SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jst'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 3jst PUTATIVE
PTERIN-4-ALPHA-CARBI
NOLAMINE DEHYDRATASE
(Brucella
melitensis) 		3 / 3 ALA A  65
VAL A  69
TRP A  62
 None
 0.95A 1tkqA-3jstA:
undetectable		 1tkqA-3jstA:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 3jst PUTATIVE
PTERIN-4-ALPHA-CARBI
NOLAMINE DEHYDRATASE
(Brucella
melitensis) 		4 / 6 TYR A  52
ALA A  53
LEU A  56
THR A  82
 None
 0.81A 3b6hA-3jstA:
undetectable		 3b6hA-3jstA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 3jst PUTATIVE
PTERIN-4-ALPHA-CARBI
NOLAMINE DEHYDRATASE
(Brucella
melitensis) 		4 / 6 TYR A  52
ALA A  53
LEU A  56
THR A  82
 None
 0.92A 3b6hB-3jstA:
undetectable		 3b6hB-3jstA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_2
(NEURAMINIDASE)		 3jst PUTATIVE
PTERIN-4-ALPHA-CARBI
NOLAMINE DEHYDRATASE
(Brucella
melitensis) 		4 / 5 LEU A  15
ASP A  19
ARG A  32
TRP A  21
 None
 1.47A 4cpzA-3jstA:
undetectable		 4cpzA-3jstA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 3jst PUTATIVE
PTERIN-4-ALPHA-CARBI
NOLAMINE DEHYDRATASE
(Brucella
melitensis) 		4 / 5 LEU A  15
ASP A  19
ARG A  32
TRP A  21
 None
 1.45A 4mwrA-3jstA:
undetectable		 4mwrA-3jstA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 3jst PUTATIVE
PTERIN-4-ALPHA-CARBI
NOLAMINE DEHYDRATASE
(Brucella
melitensis) 		3 / 3 THR A  31
THR A  72
PHE A  63
 EDO  A  98 ( 4.8A)
EDO  A  98 (-3.9A)
None
 0.85A 5cxvA-3jstA:
undetectable		 5cxvA-3jstA:
10.42