  A 299 ( 4.6A)
None
 1.09A 1tt6B-3jr7A:
undetectable		 1tt6B-3jr7A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9V_C_TMQC1270_1
(PTERIDINE REDUCTASE)		 3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307
([Ruminococcus]
gnavus) 		5 / 10 ARG A  87
ASP A  60
PHE A  32
LEU A  47
PRO A  83
 NA  A 303 (-4.2A)
None
None
None
None
 1.34A 2x9vC-3jr7A:
2.1		 2x9vC-3jr7A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307
([Ruminococcus]
gnavus) 		4 / 8 GLU A  31
SER A 138
THR A 176
ALA A 252
 None
PG6  A 299 ( 4.7A)
PG6  A 299 ( 4.2A)
None
 0.99A 3ns1L-3jr7A:
undetectable		 3ns1L-3jr7A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307
([Ruminococcus]
gnavus) 		5 / 12 VAL A 263
LEU A 230
LEU A 267
VAL A 179
GLY A 293
 None
 1.10A 3rr3C-3jr7A:
undetectable		 3rr3C-3jr7A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307
([Ruminococcus]
gnavus) 		5 / 12 VAL A 263
LEU A 230
LEU A 267
VAL A 179
GLY A 293
 None
 1.10A 3rr3D-3jr7A:
1.5		 3rr3D-3jr7A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307
([Ruminococcus]
gnavus) 		4 / 6 THR A 185
ASN A 189
GLY A 190
ILE A 217
 None
 0.78A 3w9tF-3jr7A:
undetectable		 3w9tF-3jr7A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307
([Ruminococcus]
gnavus) 		5 / 12 GLY A 118
ASN A 120
ILE A  25
ASN A 113
THR A 103
 None
 1.31A 4pooA-3jr7A:
2.0		 4pooA-3jr7A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307
([Ruminococcus]
gnavus) 		5 / 12 GLU A 258
GLU A 257
GLU A 262
GLY A 293
ALA A 289
 None
None
None
None
PG6  A 299 ( 4.6A)
 1.26A 4xe5A-3jr7A:
undetectable		 4xe5A-3jr7A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307
([Ruminococcus]
gnavus) 		4 / 7 LEU A 183
LYS A 206
PRO A 207
GLU A 181
 None
 0.79A 4z4fA-3jr7A:
undetectable		 4z4fA-3jr7A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307
([Ruminococcus]
gnavus) 		4 / 6 LEU A 183
LYS A 206
PRO A 207
GLU A 181
 None
 0.82A 4z4gA-3jr7A:
undetectable		 4z4gA-3jr7A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307
([Ruminococcus]
gnavus) 		5 / 12 VAL A 263
LEU A 230
LEU A 267
VAL A 179
GLY A 293
 None
 1.07A 5ikrB-3jr7A:
1.3		 5ikrB-3jr7A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307
([Ruminococcus]
gnavus) 		5 / 12 VAL A 263
LEU A 230
LEU A 267
VAL A 179
GLY A 293
 None
 1.09A 5jvzA-3jr7A:
undetectable		 5jvzA-3jr7A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307
([Ruminococcus]
gnavus) 		4 / 7 LEU A 183
LYS A 206
PRO A 207
GLU A 181
 None
 0.81A 5t7bA-3jr7A:
undetectable		 5t7bA-3jr7A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307
([Ruminococcus]
gnavus) 		5 / 12 PHE A  32
ASP A  59
ALA A  46
ASP A  27
ILE A  49
 None
 1.10A 6dwnD-3jr7A:
undetectable		 6dwnD-3jr7A:
13.71