SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jtj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 3jtj 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Yersinia
pestis) 		5 / 12 GLU A  64
ILE A   4
ILE A  94
ALA A  48
ARG A  44
 None
 1.06A 1ki7B-3jtjA:
undetectable		 1ki7B-3jtjA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3jtj 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Yersinia
pestis) 		5 / 9 LEU A 212
LEU A 215
ILE A 221
PHE A 155
TYR A 185
 None
None
None
None
IMD  A 301 (-3.9A)
 1.27A 2f78B-3jtjA:
undetectable		 2f78B-3jtjA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 3jtj 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Yersinia
pestis) 		4 / 7 ILE A  93
ILE A 108
LEU A 126
ILE A 184
 None
 0.86A 2q83A-3jtjA:
undetectable		 2q83A-3jtjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 3jtj 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Yersinia
pestis) 		5 / 12 GLU A 210
TYR A 187
ILE A 221
VAL A 214
PHE A 191
 IMD  A 301 ( 4.4A)
IMD  A 301 (-4.8A)
None
None
None
 1.38A 2qeoA-3jtjA:
undetectable		 2qeoA-3jtjA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3jtj 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 SER A  74
GLY A  75
THR A  76
 None
None
IMD  A 301 (-4.3A)
 0.22A 3k9wA-3jtjA:
2.7		 3k9wA-3jtjA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3jtj 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Yersinia
pestis) 		4 / 8 SER A 132
ILE A 174
PHE A 137
GLU A 135
 None
 1.21A 4cx7A-3jtjA:
undetectable
4cx7B-3jtjA:
undetectable		 4cx7A-3jtjA:
17.63
4cx7B-3jtjA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3jtj 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Yersinia
pestis) 		4 / 8 SER A 132
ILE A 174
PHE A 137
GLU A 135
 None
 1.16A 4cx7C-3jtjA:
undetectable
4cx7D-3jtjA:
undetectable		 4cx7C-3jtjA:
17.63
4cx7D-3jtjA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 3jtj 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Yersinia
pestis) 		4 / 7 SER A   2
GLY A 190
ASP A  90
GLU A  84
 None
 0.91A 4koeA-3jtjA:
undetectable
4koeB-3jtjA:
undetectable
4koeD-3jtjA:
undetectable		 4koeA-3jtjA:
19.23
4koeB-3jtjA:
19.23
4koeD-3jtjA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 3jtj 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Yersinia
pestis) 		4 / 7 GLY A 190
ASP A  90
GLU A  84
SER A   2
 None
 0.95A 4z53A-3jtjA:
undetectable
4z53B-3jtjA:
undetectable		 4z53A-3jtjA:
16.53
4z53B-3jtjA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3jtj 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Yersinia
pestis) 		4 / 5 ALA A 124
THR A 125
TYR A 185
HIS A 222
 None
None
IMD  A 301 (-3.9A)
None
 1.36A 5ecmA-3jtjA:
undetectable		 5ecmA-3jtjA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 3jtj 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Yersinia
pestis) 		4 / 7 GLN A  98
GLY A  99
GLN A 237
ASP A  50
 None
 1.14A 5vlmE-3jtjA:
undetectable		 5vlmE-3jtjA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 3jtj 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Yersinia
pestis) 		5 / 12 PRO A 106
ILE A 109
ILE A 108
VAL A  97
ILE A 184
 None
 1.09A 6hlpA-3jtjA:
2.7		 6hlpA-3jtjA:
20.20