SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3js3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 3js3 3-DEHYDROQUINATE
DEHYDRATASE
(Clostridioides
difficile) 		4 / 8 VAL A  50
LEU A 101
SER A 106
VAL A 111
 None
 1.11A 1jtvA-3js3A:
undetectable		 1jtvA-3js3A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 3js3 3-DEHYDROQUINATE
DEHYDRATASE
(Clostridioides
difficile) 		5 / 5 LEU A 224
GLY A  13
PRO A 200
ILE A 201
ILE A 202
 None
 1.37A 2q9rA-3js3A:
undetectable		 2q9rA-3js3A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3js3 3-DEHYDROQUINATE
DEHYDRATASE
(Clostridioides
difficile) 		5 / 7 ILE A  76
GLN A   6
ARG A  70
ASP A 112
LEU A 113
 None
 1.38A 2qqcB-3js3A:
undetectable
2qqcC-3js3A:
undetectable		 2qqcB-3js3A:
19.66
2qqcC-3js3A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3js3 3-DEHYDROQUINATE
DEHYDRATASE
(Clostridioides
difficile) 		5 / 7 ASP A 112
LEU A 113
ILE A  76
GLN A   6
ARG A  70
 None
 1.40A 2qqcA-3js3A:
undetectable
2qqcF-3js3A:
undetectable		 2qqcA-3js3A:
11.28
2qqcF-3js3A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3js3 3-DEHYDROQUINATE
DEHYDRATASE
(Clostridioides
difficile) 		5 / 7 ASP A 112
LEU A 113
ILE A  76
GLN A   6
ARG A  70
 None
 1.38A 2qqcI-3js3A:
undetectable
2qqcL-3js3A:
undetectable		 2qqcI-3js3A:
11.28
2qqcL-3js3A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3js3 3-DEHYDROQUINATE
DEHYDRATASE
(Clostridioides
difficile) 		3 / 3 LYS A 180
LYS A 152
VAL A 184
 None
 0.99A 3brfA-3js3A:
undetectable		 3brfA-3js3A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 3js3 3-DEHYDROQUINATE
DEHYDRATASE
(Clostridioides
difficile) 		4 / 8 PRO A  17
SER A 222
SER A 213
GLY A 217
 None
 0.93A 3lslA-3js3A:
undetectable
3lslD-3js3A:
undetectable		 3lslA-3js3A:
22.92
3lslD-3js3A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 3js3 3-DEHYDROQUINATE
DEHYDRATASE
(Clostridioides
difficile) 		5 / 9 LEU A 118
ALA A 167
ASP A 168
VAL A 116
ILE A 141
 None
 1.30A 3wsjA-3js3A:
undetectable		 3wsjA-3js3A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 3js3 3-DEHYDROQUINATE
DEHYDRATASE
(Clostridioides
difficile) 		3 / 3 PHE A  82
ASP A 115
ARG A  83
 None
None
DHS  A 301 (-3.9A)
 0.89A 4eahG-3js3A:
undetectable		 4eahG-3js3A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3js3 3-DEHYDROQUINATE
DEHYDRATASE
(Clostridioides
difficile) 		5 / 8 ALA A  41
ASP A  75
ILE A  76
ASP A  44
ILE A  10
 None
 1.38A 4kttB-3js3A:
undetectable		 4kttB-3js3A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 3js3 3-DEHYDROQUINATE
DEHYDRATASE
(Clostridioides
difficile) 		3 / 3 TYR A  98
ARG A  83
SER A  84
 None
DHS  A 301 (-3.9A)
None
 1.15A 4lf7I-3js3A:
undetectable
4lf7J-3js3A:
undetectable		 4lf7I-3js3A:
15.83
4lf7J-3js3A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 3js3 3-DEHYDROQUINATE
DEHYDRATASE
(Clostridioides
difficile) 		3 / 3 TYR A  98
ARG A  83
SER A  84
 None
DHS  A 301 (-3.9A)
None
 1.15A 4lf8I-3js3A:
undetectable
4lf8J-3js3A:
undetectable		 4lf8I-3js3A:
15.83
4lf8J-3js3A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 3js3 3-DEHYDROQUINATE
DEHYDRATASE
(Clostridioides
difficile) 		4 / 7 LEU A  78
ILE A  12
ILE A  10
VAL A   7
 None
 0.83A 4ojbA-3js3A:
undetectable		 4ojbA-3js3A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 3js3 3-DEHYDROQUINATE
DEHYDRATASE
(Clostridioides
difficile) 		5 / 12 ILE A 140
VAL A 139
ARG A  49
VAL A  62
LEU A 101
 None
None
DHS  A 301 (-4.2A)
None
None
 1.12A 5ergB-3js3A:
undetectable		 5ergB-3js3A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3js3 3-DEHYDROQUINATE
DEHYDRATASE
(Clostridioides
difficile) 		4 / 7 ILE A  19
GLY A 227
LEU A 186
PHE A 220
 None
 0.88A 5hieB-3js3A:
undetectable		 5hieB-3js3A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 3js3 3-DEHYDROQUINATE
DEHYDRATASE
(Clostridioides
difficile) 		5 / 10 TYR A  98
ILE A 114
ILE A 105
VAL A 128
TYR A  97
 None
 1.15A 5mvnD-3js3A:
undetectable		 5mvnD-3js3A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3js3 3-DEHYDROQUINATE
DEHYDRATASE
(Clostridioides
difficile) 		4 / 4 GLY A 236
PRO A 235
VAL A 232
ARG A 214
 None
None
None
DHS  A 301 (-2.8A)
 1.21A 5uunA-3js3A:
0.0
5uunB-3js3A:
0.0		 5uunA-3js3A:
20.77
5uunB-3js3A:
20.77