SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jtf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 3jtf MAGNESIUM AND COBALT
EFFLUX PROTEIN
(Bordetella
parapertussis) 		5 / 12 PHE A 165
LEU A 161
ALA A 173
LEU A 172
ILE A  81
 None
 1.10A 1mx8A-3jtfA:
undetectable		 1mx8A-3jtfA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 3jtf MAGNESIUM AND COBALT
EFFLUX PROTEIN
(Bordetella
parapertussis) 		5 / 11 LEU A 161
ALA A 149
ALA A 173
VAL A 191
LEU A 192
 None
 1.19A 1rlbF-3jtfA:
undetectable		 1rlbF-3jtfA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 3jtf MAGNESIUM AND COBALT
EFFLUX PROTEIN
(Bordetella
parapertussis) 		5 / 10 GLY A 180
ASP A 120
ILE A 122
GLY A 184
ALA A 149
 None
 1.05A 1sh9B-3jtfA:
undetectable		 1sh9B-3jtfA:
21.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 3jtf MAGNESIUM AND COBALT
EFFLUX PROTEIN
(Bordetella
parapertussis) 		4 / 6 HIS A 109
PRO A 113
LEU A 185
ASP A 190
 AMP  A   1 (-3.5A)
AMP  A   1 (-4.7A)
None
AMP  A   1 (-2.6A)
 0.57A 3oi8A-3jtfA:
18.8		 3oi8A-3jtfA:
44.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OI8_B_ADNB1_1
(UNCHARACTERIZED
PROTEIN)		 3jtf MAGNESIUM AND COBALT
EFFLUX PROTEIN
(Bordetella
parapertussis) 		6 / 9 HIS A 109
PRO A 113
LEU A 185
THR A 187
GLU A 189
ASP A 190
 AMP  A   1 (-3.5A)
AMP  A   1 (-4.7A)
None
AMP  A   1 (-3.0A)
AMP  A   1 (-3.6A)
AMP  A   1 (-2.6A)
 0.81A 3oi8A-3jtfA:
18.8
3oi8B-3jtfA:
19.3		 3oi8A-3jtfA:
44.79
3oi8B-3jtfA:
44.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3jtf MAGNESIUM AND COBALT
EFFLUX PROTEIN
(Bordetella
parapertussis) 		4 / 4 ASP A 130
ILE A 125
PRO A 113
LEU A 126
 None
None
AMP  A   1 (-4.7A)
None
 1.09A 6mkeA-3jtfA:
undetectable		 6mkeA-3jtfA:
19.53