SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3js8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		3 / 3 TRP A  32
ALA A  78
VAL A  80
 None
 0.95A 1bdwA-3js8A:
undetectable
1bdwB-3js8A:
undetectable		 1bdwA-3js8A:
2.53
1bdwB-3js8A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		5 / 12 LEU A  68
GLY A 203
VAL A 202
LEU A 540
LEU A 521
 FAD  A 541 (-4.1A)
FAD  A 541 ( 3.7A)
None
None
None
 1.45A 1mx1E-3js8A:
undetectable		 1mx1E-3js8A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		5 / 12 LEU A 347
SER A 342
ARG A 253
VAL A 124
ALA A 147
 None
 1.17A 1n5xA-3js8A:
5.1		 1n5xA-3js8A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		5 / 12 LEU A 347
SER A 342
ARG A 253
VAL A 124
ALA A 147
 None
 1.17A 1n5xB-3js8A:
5.1		 1n5xB-3js8A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		5 / 10 GLY A 123
VAL A 124
LEU A 346
LEU A 220
SER A 342
 None
 1.19A 1pbcA-3js8A:
undetectable		 1pbcA-3js8A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		4 / 4 ALA A 472
VAL A 474
ALA A 473
HIS A 432
 None
 1.25A 1q23F-3js8A:
2.7		 1q23F-3js8A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		4 / 4 ALA A 472
VAL A 474
ALA A 473
HIS A 432
 None
 1.18A 1q23K-3js8A:
undetectable		 1q23K-3js8A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		5 / 9 LEU A 374
VAL A 370
THR A 365
ILE A 148
VAL A 437
 None
 1.45A 2l8mA-3js8A:
undetectable		 2l8mA-3js8A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		5 / 12 ALA A  49
LEU A  82
VAL A  80
ILE A  12
PHE A   8
 None
 1.10A 2qk8A-3js8A:
undetectable		 2qk8A-3js8A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		5 / 12 PHE A 234
MET A 233
ILE A 228
ALA A 256
GLN A 386
 None
 1.39A 2rctA-3js8A:
undetectable		 2rctA-3js8A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		4 / 7 PHE A 226
ALA A 326
PHE A 323
PHE A 259
 None
 0.94A 2vcvL-3js8A:
undetectable		 2vcvL-3js8A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		5 / 9 ALA A  49
LEU A  82
VAL A  80
ILE A  12
PHE A   8
 None
 1.16A 3fl9H-3js8A:
undetectable		 3fl9H-3js8A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		3 / 3 SER A 531
SER A 532
HIS A 201
 None
None
FAD  A 541 (-4.2A)
 0.82A 3mzeA-3js8A:
undetectable		 3mzeA-3js8A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		4 / 6 GLY A 137
GLY A 136
LEU A 171
HIS A 201
 FAD  A 541 (-3.4A)
FAD  A 541 (-3.8A)
None
FAD  A 541 (-4.2A)
 0.77A 3o9mB-3js8A:
undetectable		 3o9mB-3js8A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		4 / 6 PHE A 318
PRO A 447
LEU A 354
VAL A 356
 None
 0.71A 4dubB-3js8A:
undetectable		 4dubB-3js8A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		5 / 12 ILE A 141
ALA A 200
LEU A 540
ILE A 500
PRO A 501
 FAD  A 541 (-4.5A)
None
None
None
None
 1.29A 4gh8B-3js8A:
undetectable		 4gh8B-3js8A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		4 / 7 ALA A 150
SER A 250
VAL A 269
ARG A 253
 None
 1.09A 4ijiH-3js8A:
undetectable		 4ijiH-3js8A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		5 / 10 ALA A 157
ALA A 215
ALA A 159
THR A 125
GLN A 218
 None
 1.19A 4j6cB-3js8A:
undetectable		 4j6cB-3js8A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		3 / 3 LEU A 135
MET A 110
ASP A  94
 None
 0.79A 4j7xB-3js8A:
undetectable		 4j7xB-3js8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		5 / 12 ILE A 195
LEU A 521
