SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jsa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3jsa HOMOSERINE
DEHYDROGENASE
(Thermoplasma
volcanium) 		5 / 10 ALA A 216
GLY A 240
ALA A 215
THR A 211
ILE A 176
 None
 1.18A 1gtnH-3jsaA:
undetectable
1gtnI-3jsaA:
undetectable		 1gtnH-3jsaA:
14.02
1gtnI-3jsaA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 3jsa HOMOSERINE
DEHYDROGENASE
(Thermoplasma
volcanium) 		3 / 3 ASN A  36
TYR A  48
SER A   7
 None
 0.85A 2gvcB-3jsaA:
undetectable		 2gvcB-3jsaA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 3jsa HOMOSERINE
DEHYDROGENASE
(Thermoplasma
volcanium) 		3 / 3 ASN A  36
TYR A  48
SER A   7
 None
 0.88A 2gvcE-3jsaA:
undetectable		 2gvcE-3jsaA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3jsa HOMOSERINE
DEHYDROGENASE
(Thermoplasma
volcanium) 		5 / 10 ILE A  22
GLY A  10
PHE A   9
VAL A  38
LEU A 320
 None
NAD  A 501 (-3.4A)
None
None
None
 1.31A 3elzB-3jsaA:
undetectable		 3elzB-3jsaA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 3jsa HOMOSERINE
DEHYDROGENASE
(Thermoplasma
volcanium) 		4 / 8 TYR A  47
SER A  43
LEU A  66
ASP A  67
 None
NAD  A 501 (-3.4A)
None
None
 1.14A 3lsfH-3jsaA:
undetectable		 3lsfH-3jsaA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3jsa HOMOSERINE
DEHYDROGENASE
(Thermoplasma
volcanium) 		3 / 3 TYR A 142
ASP A 319
ASP A 113
 None
 0.87A 3ou7B-3jsaA:
undetectable		 3ou7B-3jsaA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3jsa HOMOSERINE
DEHYDROGENASE
(Thermoplasma
volcanium) 		4 / 6 ILE A 322
ASN A 318
HIS A 225
VAL A 160
 None
 1.10A 4ejwB-3jsaA:
undetectable		 4ejwB-3jsaA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3jsa HOMOSERINE
DEHYDROGENASE
(Thermoplasma
volcanium) 		4 / 8 LEU A  11
LEU A  19
VAL A  57
ILE A  52
 NAD  A 501 (-4.9A)
None
None
None
 0.95A 4oj4A-3jsaA:
undetectable		 4oj4A-3jsaA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 3jsa HOMOSERINE
DEHYDROGENASE
(Thermoplasma
volcanium) 		3 / 3 LEU A  19
ARG A  20
ARG A  23
 None
 0.87A 4yiaB-3jsaA:
undetectable		 4yiaB-3jsaA:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 3jsa HOMOSERINE
DEHYDROGENASE
(Thermoplasma
volcanium) 		4 / 4 ILE A 201
ARG A 187
TYR A 178
GLU A 182
 None
SO4  A 502 (-3.7A)
None
None
 0.94A 4zzbD-3jsaA:
undetectable		 4zzbD-3jsaA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 3jsa HOMOSERINE
DEHYDROGENASE
(Thermoplasma
volcanium) 		4 / 5 ILE A 201
ARG A 187
TYR A 178
GLU A 182
 None
SO4  A 502 (-3.7A)
None
None
 1.01A 4zzcE-3jsaA:
undetectable		 4zzcE-3jsaA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 3jsa HOMOSERINE
DEHYDROGENASE
(Thermoplasma
volcanium) 		3 / 3 ARG A 164
THR A 296
ASP A 295
 None
 0.79A 5g5gA-3jsaA:
undetectable
5g5gB-3jsaA:
undetectable		 5g5gA-3jsaA:
22.35
5g5gB-3jsaA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 3jsa HOMOSERINE
DEHYDROGENASE
(Thermoplasma
volcanium) 		4 / 4 VAL A 255
GLU A 257
GLY A 170
LEU A 280
 None
 1.33A 5g5gC-3jsaA:
