SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jrk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
pyogenes) 		5 / 9 TYR A 141
ILE A 142
TYR A  87
ILE A 145
GLU A 148
 None
 1.35A 1mrgA-3jrkA:
undetectable		 1mrgA-3jrkA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
pyogenes) 		5 / 8 TYR A 141
ILE A 142
TYR A  87
ILE A 145
GLU A 148
 None
 1.24A 1mrjA-3jrkA:
undetectable		 1mrjA-3jrkA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
pyogenes) 		4 / 5 PRO A 205
VAL A 183
ASN A 184
VAL A 202
 None
 1.05A 1z2bC-3jrkA:
undetectable		 1z2bC-3jrkA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
pyogenes) 		5 / 12 LEU A 239
ASP A 198
PHE A 156
ILE A 160
ILE A 142
 None
 1.15A 2bl9A-3jrkA:
undetectable		 2bl9A-3jrkA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RDD_A_AICA1110_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
pyogenes) 		4 / 4 LYS A 313
ALA A 261
PHE A 230
GLY A 264
 None
 1.42A 2rddA-3jrkA:
0.0		 2rddA-3jrkA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
pyogenes) 		5 / 12 SER A 245
ILE A 304
LEU A 307
LEU A 311
VAL A 270
 None
 1.21A 3dcjA-3jrkA:
undetectable
3dcjB-3jrkA:
undetectable		 3dcjA-3jrkA:
22.46
3dcjB-3jrkA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFA_B_EDTB802_0
(ALPHA-GLUCOSIDASE)		 3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
pyogenes) 		4 / 6 ARG A  99
ASP A 169
ASN A 170
TYR A 163
 None
 1.48A 3wfaA-3jrkA:
8.3
3wfaB-3jrkA:
7.0		 3wfaA-3jrkA:
19.83
3wfaB-3jrkA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
pyogenes) 		5 / 12 PHE A 122
PRO A  67
LEU A  71
ALA A 109
SER A 108
 None
 1.38A 4a83A-3jrkA:
undetectable		 4a83A-3jrkA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
pyogenes) 		5 / 12 PHE A 122
PRO A  67
LEU A  71
ALA A 109
SER A 108
 None
 1.31A 4a84A-3jrkA:
undetectable		 4a84A-3jrkA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
pyogenes) 		5 / 12 LEU A 200
LEU A 158
ILE A 160
ASN A 135
SER A 191
 None
 1.01A 4lmnA-3jrkA:
undetectable		 4lmnA-3jrkA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
pyogenes) 		5 / 9 TYR A 141
ILE A 142
TYR A  87
ILE A 145
GLU A 148
 None
 1.10A 4yp2B-3jrkA:
undetectable		 4yp2B-3jrkA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
pyogenes) 		5 / 9 TYR A 141
ILE A 142
TYR A  87
ILE A 145
GLU A 148
 None
 1.10A 5cf9B-3jrkA:
undetectable		 5cf9B-3jrkA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
pyogenes) 		4 / 7 PRO A 101
TYR A 141
ILE A 145
ILE A 142
 None
 0.89A 5murB-3jrkA:
undetectable		 5murB-3jrkA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
pyogenes) 		5 / 12 ILE A 304
LEU A  56
TRP A 295
SER A 245
GLY A 273
 None
 1.21A 5nnaA-3jrkA:
undetectable		 5nnaA-3jrkA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
pyogenes) 		5 / 12 ILE A 304
LEU A  56
TRP A 295
SER A 245
GLY A 273
 None
 1.20A 5nnaB-3jrkA:
undetectable		 5nnaB-3jrkA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
pyogenes) 		5 / 12 ILE A 304
LEU A  56
TRP A 295
SER A 245
GLY A 273
 None
 1.19A 5nnaC-3jrkA:
undetectable		 5nnaC-3jrkA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
pyogenes) 		5 / 12 ILE A 304
LEU A  56
TRP A 295
SER A 245
GLY A 273
 None
 1.22A 5nnaD-3jrkA:
1.9		 5nnaD-3jrkA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
pyogenes) 		5 / 12 LEU A 220
LEU A 252
VAL A 248
PHE A 259
ALA A 229
 None
 1.01A 5uxdB-3jrkA:
undetectable		 5uxdB-3jrkA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
pyogenes) 		5 / 12 LEU A 252
VAL A 248
PHE A 259
PHE A 230
ALA A 229
 None
 0.85A 5uxdB-3jrkA:
undetectable		 5uxdB-3jrkA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
pyogenes) 		4 / 6 TYR A 141
TYR A  87
ILE A 145
GLU A 148
 None
 1.02A 5z3jA-3jrkA:
undetectable		 5z3jA-3jrkA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
pyogenes) 		5 / 12 GLY A  26
SER A 280
LEU A  51
VAL A  52
ASP A  66
 GOL  A 323 ( 4.3A)
None
None
None
None
 1.10A 6bxmA-3jrkA:
undetectable		 6bxmA-3jrkA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
pyogenes) 		4 / 5 ARG A 293
ALA A 292
TYR A 284
GLN A 290
 None
 1.18A 6f6sA-3jrkA:
undetectable
6f6sB-3jrkA:
undetectable		 6f6sA-3jrkA:
15.79
6f6sB-3jrkA:
12.79