VAL A 202
ALA A 200
LEU A 171
 None
 1.26A 4m11C-3js8A:
undetectable		 4m11C-3js8A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		4 / 4 ALA A 516
ALA A 519
ALA A 520
ALA A 523
 None
 0.13A 4oadA-3js8A:
undetectable		 4oadA-3js8A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		4 / 4 ASN A 294
LEU A 330
PHE A 287
TYR A 348
 None
 1.43A 4u14A-3js8A:
0.0		 4u14A-3js8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_C_EF2C151_1
(CEREBLON ISOFORM 4)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		4 / 7 ASN A 264
PHE A 226
TRP A 225
TYR A 247
 None
 1.38A 4v2yC-3js8A:
0.0		 4v2yC-3js8A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		4 / 8 ASN A 264
PHE A 226
TRP A 225
TYR A 247
 None
 1.40A 4v2zC-3js8A:
undetectable		 4v2zC-3js8A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		4 / 6 LYS A 518
LEU A 521
PRO A 197
ARG A 505
 None
 1.26A 4yv5B-3js8A:
undetectable		 4yv5B-3js8A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		4 / 6 LYS A 518
LEU A 521
PRO A 197
ARG A 505
 None
 1.21A 4yv5A-3js8A:
undetectable		 4yv5A-3js8A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		5 / 8 LEU A 135
ALA A 104
LEU A 113
LEU A 139
ALA A 210
 None
 1.06A 4z90A-3js8A:
undetectable
4z90B-3js8A:
undetectable
4z90C-3js8A:
0.7
4z90D-3js8A:
undetectable
4z90E-3js8A:
undetectable		 4z90A-3js8A:
20.98
4z90B-3js8A:
20.98
4z90C-3js8A:
20.98
4z90D-3js8A:
20.98
4z90E-3js8A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		5 / 7 LEU A 135
ALA A 104
LEU A 113
LEU A 139
ALA A 210
 None
 0.95A 4z90F-3js8A:
undetectable
4z90G-3js8A:
undetectable
4z90H-3js8A:
undetectable
4z90J-3js8A:
undetectable		 4z90F-3js8A:
20.98
4z90G-3js8A:
20.98
4z90H-3js8A:
20.98
4z90J-3js8A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		4 / 8 SER A 163
GLY A 143
ALA A 106
GLY A 137
 None
FAD  A 541 (-3.2A)
FAD  A 541 (-3.3A)
FAD  A 541 (-3.4A)
 0.88A 5albL-3js8A:
undetectable		 5albL-3js8A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMH_A_EF2A151_1
(CEREBLON ISOFORM 4)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		4 / 7 ASN A 264
PHE A 226
TRP A 225
TYR A 247
 None
 1.40A 5amhA-3js8A:
undetectable		 5amhA-3js8A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		5 / 11 ILE A 195
PHE A 188
VAL A 168
ILE A 207
ALA A 173
 None
None
None
FAD  A 541 (-4.4A)
None
 1.13A 5lg3A-3js8A:
undetectable		 5lg3A-3js8A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		5 / 12 ILE A 195
PHE A 188
VAL A 168
ILE A 207
ALA A 173
 None
None
None
FAD  A 541 (-4.4A)
None
 1.09A 5lg3E-3js8A:
undetectable		 5lg3E-3js8A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		3 / 3 LYS A 480
TRP A 490
SER A 479
 None
None
FAD  A 541 ( 4.0A)
 1.05A 5nwwA-3js8A:
undetectable		 5nwwA-3js8A:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		5 / 12 ILE A 108
SER A 424
TRP A 478
ILE A 195
LEU A 139
 None
 1.22A 5oy02-3js8A:
undetectable		 5oy02-3js8A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		5 / 12 GLN A 322
LEU A 444
LEU A 446
ILE A 306
ALA A 303
 None
 1.36A 5xprA-3js8A:
undetectable		 5xprA-3js8A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 3js8 CHOLESTEROL OXIDASE
(Chromobacterium
sp.
DS-1) 		4 / 5 VAL A  42
LEU A 206
HIS A 201
THR A  84
 None
FAD  A 541 (-4.8A)
FAD  A 541 (-4.2A)
FAD  A 541 ( 4.5A)
 1.30A 6dyoA-3js8A:
undetectable		 6dyoA-3js8A:
10.77