undetectable		 5g5gC-3jsaA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3jsa HOMOSERINE
DEHYDROGENASE
(Thermoplasma
volcanium) 		5 / 12 ALA A  79
ASP A  89
PHE A   9
GLY A  10
SER A  46
 None
None
None
NAD  A 501 (-3.4A)
None
 1.32A 5hfjA-3jsaA:
undetectable		 5hfjA-3jsaA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 3jsa HOMOSERINE
DEHYDROGENASE
(Thermoplasma
volcanium) 		4 / 7 THR A  91
ASP A  89
TYR A 104
GLY A 121
 NAD  A 501 (-4.7A)
None
None
None
 1.00A 5hwaA-3jsaA:
undetectable		 5hwaA-3jsaA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3jsa HOMOSERINE
DEHYDROGENASE
(Thermoplasma
volcanium) 		5 / 12 VAL A 115
VAL A  14
LEU A 288
GLY A 148
ALA A 144
 None
NAD  A 501 (-3.8A)
None
NAD  A 501 ( 4.7A)
NAD  A 501 (-4.9A)
 1.04A 5iktA-3jsaA:
undetectable		 5iktA-3jsaA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 3jsa HOMOSERINE
DEHYDROGENASE
(Thermoplasma
volcanium) 		5 / 10 LEU A 320
ALA A  41
SER A  46
PHE A   9
LEU A  80
 None
NAD  A 501 (-3.8A)
None
None
None
 1.38A 5mm4B-3jsaA:
undetectable		 5mm4B-3jsaA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3jsa HOMOSERINE
DEHYDROGENASE
(Thermoplasma
volcanium) 		5 / 12 ILE A   8
GLY A  10
PHE A 103
ILE A  86
VAL A 115
 None
NAD  A 501 (-3.4A)
None
None
None
 1.02A 5n0sA-3jsaA:
undetectable		 5n0sA-3jsaA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3jsa HOMOSERINE
DEHYDROGENASE
(Thermoplasma
volcanium) 		5 / 12 ILE A   8
GLY A  10
PHE A 103
ILE A  86
VAL A 115
 None
NAD  A 501 (-3.4A)
None
None
None
 0.97A 5n0tA-3jsaA:
2.2		 5n0tA-3jsaA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3jsa HOMOSERINE
DEHYDROGENASE
(Thermoplasma
volcanium) 		5 / 12 ILE A   8
GLY A  10
PHE A 103
ILE A  86
VAL A 115
 None
NAD  A 501 (-3.4A)
None
None
None
 0.96A 5n0tB-3jsaA:
undetectable		 5n0tB-3jsaA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3jsa HOMOSERINE
DEHYDROGENASE
(Thermoplasma
volcanium) 		5 / 12 ILE A   8
GLY A  10
PHE A 103
ILE A  86
VAL A 115
 None
NAD  A 501 (-3.4A)
None
None
None
 0.97A 5n0wB-3jsaA:
2.4		 5n0wB-3jsaA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3jsa HOMOSERINE
DEHYDROGENASE
(Thermoplasma
volcanium) 		5 / 12 ILE A   8
GLY A  10
PHE A 103
ILE A  86
VAL A 115
 None
NAD  A 501 (-3.4A)
None
None
None
 0.99A 5n0xA-3jsaA:
2.2		 5n0xA-3jsaA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3jsa HOMOSERINE
DEHYDROGENASE
(Thermoplasma
volcanium) 		5 / 12 ILE A   8
GLY A  10
PHE A 103
ILE A  86
VAL A 115
 None
NAD  A 501 (-3.4A)
None
None
None
 0.96A 5n4iA-3jsaA:
undetectable		 5n4iA-3jsaA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 3jsa HOMOSERINE
DEHYDROGENASE
(Thermoplasma
volcanium) 		5 / 12 ALA A 216
SER A 269
GLU A 257
LEU A 254
ILE A 271
 None
 1.45A 5vlmA-3jsaA:
undetectable		 5vlmA-3jsaA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3jsa HOMOSERINE
DEHYDROGENASE
(Thermoplasma
volcanium) 		4 / 6 LEU A   6
VAL A  88
LEU A  18
VAL A 115
 None
 0.91A 5x7zA-3jsaA:
undetectable		 5x7zA-3jsaA:
20.00